|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 2 | Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial显示文摘 | John Primrose Stephen Falk Meg Finch-Jones Juan Valle Derek O’Reilly Ajith Siriwardena Joanne Hornbuckle Mark Peterson Myrddin Rees Tim Iveson Tamas Hickish Rachel Butler Louise Stanton Elizabeth Dixon Louisa Little Megan Bowers Sian Pugh O James Garden D | 2014 | Lancet Oncology2014，，6： | 2 |
| 3 | Relationships among bile tolerance, bile salt deconjungation and assimilation of cholesterol by lactobacillus acidophilus显示文摘 | Derek K Walker D K Gilliland S E | 1993 | J Dairy SCI1993，76，： | 2 |
| 4 | Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression显示文摘 | Yoo Byoung Kwon Emdad Luni Su Zao-zhong Villanueva Augusto Chiang Derek Y Mukhopadhyay Nitai D Mills Alan Scott Waxman Samuel Fisher Robert A Llovet Josep M Fisher Paul B Sarkar Devanand | 2009 | Journal of Clinical Investigation2009，，3： | 2 |
| 5 | Lethal and sub-lethal effects of the salmon delousing agent dichlorvos on the larvae of the lobster (Homarus gammarus L) and herring (Clupea harengus L)显示文摘 | JOHN G M DEREK S DUNCAN D S | 1991 | Aquaculture1991，98，： | 1 |
| 6 | B-type natriuretic peptide limits infarct size in rate isolated hearts via KATP channel opening显示文摘 | Savio P Souza D Derek M | 2003 | Sm J Physiol Heart Circ Physiol2003，284，6： | 1 |
| 7 | From Rumors to Facts, and Facts to Rumors: The Role of Certainty Decay in Consumer Communications 显示文摘 | Dubois D Derek D R Zakary L T | 2011 | Journal of Marketing Research2011，48，6： | 1 |
| 8 | The Use of an Interspinous Implant in Conjunction With a Graded Facetectomy Procedure 显示文摘 | Fuchs P D Derek PL Ken YH | 2005 | SPINE2005，30，11： | 1 |
| 9 | B-type natriuretic peptide limits infarct size in rate isolated hearts via KATPchannel opening显示文摘 | Savio P D'Souza Derek M | 2003 | Sm J Physiol Heart Circ Physiol2003，284，： | 1 |
| 10 | Wet-end behavior of dry strength addi- fives 显示文摘 | Derek Abson Brooks D F | 1985 | TAPPI J1985，68，1： | 1 |
| 11 | Myocardial reperfusion injury显示文摘 | Derek M Yellon D Sc Derek J Hausenloy | 2007 | N Engl J Med2007，357，： | 1 |
| 12 | Short-term alcohol and drug treatment outcomes predict long-term outcome显示文摘 | Constance Weisner G Thomas Ray Jennifer R Mertens Derek D Satre Charles Moore | 2003 | Drug and Alcohol Dependence2003，，3： | 1 |
| 13 | Comparison of various online IGRT strategies : The benefits of online treatment plan re-optimization 显示文摘 | Derek S Liang J Yan D | 2009 | Radiother Onco12009，90，3： | 1 |
| 14 | Waterborne epoxy protective coatings for metal显示文摘 | Jim D Elmore Derek S Kincaid Pratap C Komar | 2002 | Journal of Coatings Technology2002，74，931： | 1 |
| 15 | Safety and feasibility of motexafin gadolinium administration with whole brain radiation therapy and ster- eotactic radiosurgery boost in the treatment of 6 brain metastases: a multi - institutional phase II trim 显示文摘 | Derek R M Pierre C Anne D | 2011 | Journal of Neuro -Oncology2011，105，2： | 1 |
| 16 | Mucoepidermoid Carcinoma of the Parotid Gland:The Mayo Clinic Experience显示文摘 | Derek Kofi O Boahene Kerry D | 2004 | Arch Otolaryngol Head NeckSurg2004，130，： | 1 |
| 17 | Syntheses and absolute configu- ration assignments of mono ~ and di - substituted chiral quinoline al- kaloids obtained by asymmetric oxidation 显示文摘 | Stephen A Derek R Narain D | 2009 | Heterocycles2009，19，： | 1 |
| 18 | In situ light scattering measurements of mainstream and sidestream cigarette smoke显示文摘 | CHUNG I P DEREK D R | 1996 | Aerosol Science and Technology1996，24，2： | 1 |
| 19 | Understanding the origin, activation and regulation of matrix‐producing myofibroblasts for treatment of fibrotic disease显示文摘 | Rafael Kramann Derek P DiRocco Benjamin D Humphreys | 2013 | J Pathol2013，，3： | 1 |
| 20 | Potential effects of flavonoids on the etiology of vascular disease 显示文摘 | Schramm Derek D German J | 1998 | J Nutri Biochem1998，9，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员