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| 1 | Relative peripheral refraction across 4 meridians after orthokeratology and LASIK surgery显示文摘Background:To characterize the axial and off-axis refraction across four meridians of the retina in myopic eyes before and after Orthokeratology(OK)and LASIK surgery.Methods:Sixty right eyes with a spherical equivalent(M)between−0.75 to−5.25 D(cylinder<−1.00 D)underwent LASIK(n=26)or OK(n=34)to treat myopia.Axial and off-axis refraction were measured with an open-field autorefractometer before and after stabilized treatments.Off-axis measurements were obtained for the horizontal(35°nasal and temporal retina)and vertical(15°superior and inferior retina)meridians,and for two oblique directions(45–225°and 135–315°)up to 20°of eccentricity.The refractive profile was addressed as relative peripheral refractive error(RPRE).Results:OK and LASIK post-treatment results showed an increase of myopic relative refraction at several eccentric locations.At the four meridians evaluated,the M component of the pre-treatment RPRE values was not statistically different(p>0.05)from the post-treatment RPRE within 30°and 20°of the central visual field after LASIK and OK,respectively.These results demonstrated that the treatment zone warrants an optimal central field of vision.Conclusions:The present study gives an overview of RPRE after refractive corneal reshaping treatments(OK and LASIK)across vertical,horizontal and two oblique meridians together.This allows a 3D representation of RPRE at the retina and shows that the myopic shift induced by both treatments is more relevant in horizontal directions. | António Queirós Ana Amorim-de-Sousa Daniela Lopes-Ferreira César Villa-Collar Ángel Ramón Gutiérrez JoséManuel González-Méijome | 2018 | Eye and Vision2018，5，1： | 8 |
| 2 | DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection显示文摘 | Oertli Mathias Sundquist Malin Hitzler Iris Engler Daniela B Arnold Isabelle C Reuter Sebastian Maxeiner Joachim Hansson Malin Taube Christian Quiding-J?rbrink Marianne Müller Anne | 2012 | EN2012，，3： | 5 |
| 3 | Prognostic and predictive biomarkers in metastatic colorectal cancer anti-EGFR therapy显示文摘AIM: To reviewing genetic and epigenetic make-up of metastatic colorectal cancers(m CRCs) addicted to epidermal growth factor receptor(EGFR) signalling.METHODS: The present study summarizes the potential value of prognostic and predictive biomarkers in selecting m CRC patients treated with anti-EGFR therapy. A meta-analysis was performed using a systematic search of Pub Med, Medline and Web of Science to identify eligible papers until March 21 st, 2016 using these following terms: ‘‘colorectal cancer'', 'predictive biomarkers' ', 'anti-EGFR therapy', 'KRAS', 'NRAS'', 'PIK3CA', 'TP53', 'PTEN', ‘‘EGFR', 'MET', 'HER2', 'epiregulin', 'amphiregulin', 'prognostic biomarkers', 'BRAF', 'miR NA' and 'antibody-dependent cell-mediated cytotoxicity(ADCC) activity'. Two investigators independently evaluated and extracted data from each identified studies based on selected criteria of inclusion and exclusion. RESULTS: The introduction of agents targeting EGFR such as cetuximab and panitumumab increased overall survival of mC RCs. Nevertheless, it has firstly became evident that response rates to cetuximab regimens in unselected patient populations were typically lower than 30%. Clinical data confirmed the predictive value of RAS mutations for resistance to cetuximab and panitumumab leading to the license of these monoclonal antibodies exclusively for the management of patients with RAS-wild type colorectal cancers. So far the identification of predictive biomarkers have generated interesting, though preliminary and, at times, conflicting data on the importance of tumour mR NA levels of EGFR ligands, of activating mutations in other genes such as NRAS and PIK3 CA. The prognostic value of selected micro RNAs level and ADCC activity is under investigation, while the prognostic impact of BRAF status remains controversial.CONCLUSION: This review focuses on the personalized treatment of m CRC and discusses the potential of new prognostic and predictive biomarkers in selecting patients treated with anti-EGFR therapy. | Cristiana Lo Nigro Vincenzo Ricci Daniela Vivenza Cristina Granetto Teresa Fabozzi Emanuela Miraglio Marco C Merlano | 2016 | World Journal of Gastroenterology2016，22，30： | 5 |
