|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Insulin resistance and chronic liver disease显示文摘Increased insulin resistance is frequently associated with chronic liver disease and is a pathophysiological feature of hepatogenous diabetes.Distinctive factors including hepatic parenchymal cell damage,portalsystemic shunting and hepatitis C virus are responsible for the development of hepatogenous insulin resistance/diabetes.Although it remains unclear whether insulin secretion from pancreatic beta cells is impaired as it is in type 2 diabetes,retinopathic and cardiovascular risk is low and major causes of death in cirrhotic patients with diabetes are liver failure,hepatocellular carcinoma and gastrointestinal hemorrhage.Hemoglobin A1c is an inaccurate marker for the assessment and management of hepatogenous diabetes.Moreover,exogenous insulin or sulfonylureas may be harmful because these agents may promote hepatocarcinogenesis.Thus,pathogenesis,cause of death,assessment and therapeutic strategy for hepatogenous insulin resistance/diabetes differ from those for lifestyle-related type 2 diabetes.In this article,we review features of insulin resistance in relationship to chronic liver disease.We also discuss the impact of anti-diabetic agents on interferon treatment and hepatocarcinogenesis. | Takumi Kawaguchi Eitaro Taniguchi Minoru Itou Masahiro Sakata Shuji Sumie Michio Sata | 2011 | World Journal of Hepatology2011，3，5： | 25 |
| 2 | Dipeptidyl peptidase-4: A key player in chronic liver disease显示文摘Dipeptidyl peptidase-4 (DPP-4) is a membrane-associated peptidase, also known as CD26. DPP-4 has widespread organ distribution throughout the body and exerts pleiotropic effects via its peptidase activity. A representative target peptide is glucagon-like peptide-1, and inactivation of glucagon-like peptide-1 results in the development of glucose intolerance/diabetes mellitus and hepatic steatosis. In addition to its peptidase activity, DPP-4 is known to be associated with immune stimulation, binding to and degradation of extracellular matrix, resistance to anti-cancer agents, and lipid accumulation. The liver expresses DPP-4 to a high degree, and recent accumulating data suggest that DPP-4 is involved in the development of various chronic liver diseases such as hepatitis C virus infection, non-alcoholic fatty liver disease, and hepatocellular carcinoma. Furthermore, DPP-4 occurs in hepatic stem cells and plays a crucial role in hepatic regeneration. In this review, we described the tissue distribution and various biological effects of DPP-4. Then, we discussed the impact of DPP-4 in chronic liver disease and the possible therapeutic effects of a DPP-4 inhibitor. | Minoru Itou Takumi Kawaguchi Eitaro Taniguchi Michio Sata | 2013 | World Journal of Gastroenterology2013，19，15： | 22 |
| 3 | Augmentation of tumor necrosis factor family-induced apoptosis by E3330 in human hepatocellular carcinoma cell lines via inhibition of NFκB显示文摘AIM: To investigate the reduction of cell viability in human hepatocellular carcinoma (HCC) cell lines induced by inhibition of nuclear factor κB (NFκB). METHODS: HLE, SKHep1, and HepG2 were incubated and E3330 was used to compare the stimulation of some chemotherapeutic drugs with that of TNF family, Fas ligand, TNFα and TNF-related apoptosis-inducing ligand (TRAIL) at the point of the reduction of cell viability by inhibiting NFκB. RESULTS: E3330 decreased NFκB levels in HLE cells stimulated by TNF and TRAIL. The cytotoxicity of the combination of TRAIL, TNFα, Fas ligand, and E3330 increased synergistically in a dose-dependent manner compared to either E3330 alone in all HCC cell lines by MTT assay. However, the combination of some chemotherapeutic drugs and E3330 did not decrease the cell viability. CONCLUSION: Inhibition of NFκB sensitizes human HCC cell lines to TNF-mediated apoptosis including TRAIL, and TRAIL-based tumor therapy might be a powerful potential therapeutic tool in the treatment of human HCC. | Yukiko Saitou Katsuya Shiraki Takenari Yamanaka Kazumi Miyashita Tomoko Inoue Yutaka Yamanaka Yumi Yamaguchi Naoyuki Enokimura Norihiko Yamamoto Keiichi Itou Kazushi Sugimoto Takeshi Nakano | 2005 | World Journal of Gastroenterology2005，11，40： | 3 |
