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| 1 | Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?显示文摘Metastasis is the principal cause of cancer mortality, with the lymphatic system being the first route of tumor dissemination. The glycoproteins VEGF-C and VEGF-D are members of the vascular endothelial growth factor (VEGF) family, whose role has been recently recognized as lymphatic system regulators during embryogenesis and in pathological processes such as inflammation, lymphatic system disorders and malignant tumor metastasis. They are ligands for the VEGFR-3 receptor on the membrane of the lymphatic endothelial cell, resulting in dilatation of existing lymphatic vessels as well as in vegetation of new ones (lymphangiogenesis). Their determination is feasible in the circulating blood by immunoabsorption and in the tissue specimen by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). Experimental and clinicopathological studies have linked the VEGF-C, VEGF-D/VEGFR3 axis to lymphatic spread as well as to the clinical outcome in several human solid tumors. The majority of these data are derived from surgical specimens and malignant cell series, rendering their clinical application questionable, due to subjectivity factors and post-treatment quantification. In an effort to overcome these drawbacks, an alternative method of immunodetection of the circulating levels of these molecules has been used in studies on gastric, esophageal and colorectal cancer. Their results denotethat quantification of VEGF-C and VEGF-D in blood samples could serve as lymph node metastasis predictive biomarkers and contribute to preoperative staging of gastrointestinal malignancies. | Theodore D Tsirlis George Papastratis Kyriaki Masselou Christos Tsigris Antonis Papachristodoulou Alkiviadis Kostakis Nikolaos I Nikiteas | 2008 | World Journal of Gastroenterology2008，14，17： | 12 |
| 2 | Propranolol for the prevention of postoperative arrhythmias in general thoracic surgery显示文摘 | Charles D Bayliff David R Massel Richard I Inculet Richard A Malthaner Susan D Quinton Frank S Powell Renee S Kennedy | 1999 | The Annals of Thoracic Surgery1999，，1： | 2 |
| 3 | Diagnosing acute myocardial infarction in the setting of left bundle branch block : prevalence and observer variability from a large communituy study 显示文摘 | Gula LJ Dick A Massel D | 2003 | Coron Artery Dis2003，14，5： | 1 |
| 4 | Increasing Rail Life by Forecasting Fatigue Failure显示文摘 | Massel A Radomski R | 2003 | NDR&E International2003，36，： | 1 |
| 5 | Surface wave propagation in mangrove forests 显示文摘 | S R Massel K Furukawa R M Brinkman | 1999 | Fluid Dynamics Research1999，24，： | 1 |
| 6 | A disaggregated view of technical change 显示文摘 | Massell B F | 1961 | The Journal of Political Economy1961，69，6： | 1 |
| 7 | Addition of sodium caseinate to skim milk inhibits rennet-induced aggregation of casein micelles显示文摘 | Gaygadzhiev Z Massel V Alexander M | 2012 | Food Hydrocolloids2012，26，2： | 1 |
| 8 | Evaluating the capacity to work of the mentally ill显示文摘 | Massel HK Liberman RP Mintz J | 1990 | Psychiatry1990，53，： | 1 |
| 9 | Clot-bound thrombin is protected from inhibition by heparin-antithrombin Ⅲ but is susceptible to inactivation by antithrombin Ⅲ-independent inhibitors显示文摘 | Weitz JI Hudoba M Massel D | 1990 | J Clin Invest1990，86，： | 1 |
| 10 | Reducing bedrest following arterial puncture for coronary interventional procedures-impact on vascular complication:the BAC Trial显示文摘 | Vlasic W Almond D Massel D | 2001 | J Invasive Cardiol2001，13，12： | 1 |
| 11 | Anaphylactoid reaction during an infu- sion of recombinant tissue-type plasminogen activator for acute myo- cardial infhrction 显示文摘 | Massel D Gill JB Cairns JA | 1991 | Can J Cardiot1991，7，： | 1 |
| 12 | Mediastinal irradiation: a risk factor for atherosclerosis of the internal thoracic arteries 显示文摘 | RENNER S M MASSEL D MOON B C | 1999 | Can J Cardiol1999，15，5： | 1 |
| 13 | Export Instability and Economic Structure 显示文摘 | Massell F | 1970 | The American Economic Review1970，60，4： | 1 |
| 14 | How sound is the evidence that thromblysis increases the risk of cardiac rupture显示文摘 | Massel DR | 1993 | Br Heart J1993，69，4： | 1 |
| 15 | Clot-bound Thrombin is Protected from Inhibition by Heparin-antithrombin- Ⅲ but Its Susceptible to Inactivation by Antithrombin Ⅲ - independent Inhibitiors 显示文摘 | WEITZ J I HUDOBA M MASSEL D | 1990 | Clin Invest1990，86，： | 1 |
| 16 | Diagnosing acute myocardial infarction in the setting of left bundle branch block:prevalence and observer variability from a large comunity study显示文摘 | Gula LJ Dick A Massel D | 2003 | Coron Artery Dis2003，14，： | 1 |
| 17 | Clot bound thrombin is protected from inhibition by heparin-antithrombin Ⅲ but is susceptible to inactivation by antithrombin Ⅲ -independent inhibitors显示文摘 | Weitz JI Hudoba M Massel D | 1994 | J Clin Invest1994，86，： | 1 |
| 18 | How sound is the evidence that thrombolysis increases the risk of cardiac rupture?显示文摘 | MASSEL D R | 1993 | Br Heart J1993，69，： | 1 |
| 19 | Export Concentration and Fluctuations in Export Earnings: A Cross-Section Analysis显示文摘 | Massell B F | 1964 | The Amer- ican Economic Review1964，，2： | 1 |
| 20 | Export Instability and Economic Structure显示文摘 | Massell B F | 1970 | The American Economic Review1970，，4： | 1 |
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