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| 1 | 急性心肌梗死医疗保险患者介入治疗与药物治疗强度区域变化对远期预后的影响显示文摘背景:与药物治疗比较,急性心肌梗死(acute myocardial infarction,AMI)患者介入治疗强度存在显著的地区差异,这种差异在卫生及政策方面的意义还不清楚。目标:评价接受积极治疗患者的相关临床特征;评估居住于积极采取介入治疗策略地区的AMI患者与居住于积极采取药物治疗策略地区的患者相比,是否具有更好的远期生存率。设计、地点及患者:在158831例老年医疗保险患者中进行该项全国性队列研究。患者于1994~1995年因首次发生并确诊AMI而入院,随访7年(平均随访3.6年)。根据居住地区介入治疗(30天内接受心导管手术)与药物治疗(出院时对适宜的患者应用β-阻滞剂)强度进行分析。基线资料来自心血管协作项目,并与医疗保险管理资料联合。主要观察指标:7年随访期间的远期生存率。结果:各地区AMI基线严重程度相似。在所有地区,较年轻、较健康的患者与年老的高危患者相比,更可能接受介入治疗和药物治疗。更多实施介入治疗的地区具备更多的心脏导管室条件;这些地区的患者无论年龄、临床指征还是危险特点如何,均更多接受介入治疗。介入和药物治疗策略采用率最高的地区与介入和药物治疗采用率最低的地区,两者未经校正的7年绝对生存率差异为6.2%。对于ST抬高和非ST抬高AMI患者,其生存率随着地区介入治疗和药物治疗强度的增高而升高。在药物治疗比例较高的地区,随着介入治疗的增加,相应的生存率提高很少甚或没有提高。结论:老年医疗保险AMI患者接受较为积极的药物治疗对改善人群的生存有益。 | Therese A. Stukel F. Lee Lucas David E. Wennberg 王淑敏(译) 胡大一(校) | 2005 | 美国医学会杂志(中文版)2005,24,4: | 15 |
| 2 | Hospital Volume and Late Survival After Cancer Surgery显示文摘 | John D. Birkmeyer Yating Sun Sandra L. Wong Therese A. Stukel | 2007 | Annals of Surgery2007,,5: | 4 |
| 3 | 对存在治疗选择偏倚的观察性研究的分析:采用倾向评分和工具变量法评价有创性心脏治疗对AMI患者生存率的影响显示文摘背景:在观察性研究中,对治疗组和非治疗组间结果的比较可能会因组间患者预后的差异而产生偏倚,常见的原因是未发现的治疗选择偏倚。目的:比较4种分析方法排除观察性研究中选择偏倚的效果:多因素模型风险校正、倾向评分风险校正、倾向评分匹配法和工具变量法。设计、地点和患者:此项全国性队列研究纳入1994—1995年间122124例享有医疗保险的老年急性心肌梗死(AMI)住院患者(65~84岁),所有病例均适合行心导管术。基线资料来自心血管合作项目,并与医疗保险管理数据连接,以确保足够充分的预后参数。 | Stukel T.A. Fisher E.S. Wennberg D.E. 黄浙勇 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007,3,7: | 4 |
| 4 | Maple phylogeny and biogeography inferred from phylogenomic data显示文摘Acer(the maple genus)is one of the diverse tree genera in the Northern Hemisphere with about 152 species,most of which are in eastern Asia.There are roughly a dozen species in Europe/western Asia and a dozen in North America.Several phylogenetic studies of Acer have been conducted since 1998,but none have provided a satisfactory resolution for basal relationships among sections of Acer.Here we report the first well-resolved phylogeny of Acer based on DNA sequences of over 500 nuclear loci generated using the anchored hybrid enrichment method and explore the implications of the robust phylogeny for Acer systematics and biogeography.Our phylogenetic results support the most recent taxonomic treatment of Acer by de Jong with some modifications;section Pentaphylla may be expanded to include section Trifoliata,and A.yangbiense may be included in section Lithocarpa.Sections Spicata,Negundo,Arguta,and Palmata form a clade sister to the rest of the genus where sections Glabra and Parviflora comprise the first clade followed by section Macrantha,sections Ginnala,Lithocarpa,Indivisa,sections Platanoidea and Macrophylla,section Rubra,section Acer,and section Pentaphylla.Monotypic sections Glabra and Macrophylla in North America are sister to the Japanese section Parviflora and Eurasian section Platanoidea,respectively.Ancestral area inferences using statistical dispersal and vicariance analysis(S-DIVA)and dispersal and extinction cladogenesis(DEC)methods suggest that Asia might be the most likely ancestral area of Acer as proposed by Wolfe and Tanai and molecular dating using Bayesian evolutionary analysis by sampling trees(BEAST)indicate that section diversifications of Acer might have completed largely in the late Eocene and the intercontinental disjunctions of Acer between eastern Asia and eastern North America formed mostly in the Miocene. | Jianhua Li Mark Stukel Parker Bussies Kaleb Skinner Alan R.Lemmon Emily Moriarty Lemmon Kenneth Brown Airat Bekmetjev Nathan G.Swenson | 2019 | Journal of Systematics and Evolution2019,57,6: | 3 |
