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| 1 | Normal aspects of colorectal motility and abnormalities in slow transit constipation显示文摘Human colonic motility is a relatively difficult topic to investigate. However, the refinement of manometric techniques in recent years enabled us to study both the proximal and distal segments of the viscus. The present paper reviews our knowledge about normal aspects of colorectal motility in man and the abnormalities found in slow transit constipation (STC), one of the most frequent and difficult to treat subtypes of constipation. An internetbased search strategy of the Medline and Science Citation Index was performed using the keywords colon, colonic,colorectal, constipation, slow transit, motility, recal, rectum in various combinations with the Boolean operators AND, OR and NOT. Only articles related to human studies were used, and manual cross-referencing was also performed.Most of colonic motor activity is represented by single nonpropagated contractions, rarely organized in bursts; this activity is maximal during the day, especially after waking and following meals. In addition, a specialized propagated activity with propulsive features is detectable, represented by high- and low-amplitude propagated contractions. In the severe form of constipation represented by the slow transit type, the above motor activity is completely deranged. In fact, both basal segmental activity (especially in response to meals) and propagated activity (especially that of high amplitude) are usually decreased, and this may represent a physiologic marker of this disorder. Human colonic motor activity is quite a complex issue, still only partly understood and investigated, due to anatomic and physiological difficulties. In recent years, however, some more data have been obtained, even in proximal segments. These data have helped in elucidating, althoughonly in part, some pathophysiological mechanisms of chronic constipation, and especially of the STC subtype. | Gabrio Bassotti Giuseppe de Roberto Danilo Castellani Luca Sediari Antonio Morelli | 2005 | World Journal of Gastroenterology2005，11，18： | 21 |
| 2 | Evaluation of latent links between irritable bowel syndrome and sleep quality显示文摘AIM:To examine the links between quality of sleep and the severity of intestinal symptoms in irritable bow-el syndrome(IBS).METHODS:One hundred and forty-two outpatients(110female,32 male)who met the Rome Ⅲ criteria for IBS with no psychiatric comorbidity were consecutively en-rolled in this study.Data on age,body mass index(BMI),and a set of life-habit variables were recorded,and IBS symptoms and sleep quality were evaluated using the questionnaires IBS Symptom Severity Score(IBS-SSS)and Pittsburgh Sleep Quality Index(PSQI).The associa-tion between severity of IBS and sleep disturbances was evaluated by comparing the global IBS-SSS and PSQI score(Pearson's correlation and Fisher's exact test)and then analyzing the individual items of the IBS-SSS and PSQI questionnaires by a unitary bowel-sleep model based on item response theory(IRT).RESULTS:IBS-SSS ranged from mild to severe(120-470).The global PSQI score ranged from 1 to 17(median 5),and 60 patients were found to be poor sleepers(PSQI>5).The correlation between the global IBS-SSS and PSQI score indicated a weak association(r=0.2 and 95% CI:-0.03 to 0.35,P<0.05),which becomes stronger using our unitary model.Indeed,the IBS and sleep disturbances severities,estimated as latent variables,resulted significantly high intra-subject cor-relation(posterior mean of r=0.45 and 95% CI:0.17 to 0.70,P<0.05).Moreover,the correlations between patient features(age,sex,BMI,daily coffee and alcohol intake)and IBS and sleep disturbances were also ana-lyzed through our unitary model.Age was a signif icant regressor,with patients≤50 years old showing more severe bowel disturbances(posterior mean=-0.38,P<0.05)and less severe sleep disturbances(posterior mean=0.49,P<0.05)than older patients.Higher daily coffee intake was correlated with a lower sever-ity of bowel disturbances(posterior mean=-0.31,P<0.05).Sex(female)and daily alcohol intake(modest)were correlated with less severe sleep disturbances.CONCLUSION:The unitary bowel-sleep model based on IRT revealed a strong positive correlation between the severity of IBS symptoms and sleep disturbances. | Massimo Bellini Angelo Gemignani Dario Gambaccini Simona Toti Danilo Menicucci Cristina Stasi Francesco Costa Maria Gloria Mumolo Angelo Ricchiuti Remo Bedini Nicola de Bortoli Santino Marchi | 2011 | World Journal of Gastroenterology2011，17，46： | 17 |
