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| 1 | Larvicidal activity of Dregea volubilis and Bombax malabaricum leaf extracts against the filarial vector Culex quinquefasciatus显示文摘Objective:To analyze the larvicidal activity of two plant leaf powder and leaf-extracts, Dregea volubilis and Bombax malabaricum against Culex quinquefasciatus.Methods:The larvicidal bioassay was done for powdered leaves of Dregea volubilis and Bombax malabaricum individually and their methanol extracts against first-,second-,third- and fourth-instar larval forms of Culex quinquefasciatus.Mortality rate was recorded after 24,48 and 72 h of postexposure. LC50 and LG90 values were calculated at different time intervals for third instar larvae. Results:All the graded concentration(0.1%,0.2%,0.3%,0.4%,0.5%) of powdered leaves showed significant(P <0.05) larval mortality.The mortality rate was higher in 50 ppm doses of methanolic extracts of both the plants against Culex quinquefaciatus.The corresponding <C50 values were 56.97 ppm and 48.85 ppm,respectively after 24 h of exposure.There is no mortality of non-target organism such as Chironomous circumdatus,Oreochromis niloticus niloticus and Diplonichus annulatum within 72 h of post exposure to 0.1%,0.2%,0.3%crude powdered leaves and methanolic extracts of both the two individual plants under the laboratory condition.The results of preliminary qualitative phytochemical analysis of both the plants revealed the presence of many bioactive principles such as steroids,tannins,flavonoids,triterpenoids,saponins,etc. that may be responsible for their bio-control potentiality.Conclusions:The results have shown potential and eco-friendly use of both plant extracts against larva of Culex quinquefasciatus for the first time. | Emdad Hossain Anjali Rawani Goutam Chandra Subhash C.Mandal Jayanta Kumar Gupta | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，6： | 3 |
| 2 | Leonurus sibiricus L.(honeyweed):A review of its phytochemistry and pharmacology显示文摘Leonurus sibiricus is a herbaceous plant found in many countries in Asia and America.This plant is widely practiced as a remedy for the treatment of diabetes,menstrual irregularities,and bronchitis.The approval of therapeutic implications of any drugs depends on the well characterized mode of actions of the compounds.The bioactive compounds like diterpenes,triterpenes,flavonoids and phenolic acids in Leonurus sibiricus show analgesic,anti-inflammatory,anti-oxidant,anti-atherogenic and antihemorrhagic,anti-diabetic,anti-bacterial and allelopathic potency.Interestingly,the expression level of some genes is altered by the crude extract treatments,which are effective against cancers,diabetes and cardiovascular diseases where the molecular mechanisms are yet to be explored.Intriguingly,the extracts significantly induce nitric oxide production by endothelial nitric oxide synthase,a signaling molecule of vasodilation in combination with interferon-y indicating positive effect on atherosclerosis.Further investigations are required to unlock the effects of bioactive compounds found in extracts at clinical settings. | Abu Sayed AshraM Alam Shariful Islam Taif Ali Emdad Ullah Abu Zaffar Shibly Aslam Ali Mahdi Hasan-Olive | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，12： | 2 |
| 3 | Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression显示文摘 | Yoo Byoung Kwon Emdad Luni Su Zao-zhong Villanueva Augusto Chiang Derek Y Mukhopadhyay Nitai D Mills Alan Scott Waxman Samuel Fisher Robert A Llovet Josep M Fisher Paul B Sarkar Devanand | 2009 | Journal of Clinical Investigation2009，，3： | 2 |
| 4 | Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling显示文摘 | Lee SG Su ZZ Emdad L | 2008 | Oncogene2008，27，8： | 1 |
| 5 | Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and reglxlates angiogenesis显示文摘 | Emdad L Lee S G Su Z Z | 2009 | Proc Natl Acad Sci USA2009，106，21： | 1 |
| 6 | Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression 显示文摘 | Yoo BK Emdad L Su ZZ | 2009 | J Clin Invest2009，119，3： | 1 |
| 7 | Astroeyte elevated gene - 1 : a no- vel target for human glioma therapy 显示文摘 | Emdad L Sarkar D Lee SG | 2010 | Mol Cancer Ther2010，9，1： | 1 |
| 8 | Cloning and characterization of SARI ( suppressor of AP-1, regulated by IFN) 显示文摘 | Su Z Z Lee S G Emdad L | 2008 | Proc Natl Acad Sci U S A2008，105，20： | 1 |
| 9 | Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinosito) 3-kinase and c-Myc 显示文摘 | Lee SG Su ZZ Emdad L | 2006 | Proc Natl Acad Sci USA2006，103，17： | 1 |
| 10 | mda-9/Syntenin regulates the metastatic phenotype in human melanoma cells by activating nuclear factor-kappaB 显示文摘 | Boukerche H Su Z Z Emdad L | 2007 | Cancer Res2007，67，4： | 1 |
| 11 | Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis 显示文摘 | Emdad L Lee SG Su ZZ | 2009 | Proc Natl Acad Sci USA2009，106，21： | 1 |
| 12 | Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal ceHs显示文摘 | Su Z Emdad L Sauane M | 2005 | Oncogene2005，24，51： | 1 |
| 13 | Astrocyte elevated gene - 1 regulates hepatocellular carcinoma development and progres- sion 显示文摘 | Yoo BK Emdad L Su ZZ | 2009 | J Clin Invest2009，119，3： | 1 |
| 14 | Embryonic stem cell (ESC)-mediated tmnsgene delivery induces growth suppression,apoptosis and radiosensitization,and over- comes temozolomide resistance in malignant gliomas 显示文摘 | Germano M Emdad L Qadeer Z A | 2010 | CancerGene Ther2010，17，9： | 1 |
| 15 | Enterovirus 2Apro targets MDA5and MAVS in infected cells显示文摘 | Feng Q Langereis M A Lork M Nguyen M Hato S V Lanke K Emdad L Bhoopathi P Fisher P B Lloyd R E van Kuppeveld F J | 2014 | J Virol2014，88，6： | 1 |
| 16 | Astrocyte elevated gene- 1 regulates hepatocellular carcinoma development and progres- sion显示文摘 | Yoo BK Emdad L Su ZZ | 2009 | J Clin Invest2009，119，3： | 1 |
| 17 | Historical perspective and recent insights into our understanding of the molecular and biochemical basis of the antitumor properties of mda-7/IL-24 显示文摘 | Emdad L Lebedeva I V Su Z Z | 2009 | Cancer Biol Ther2009，8，： | 1 |
| 18 | Activation of the nuclear factor kappaB pathway by astrocyte elevated gene - 1 :impli- cations for tumor progression and metastasis 显示文摘 | Emdad L Sarkar D Su ZZ | 2006 | Cancer Res2006，66，： | 1 |
| 19 | mda-7/IL-24, novel antican- cer cytokine : focus on bystander antitumor, radiosensitization and antiangiogenie properties and overview of the phase I clinical expe- rience 显示文摘 | Lebedeva I V Emdad L Su Z Z | 2007 | Int J Oncol2007，31，5： | 1 |
| 20 | Astrocyte elevated gene-1(AEG-1):A multifunctional regulator of normal and abnormal physiology显示文摘 | Yoo BK Emdad L Lee SG | 2011 | Pharmacol Ther2011，130，1： | 1 |
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