| 5 | 治疗选择偏倚的存在与观察性研究分析:使用倾向积分法和工具变量法评价心脏介入治疗对AMI存活的影响显示文摘背景:对观察性研究中治疗与未治疗患者的结果进行比较时,由于患者预后存在组间差异,因此可发生偏倚,后者常常是因为存在未予观察的治疗选择偏倚。
目的:对下列4种去除观察性研究选择偏倚的分析方法进行比较:多变量模型危险校正法(muhivariable model risk adjustment)、倾向积分危险校正法(propensity score risk adjustment)、倾向匹配法(propensity—based matching)以及工具变量分析法(instrumental variable analysis)。
设计、地点及患者:122124例因急性心肌梗死(AMI)而于1994~1995年住院的、接受医疗保险的老年(年龄65~84岁)患者全国队列。这些患者适合心脏导管检查。基线图表审查取自心血管协作项目并与医疗保险健康管理数据联合以便提供系列预后变量。患者随访7年(至2001年12月31日)以便评估长期存活与住院30天内心脏导管检查两者的关系。
主要观测指标:使用各种分析方法获得的危险校正后相对死亡率。
结果:与未接受心导管检查的患者相比,接受心导管检检查的患者较年轻而且急性心肌梗死的严重度较低。采用标准的统计学危险校正法校正预后因素后,心导管检查与死亡率相对下降50%相关(多变量模型危险矫正法:校正后相对危险度[relative risk,RR],〉0.51;95%可信区间[confidence interval,CI],0.50~0.52。倾向积分危险校正法:校正后RR,0.54;95%CI,0.53~0.55]。倾向配对法:校正后RR,0.54;95%CI,0.52~0.56)。使用局部插管作为一种工具,工具变量分析显示死亡率相对下降16%(校正后RR,0.84;95%CI,0.79~0.90)。随机临床试验中常规介入治疗的生存获益在8%和21%之间。
结论:心导管检查与急性心肌梗死长期死亡率的关系对分析方法高度敏感。对于去除未测量的治疗选择偏倚而言,各种标准危险校正方法具有同样的局限。与标准建模法比较,工具变量分析法可以减少治疗效果偏倚。但是相对于特殊的临床问题,该法更适合回答政策策略问题。 | Thérèse A. Stukel Elliott S. Fisher David E. Wennberg 李呈亿(译) | 2007 | 美国医学会杂志(中文版)2007,26,6: | 2 |
| 6 | Survival following hepatic resection of colorectal cancer metastases: a national experience 显示文摘 | Robertson D J Stukel TA Gottlieb D J | 2009 | Cancer2009,115,4: | 1 |
| 7 | Changing patterns in competing causes of death in men with prostate cancer:a population based study显示文摘 | Lu-Yao G Stukel T A Yao S L | 2004 | J Urol2004,171,6: | 1 |
| 8 | Hospital Volume, Length of Stay, and Readmission Rates in High-Risk Surgery显示文摘 | Philip P. Goodney Therese A. Stukel F. Lee Lucas Emily V.A. Finlayson John D. Birkmeyer | 2003 | Annals of Surgery2003,,2: | 1 |
| 9 | A comparison of clomiphene citrate and human menopausa gonadotropin for use in conjunction with intrauterine insemination显示文摘 | Manganiello PD Stern JE Stukel TA | 1997 | Fertil Steril1997,68,3: | 1 |
| 10 | Laryngeal complications of pro- longed intubation 显示文摘 | Co|ice GL Stukel TA Dain B | 1989 | Chest1989,96,4: | 1 |
| 11 | Immunohistochemical staining fortransforming growth factor - β1 associates with disease progression in human breastcancer显示文摘 | Gorsch SM Memoli VA Stukel TA | 1992 | Cancer Res1992,52,: | 1 |
| 12 | Collection of hydrophilic any hydrophobic charged submicron particles by charged water droplets显示文摘 | Wang H C Leong K H Stukel J J | 1983 | Journal of Aerosol Science1983,14,6: | 1 |
| 13 | A meta-analytic method for summarizing diagnostic test performances:receiver-operatingcharacteristics-sunnnaty point estimates显示文摘 | Midgette AS Stukel TA Littenberg B | 1993 | Med Decis Making1993,13,3: | 1 |
| 14 | Surgeon volume and operative mortality in the United States显示文摘 | Birkmeyer JD Stukel TA Siewers AE | 2003 | N Engl J Med2003,349,22: | 1 |
| 15 | Determinants of plasma levels of beta -carotene and retinal显示文摘 | Nierenberg DW Stukel TA Baron JA | 1989 | Am J Epidemiol1989,130,1: | 1 |
| 16 | 急性心肌梗死的医保患者的介入与药物治疗强度存在地区差别的长期结果 | Stukel T.A. Lucas F.L. Wennberg D.E. 任付先 | 2005 | 世界核心医学期刊文摘(心脏病学分册)2005,0,9: | 1 |
| 17 | Surgeon volume and operative mortality in the Unitaed States显示文摘 | Birkmeyer JD Stukel TA Siewers AE | 2003 | N Engl J Med2003,349,22: | 1 |
| 18 | Is surgery getting safe? National trends in operative mortality显示文摘 | Goodney P P Siewers A E Stukel | 2002 | J Am Coil Surg2002,236,3: | 1 |
| 19 | Immunohistochemical staining for transforming growth factor-beta1 associated with disease progression in human breast cancer显示文摘 | Girsch SM Memoli VA Stukel TA | 1992 | Cancer Res1992,52,: | 1 |
| 20 | Aerosol deposition on plant leaves显示文摘 | Wedding J B Carlson R W Stukel J J | 1975 | Environment Science Technology1975,9,: | 1 |