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| 1 | Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence显示文摘AIM: To investigate biological prevention with flavonoids the recurrence risk of neoplasia was studied in patients with resected colorectal cancer and after adenoma polypectomy. METHODS: Eighty-seven patients, 36 patients with resected colon cancer and 51 patients after polypectomy, were divided into 2 groups: one group was treated with a flavonoid mixture (daily standard dose 20 mg apigenin and 20 mg epigallocathechin-gallat, n = 31) and compared with a matched control group (n = 56). Both groups were observed for 3-4 years by surveillance colonoscopy and by questionnaire. RESULTS: Of 87 patients enrolled in this study, 36 had resected colon cancer and 29 of these patients had surveillance colonoscopy. Among the flavonoid-treated patients with resected colon cancer (n = 14), there was no cancer recurrence and one adenoma developed. In contrast the cancer recurrence rate of the 15 matched untreated controls was 20% (3 of 15) and adenomas evolved in 4 of those patients (27%). The combined recurrence rate for neoplasia was 7% (1 of 14) in the treated patients and 47% (7 of 15) in the controls (P = 0.027). CONCLUSION: Sustained long-term treatment with a flavonoid mixture could reduce the recurrence rate of colon neoplasia in patients with resected colon cancer. | Harald Hoensch Bertram Groh Lutz Edler Wilhelm Kirch | 2008 | World Journal of Gastroenterology2008，14，14： | 12 |
| 2 | A terrestrial observatory approach to the integrated investigation of the effects of deforestation on water,energy,and matter fluxes显示文摘Integrated observation platforms have been set up to investigate consequences of global change within a terrestrial network of observatories(TERENO)in Germany.The aim of TERENO is to foster the understanding of water,energy,and matter fluxes in terrestrial systems,as well as their biological and physical drivers.Part of the Lower Rhine Valley-Eifel observatory of TERENO is located within the Eifel National Park.Recently,the National Park forest management started to promote the natural regeneration of near-natural beech forest by removing a significant proportion of the spruce forest that was established for timber production after World War II.Within this context,the effects of such a disturbance on forest ecosystem functioning are currently investigated in a deforestation experiment in the Wüstebach catchment,which is one of the key experimental research sites within the Lower Rhine Valley-Eifel observatory.Here,we present the integrated observation system of the Wüstebach test site to exemplarily demonstrate the terrestrial observatory concept of TERENO that allows for a detailed monitoring of changes in hydrological and biogeochemical states and fluxes triggered by environmental disturbances.We present the observation platforms and the soil sampling campaign,as well as preliminary results including an analysis of data consistency.We specifically highlight the capability of integrated datasets to enable improved process understanding of the post-deforestation changes in ecosystem functioning. | H. R. BOGENA R BOL N. BORCHARD N. BRuGGEMANN B. DIEKKRtiGER C. DRuE J. GROH N. GOTTSELIG J. A. HUISMAN A. LuCKE A. MISSONG B. NEUWIRTH T. PuTZ M. SCHMIDT M. STOCKINGER W. TAPPE L. WEIHERMuLLER I. WIEKENKAMP H. VEREECKEN | 2015 | Science China Earth Sciences2015，58，1： | 6 |
| 3 | A new small -color-difference equation for dental shades显示文摘 | O'Brien WJ Groh CL Boenke KM | 1990 | J Dent Res1990，69，11： | 1 |
| 4 | Sonographic measurement of gallbladder volume 显示文摘 | Dodds WJ Groh W J Darweesh RM | 1985 | A JR Am J Roentgenol1985，145，5： | 1 |
| 5 | Challenges in cervical cancer screening: what clini-cians, patients and the general public need to know显示文摘 | GROHS D H | 1996 | Acta Cy-tol1996，40，1： | 1 |
| 6 | Sonographic measurement of gallbladder Volume显示文摘 | Dodds W J Groh W J Darweesh RM | | 0，，5： | 1 |
| 7 | Pharmacological study of cefoxitin as an alternative antibiotic therapy to carbapenems in treatment of urinary tract infections due to extended-spectrumβ-lactamase-producing Escherichia coli显示文摘 | Guet-Revillet H Emirian A Groh M | 2014 | Antimicrob Agents Chemother2014，58，8： | 1 |
| 8 | Environmental tobacco smoke and deaths from coronary heart disease in Canada 显示文摘 | de Groh M Morrison H I | 2002 | Chronic Dis Can2002，23，1： | 1 |
| 9 | Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation显示文摘 | Groh V Wu J Yee C | 2002 | Nature2002，419，6908： | 1 |
| 10 | Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB显示文摘 | Groh V Rhinehart R Secrist H | 1999 | Proc Natl Acad Sci U S A1999，96，12： | 1 |
| 11 | Nutrition management for the promotion of growth in very low birth weight premature infants 显示文摘 | Prince A Groh - Wargo S | 2013 | Nutr Clin Pract2013，28，6： | 1 |
| 12 | Human mesenchymal stem cells require monocyet mediated activation to suppress alloreactive T cells显示文摘 | Groh ME Maitra B Szekely E | 2005 | Exp Hematol2005，33，8： | 1 |
| 13 | Synthesis- driven structure revision of' plagiochin E', a highly bioacfive bisbibenzyl显示文摘 | SPEICHER A GROH M ZAPP J | 2009 | Synlett2009，，11： | 1 |
| 14 | Selective COX-2 inhibitor versus indomethacin for the prevention of heterotopic ossification after hip replacement: a double-blind randomized trial of 100 patients with 1-year follow-up 显示文摘 | Grohs JG Schmidt M Wanivenhaus A | 2007 | Acta Orthop2007，78，1： | 1 |
| 15 | Beta interferon is produced by Chlamydia trachomatis-infected fibroblast-like synoviocytes and inhibits gamma interferon-induced HLA-DR expression显示文摘 | R(o)del J Groh A Vogelsang H | | 0，，09： | 1 |
| 16 | Management of traumatic sternocla vicular joint inj uries显示文摘 | Groh GI Wirth MA | 2011 | J Am Acad Orthop Surg2011，19，1： | 1 |
| 17 | Tumour- derived soluble MIC ligands impair expression of NKG2D and T-cell activation显示文摘 | Groh V Wu J Yee C | 2002 | Nature2002，419，6908： | 1 |
| 18 | Costimulation of CD8 alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells显示文摘 | Groh V Rhinehart R Randolph-Habecker J | 2001 | Nat Immunol2001，2，3： | 1 |
| 19 | Damagesimulation of brittle heterogeneous materials at the grainsize level显示文摘 | GROH U KONIETZKY H WALTER K | 2011 | Theoretical and Applied FractureMechanics2011，55，1： | 1 |
| 20 | The burden of adult obesity in Canada显示文摘 | Morrison H de Groh M | 2007 | Chronic Dis Can2007，27，： | 1 |
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