| 3 | Nonalcoholic fatty liver disease in patients with inflammatory bowel disease: Beyond the natural history显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a frequently reported condition in patients with inflammatory bowel disease(IBD).Both intestinal inflammation and metabolic factors are believed to contribute to the pathogenesis of IBDassociated NAFLD.AIM To evaluate the prevalence of steatosis and liver fibrosis(LF)in a cohort of IBD patients and the identification of metabolic-and IBD-related risk factors for NAFLD and LF.METHODS IBD patients were consecutively enrolled from December 2016 to January 2018.Demographic,anthropometric and biochemical data were collected so as eating habits.Abdominal ultrasound and transient elastography were performed to evaluate the presence of NAFLD and LF respectively.RESULTS A total of 178 consecutive patients were enrolled and included in the analysis(95 Ulcerative colitis,83 Crohn’s disease).NAFLD was detected by imaging in 72(40.4%)patients.Comparison between patients with and without NAFLD showed no significant differences in terms of IBD severity,disease duration,location/extension,use of IBD-related medications(i.e.,steroids,anti-TNFs,and immunomodulators)and surgery.NAFLD was significantly associated with the presence of metabolic syndrome[MetS;odds ratio(OR):4.13,P=0.001]and obesity defined by body mass index(OR:9.21,P=0.0002).IBD patients with NAFLD showed higher caloric intake and lipid consumption than those without NAFLD,regardless disease activity.At the multivariate analysis,male sex,advanced age and high lipid consumption were independent risk factors for the development of NAFLD.An increased liver stiffness was detected in 21 patients(16%)and the presence of MetS was the only relevant factor associated to LF(OR:3.40,P=0.01).CONCLUSION In this study,we demonstrate that risk factors for NAFLD and LF in the IBD population do not differ from those in the general population. | Salvatore Magrì Danilo Paduano Fabio Chicco Arianna Cingolani Cristiana Farris Giovanna Delogu Francesca Tumbarello Mariantonia Lai Alessandro Melis Laura Casula Massimo C Fantini Paolo Usai | 2019 | World Journal of Gastroenterology2019，25，37： | 8 |
| 4 | Diagnosis of gluten related disorders: Celiac disease, wheat allergy and non-celiac gluten sensitivity显示文摘Cereal crops and cereal consumption have had a vital role in Mankind's history. In the recent years gluten ingestion has been linked with a range of clinical disorders. Gluten-related disorders have gradually emerged as an epidemiologically relevant phenomenon with an estimated global prevalence around 5%. Celiac disease, wheat allergy and non-celiac gluten sensitivity represent different gluten-related disorders. Similar clinical manifestations can be observed in these disorders, yet there are peculiar pathogenetic pathways involved in their development. Celiac disease and wheat allergy have been extensively studied, while non-celiac gluten sensitivity is a relatively novel clinical entity, believed to be closely related to other gastrointestinal functional syndromes. The diagnosis of celiac disease and wheat allergy is based on a combination of findings from the patient's clinical history and specific tests, including serology and duodenal biopsies in case of celiac disease, or laboratory and functional assays for wheat allergy. On the other hand, non-celiac gluten sensitivity is still mainly a diagnosis of exclusion, in the absence of clear-cut diagnostic criteria. A multimodal pragmatic approach combining findings from the clinical history, symptoms, serological and histological tests is required in order to reach an accurate diagnosis. A thorough knowledge of the differences and overlap in clinical presentation among gluten-related disorders, and between them and other gastrointestinal disorders, will help clinicians in the process of differential diagnosis. | Luca Elli Federica Branchi Carolina Tomba Danilo Villalta Lorenzo Norsa Francesca Ferretti Leda Roncoroni Maria Teresa Bardella | 2015 | World Journal of Gastroenterology2015，21，23： | 8 |
