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| 1 | Phage therapy: An alternative to antibiotics in the age of multi-drug resistance显示文摘The practice of phage therapy, which uses bacterial viruses(phages) to treat bacterial infections, has been around for almost a century. The universal decline in the effectiveness of antibiotics has generated renewed interest in revisiting this practice. Conventionally, phage therapy relies on the use of naturally-occurring phages to infect and lyse bacteria at the site of infection. Biotechnological advances have further expanded the repertoire of potential phage therapeutics to include novel strategies using bioengineered phages and purified phage lytic proteins. Current research on the use of phages and their lytic proteins against multidrug-resistant bacterial infections, suggests phage therapy has the potential to be used as either an alternative or a supplement to antibiotic treatments. Antibacterial therapies, whether phage-or antibiotic-based, each have relative advantages and disadvantages; accordingly, many considerations must be taken into account when designing novel therapeutic approaches for preventing and treating bacterial infection. Although much about phages and human health is still being discovered, the time to take phage therapy serious again seems to be rapidly approaching. | Derek M Lin Britt Koskella Henry C Lin | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，3： | 20 |
| 2 | Diagnosis and surgical management of breast cancer metastatic to the spine显示文摘Breast cancer is the most common malignancy and the second leading cause of death in Western women. Breast cancer most commonly metastasizes to the bone and has a particular affinity with the spine, accounting for 2/3 of osseous metastases discovered. With significant improvements in cancer therapies, the number of patients at risk for symptomatic spinal metastases is likely to increase. Patients may suffer from intractable pain and neurological dysfunction, negatively influencing their quality of life. Timely diagnosis of patients is crucial and has been aided by several breakthrough advances in imaging techniques which aid in detection, staging, and follow-up of bone metastases. Breast metastases are usually responsive to hormonal therapy and pharmacologic interventions, but skeletal metastases often require surgical intervention. The treatments are palliative but goals include the preserving or restoring neurologic function, ensuring spinal stability, and relieving pain. Advances in surgical techniques and instrumentation have allowed more effective decompres-sion and stabilization of the spine, and with the support of recent evidence the trend has shifted towards using more advanced surgical options in appropriately selected patients. In this review, the clinical presentation, diagnosis, patient selection, and surgical management of breast cancer metastatic to the spine are discussed. | Derek G Ju Alp Yurter Ziya L Gokaslan Daniel M Sciubba | 2014 | World Journal of Clinical Oncology2014，5，3： | 4 |
| 3 | Modified technique of advanced core decompression for treatment of femoral head osteonecrosis显示文摘BACKGROUND Osteonecrosis of the femoral head(ONFH)is a destructive condition most commonly affecting young and middle-aged patients.The leading consequence of ONFH is often a significant articular disability.Effective joint-preserving surgical treatments are urgently needed for patients with early stage ONFH when outcomes of treatment are in general better than the advanced stage disease.AIM To introduce a new surgery procedure called percutaneous expanded core decompression and mixed bone graft technique,which is a new way of jointpreserving surgical treatments.METHODS The clinical data of 6 patients with ONFH diagnosed and treated with the procedure called percutaneous expanded core decompression and mixed bone graft technique at The First Hospital of Qiqihar from March 2013 to August 2019 were