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| 1 | Aerobic bacteria associated with chronic suppurative otitis media in Angola显示文摘Background:Chronic suppurative otitis media(CSOM)is an important cause of hearing loss in children and constitutes a serious health problem globally with a strong association to resource-limited living conditions.Topical antibiotics combined with aural toilet is the first-hand treatment for CSOM but antimicrobial resistance and limited availability to antibiotics are obstacles in some areas.The goal of this study was to define aerobic pathogens associated with CSOM in Angola with the overall aim to provide a background for local treatment recommendations.Methods:Samples from ear discharge and the nasopharynx were collected and cultured from 152 patients with ear discharge and perforation of the tympanic membrane.Identification of bacterial species was performed with matrix-assisted laser desorption/ionization-time of flight mass spectrometry and pneumococci were serotyped using multiplex polymerase chain reactions.Antimicrobial susceptibility testing was done according to EUCAST.Results:One hundred eighty-four samples from ear discharge and 151 nasopharyngeal swabs were collected and yielded 534 and 289 individual isolates,respectively.In all patients,correspondence rate of isolates from 2 ears in patients with bilateral disease was 27.3%and 9.3%comparing isolates from the nasopharynx and ear discharge,respectively.Proteus spp.(14.7%),Pseudomonas aeruginosa(13.2%)and Enterococcus spp.(8.8%)were dominating pathogens isolated from ear discharge.A large part of the remaining species belonged to Enterobacteriaceae(23.5%).Pneumococci and Staphylococcus aureus were detected in approximately 10%of nasopharyngeal samples.Resistance rates to quinolones exceeded 10%among Enterobacteriaceae and was 30.8%in S.aureus,whereas 6.3%of P.aeruginosa were resistant.Conclusions:The infection of the middle ear in CSOM is highly polymicrobial,and isolates found in nasopharynx do not correspond well with those found in ear discharge.Pathogens associated with CSOM in Angola are dominated by gram-negatives including Enterobacteriaceae and P.aeruginosa,while gram-positive enterococci also are common.Based on the results of antimicrobial susceptibility testing topical quinolones would be the preferred antibiotic therapy of CSOM in Angola.Topical antiseptics such as aluminium acetate,acetic acid or boric acid,however,may be more feasible options due to a possibly emerging antimicrobial resistance. | Fabian Udden Matuba Filipe Ake Reimer Maria Paul Erika Matuschek John Thegerstrom Sven Hammerschmidt Tuula Pelkonen Kristian Riesbeck | 2018 | Infectious Diseases of Poverty2018，7，1： | 6 |
| 2 | Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium显示文摘 | CHARLES E. MURRY ROBERT B. JENNINGS KEITH A. REIMER | 1986 | Circulation1986，，5： | 4 |
| 3 | SJWD15012600002640显示文摘 | Jens Ricke Karsten Bulla Frank Kolligs Markus Peck‐Radosavljevic Peter Reimer Bruno Sangro Eckart Schott Kerstin Schütte Chris Verslype Jerzy Walecki Peter Malfertheiner | 2015 | Liver Int2015，，2： | 3 |
| 4 | An open-label, multicentre biomarker-oriented AIO phase II trial of sunitinib for patients with chemo-refractory advanced gastric cancer显示文摘 | M. Moehler A. Mueller J.T. Hartmann M.P. Ebert S.E. Al-Batran P. Reimer M. Weihrauch F. Lordick T. Trarbach S. Biesterfeld M. Kabisch D. Wachtlin P.R. Galle | 2011 | European Journal of Cancer2011，，10： | 3 |
| 5 | Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium显示文摘 | Murry CE Jennings RB Reimer KA | 1986 | Circulation1986，74，5： | 2 |
| 6 | Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium显示文摘 | CHARLES E. MURRY ROBERT B. JENNINGS KEITH A. REIMER | 1986 | Circulation1986，，5： | 2 |
| 7 | Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions显示文摘 | Renate Hammerstingl Alexander Huppertz Josy Breuer Thomas Balzer Anthony Blakeborough Rick Carter Lluis Castells Fusté Gertraud Heinz-Peer Werner Judmaier Michael Laniado Riccardo M. Manfredi Didier G. Mathieu Dieter Müller Koenraad Mortelè Peter Reimer M | 2008 | European Radiology2008，，： | 2 |
| 8 | Micro-optic fabrication using one-level gray-tone lithography 显示文摘 | REIMER K QUENZER H J | 1997 | SPIE1997，3008，： | 2 |
| 9 | 市场、层级与联合:信息技术对经济组织影响的重新评估显示文摘本文回顾了Malone等人(1987)提出的'市场化'假设,这一观点认为,与层级相比,信息技术在各类经济活动中的协调作用更多依赖于市场。尽管这一假设得到了实证结果的支持,但反对的声音认为,由于未明确协调机制和治理形式的差别,其理论基础存在缺陷。基于这一差别,本文提出了一系列假设及其理论框架。如果能得到实证分析的印证,那么这一框架将增进我们对信息技术与经济组织间因果关系本质的认识。这些假设的创新强调了治理的联合形式对信息技术在经济活动中发挥持续协调作用的影响。文中还从管理和制度的角度探讨了这些假设的潜在意义。 | REIMERS Kai | 2009 | 信息系统学报2009，3，1： | 2 |
| 10 | Basement membrane formation during wound healing is dependent on epidermal transplants显示文摘 | Andree C Reimer C Page CP | 2001 | Plast Reconstr Surg2001，107，1： | 1 |
| 11 | Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium 显示文摘 | Murry CF Jennings RB Reimer KA | 1986 | Circulation1986，74，： | 1 |
| 12 | Thermal stability of 18650 size Li-ion cells containing LiBOB dectrolyte salt显示文摘 | Jiang J W Fortier H Reimers J N | 2004 | J ElectrochemSoc2004，151，4： | 1 |
| 13 | Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium 显示文摘 | Murry CE Jennings RB Reimer KA | 1986 | Circulation1986，74，5： | 1 |
| 14 | Microarray analysis of differentially expressed genes in placental tissue of preeclampsia:up-regulation of obesity-related genes显示文摘 | Koczan D Gerber B | 2002 | Mol Hum Reprod2002，8，： | 1 |
| 15 | Preconditioning with ischemia:a delay of lethal cell injury in ischemic myocardium显示文摘 | Jennings RB Reimer KA | 1986 | Circulation1986，74，5： | 1 |
| 16 | Preconditioning with ischemia:a delay of lethal cell injury in myocardium显示文摘 | MURRY C E JENNINGS R B REIMER K A | 1986 | Circulation1986，74，： | 1 |
| 17 | Routin use of cerebral protection during carotid artery stenting:results of a multicenter registry of 753 patients显示文摘 | Reimers B Schluter M Castriota F | 2004 | Am J Med2004，116，： | 1 |
| 18 | Long-term clini-cal follow-up after successful repeat percutaneous interven-tion for stent restenosis显示文摘 | Reimers S Moussa L Akiyama T | 1997 | J Am Coll Cardial1997，30，1： | 1 |
| 19 | Cerebral protection with filter devices during carotid artery stenting显示文摘 | Reimers B Corvaja N Moshiri S | 2001 | Circulation2001，104，： | 1 |
| 20 | Preconditioning with ischemia;a delay of lethal cell injury in ischemic myocardium显示文摘 | Murry CE Jenning RB Reimer KA | 1986 | Circulation1986，74，2： | 1 |
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