| 5 | Effects of percutaneous varicocele repair on testicular volume:results from a 12-month follow-up显示文摘Varicocele is a comm on fin ding in men. Varicocele correcti on has bee n advocated for young patients with testicular hypotrophy, but there is a lack of morphofunctional follow-up data. We assessed whether percutaneous treatment of left varicocele is associated with testicular 'catch-up growth' in the following 12 months by retrospectively reviewing data from an electronic database of 10 656 patients followed up in our clinic between 2006 and 2016. We selected all young adults (<35 years) with left varicocele who un derwe nt percuta neous treatment, had a minimum of 12 mon ths' ultraso und imagi ng follow-up, and had no other con ditions affecting testicular volume. One hundred and fourteen men (mean±standard deviation [s.d.] of age: 22.8 ± 5.4 years) met the inclusion and exclusion criteria. Left testicular hypotrophy (LTH), defined as a >20% difference between left and right testicular volume at baseline, was observed in 26 (22.8%) men. Participants with LTH (mean±s.d.: 14.5 ± 2.7 ml) had lower baseline testicular volume compared to those without LTH (mean±s.d.: 15.7 ± 3.8 ml;P= 0.032). Repeated measures mixed models showed a sign ifica nt in teraction betwee n LTH and time posttreatme nt when correcting for baseli ne left testicular volume (β= 0.114, 95% confidence interval [Cl]: 0.018-0.210, P=0.020), resulting in a catch-up growth of up to 1.37 ml per year (95% Cl: 0.221- 2.516). Age at intervention was also associated with reduced testicular volume (-0.072 ml per year, 95% Cl:-0.135--0.009;P = 0.024). Percutaneous treatment of left varicocele in young adults with LTH can result in catch-up growth over 1 year of follow-up. The reproductive and psychological implicati ons of these findings n eed to be confirmed in Ion ger and larger prospective studies. | Andrea Sansone Danilo Alunni Fegatelli Carlotta Pozza Giorgio Fattorini Rosa Lauretta Marianna Minnetti Francesco Romanelli Pierleone Lucatelli Mario Corona Mario Bezzi Francesco Lombardo Andrea Lenzi Daniele Gianfrilli | 2019 | Asian Journal of Andrology2019，21，4： | 8 |
| 6 | Separation of middle rare earths by solvent extraction using 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester as an extractant显示文摘The extraction of the trivalent middle rare earths from chloride media by kerosene solutions of 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester as an extractant was studied. The separation factors between the elements using solution simulating wastes from NiMH spent batteries have been evaluated: the order of the extractive ability of extractant can be confirmed in Tb>Gd>Eu>Sm. | Danilo Fontana Loris Pietrelli | 2009 | Journal of Rare Earths2009，27，5： | 7 |
| 7 | Linear endoscopic ultrasonography vs magnetic resonance imaging in ampullary tumors显示文摘AIM:To assess linear endoscopic ultrasound (L-EUS) and magnetic resonance imaging (MRI) in biliary tract dilation and suspect small ampullary tumor.METHODS:L-EUS and MRI data were compared in 24 patients with small ampullary tumors;all with subsequent histological confirmation.Data were collected prospectively and the accuracy of detection,histological characterization and N staging were assessed retrospectivelyusing the results of surgical or endoscopic treatment as a benchmark.RESULTS:A suspicion of ampullary tumor was present in 75% of MRI and all L-EUS examinations,with 80% agreement between EUS and histological findings at endoscopy.However,L-EUS and histological TN staging at surgery showed moderate agreement (κ=0.54).CONCLUSION:L-EUS could be a useful adjunct as a diagnostic tool in the evaluation of patients with sus-pected ampullary tumors. | Raffaele Manta Rita Conigliaro Danilo Castellani Alessandro Messerotti Helga Bertani Giuseppe Sabatino Elena Vetruccio Luisa Losi Vincenzo Villanacci Gabrio Bassotti | 2010 | World Journal of Gastroenterology2010，16，44： | 6 |
