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| 1 | Nonalcoholic fatty liver disease in patients with inflammatory bowel disease: Beyond the natural history显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a frequently reported condition in patients with inflammatory bowel disease(IBD).Both intestinal inflammation and metabolic factors are believed to contribute to the pathogenesis of IBDassociated NAFLD.AIM To evaluate the prevalence of steatosis and liver fibrosis(LF)in a cohort of IBD patients and the identification of metabolic-and IBD-related risk factors for NAFLD and LF.METHODS IBD patients were consecutively enrolled from December 2016 to January 2018.Demographic,anthropometric and biochemical data were collected so as eating habits.Abdominal ultrasound and transient elastography were performed to evaluate the presence of NAFLD and LF respectively.RESULTS A total of 178 consecutive patients were enrolled and included in the analysis(95 Ulcerative colitis,83 Crohn’s disease).NAFLD was detected by imaging in 72(40.4%)patients.Comparison between patients with and without NAFLD showed no significant differences in terms of IBD severity,disease duration,location/extension,use of IBD-related medications(i.e.,steroids,anti-TNFs,and immunomodulators)and surgery.NAFLD was significantly associated with the presence of metabolic syndrome[MetS;odds ratio(OR):4.13,P=0.001]and obesity defined by body mass index(OR:9.21,P=0.0002).IBD patients with NAFLD showed higher caloric intake and lipid consumption than those without NAFLD,regardless disease activity.At the multivariate analysis,male sex,advanced age and high lipid consumption were independent risk factors for the development of NAFLD.An increased liver stiffness was detected in 21 patients(16%)and the presence of MetS was the only relevant factor associated to LF(OR:3.40,P=0.01).CONCLUSION In this study,we demonstrate that risk factors for NAFLD and LF in the IBD population do not differ from those in the general population. | Salvatore Magrì Danilo Paduano Fabio Chicco Arianna Cingolani Cristiana Farris Giovanna Delogu Francesca Tumbarello Mariantonia Lai Alessandro Melis Laura Casula Massimo C Fantini Paolo Usai | 2019 | World Journal of Gastroenterology2019，25，37： | 8 |
| 2 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 3 | 3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration显示文摘Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field.In order to avoid high doses of systemic drug administration,optimized local antibiotic release from scaffolds is required.3D additive manufactured(AM)scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics.In this study,ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides(MgAl)andα-zirconium phosphates(ZrP),respectively,are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM(~190◦C)into 3D scaffolds.The inorganic fillers enable a sustained antibiotics release through the polymer matrix,controlled by antibiotics counterions exchange or pH conditions.Importantly,both antibiotics retain their functionality after the manufacturing process at high temperatures,as verified by their activity against both Gram+and Gram-bacterial strains.Moreover,scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation,allowing matrix mineralization and the expression of relevant osteogenic markers.Overall,these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention. | María C´amara-Torres Stacy Duarte Ravi Sinha Ainhoa Egizabal Noelia´Alvarez Maria Bastianini Michele Sisani Paolo Scopece Marco Scatto Alessandro Bonetto Antonio Marcomini Alberto Sanchez Alessandro Patelli Carlos Mota Lorenzo Moroni | 2021 | Bioactive Materials2021，6，4： | 2 |
| 4 | Direct anterior approach hip arthroplasty:How to reduce complications-A 10-years single center experience and literature review显示文摘BACKGROUND The direct anterior approach for total hip arthroplasty(DAA-THA)is increasing in popularity due to some advantages such as less surgical trauma,minimal dissection of soft tissues,shorter rehabilitation times,faster return to daily activities,lower incidence of dislocation.On the other hand,the literature reports a high rate of intraoperative complications,with many different rates and complication types in the published papers.AIM To analyze our complications comparing results with the literature;to report measures that we have taken to reduce complications rate.METHODS All DAA-THA patients with one year minimum follow up who were operated at a single high-volume centre,between January 2010 and December 2019 were included in this retrospective study.All surgeries were performed using cementless short anatomical or straight stems and press fit cups.Patients’followup was performed,at 6 wk,3 mo,then annually post-surgery with clinical and radiological