retrospectively analyzed;the follow-up ended in December 2019.RESULTS There were 6 male patients with an average age of 43 years in our study.Gratifying results have been obtained from the comparison of Harris hip score,visual analogue scale,and imaging examination before and after operation.CONCLUSION This new modified technique is simple,safe,and reliable.No serious perioperative complications were observed in our cases.Advantages of the single blade expandable reamer are obvious.The adjuvant substance is inexpensive and easy to obtain.Thus,this technique is an effective joint-preserving surgical treatment for patients with early stage of ONFH. | Lin Lin Yan Jiao Xian-Guo Luo Jin-Zhu Zhang He-Liang Yin Li Ma Bo-Ran Chen Derek M Kelly Wei-Kuan Gu Hong Chen | 2020 | World Journal of Clinical Cases2020，8，13： | 3 |
| 4 | Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression显示文摘 | Yoo Byoung Kwon Emdad Luni Su Zao-zhong Villanueva Augusto Chiang Derek Y Mukhopadhyay Nitai D Mills Alan Scott Waxman Samuel Fisher Robert A Llovet Josep M Fisher Paul B Sarkar Devanand | 2009 | Journal of Clinical Investigation2009，，3： | 2 |
| 5 | Lethal and sub-lethal effects of the salmon delousing agent dichlorvos on the larvae of the lobster (Homarus gammarus L) and herring (Clupea harengus L)显示文摘 | JOHN G M DEREK S DUNCAN D S | 1991 | Aquaculture1991，98，： | 1 |
| 6 | B-type natriuretic peptide limits infarct size in rate isolated hearts via KATP channel opening显示文摘 | Savio P Souza D Derek M | 2003 | Sm J Physiol Heart Circ Physiol2003，284，6： | 1 |
| 7 | The immunophysiological impaet of bacterlal CpC DNA on the gut显示文摘 | James L Derek M | 2006 | Clin Chim Acta2006，364，12： | 1 |
| 8 | Temperature dependence of particle-particle adherence forces in ice and clathrate hydrates显示文摘 | Yang Sung-oh Kleehammer Derek M | 2004 | Journal of Colloid and Interface Science2004，277，： | 1 |
| 9 | New insights into magnetic derivatives for structural mapping 显示文摘 | Verduzco Bruno Fairhead J Derek Green Chris M | 2004 | The Leading Edge2004，23，： | 1 |
| 10 | Biological activity of cryopreserved bovine spermatogonial stem cells during in vitro culture显示文摘 | Jon M O Jerry J R Derek J M | 2004 | Biology of Reproduction2004，71，： | 1 |
| 11 | Engineered and Designed Peptide-based Fibrous Biomaterials显示文摘 | CAIT E M DEREK P WPPLFSON N | 2004 | Current Opinion in Solid State and Materials and Science2004，，8： | 1 |
| 12 | B-type natriuretic peptide limits infarct size in rate isolated hearts via KATPchannel opening显示文摘 | Savio P D'Souza Derek M | 2003 | Sm J Physiol Heart Circ Physiol2003，284，： | 1 |
| 13 | Temperature dependence of particle-particle adherence forces in ice and clathrate hydrates显示文摘 | Sung-oh Yang Derek M K Zhong Xinhuo | 2004 | Journal of Colloid and Interface Science2004，277，： | 1 |
| 14 | New insights into magnetic derivatives for structural mapping显示文摘 | Derek J Airhead F Chris G M | 2004 | The Leading Edge2004，23，2： | 1 |
| 15 | Perceptual-Cognitive Expertise in Sport: A Meta-Analysis 显示文摘 | DEREK T Y WILLIAMS M A CHRISTOPHER M | 2007 | Journal of Sport & Exercise Psychology2007，，29： | 1 |
| 16 | The interactive effects of feeding and exercise on oxygen consumption,swimming performance and protein usage in Juvenile rainbow trout (Oncorhynchus mykiss) 显示文摘 | Derek H A Chris M W | 1997 | The Journal of Experimental Biology1997，200，： | 1 |
| 17 | Improving health care through re- design显示文摘 | Derek B Nieki M Mike J | 2006 | BMJ2006，332，： | 1 |
| 18 | Cooperative control for oceansampling: the glider coordinated control system 显示文摘 | Derek P Zhang F M Leonard N E | 2008 | IEEE Trans-actions on Control Systems Technology2008，16，4： | 1 |
| 19 | Myocardial reperfusion injury显示文摘 | Derek M Yellon D Sc Derek J Hausenloy | 2007 | N Engl J Med2007，357，： | 1 |
| 20 | High bandwidth fast steering mirror 显示文摘 | Francisc M Tapos Derek J Edinger Timothy R Hilby | 2005 | SPIE2005，5877，： | 1 |
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