| 8 | Modelling of adsorption of textile dyes over multi-walled carbon nanotubes:Equilibrium and kinetic显示文摘The paper deals with the application of multiwall carbon nanotubes(CNTs) to the adsorption of dyes from wastewater. Textile dyes are dangerous and diffused pollutant in wastewater, and the paper results confirmed the good adsorption ability of CNTs, with respect to classic active carbon, even for different dye types. The effect of surface treatments of CNTs was primarily investigated, revealing that neither the presence of residual catalyst nor common surface treatment(oxidation) affects the CNT's performances. Therefore less expensive nonpurified CNTs were assessed as good and economically convenient alternative for the process. In order to gain in generality in adsorption kinetic modelling, the parameters of the 'best fitting' pseudo-second order model have been correlated to the main process variables(the dye initial concentration and the specific mass of CNTs.) setting-up a predictive kinetic model useful design new application of these materials in currently operating industrial operations for adsorption. In addition, isothermal data were used to screen all the relevant adsorption isotherms models and the Temkin model was confirmed as the more effective to accurately fit equilibrium data for any of the considered different dye types. | Danilo Vuono Enrico Catizzone Alfredo Aloise Alfonso Policicchio Raffaele G.Agostino Massimo Migliori Girolamo Giordano | 2017 | Chinese Journal of Chemical Engineering2017，25，4： | 6 |
| 9 | Perspectives on new biomarkers in gastric cancer: Diagnostic and prognostic applications显示文摘Gastric cancer is considered one of the most deadly tumors worldwide. Even with the decline in its incidence, the mortality rate of this disease has remained high, mainly due to its late diagnosis and to the lack of precise prognostic markers. The main purpose of this review is to present genetic, epigenetic and proteomic molecular markers that may be used in a diagnostic and prognostic manner and to discuss the pros and cons of each type of marker for improving clinical practice. In this sense, we observed that the use of genetic markers, especially mutations and polymorphisms, should be carefully considered, as they are strongly affected by ethnicity. Proteomic-based markers show promise, but the higher costs of the associated techniques con-tinue to make this approach expensive for routine use. Alternatively, epigenetic markers appear to be very promising, as they can be detected in bodily fluids as well as tissues. However, such markers must be used carefully because epigenetic changes may occur due to environmental factors and aging. Despite the advances in technology and its access, to date, there are few defined biomarkers of prognostic and diagnostic use for gastric tumors. Therefore, the use of a panel of several approaches(genetic, epigenetic and proteomic) should be considered the best alternative for clinical practice. | Danilo do Rosário Pinheiro Wallax Augusto Silva Ferreira Mariceli Baia Leo Barros Mariana Diniz Araújo Symara Rodrigues-Antunes Bárbara do Nascimento Borges | 2014 | World Journal of Gastroenterology2014，20，33： | 4 |
| 10 | High density lipoproteins and atherosclerosis: emerging aspects显示文摘High density lipoproteins (HDL) promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. This ability is responsible for the most relevant anti-atherogenic effect of HDL. The ability of HDL to promote cholesterol efflux results also in the modulation of a series of responses in the immune cells involved in atherosclerosis,includingmonocyte-macrophages, B and T lymphocytes.Furthermore, during inflammation, the composition of this class of lipoproteins varies to a large extent, thus promoting the formation of dysfunctional HDL. The aim of this review is to discuss the emerging role of HDL in modulating the activity of immune cells and immune-inflammatory mediators during atherogenesis. | Federica Sala Alberico Luigi Catapano Giuseppe Danilo Norata | 2012 | Journal of Geriatric Cardiology2012，9，4： | 4 |
| 11 | 在准备生产无抗生猪时需要考虑的4个因素显示文摘是否有可能成功地生产出无抗生素的猪?加拿大马尼托巴省枫叶食品公司的Le Ann Peters说,他们已经成功地生产出无抗生素猪大约有4年的时间了。生产无抗生素猪有时会失败,但这种情况并不是你认为的那样会经常发生。 | 潘余乐 Danilo Sotto | 2015 | 国外畜牧学(猪与禽)2015，35，12： | 3 |