evaluation.Primary outcomes were stem revision for aseptic loosening and all-cause stem revision.Second outcome was intra-operative and post-operative complications identification.RESULTS A total of 394 patients underwent DDA-THA from January 2010 and December 2019,for a total of 412 hips;twelve patients lost to follow-up and one patient who died from causes not related to surgery were excluded from the study.The average age at the time of surgery was 61 years(range from 28 to 78 years).Mean follow-up time was 64.8 mo(range 12-120 mo).Seven stems were revised.One cortical perforation,one trochanteric and lateral cortical wall intraoperative fracture,one diaphyseal fracture,three clinically symptomatic early subsidence and one late aseptic loosening.We also observed 3 periprosthetic fractures B1 according to the Vancouver Classification.Other minor complications not requiring stem revision were 5 un-displaced fractures of the calcar region treated with preventive cerclage,one early infection,one case of late posterior dislocation,18 case of asymptomatic stem subsidence,6 cases of lateral cutaneous femoral nerve dysesthesia.CONCLUSION DAA is associated to good outcomes and lower incidence of dislocation.Complication rate can be reduced by mindful patient selection,thorough preoperative planning,sufficient learning curve and use of intraoperative imaging. | Fabrizio Rivera Luca C Comba Alessandro Bardelli | 2022 | World Journal of Orthopedics2022，13，4： | 2 |
| 5 | Effect of different probiotic preparations on anti- Helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study显示文摘 | Filippo Cremonini Simona Di Caro Marcello Covino Alessandro Armuzzi Maurizio Gabrielli Luca Santarelli Enrico C Nista Giovanni Cammarota Giovanni Gasbarrini Antonio Gasbarrini | 2002 | The American Journal of Gastroenterology2002，，11： | 2 |
| 6 | Nerve growth factor control of neuronal expression of angiogenetic and vasoactive factors显示文摘 | Laura C Luciana G Alessandro G | 2001 | PNAS2001，98，11： | 1 |
| 7 | DNA and RNA binding properties of an arginine-based ' Extended Chiral Box' Peptide Nucleic Acid显示文摘 | Alessandro C Tullia T Roberto C | | 0，，02： | 1 |
| 8 | A single measurement of CD38CD3 cells in HIV+,long-term surviving injecting drugs uses distinguishes these who will progress to AIDS from those who will remain stable显示文摘 | Forebel KS Raab GM D'Alessandro C | 2000 | Clin Exp Immunol2000，122，1： | 1 |
| 9 | Improvement of Biohydrogen Production from Solid Wastes by Intermittent Venting and Gas Flushing of Batch Reactors Headspace显示文摘 | Idania V V Elvira R L Alessandro C M | 2006 | Environ Sci Technol2006，40，10： | 1 |
| 10 | Physical activity and exercise training:a relevant aspect of the dialysis patient's care 显示文摘 | Cupisti A D'Alessandro C Bottai A | 2013 | Intern Emerg Med2013，8，1： | 1 |
| 11 | Bronchopulmonary kctinomycosis Associated With Hiatal Hernia显示文摘 | Alessandro A Alberto C Alessandro M | 2009 | Mayo Clinic Proceedings2009，84，2： | 1 |
| 12 | Nutrition knowledge and dietary composition in Italian adolescent female ath- letes and non-athletes显示文摘 | Cupisti A D'Alessandro C Castrogiovanni S | 2002 | International Journal of Sport Nutrition & Exercise Metabolism2002，12，2： | 1 |
| 13 | An implicit Gain-scheduling controller for Cranes 显示文摘 | GIORGIO C ALESSANDRO G GIAMPAOLO U | 1998 | IEEE Trans on Control Systems Technology1998，6，1： | 1 |
| 14 | Pt (II) Chiral Catalyst De- sign for Asymmetric Baeyer-Villiger Oxidation of Cyclic Ketones with Hy- drogen Peroxide 显示文摘 | Marco C Alessandro S Giorgio S | 2006 | Synlett2006，20，： | 1 |
| 15 | Geographic variation and environmental conditions as cofactors in Chlamydia psittaci association with ocular adnexal lymphomas:a comparison between Italian and African samples显示文摘 | Alessandro C Anna O Giuseppina A | 2010 | Hernatol Oncol2010，28，： | 1 |
| 16 | Atrazine interactions with soil Humic substances of different molecular structure显示文摘 | Alessandro P Pellegrino C Irene S | 1998 | J Environ Qual1998，27，： | 1 |
| 17 | HLA expression in cancer :Implication for T - cell based immunotherary 显示文摘 | Alessandro S Ronert C John F | 2001 | Immuno Geneties2001，53，4： | 1 |
| 18 | Dual mechanism for the control of inducible-type NO synthase ene expression in macrophages during activation by interferon-γ and lipopolysaccharide显示文摘 | Alessandro W Shinobu L Luigi C | 1994 | J Biol Chem1994，269，11： | 1 |
| 19 | Influence of the tool edge geometry on specific cutting energy at high-speed cutting显示文摘 | ALESSANDRO R R REGINALDO T C | 2007 | Journal of the Brazilian Society of Mechanical Sciences and Engineering2007，29，3： | 1 |
| 20 | Food intake and nutritional status in stable hemodialysis patients显示文摘 | Cupisti A D'Alessandro C Valeri A | 2010 | Ren Fail2010，32，： | 1 |
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