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| 1 | Synthesis, docking and ADMET prediction of novel 5-((5-substituted-1-H-1,2,4-triazol-3-yl) methyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine as antifungal agents显示文摘A novel series of 5-((5-substituted-1H-1,2,4-triazol-3-yl)methyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridines 5(a–i) has been synthesized from thienopyridine hydrazide, substituted aromatic nitriles using 4-dimethylaminopyridine(DMAP) as a catalyst under microwave irradiation and evaluated for their in vitro antifungal activity. Compound 5g is found to be more potent against Candida albicans when compared with miconazole. Docking study of the newly synthesized compounds was performed, and results showed good binding mode in the active site of fungal enzyme P450 cytochrome lanosterol 14 ademethylase. ADMET properties of synthesized compounds were also analyzed and showed good drug like properties. The results of in vitro antifungal activity, docking study and ADMET prediction revealed that the synthesized compounds have potential antifungal activity and can be further optimized and developed as a lead compound. | Jaiprakash N. Sangshetti Firoz A. Kalam Khan Rashmi S. Chouthe Manoj G. Damale Devanand B. Shinde | 2014 | Chinese Chemical Letters2014，25，7： | 6 |
| 2 | Sulphamic Acid (H2NSO3H)-Catalyzed Multicomponent Reaction of β-Naphthol: An Expeditious Synthesis of Amidoalkyl Naphthols显示文摘Sulphamic 酸(H2NSO3H ) 被发现是为 -naphthol, 的 multicomponent 冷凝作用反应的有效催化剂芳香的醛和脲或酰胺到在好收益负担得起相应 -amidoalkyl--naphthols。这个新过程的显著特征是高变换,短反应时间,干净反应侧面并且简单试验性并且病情的检查过程。 | NAGAWADE, Rahul R. SHINDE, Devanand B. | 2007 | Chinese Journal of Chemistry2007，25，11： | 6 |
| 3 | Oxalic acid catalyzed solvent-free one pot synthesis of coumarins显示文摘草酸酸被发现是为 Pechmann 冷凝作用的有效催化剂,它包括在酚和香豆素衍生物的β - keto 酉旨导致形成之间的反应。现在的方法的优点是便宜、容易的可得到的催化剂,没有溶剂的反应条件,更好的收益和更短的反应时间的使用。 | Nagnnath D.Kokare Jaiprkash N.Sangshetti Devanand B.Shinde | 2007 | Chinese Chemical Letters2007，18，11： | 4 |
| 4 | 经支气管超声引导针吸活检(EBUS-TBNA)在肺癌诊断及分期中的应用显示文摘经支气管超声引导针吸活检(endobronchial ultrasound guided tranbronchial needle aspiration,EBUS-TBNA)支气管镜具有一置入的微型超声探头,以便实现实时的TBNA活检。在肺癌中,EBUS-TBNA的敏感性为88%-90%,特异性为100%。受试者工作特征曲线下面积低于0.99时,测试效果良好。其诊断率显著优于传统盲法TBNA。然而,其假阴性率仍然很高,大约为20%。因此,阴性针吸结果需经纵隔镜检查、外科取样或临床随访证实。新辅助化疗后纵隔的再分期并不十分乐观,据报道,EBUS-TBNA的敏感性仅为76%,阴性预测值仅为20%。该方法亦已被成功用于获取气管旁及支气管周围区域原发肿瘤的活检标本,敏感性为82%-94%。EBUS-TBNA的优势在于其可在门诊中实施,患者仅需中度镇静,且无需电离辐射消毒。尽管在多数研究机构中EBUS-TBNA目前仍仅用于肿大淋巴结的靶向取样,但也有可能实现影像学检查正常的纵隔的完全分期。因此,如果设备及专家条件具备,EBUS-TBNA可作为肺癌诊断及有创分期的一线方案之一。 | Devanand ANANTHAM Mariko Siyue KOH 丁燕(译) 南娟(译) 刘谦(校) | 2010 | 中国肺癌杂志2010，13，5： | 4 |
| 5 | BF_3·OEt_2 Promoted Solvent-free Synthesis of Benzimidazole Derivatives显示文摘Differently substituted benzimidazoles have been synthesized in very good yields in solvent-free conditions from o-phenylenediamine and aldehydes in the presence of BF3·OEt2 as a catalyst. The method is applicable to aromatic, unsaturated and aliphatic aldehydes and to substituted o-phenylenediamines without significant differences. | Rahul R.NAGAWADE Devanand B.SHINDE | 2006 | Chinese Chemical Letters2006，17，4： | 2 |
| 6 | Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression显示文摘 | Yoo Byoung Kwon Emdad Luni Su Zao-zhong Villanueva Augusto Chiang Derek Y Mukhopadhyay Nitai D Mills Alan Scott Waxman Samuel Fisher Robert A Llovet Josep M Fisher Paul B Sarkar Devanand | 2009 | Journal of Clinical Investigation2009，，3： | 2 |