| 12 | Comparative outcome of stapled trans-anal rectal resection and macrogol in the treatment of defecation disorders显示文摘AIM:To prospectively assess the eff icacy and safety of stapled trans-anal rectal resection(STARR) compared to standard conservative treatment,and whether preoperative symptoms and findings at defecography and anorectal manometry can predict the outcome of STARR.METHODS:Thirty patients(Female,28;age:51 ± 9 years) with rectocele or rectal intussusception,a defecation disorder,and functional constipation were submitted for STARR.Thirty comparable patients(Female,30;age 53 ± 13 years),who presented with symptoms of rectocele or rectal intussusception and were treated with macrogol,were assessed.Patients were interviewed with a standardized questionnaire at study enrollment and 38 ± 18 mo after the STARR procedure or during macrogol treatment.A responder was def ined as an absence of the Rome Ⅲ diagnostic criteria for functional constipation.Defecography and rectoanal manometry were performed before and after the STARR procedure in 16 and 12 patients,respectively.RESULTS:After STARR,53% of patients were responders;during conservative treatment,75% were responders.After STARR,30% of the patients reported the use of laxatives,17% had intermittent anal pain,13% had anal leakage,13% required digital facilitation,6% experienced defecatory urgency,6% experienced fecal incontinence,and 6% required re-intervention.During macrogol therapy,23% of the patients complained of abdominal bloating and 13% of borborygmi,and 3% required digital facilitation.No preoperative symptom,defecographic,or manometric finding predicted the outcome of STARR.Post-operative defecography showed a statistically significant reduction(P < 0.05) of the rectal diameter and rectocele.The postoperative anorectal manometry showed that anal pressure and rectal sensitivity were not significantly modified,and that rectal compliance was reduced(P = 0.01).CONCLUSION:STARR is not better and is less safe than macrogol in the treatment of defecation disorders.It could be considered as an alternative therapy in patients unresponsive to macrogol. | Ivano Biviano Danilo Badiali Laura Candeloro Fortunée Irene Irene Habib Massimo Mongardini Angelo Caviglia Fiorella Anzini Enrico S Corazziari | 2011 | World Journal of Gastroenterology2011，17，37： | 3 |
| 13 | Chronic myeloid leukemia: mechanisms of blastic transformation显示文摘 | Perrotti Danilo Jamieson Catriona Goldman John Skorski Tomasz | 2010 | Journal of Clinical Investigation2010，，7： | 3 |
| 14 | Regular nonlinear response of the driven Duffng oscillator to chaotic time series显示文摘Nonlinear response of the driven Duffng oscillator to periodic or quasi-periodic signals has been well studied.In this paper,we investigate the nonlinear response of the driven Duffng oscillator to non-periodic,more specifically,chaotic time series.Through numerical simulations,we find that the driven Duffng oscillator can also show regular nonlinear response to the chaotic time series with different degree of chaos as generated by the same chaotic series generating model,and there exists a relationship between the state of the driven Duffng oscillator and the chaoticity of the input signal of the driven Duffng oscillator.One real-world and two artificial chaotic time series are used to verify the new feature of Duffng oscillator.A potential application of the new feature of Duffng oscillator is also indicated. | 袁野 李月 Danilo P.Mandic 杨宝俊 | 2009 | Chinese Physics B2009，18，3： | 3 |
| 15 | Role of aryl hydrocarbon receptor in mesenchymal stromal cell activation:A minireview显示文摘Mesenchymal stromal cells(MSCs) possess great therapeutic advantages due to their ability to produce a diverse array of trophic/growth factors related to cytoprotection and immunoregulation.MSC activation via specific receptors is a crucial event for these cells to exert their immunosuppressive response.The aryl-hydrocarbon receptor(Ah R) is a sensitive molecule for external signals and it is expressed in MSCs and,upon positive activation,may potentially regulate the MSC-associated immunomodulatory function.Consequently,signalling pathways linked to Ah R activation can elucidate some of the molecular cascades involved in MSC-mediated immunosuppression.In this minireview,we have noted some important findings concerning MSC regulation via Ah R,highlighting that its activation is associated with improvement in migration and immunoregulation,as well as an increase in pro-regenerative potential.Thus,Ah R-mediated MSC activation can contribute to new perspectives on MSC-based therapies,particularly those directed at immune-associated disorders. | Danilo Candido de Almeida Laura Sibele Martins Evangelista Niels Olsen Saraiva Camara | 2017 | World Journal of Stem Cells2017，9，9： | 2 |
