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| 1 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 2 | International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma显示文摘 | William D. Travis Elisabeth Brambilla Masayuki Noguchi Andrew G. Nicholson Kim R. Geisinger Yasushi Yatabe David G. Beer Charles A. Powell Gregory J. Riely Paul E. Van Schil Kavita Garg John H. M. Austin Hisao Asamura Valerie W. Rusch Fred R. Hirsch Giorg | 2011 | Journal of Thoracic Oncology2011，，2： | 4 |
| 3 | 圈养大熊猫性情、饲养管理和社群-性行为的关系(英文)显示文摘以往研究表明,许多成年雄性大熊猫在圈养状态下不能表达正常的社群性行为。我们设计了一个实验来研究大熊猫正常社群性行为与性情特征、展示、以及饲养管理的关系。通过调查获得大熊猫展示和饲养管理的数据,询问饲养员得知2001年繁殖季节中大熊猫的社群性行为发生频次,然后评估社群性行为能力。研究对象是分布在中国4个繁育中心的37头(12头雄性和25头雌性)成体大熊猫。通过提供新物品和气味来评估大熊猫情绪反应状况。情绪反应分为3类:畏惧、访问和访问玩耍。在有饲养员陪同玩耍的一组里,雌、雄大熊猫的'访问玩耍'的分值都较高。'畏惧'类的雌性大熊猫气味标记行为少,表达的性行为也少,并且更多地攻击接近它们的雄性,或者不理睬雄性。在繁殖季节前就接近雄性大熊猫围栏的雌性,表现出更多的气味标记行为和性行为。这些雌性的'访问玩耍'分值也高。'访问'分值高的雄性大熊猫,接近雌性的行为更多。那些与饲养员接触时间少的雄性大熊猫倾向于攻击雌性,与那些攻击性小的雄性相比,这些雄性倾向于能够接受丰富性低的环境。这些结果表明,应该采取措施减少大熊猫的畏惧,在大熊猫和饲养员之间建立积极的关系,在繁殖季节之前,增加雌性和雄性之间的熟悉程度。 | David POWELL 林虹 Kathy CARLSTEAD Devra KLEIMAN 张和民 张贵权 张志和 余建秋 张金国 卢雁平 Timothy S.K.NG Jason C.L.TANG Rebecca SNYDER | 2008 | 动物学报2008，54，1： | 3 |
| 4 | Progressive Fibrosis in Nonalcoholic Steatohepatitis: Association With Altered Regeneration and a Ductular Reaction显示文摘 | Michelle M. Richardson Julie R. Jonsson Elizabeth E. Powell Elizabeth M. Brunt Brent A. Neuschwander–Tetri Prithi S. Bhathal John B. Dixon Martin D. Weltman Herbert Tilg Alexander R. Moschen David M. Purdie Anthony J. Demetris Andrew D. Clouston | 2007 | Gastroenterology2007，，1： | 2 |
| 5 | Propranolol for the prevention of postoperative arrhythmias in general thoracic surgery显示文摘 | Charles D Bayliff David R Massel Richard I Inculet Richard A Malthaner Susan D Quinton Frank S Powell Renee S Kennedy | 1999 | The Annals of Thoracic Surgery1999，，1： | 2 |
| 6 | International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma显示文摘 | William D. Travis Elisabeth Brambilla Masayuki Noguchi Andrew G. Nicholson Kim R. Geisinger Yasushi Yatabe David G. Beer Charles A. Powell Gregory J. Riely Paul E. Van Schil Kavita Garg John H. M. Austin Hisao Asamura Valerie W. Rusch Fred R. Hirsch Giorg | 2011 | Journal of Thoracic Oncology2011，，2： | 1 |
| 7 | Effects of Construction Noise on Behavior and Cortisol Levels in a Pair of Captive Giant Pandas (Ailuropoda melanoleuca)显示文摘 | David M Powell Kathy Carlstead Loraine R Tarou | 2006 | Zoo Biology2006，25，： | 1 |
| 8 | Overview of the CALIPSO Mission and CALIOP Data Processing Algorithms显示文摘 | Winker David M Vaughan Mark A Omar Ali Hu Yongxiang Powell Kathleen A Liu Zhaoyan Hunt William H Young Stuart A | 2009 | Journal of Atmospheric and Oceanic Technology2009，，11： | 1 |
