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| 1 | Angiotensin receptor blocker drugs and inhibition of adrenal beta-arrestin-1-dependent aldosterone production: Implications for heart failure therapy显示文摘Aldosterone mediates many of the physiological and pathophysiological/cardio-toxic effects of angiotensin II(Ang II). Its synthesis and secretion from the zona glomerulosa cells of the adrenal cortex, elevated in chronic heart failure(HF), is induced by Ang II type 1 receptors(AT1Rs). The AT1R is a G protein-coupled receptor, mainly coupling to Gq/11 proteins. However, it can also signal through β-arrestin-1(βarr1) or-2(βarr2), both of which mediate G protein-independent signaling. Over the past decade, a second, Gq/11 proteinindependent but βarr1-dependent signaling pathway emanating from the adrenocortical AT1R and leading to aldosterone production has become appreciated. Thus, it became apparent that AT1R antagonists that block both pathways equally well are warranted for fully effective aldosterone suppression in HF. This spurred the comparison of all of the currently marketed angiotensin receptor blockers(ARBs, AT1R antagonists or sartans) at blocking activation of the two signaling modes(G protein-, and βarr1-dependent) at the Ang IIactivated AT1R and hence, at suppression of aldosterone in vitro and in vivo. Although all agents are very potent inhibitors of G protein activation at the AT1R, candesartan and valsartan were uncovered to be the most potent ARBs at blocking βarr activation by Ang II and at suppressing aldosterone in vitro and in vivo in post-myocardial infarction HF animals. In contrast, irbesartan and losartan are virtually G protein-'biased' blockers at the human AT1R, with very low efficacy for βarr inhibition and aldosterone suppression. Therefore, candesartan and valsartan(and other, structurally similar compounds) may be the most preferred ARB agents for HF pharmacotherapy, as well as for treatment of other conditions characterized by elevated aldosterone. | Anastasios Lymperopoulos Beatrix Aukszi | 2017 | World Journal of Cardiology2017，9，3： | 11 |
| 2 | PCH1 and PCHL Directly Interact with PIF1,Promote Its Degradation,and Inhibit Its Transcriptional Function during Photomorphogenesis显示文摘PHOTOPERIODIC CONTROL OF HYPOCOTYL 1(PCH1)and PCH1-LIKE(PCHL)were shown to directly bind to phytochrome B(phyB)and suppress phyB thermal reversion,resulting in plants with dramatically enhanced light sensitivity.Here,we show that PCH1 and PCHL also positively regulate various light responses,including seed germination,hypocotyl gravitropism,and chlorophyll biosynthesis,by physically interacting with PHYTOCHROME INTERACTING FACTOR 1(PIF1)and CONSTITUTIVE PHOTOMORPHO-GENIC 1(COP1).PCH1 and PCHL interact with PIF1 both in the dark and light,and regulate PIF1 abundance.Moreover,PCH1 and PCHL facilitate the physical interaction between phyB and PIF1 in vivo to promote the light-induced degradation of PIF1.PCH1 and PCHL also inhibit the DNA-binding ability of PIF1 to negatively regulate the expressions of PIF1 target genes.In addition,PCH1 and PCHL interact with COP1 and undergo degradation through the 26S proteasome pathway in the dark.Consistently,pch1 suppresses cop1 phenotype in darkness.Collectively,our study reveals a novel mechanism by which PCH1 and PCHL regulate diverse light responses not only by stabilizing phyB Pfrform but also by directly interacting with PIF1 and COP1,providing a molecular understanding of the control of hypocotyl growth by these proteins. | Mei-Chun Cheng Beatrix Enderle Praveen Kumar Kathare Rafya Islam Andreas Hiltbrunner Enamul Huq | 2020 | Molecular Plant2020，13，3： | 3 |
| 3 | Black locust(Robinia pseudoacacia L.)as a multi-purpose tree species in Hungary and Romania:a review显示文摘Black locust(Robinia pseudoacacia L.) was the first North-American tree species imported to Europe at the beginning of the seventeenth century. It is commonly planted worldwide because of its adaptability to environmental stresses, its valuable wood, easy propagation, frequent and abundant seed production, excellent coppicing,high seedling survival, and relatively high wood yield. In Europe, Romania and Hungary have the most highly-developed black locust growing techniques and experiences.As a result of increasing interest in black locust in many countries, this review aims to provide a comprehensive overview of state-of-the-art site requirements, propagation, improvement and management(including growth and yield as well as use in energy plantations). | Valeriu-Norocel Nicolescu Cornelia Hernea Beatrix Bakti Zsolt Keseru Borbála Antal Károly Rédei | 2018 | Journal of Forestry Research2018，29，6： | 2 |