| 16 | Distributed Differences Structures Underlie Gating between the Kin Channel KAT1 and the Kout Channel SKOR显示文摘 | Janin Riedelsberger Tripti Sharma Wendy Gonzalez Pawel Gajdanowicz Samuel Elias Morales-Navarro Carlos Garcia-Mata Bernd Mueller-Roeber Fernando Danilo Gonzalez-Nilo Michael R. Blatt Ingo Dreyer | 2010 | Molecular Plant2010，3，1： | 2 |
| 17 | Complete mesocolic excision and central vascular ligation in colorectal cancer in the era of minimally invasive surgery显示文摘Since the 19th century,appropriate lymphadenectomy has been considered a cornerstone of oncologic surgery and one of the most important prognostic factors.This approach can be applied to any surgery for gastrointestinal cancer.During surgery for colon and rectal cancer,an adequate portion of the mesentery is removed together with the segment of bowel affected by the disease.The adequate number of lymph nodes to be removed is standardized and reported by several guidelines.It is mandatory to determine the appropriate extent of lymphadenectomy and to balance its oncological benefits with the increased morbidity associated with its execution in cancer patients.Our review focuses on the concept of“complete mesenteric excision(CME)with central vascular ligation(CVL),”a radical lymphadenectomy for colorectal cancer that has gained increasing interest in recent years.The aim of this study was to evaluate the evolution of this approach over the years,its potential oncologic benefits and potential risks,and the improvements offered by laparoscopic techniques.Theoretical advantages of CME are improved local-relapse rates due to complete removal of the intact mesocolic fascia and improved distance recurrence rates due to ligation of vessels at their origin(CVL)which guarantees removal of a larger number of lymph nodes.The development and worldwide diffusion of laparoscopic techniques minimized postoperative trauma in oncologic surgery,providing the same oncologic results as open surgery.This has been widely applied to colorectal cancer surgery;however,CME entails a technical complexity that can limit its wide minimally-invasive application. This review analyzesresults of these procedures in terms of oncological outcomes, technical feasibilityand complexity, especially within the context of minimally invasive surgery. | Marzia Franceschilli Sara Di Carlo Danilo Vinci Bruno Sensi Leandro Siragusa Vittoria Bellato Roberto Caronna Piero Rossi Giuseppe Cavallaro Andrea Guida Simone Sibio | 2021 | World Journal of Clinical Cases2021，9，25： | 2 |
| 18 | Delving into the variations in tree species composition and richness across south american subtropical atlantic and Pampean forests显示文摘Aims We analyse here the variations in species composition and richness and the geographic ranges of the tree species occurring in south american subtropical atlantic and Pampean forests.our goals were to assess(i)the floristic consistency of usual classifications based on vegetation physiognomy,climate and elevation;(ii)the leading role of temperature-related variables on the variations in species composition and richness;(iii)the predominance of species with tropical-subtropical ranges,possibly as a result of forest expansion over grasslands after the last glacial maximum(LGM);(iv)the restriction of most subtropical endemics to stressful habitats as a possible result of past forest refuges during the LGM.Methods The region was defined by the Tropic of Capricorn to the north,the rio de la Plata to the south,the atlantic shoreline to the east and the catchment areas of the upper Paranáand uruguay rivers to the west.multivariate analyses,multiple regression modelling and variance partition analyses were performed on a database containing 63994 occurrence records of 1555 tree species in 491 forest sites and 48 environmental variables.all