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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Diuretic and antioxidant activities of the aqueous extract of leaves of Cassia occidentalis(Linn.) in rats显示文摘Objective: To assess the putative diuretic and antioxidant properties of Cassia occidentalis(C. occidentalis) leaves' aqueous extract. Methods: Adult rats were administered with C. occidentalis leaves aqueous extract acutely(24-h) and subchronically(7 d), at doses 80, 160, 240, 320, and 400 mg/kg(per os). Negative control group received only an equivalent volume of distilled water, while the two positive control groups received the diuretic drugs furosemide(20 mg/kg, i.p.) and hydrochlorothiazide(HCTZ, 20 mg/kg, i.p.). Urinary elimination of electrolytes in response to treatments was evaluated, together with changes in concentrations of creatinine, urea, aldosterone, glucose, and albumin in urine and plasma. Various urinary indicators of kidney function and plasmatic markers of oxidative stress were also assessed. Results: The acute administration of C. occidentalis increased the urinary excretion of 107.58% at the higher dose tested, compared to negative control. The reference drugs furosemide and HCTZ induced increases of 84.27 % and 48.05 %, respectively. Acutely, the extract induced Na+ and Cl- elimination, whereas subchronically an increase in K+ elimination was also observed. The extract also improved the kidney function indexes and oxidative stress markers. These effects were dose-dependent and comparable with positive control observations. Conclusions: Our i ndings strongly suggest that C. occidentalis aqueous extract has diuretic and antioxidant activities, and deserves further studies considering the potential for the treatment of hypertension. | Théophile Dimo Fidèle Ntchapda Joseph Barama David Romain Kemeta Azambou Paul Faustin Seke Etet | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，9： | 2 |
| 3 | 治疗选择偏倚的存在与观察性研究分析:使用倾向积分法和工具变量法评价心脏介入治疗对AMI存活的影响显示文摘背景:对观察性研究中治疗与未治疗患者的结果进行比较时,由于患者预后存在组间差异,因此可发生偏倚,后者常常是因为存在未予观察的治疗选择偏倚。
目的:对下列4种去除观察性研究选择偏倚的分析方法进行比较:多变量模型危险校正法(muhivariable model risk adjustment)、倾向积分危险校正法(propensity score risk adjustment)、倾向匹配法(propensity—based matching)以及工具变量分析法(instrumental variable analysis)。
设计、地点及患者:122124例因急性心肌梗死(AMI)而于1994~1995年住院的、接受医疗保险的老年(年龄65~84岁)患者全国队列。这些患者适合心脏导管检查。基线图表审查取自心血管协作项目并与医疗保险健康管理数据联合以便提供系列预后变量。患者随访7年(至2001年12月31日)以便评估长期存活与住院30天内心脏导管检查两者的关系。
主要观测指标:使用各种分析方法获得的危险校正后相对死亡率。
结果:与未接受心导管检查的患者相比,接受心导管检检查的患者较年轻而且急性心肌梗死的严重度较低。采用标准的统计学危险校正法校正预后因素后,心导管检查与死亡率相对下降50%相关(多变量模型危险矫正法:校正后相对危险度[relative risk,RR],〉0.51;95%可信区间[confidence interval,CI],0.50~0.52。倾向积分危险校正法:校正后RR,0.54;95%CI,0.53~0.55]。倾向配对法:校正后RR,0.54;95%CI,0.52~0.56)。使用局部插管作为一种工具,工具变量分析显示死亡率相对下降16%(校正后RR,0.84;95%CI,0.79~0.90)。随机临床试验中常规介入治疗的生存获益在8%和21%之间。
结论:心导管检查与急性心肌梗死长期死亡率的关系对分析方法高度敏感。对于去除未测量的治疗选择偏倚而言,各种标准危险校正方法具有同样的局限。与标准建模法比较,工具变量分析法可以减少治疗效果偏倚。但是相对于特殊的临床问题,该法更适合回答政策策略问题。 | Thérèse A. Stukel Elliott S. Fisher David E. Wennberg 李呈亿(译) | 2007 | 美国医学会杂志(中文版)2007，26，6： | 2 |
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| 6 | postinjury muhiple organ failure: the role of the gut显示文摘 | Heithan th bruce ck david wm | 2011 | shock2011，151，： | 1 |
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| 11 | Current Practice, Demo- graphics,and Trends of Critical Care Trained Emergency Physicians in the United States显示文摘 | Julie AM Kyle JG David TH | 2010 | Acadaemic Emergency Medicine2010，17，3： | 1 |
| 12 | Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: a meta-analysis of all major randomised clinical trials显示文摘 | Eric Boersma Robert A Harrington David J Moliterno Harvey White Pierre Théroux Frans Van de Werf Anneke de Torbal Paul W Armstrong Lars C Wallentin Robert G Wilcox John Simes Robert M Califf Eric J Topol Maarten L Simoons | 2002 | The Lancet2002，，9302： | 1 |
| 13 | β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner显示文摘 | Béla Horváth Partha Mukhopadhyay Malek Kechrid Vivek Patel Galin Tanchian David A. Wink Jürg Gertsch Pál Pacher | 2012 | Free Radical Biology and Medicine2012，，8： | 1 |
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| 15 | 玻璃游戏 上海儿童玻璃博物馆2.0显示文摘众打造的当代艺术与设计博物馆。由玻璃工作车间改造而成的博物馆占地2320 m2,为儿童设计的内容结合探索性的参观体验,鼓励孩子们进行独立自主的学习。博物馆的展览在多个层面吸引观众,与其开展互动,而且所有展品都由一个寻宝游戏串联,邀请观众们在空间中寻找线索。互动性十足的博物馆让孩子们主导参观体验,探索更多他们感兴趣的主题,并积极主动学习关于玻璃、环境、科学、技术、艺术、设计与人类文明的知识。多媒体与数字内容在展览设计中扮演着重要的角色,包含镜子迷宫、声音装置、追踪动态的互动展项以及探讨与玻璃相关的各种主题视频。 | 无 Tilman Thürmer(设计) Francesca Inchingolo(设计) David Keohane(设计) María Fernanda González Prendes(设计) 陈怡君(设计) 文思宁(设计) | 2021 | 室内设计与装修2021，，9： | 1 |
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