| 4 | Preoperative Chemotherapy Does Not Increase Morbidity or Mortality of Hepatic Resection for Colorectal Cancer Metastases显示文摘 | Charles R. Scoggins Michael L. Campbell Christine S. Landry Beatrix A. Slomiany Charles E. Woodall Kelly M. McMasters Robert C. G. Martin | 2009 | Annals of Surgical Oncology2009，，1： | 2 |
| 5 | Regular scintigraphic measurements of food transit following different types of reconstruction after total gastrectomy显示文摘 | Beatrix H Has-vdo Z Joachim MM | 1999 | Ardhieveof Surgery1999，134，11： | 1 |
| 6 | The alpha and beta subunit of the nascent polypeptide-associated complex have distinct functions显示文摘 | Beatrix B Sakai H Wiedmann M | 2000 | The Journal of Biological Chemistry2000，275，37： | 1 |
| 7 | Insulin-like growth factor binding protein-6 delays replicative senescence of human fibroblasts显示文摘 | Lucia Micutkova Thomas Diener Chen Li Adelina Rogowska-Wrzesinska Christoph Mueck Eveline Huetter Birgit Weinberger Beatrix Grubeck-Loebenstein Peter Roepstorff Rong Zeng Pidder Jansen-Duerr | 2011 | Mechanisms of Ageing and Development2011，，10： | 1 |
| 8 | Tumor-infiltrating B cell immunoglobulin variable region gene usage in invasive ductal breast carcinoma显示文摘 | Peter Simsa Jean-Luc Teillaud David I. Stott József Tóth Beatrix Kotlan | 2005 | Pathology & Oncology Research2005，，2： | 1 |
| 9 | Effect of cardiac resynchronization therapy on the incidence of electrical storm显示文摘 | Peter Nordbeck Bernhard Seidl Beatrix Fey Wolfgang R. Bauer Oliver Ritter | 2009 | International Journal of Cardiology2009，，3： | 1 |
| 10 | Quality of Life after Gastrectomy: Longmire’s ReconstructionAlone Compared with Additional Pouch Reconstruction显示文摘 | Beatrix Hoksch Bernhard Ablassmaier Juergen Zieren Joachim M. Müller | 2002 | World Journal of Surgery2002，，3： | 1 |
| 11 | A general mechanism for regulation of access to the translocon:Competition for a membrane attachment site on ribosomes显示文摘 | Moller I Jung M Beatrix B | 1998 | Proc Natl Acad Sci USA1998，95，13： | 1 |
| 12 | A color in situ hybridization method with improved sensitivity for the detection of low-abundance mRNAs 显示文摘 | Beatrix Kovacs Karoly Gulya | 2001 | Acta Biologica Szegediensis2001，45，14： | 1 |
| 13 | The alpha and beta subunit of the nascent polypeptide associated complex have distinct functions显示文摘 | Beatrix B Sakai H Wiedmann M | 2000 | J Biol Chem2000，275，37： | 1 |
| 14 | gene expression profiling and genetic markers in glioblastoma survival显示文摘 | Jeremy N Rich Christopher Hans Beatrix Jones | 2005 | Cancer Res2005，65，10： | 1 |
| 15 | Immunosenescence and vaccine failure in the elderly显示文摘 | Beatrix Grubeck-Loebenstein Silvia Bella Anna Maria Iorio Jean-Pierre Michel Graham Pawelec Rafael Solana | 2009 | Aging Clinical and Experimental Research2009，，3： | 1 |
| 16 | Protein identification using sequential ion/ion reactions and tandem mass spectrometry显示文摘 | JOSHUA J C BEATRIX U JOHN E P S | 2005 | Proc Natl cad Sci USA72005，102，27： | 1 |
| 17 | The crystal structure of archaeal nascent polypeptide associated complex(NAC)reveals a unique fold and the presence of a ubiquitin associated domain显示文摘 | Spreter T Pech M Beatrix B | 2005 | J Biol Chem2005，280，15： | 1 |
| 18 | Cell-Cell Adhesion Mediated by Binding of Membrane-anchored Ligand LERK-2 to the EPH-related Receptor Human Embryonal Kinase 2 Promotes Tyrosine Kinase Activity显示文摘 | Beatrix Bhme Tim VandenBos Douglas Pat Cerretti | | 0，，： | 1 |
| 19 | Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in beta-thalassaemia显示文摘 | Lisa J Anderson Beatrix Wonke Emma Prescott Sally Holden J Malcolm Walker Dudley J Pennell | 2002 | The Lancet . 2002 (9332)2002，，： | 1 |
| 20 | Maturity of concrete:concept,tests and applications显示文摘 | Beatrix Kerkhoff John G | 2005 | Concrete Technology Today December2005，，： | 1 |
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