species were also classified according to their known geographic range.Important Findingsa main differentiation in species composition and richness was observed between the eastern windward coastlands(rain and cloud forests)and western leeward hinterlands(Araucaria and semi-decid-uous forests).Pre-defined forest types on both sides were consistent with variations in tree species composition,which were significantly related to both environmental variables and spatial proximity,with extremes of low temperature playing a chief role.Tree species rich-ness declined substantially towards the south and also from rain to seasonal forests and towards the highland summits and sandy shores.species richness was significantly correlated with both minimum temperature and actual evapotranspiration.about 91%of the subtropical flora is shared with the much richer tropical flora,prob-ably extracting species that can cope with frost outbreaks.The 145 subtropical endemics were not concentrated in harsher habitats. | Ary T.Oliveira-Filho Jean C.Budke João A.Jarenkow Pedro V.Eisenlohr Danilo R.M.Neves | 2015 | Journal of Plant Ecology2015，8，3： | 2 |
| 19 | Eye reflux:an ocular extraesophageal manifestation of gastric reflux显示文摘AIM: To suspect laryngopharyngeal reflux(LPR) in patients with ocular surface disease(OSD). METHODS: The present study evaluated a group of subjects with OSD assessing the Ocular Surface Disease Index(OSDI) and the Reflux Symptom Index(RSI) to detect patients with suspected LPR and define a possible relationship between tests.RESULTS: Two hundred and ninety subjects(175 females, mean age: 60.41±15.68y) were consecutively visited at ophthalmologist offices. One hundred and one(34%) patients had pathological RSI(>13) and consequently a suspected LPR.CONCLUSION: The current study shows that suspected LPR may be common(34%) in patients with OSD and a suspected LPR may be considered in OSD patients when RSI score is >13 and OSDI score is >42. | Danilo Mazzacane Valerio Damiani Michela Silvestri Giorgio Ciprandi Pierfranco Marino | 2018 | International Journal of Ophthalmology(English edition)2018，11，9： | 2 |
| 20 | Precision Phenotyping Reveals Novel Loci for Quantitative Resistance to Septoria Tritici Blotch显示文摘Accurate,high-throughput phenotyping for quantitative traits is a limiting factor for progress in plant breeding.We developed an automated image analysis to measure quantitative resistance to septoria tritici blotch(STB),a globally important wheat disease,enabling identification of small chromosome intervals containing plausible candidate genes for STB resistance.335 winter wheat cultivars were included in a replicated field experiment that experienced natural epidemic development by a highly diverse but fungicide-resistant pathogen population.More than 5.4 million automatically generated phenotypes were associated with 13,648 SNP markers to perform the GWAS.We identified 26 chromosome intervals explaining 1.9-10.6%of the variance associated with four independent resistance traits.Sixteen of the intervals overlapped with known STB resistance intervals,suggesting that our phenotyping approach can identify simultaneously(i.e.,in a single experiment)many previously defined STB resistance intervals.Seventeen of the intervals were less than 5 Mbp in size and encoded only 173 genes,including many genes associated with disease resistance.Five intervals contained four or fewer genes,providing high priority targets for functional validation.Ten chromosome intervals were not previously associated with STB resistance,perhaps representing resistance to pathogen strains that had not been tested in earlier experiments.The SNP markers associated with these chromosome intervals can be used to recombine different forms of quantitative STB resistance that are likely to be more durable than pyramids of major resistance genes.Our experiment illustrates how high-throughput automated phenotyping can accelerate breeding for quantitative disease resistance. | Steven Yates Alexey Mikaberidze Simon GKrattinger Michael Abrouk Andreas Hund Kang Yu Bruno Studer Simone Fouche Lukas Meile Danilo Pereira Petteri Karisto Bruce A.McDonald | 2019 | Plant Phenomics2019，1，1： | 2 |
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