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| 1 | Clinical End Points in Coronary Stent Trials: A Case for Standardized Definitions显示文摘 | Donald E. Cutlip Stephan Windecker Roxana Mehran Ashley Boam David J. Cohen Gerrit-Anne van Es P Gabriel Steg Marie-angèle Morel Laura Mauri Pascal Vranckx Eugene McFadden Alexandra Lansky Martial Hamon Mitchell W. Krucoff Patrick W. Serruys | 2007 | Circulation2007，，17： | 4 |
| 2 | Novel nutraceutic therapies for the treatment of metabolic syndrome显示文摘Nutraceutic therapies such as berberine, bitter melon,Gymnema sylvestre, Irvingia gabonensis, resveratrol and ursolic acid have been shown to help control metabolic syndrome(MetS). The effect of berberine on glucose and lipid metabolism, hypertension, obesity and MetS has been evaluated in animal models and humans. Most clinical trials involving bitter melon have been conducted to evaluate its effect on glucose metabolism; nevertheless, some studies have reported favorable effects on lipids and blood pressure although there is little information about its effect on body weight. Gymnema sylvestre helps to decrease body weight and blood sugar levels; however, there is limited information on dyslipidemia and hypertension. Clinical trials of Irvingia gabonensis have shown important effects decreasing glucose and cholesterol concentrations as well decreasing body weight. Resveratrol acts through different mechanisms to decrease blood pressure, lipids, glucose and weight, showing its effects on the population with Met S. Finally, there is evidence of positive effects with ursolic acid in in vitro and in vivo studies on glucose and lipid metabolism and on body weight and visceral fat. Therefore, a review of the beneficial effects and limitations of the above-mentioned nutraceutic therapies is presented. | Esperanza Martínez-Abundis Miriam Mendez-del Villar Karina G Pérez-Rubio Laura Y Zuniga Marisol Cortez-Navarrete Alejandra Ramírez-Rodriguez Manuel González-Ortiz | 2016 | World Journal of Diabetes2016，7，7： | 3 |
| 3 | Lipotoxicity in the liver显示文摘Obesity due to excessive food intake and the lack of physical activity is becoming one of the most serious public health problems of the 21stcentury. With the increasing prevalence of obesity, non-alcoholic fatty liver disease is also emerging as a pandemic. While previously this pathophysiological condition was mainly attributed to triglyceride accumulation in hepatocytes,recent data show that the development of oxidative stress, lipid peroxidation, cell death, inflammation and fibrosis are mostly due to accumulation of fatty acids,and the altered composition of membrane phospholipids. In fact, triglyceride accumulation might play a protective role, and the higher toxicity of saturated or trans fatty acids seems to be the consequence of a blockade in triglyceride synthesis. Increased membrane saturation can profoundly disturb cellular homeostasis by impairing the function of membrane receptors,channels and transporters. However, it also inducesendoplasmic reticulum stress via novel sensing mechanisms of the organelle's stress receptors. The triggered signaling pathways in turn largely contribute to the development of insulin resistance and apoptosis. These findings have substantiated the lipotoxic liver injury hypothesis for the pathomechanism of hepatosteatosis.This minireview focuses on the metabolic and redox aspects of lipotoxicity and lipoapoptosis, with special regards on the involvement of endoplasmic reticulum stress responses. | Veronika Zámbó Laura Simon-Szabó Péter Szelényi va Kereszturi Gábor Bánhegyi Miklós Csala | 2013 | World Journal of Hepatology2013，5，10： | 3 |
| 4 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 5 | CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients显示文摘AIM To characterize peripheral blood natural killer(NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected patients.METHODS Peripheral mononuclear cells from 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4. NK surface cell staining was performed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(FITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(FITC); anti-CD62L(PE/Cy7), anti-CCR7(PE), anti-TRAIL(PE), anti-Fas L(PE), anti CD94(FITC). Flow cytometry data acquisition was performed on BD FACSCanto, analyzed using Flow Jo software. Frequency of fluorescence was analyzed for all single markers. Clinical records were reviewed, and epidemiological and clinical data were obtained.RESULTS Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was(6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damage. | Natalia Laufer Diego Ojeda María Laura Polo Ana Martinez Héctor Pérez Gabriela Turk Pedro Cahn Norberto Walter Zwirner Jorge Quarleri | 2017 | World Journal of Hepatology2017，9，25： | 2 |