| 9 | Changes in the financial services sector显示文摘 | David Powell | 1998 | Journal of Strategies Information Systems1998，，6： | 1 |
| 10 | Calibration of strapdown magnetome- ters in magnetic field domain 显示文摘 | GEBRE-EGZIABHER D ELKAIM G H DAVID POWELL J | 2006 | Journal of Aerospace Engineering2006，19，2： | 1 |
| 11 | Vincristine treatment of nephrotic syndrome complicated by Kimura disease显示文摘 | Annette Connelly Harley R. Powell Yuen F. Chan David Fuller Russell G. Taylor | 2005 | Pediatric Nephrology2005，，4： | 1 |
| 12 | Detection of Financial Time Series Turning Points: A New CUSUM Approach Applied to IPO Cycles显示文摘 | David Blondell Philip Hoang John G. Powell Jing Shi | 2002 | Review of Quantitative Finance and Accounting2002，，3： | 1 |
| 13 | Extracts of Flourensia cernua (L): Volatile Constituents and Antifungal, Antialgal, and Antitermite Bioactivities显示文摘 | Mario Tellez Rick Estell Ed Fredrickson Janine Powell David Wedge Kevin Schrader Mozaina Kobaisy | 2001 | Journal of Chemical Ecology2001，，11： | 1 |
| 14 | A versatile divide and conquer technique for optimal string alignment显示文摘 | David R Powell Lloyd Allison Trevor I Dix | 1999 | Information Processing Letters1999，70，： | 1 |
| 15 | Land-vehicle navigation using GPS显示文摘 | Eric Abbott David Powell | 1999 | proceeding of the IEEE[C]//Jan1999，87，1： | 1 |
| 16 | White matter integrity and vulnerability to Alzheimer’s disease: Preliminary findings and future directions显示文摘 | Brian T. Gold Nathan F. Johnson David K. Powell Charles D. Smith | 2011 | BBA - Molecular Basis of Disease2011，，3： | 1 |
| 17 | A comparison of commercial enzymes for the aqueous enzymatic extraction of corn oil from corn germ显示文摘 | Robert A. Moreau David B. Johnston Michael J. Powell Kevin B. Hicks | 2004 | Journal of the American Oil Chemists’ Society2004，，11： | 1 |
| 18 | International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma显示文摘 | William D. Travis Elisabeth Brambilla Masayuki Noguchi Andrew G. Nicholson Kim R. Geisinger Yasushi Yatabe David G. Beer Charles A. Powell Gregory J. Riely Paul E. Van Schil Kavita Garg John H. M. Austin Hisao Asamura Valerie W. Rusch Fred R. Hirsch Giorg | 2011 | Journal of Thoracic Oncology2011，，2： | 1 |
| 19 | Steatosis Is a Cofactor in Liver Injury in Hemochromatosis显示文摘 | Elizabeth E. Powell Azmat Ali Andrew D. Clouston Jeannette L. Dixon Douglas J. Lincoln David M. Purdie Linda M. Fletcher Lawrie W. Powell Julie R. Jonsson | 2005 | Gastroenterology2005，，6： | 1 |
| 20 | c-kit Is Required for Cardiomyocyte Terminal Differentiation显示文摘 | Ming Li Nawazish Naqvi Eiji Yahiro Ke Liu Pamela C. Powell Wayne E. Bradley David I.K. Martin Robert M. Graham Louis J. Dell’Italia Ahsan Husain | 2008 | Circulation Research2008，，6： | 1 |
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