| 4 | Decreased death from gastric cancer by endoscopic screening: Association with a population-based cancer registry显示文摘 | Osamu Hosokawa Tamon Miyanaga Yasuharu Kaizaki Masakazu Hattori Kenji Dohden Kouji Ohta Yoshitaka Itou Hiroyuki Aoyagi | 2008 | Scandinavian Journal of Gastroenterology2008，，9： | 2 |
| 5 | Detection of rabies virus RNA isolated from several species of animals in Brazil by RT-PCR显示文摘 | Ito M Itou T Sakai T | 2001 | J Vet Med Sci2001，63，12： | 1 |
| 6 | Diffraction of an antiplane shear wave by two coplanar giffith cracks in an infinite elastic medium显示文摘 | Itou S | 1995 | Int J Solid Structure1995，，16： | 1 |
| 7 | B1500,a small membrane protein,connects the two-component systems EvgS/EvgA and PhoQ/PhoP in Escherichia coli显示文摘 | Eguchi Y K Itou J J Yamane M T | 2007 | Proc Natl Acad Sci USA2007，104，18： | 1 |
| 8 | Genetic and phylogenetic analysis of glycoprotein of rabies virus isolated from several species in Brazil 显示文摘 | Sato G Itou T Shoji Y | 2004 | J Vet Med Sci2004，66，7： | 1 |
| 9 | Serum level of free fatty acids is associated with nocturnal hypoglycemia in cirrhotic patients with HCV infection: a pilot study 显示文摘 | Kawaguchi T Itou M Tanlguchi E | 2011 | Hepatogastroenterology2011，58，105： | 1 |
| 10 | Soft X-ray monochromator with a varied-space plane grating for synchrotron radiation: design and evaluation显示文摘 | M Itou T Harada T Kita | 1989 | Appl Opt1989，28，1： | 1 |
| 11 | Development of the Shaking Vibration Control for Electric Vehicles显示文摘 | KARIKOMI T ITOU K OKUBO T | 2006 | SICE-ICASE International Joint Conference 2006:2434-24392006，2006，： | 1 |
| 12 | Antihypertensive effect of narezushi, a fermented mackerel product, on spontaneously hypertensive rats 显示文摘 | Itou K Nagahashi R Saitou M | 2007 | Fisheries Science2007，73，： | 1 |
| 13 | Genomic regions affecting backfat thickness and cannon bone circumference identified by genome‐wide association study in a D uroc pig population显示文摘 | Naohiko Okumura Toshimi Matsumoto Takeshi Hayashi Kensuke Hirose Kazuo Fukawa Tetsuya Itou Hirohide Uenishi Satoshi Mikawa Takashi Awata | 2013 | Anim Genet2013，，4： | 1 |
| 14 | Identifi-cation of new genetic subtypes of bovine viral diar-rhea virus genotype 1isolated in Japan显示文摘 | NAGAI M HAYASHI M ITOU M | 2008 | VirusGen2008，36，1： | 1 |
| 15 | Safety and efficacy of oral re- hydration therapy until 2h before surgery: A multicenter randomized controlled triM显示文摘 | Itou K Fukuyama T Sasabuchi Y | 2012 | J Anesthe2012，26，1： | 1 |
| 16 | 查看详情显示文摘 | Ahmed A Itou M Xu S G | | 0，，： | 1 |
| 17 | Development of large-capacity,highly efficient welded rotor for steam turbines显示文摘 | Shige T Magoshi R Itou S | 2001 | Mitsubishi Heavy Industries Technical Review2001，38，1： | 1 |
| 18 | Dipeptidyl peptidase IV inhibitor improves insulin resistance and steatosis in a refrac- tory nonalcoholic fatty liver disease patient: a case report 显示文摘 | Itou M Kawaguchi T Taniguchi E | 2012 | Gastroenterology2012，6，2： | 1 |
| 19 | Genetic and phylogenetic analysis of glycoprotein of rabies virus isolated from several species in Brazil显示文摘 | Sato G Itou T Shoji Y | 2004 | J Vet Med Sei2004，66，： | 1 |
| 20 | Soft X-ray monochromator with a varied-space plane grating for synchrotron radiation:design and evaluation显示文摘 | ITOU M HARADA T | 1989 | Applied Optics1989，28，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员