| 7 | Oxalic acid as a catalyst for efficient synthesis of bis-(indolyl)methanes,and 14-aryl-14H-dibenzo[a,j]xanthenes in water显示文摘一简单,有效,并且环境良性的线路为二度的准备被开发 --(indolyl ) 甲烷和 14-aryl-14H-dibenzo [一, j ] 从有吲哚的各种各样的芳香的醛或酉同类的冷凝作用的氧杂蒽,和 2 萘粉在水的媒介的分别地,使用的草酸酸催化剂。便宜、容易可得到的催化剂,更好的收益和简单反应协议的使用是现在的方法的优点。 | Nagnnath D.Kokare Jaiprakash N.Sangshetti Devanand B.Shinde | 2008 | Chinese Chemical Letters2008，19，10： | 2 |
| 8 | ZrOCl_2·8H_2O catalyzed one-pot synthesis of 2,4,5-triaryl-1H-imidazoles and substituted 1,4-di(4,5-diphenylimidazolyl)benzene显示文摘一个简单一个壶为从安息香或 benzil,铵醋酸盐,芳香的醛,和 ZrOCl2 路 8 H2O 催化剂的 2,4,5-triaryl-1H-imidazoles 的准备的合成方法被描述。ZrOCl2 路 8 H2O 催化剂被发现同等地有效为芳香并且 heteroaromatic 醛并且另外为代替的 1,4-di (4,5-diphenylimidazol-yl ) 的准备苯。 | Jaiprakash N.Sangshetti Nagnnath D.Kokare Sandeep A.Kotharkar Devanand B.Shinde | 2008 | Chinese Chemical Letters2008，19，7： | 2 |
| 9 | Psychopathological features in Alzheimer's disease:Course and relationship with cognitive status显示文摘 | Holtzer R Tang MX Devanand DP | 2003 | JAGS2003，51，： | 1 |
| 10 | Hippocampal and entorhinal atrophy in mild cognitive impairment:prediction of Alzheimer disease显示文摘 | Devanand DP Pradhaban G Liu X | | 0，，11： | 1 |
| 11 | Absence of cognitive impairment after more than 100 lifetime ECT treatments 显示文摘 | Devanand DP Verma AK Tirumalasetti F | 1991 | Am J Psychiatry1991，148，7： | 1 |
| 12 | Hippocampal and entorhinal atrophy in mild cognitive impairment prediction of Alzheimer disease显示文摘 | Devanand DP Pradhaban G Liu X | 2007 | Neurology2007，68，11： | 1 |
| 13 | Zirconyl Chloride Promoted Highly Efficient Domino Synthesis of New 1, 2, 3, 4-Tetrahydroquinoline Derivatives in Water显示文摘The tetrahydroquinoline moiety is a structural feature of many natural products. By using a domino reaction of aromatic amines and cyclic enol ethers catalyzed by zirconyl chloride in water, various tetrahydroquinoline derivatives were synthesized efficiently. Most cyclized products showed cis selectivity. The cis selectivity was tentatively rationalized due to chelation control in water. | Rahul R.NAGAWADE Devanand B.SHINDE | 2006 | Chinese Chemical Letters2006，17，9： | 1 |
| 14 | Subjective side effects during electroconvulsive therapy显示文摘 | Devanand DP Fitzsimons L Prudic J | 1995 | Convuls Ther1995，11，4： | 1 |
| 15 | Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease显示文摘 | Devanand DP Pradhaban G Liu X | 2007 | Neurology2007，68，11： | 1 |
| 16 | (99m)Tchexamethyl propylene-aminoxime single-photon emissioncomputed tomography prediction of conversion from mildcognitive impairment to Alzheimer disease 显示文摘 | Devanand DP Van Heertum RL Kegeles LS | 2010 | Am J GeriatrPsychiatry2010，18，11： | 1 |
| 17 | Effect of electroconvulsive therapy on plasma vasorpression显示文摘 | Lisanby S Lo ES | 1998 | Biol Psychiatry1998，44，： | 1 |
| 18 | Questionable demantia:Clinial course and predictors of outcome显示文摘 | Devanand DP Folz M Gorly M | 1997 | J Am Geriatr Soc1997，45，3： | 1 |
| 19 | (99m) Tchexa- methyl-propylene-aminoxime single-photon emission computed tomography prediction of conversion from mild cognitive impairment to Alzheimer disease 显示文摘 | Devanand DP Van Heertum RL Kegeles LS | 2010 | Am J Geriatr Psychiatry2010，18，： | 1 |
| 20 | Adverse life events in elderly patients with major depression or dysthymic disorder and in healthy-control subjects 显示文摘 | Devanand DP Kim MK Paykina N | 2002 | Am J Geriatr Psychiatry2002，10，3： | 1 |
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