| 6 | The effects of Spirulina on anemia and immune function in senior citizens显示文摘Anemia and immunological dysfunction(i.e.immunosenescence)are commonly found in older subjects and nutritional approaches are sought to counteract these phenomena.Spirulina is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant effects.We hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of anemia.We enrolled 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic diseases.Participants took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the study.Complete cell count(CCC)and indoleamine 2,3-dioxygenase(IDO)enzyme activity,as a sign of immune function,were determined at baseline and weeks 6 and 12 of supplementation.Thirty study participants completed the entire study and the data obtained were analyzed.Over the 12-week study period,there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both sexes.In addition,mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male participants.Older women appeared to benefit more rapidly from Spirulina supplements.Similarly,the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina supplementation.Spirulina may ameliorate anemia and immunosenescence in older subjects.We encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials. | Carlo Selmi Patrick SC Leung Laura Fischer Bruce German Chen-Yen Yang Thomas P Kenny Gerry R Cysewski M Eric Gershwin | 2011 | Cellular & Molecular Immunology2011，8，3： | 2 |
| 7 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 8 | 渔民的利益和合作:瑞典沿岸渔业共同管理的前提显示文摘本文在'共同管理'、'参与性管理'或'地方管理'等概念下用不同的理念探讨了渔民参与渔业管理的问题。瑞典渔业范围内的经验研究阐明了关于渔民参与渔业管理先决条件的新观点。在影响成败的重要因素中,我们这里着重探讨了其中两个:渔民利益的明确表达、组织及代表问题和通常参与资源管理合作的各群体即:渔民、政府管理人员以及研究人员之间的信任。本文所概述的研究论及了渔民在资源管理、地方渔业管理方面的利益以及渔民的参与。连接这三个主题的问题是:在渔业管理中如何更好地反映渔民的利益?利益与信任,即'软事实',对于渔业管理和参与的成败而言,可以犹如所有权、资源的数量和质量或资源的货币价值之类的'硬事实'一样的重要。 | Karl Bruckmeier Anders Ellegrd Laura Píriz 林宝法 | 2005 | AMBIO-人类环境杂志2005，34，2： | 2 |
| 9 | Global prevalence of dementia: a Delphi consensus study显示文摘 | Cleusa P Ferri Martin Prince Carol Brayne Henry Brodaty Laura Fratiglioni Mary Ganguli Kathleen Hall Kazuo Hasegawa Hugh Hendrie Yueqin Huang Anthony Jorm Colin Mathers Paulo R Menezes Elizabeth Rimmer Marcia Scazufca | 2005 | The Lancet2005，，9503： | 2 |
| 10 | Global prevalence of dementia: a Delphi consensus study显示文摘 | Cleusa P Ferri Martin Prince Carol Brayne Henry Brodaty Laura Fratiglioni Mary Ganguli Kathleen Hall Kazuo Hasegawa Hugh Hendrie Yueqin Huang Anthony Jorm Colin Mathers Paulo R Menezes Elizabeth Rimmer Marcia Scazufca | 2005 | The Lancet . 2005 (9503)2005，，9503： | 2 |
| 11 | Selective oxidation of d-glucose on gold catalyst显示文摘 | Serena B Laura P Michele R | 2002 | Journal of Catalysis2002，206，2： | 1 |
| 12 | Cystatin C and estimates of renal function:searching for a better measure of kidney function in diabetic patients显示文摘 | Laura P Stefano T Lucchesi D | 2007 | Clin Chem2007，53，3： | 1 |
| 13 | The role of root exudates in rhizosphere interactions with plants and other organisms显示文摘 | Harsh P B Tiffany L W Laura G P | 2006 | Plant Biology2006，57，： | 1 |
| 14 | Modeling of mini-proinsulin production on Pichia pastoris using the AOX promoter显示文摘 | Jose M P Laura Varas | 2003 | Biotechnol Lett2003，22，： | 1 |
| 15 | T S Internal Monitoring Mechanisms and CEO Turnover: Along-term Perspective 显示文摘 | Mark R H Robert P Laura | 2001 | The Journal of Fi- nance2001，，6： | 1 |
| 16 | Postoperative delirium: the importance of pain and pain management显示文摘 | Linnea E Vaurio Laura P Sands Wang Yun | 2006 | Anesth Analg2006，102，4： | 1 |
| 17 | Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy显示文摘 | Vincenzo P Isabella M Eloisa A Barbel LS Laura V Monika A | 1998 | Am Heart Assoc1998，97，10： | 1 |
| 18 | Synthesis and biological evaluation of an anticancer vaccine containing the C-glycoside analogue of the Tn epitope 显示文摘 | Francesco P Laura C Maria R | 2001 | Bioconjug Chem2001，12，3： | 1 |
| 19 | Antioxidant activity of dietary polyphenols as determined by a modified ferric reducing/an- tioxidant power assay显示文摘 | RAQUEL P LAURA B FULGENCIO S C | 2000 | Journal of Agricultural and Food Chemistry2000，48，： | 1 |
| 20 | Utility of pretreatment bilirubin level and UGT1A1polymorphisms in multivariate predictive models of neutropenia associated with irinotecan treatment in previously un-treated patients with colorectal cancer显示文摘 | Luis P Eve P Laura AC | 2008 | Arch Drug Inf2008，1，3： | 1 |
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