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| 1 | Inflammatory bowel disease: A descriptive study of 716 local Chilean patients显示文摘AIM: To demographically and clinically characterize inflammatory bowel disease(IBD) from the local registry and update data previously published by our group.METHODS: A descriptive study of a cohort based on a registry of patients aged 15 years or older who were diagnosed with IBD and attended the IBD program at Clínica Las Condes in Santiago, Chile. The registry was created in April 2012 and includes patients registered up to October 2015. The information was anonymously downloaded in a monthly report, and the information on patients with more than one visit was updated. The registry includes demographic, clinical and disease characteristics, including the Montreal Classification, medical treatment, surgeries and hospitalizations for crisis. Data regarding infection with Clostridium difficile(C. difficile) were incorporated in the registry in 2014. Data for patients who received consultations as second opinions and continued treatment at this institution were also analyzed. RESULTS: The study included 716 patients with IBD: 508 patients(71%) were diagnosed with ulcerative colitis(UC), 196 patients(27%) were diagnosed with Crohn's disease(CD) and 12 patients(2%) were diagnosed with unclassifiable IBD. The UC/CD ratio was 2.6/1. The median age was 36 years(range 16-88), and 58% of the patients were female, with a median age at diagnosis of 29 years(range 5-76). In the past 15 years, a sustained increase in the number of patients diagnosed with IBD was observed, where 87% of the patients were diagnosed between the years 2001 and 2015. In the cohort examined in the present study, extensive colitis(50%) and colonic involvement(44%) predominated in the patients with UC and CD, respectively. In CD patients, nonstricturing/non-penetrating behavior was more frequent(80%), and perianal disease was observed in 28% of the patients. There were significant differences in treatment between UC and CD, with a higher use of corticosteroids, and immunosuppressive and biological therapies was observed in the patients with CD(P < 0.05 and P < 0.01). Significant surgical differences were also observed: 5% of the UC patients underwent surgery, whereas 38% of the CD patients required at least one surgery(P < 0.01). The patients with CD were hospitalized more often during their disease course than the patients with UC(55% and 35% of the patients, respectively; P < 0.01). C. difficile infection was acquired by 5% of the patients in each group at some point during the disease course. Nearly half of the patients consulted at the institution for a second opinion, and 32% of these individuals continued treatment at the institution. CONCLUSION: IBD has continued to increase in the study cohort, slowly approaching the level reported in developed countries. | Daniela Simian Daniela Fluxá Lilian Flores Jaime Lubascher Patricio Ibánez Carolina Figueroa Udo Kronberg Raúl Acuna Mauricio Moreno Rodrigo Quera | 2016 | World Journal of Gastroenterology2016，22，22： | 2 |
| 2 | Science Letters:Quantification of Helicobacter pylori levels in soil samples from public playgrounds in Spain显示文摘Helicobacter pylori are ubiquitous Gram-negative bacteria with a high estimated level of infection in the world populations, but a majority of the infected persons are asymptomatic. This pathogen has been classified by the World Health Organization as a class I carcinogen and recognized as the causal agent of most peptic ulcers and chronic gastritis that might lead to stomach cancer. Although not all the transmission pathways of these bacteria into humans have been properly identified, enough data have suggested that the oral-oral or fecal-oral ones are the main infection routes. Helicobacter pylori have been detected in non-treated water and in drinking water, which suggested that water might be an important infection source. As childhood is the critical period of infection, the aim of the present work was to examine the presence of Helicobacter pylori in soil samples from public playing areas of Spanish parks. | Leonardo Martín PéREZ Francesc CODONY Daniela LóPEZ LEYTON Mariana FITTIPALDI Bárbara ADRADOS Jordi MORATó | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，1： | 2 |
| 3 | Viral Hepatitis in Alcohol-Dependent Inpatients: Prevalence, Risk Factors, and Treatment Uptake显示文摘 | Christiane Sybille Schmidt Daniela Sch?n Bernd Schulte Stefan Lüth Susanne Polywka Jens Reimer | 2013 | Journal of Addiction Medicine2013，，6： | 1 |
| 4 | Database techniques for the World Wide Web显示文摘 | DANIELA F ALON L ALBERTO M | 2005 | Sigmod Record2005，32，3： | 1 |
| 5 | The chaperoning and assistance roles of the HIV-1 nucleocapsid protein in proviral DNA synthesis and maintenance显示文摘 | CAROLE B SANDRINE J DANIELA L | 2004 | Int J Biochem Cell Biol2004，36，： | 1 |
| 6 | Neurospheres enriched in cancer stem like cells are highly effective in eliciting a den- dritic cell mediated immune response against malignant gliomas 显示文摘 | Serena P Pietro L P Daniela C | 2006 | Cancer Res2006，66，10： | 1 |
| 7 | TP53 mutation and p53 overexpression for prediction of response to neoadjuvant treatment in breat cancer patients显示文摘 | Daniela KE Carmen L Margarethe R | 2000 | Clin Cancer Res2000，6，1： | 1 |
| 8 | Microwave Promoted Suzuki Reactions between Aroyl Chlorides and Boronic Acids Catalyzed by Het- erogeneous and Homogeneous Phosphine-free Palla- dium Catalysts 显示文摘 | DANIELA DE L M AGUIAR L C ANTUNES O A | 2011 | J of Organomet Chem2011，696，1516： | 1 |
| 9 | A switch to high-flux helixonee membranes reverse suppressed interferon-γ production in patients on low-flux dialysis显示文摘 | Gerhard L Daniela N Menachem R | 2003 | Blood Purification2003，21，： | 1 |
| 10 | A PEST-Like Sequence in Listeriolysin O Essential for Listeria monocytogenes Pathogenicity显示文摘 | AMY L DECATUR DANIELA | 2000 | Science2000，3，： | 1 |
| 11 | Detection of Fog and Low Cloud Boundaries with Ground-Based Remote Sensing Systems显示文摘 | Nowak Daniela Ruffieux Dominique Agnew Judith L Vuilleumier Laurent | 2008 | Journal of Atmospheric and Oceanic Technology2008，，8： | 1 |
| 12 | Wavelet Analysis For Wind Fields Estimation显示文摘 | GLADESTON C L DANIELA M U F 6 TIMA N S M | 2010 | Sensors2010，10，： | 1 |
| 13 | The stem cells as a potential treatment for neurodegeneration 显示文摘 | Daniela F Vescovi A L Bottai D | 2007 | Methods Mol Biol2007，399，： | 1 |
| 14 | Adiponectin is associated with abnormal lipid profile and coronary microvascular dysfunction in patients with dilated cardiomyopathy without overt heart failure显示文摘 | Daniela Giannessi Chiara Caselli Silvia Del Ry Maristella Maltinti Silvia Pardini Stefano Turchi Manuela Cabiati Tiziana Sampietro Nader Abraham Antonio L’Abbate Danilo Neglia | 2011 | Metabolism2011，，2： | 1 |
| 15 | Preparation of medium chain triglycerides with the use of physical refining显示文摘 | L Hartman Daniela Reimann | 1989 | Fat Sci Technol1989，91，8： | 1 |
| 16 | Anthracycline- induced cardiomyopathy显示文摘 | Daniela C Alessandro C Giuseppina L | 2010 | JACC2010，55，3： | 1 |
| 17 | Cystatin C and Estimates of renal function:Searching for a better measure of kidney function in diabetic patients显示文摘 | Laura P Stefno T Daniela L | 2007 | Clin Chem2007，55，3： | 1 |
| 18 | Revista Romng de Medicin de Labrator显示文摘 | Daniela S P Laurian V Daciana Chirilfi Felicia L | 2010 | 18 (4) : 42010，18，4： | 1 |
| 19 | A re-view on lipase-catalyzed reactions in ultrasound-assis- ted systems 显示文摘 | Lindomar A L Raquel A L Daniela R | 2014 | Bioprocess Biosystems Engineering2014，37，12： | 1 |
| 20 | Riboflavin-overproducing strains of Lactobacillus fermentum for riboflavin-enriched bread显示文摘 | Pasquale Russo Vittorio Capozzi Mattia Pia Arena Giuseppina Spadaccino María Teresa Due?as Paloma López Daniela Fiocco Giuseppe Spano | 2014 | Applied Microbiology and Biotechnology2014，，8： | 1 |
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