| 4 | Odd couple: The unexpected partnership of glucocorticoid hormones and cysteinyl-leukotrienes in the extrinsic regulation of murine bone-marrow eosinopoiesis显示文摘Granulopoiesis in murine bone-marrow is regulated by both intrinsic and extrinsic factors(including hormones, drugs, inflammatory mediators and cytokines). Eosinophils, a minor subpopulation of circulating leukocytes, which remains better understood in its contributions to tissue injury in allergic disease than in its presumably beneficial actions in host defense, provide a striking example of joint regulation of granulopoiesis within murine bone-marrow by all of these classes of extrinsic factors. We first described the upregulation of eosinopoiesis in bone-marrow of allergen-sensitized mice following airway allergen challenge. Over the last decade, we were able to show a critical role for endogenous glucocorticoid hormones and cytokines in mediating this phenomenon through modification of cytokine effects, thereby supporting a positive association between stress hormones and allergic reactions. We have further shown that cysteinylleukotrienes(Cys LT), a major proinflammatory class of lipid mediators, generated through the 5-lipoxygenase pathway, upregulate bone-marrow eosinopoiesis in vivo and in vitro. Cys LT mediate the positive effects of drugs(indomethacin and aspirin) and of proallergic cytokines(eotaxin/CCL11 and interleukin-13) on in vitro eosinopoiesis. While these actions of endogenous GC and Cys LT might seem unrelated and even antagonistic, we demonstrated a critical partnership of these mediators in vivo, shedding light on mechanisms linking stress to allergy: GC are required for Cys LT-mediated upregulation of bone-marrow eosinopoiesis in vivo, but also attenuate subsequent ex vivo responses to Cys LT. GC and Cys LT therefore work together to induce eosinophilia, but through subtle regulatory mechanisms also limit the magnitude of subsequent bone-marrow responses to allergen. | Pedro Xavier-Elsas Daniela Masid-de-Brito Bruno Marques Vieira Maria Ignez C Gaspar-Elsas | 2017 | World Journal of Experimental Medicine2017，7，1： | 2 |
| 5 | Effect of high-pressure treatment on microbiology, proteolysis, lipolysis and levels of flavour compounds in mature blue-veined cheese 显示文摘 | Daniela D Voigt Francios Chevalier Michael C Qian | 2010 | Innovative Food Science and Emerging Technologies2010，11，： | 1 |
| 6 | Psychiatric comorbility in patientswith chronic daily headache and migraine:A selective overviewincluding personality traits and suicide risk显示文摘 | Pompili M Daniela D C Marco I | 2009 | Headache Pain2009，10，4： | 1 |
| 7 | Excitotoxic damage,disrupted energy metabolism,and oxidative stress in the rat brain:antioxidant and neuroprotective effects of L-carnitine显示文摘 | DANIELA S A VERONICA P D C MARA N H M | 2008 | Jonrnal of Neurochemistry2008，105，： | 1 |
| 8 | Physical interactions in macroporous scaffolds based on poly(e-caprolactone)/chitosan semi- interpenetrating polymer networks 显示文摘 | Dunia M Garcfa C Daniela F | 2009 | Polymer2009，50，9： | 1 |
| 9 | Improved synthesis of graphene oxide 显示文摘 | Daniela C Marcano Dmitry V Kosynkin Jacob M Berlin | 2010 | ACS Nano2010，4，8： | 1 |
| 10 | Modification of glass transition temperature through carbohydrates addition and anthocyanin and soluble phenol stability of frozen blueberry juices显示文摘 | Anna R Renato C N Daniela V | 2003 | Food Eng2003，56，23： | 1 |
| 11 | Synthesis of pyrimidine- containing 3-aminobutenolides显示文摘 | Ugo C Daniela I Anna P | 2004 | Tetrahedron2004，60，： | 1 |
| 12 | Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway显示文摘 | Pen J Daniela C Zamescu JA | 2004 | Nature neuroscience2004，7，2： | 1 |
| 13 | Neurospheres enriched in cancer stem like cells are highly effective in eliciting a den- dritic cell mediated immune response against malignant gliomas 显示文摘 | Serena P Pietro L P Daniela C | 2006 | Cancer Res2006，66，10： | 1 |
| 14 | Varicocelectomy does not impact pregnancy outcomes following intracytoplasmic sperm injection procedures显示文摘 | Fabio F Daniela P Rita C | 2012 | J Androl2012，33，2： | 1 |
| 15 | Inhibition of MIF leads to cell cycle arrest and apoptosis in pancreatic cancer cells显示文摘 | Denz A Pilarsky C Daniela M | 2010 | J Surg Res2010，160，1： | 1 |
| 16 | Functional assay for BRCA1:mutagenesis of the COOH-terminal region reveals critical residues for transcription activation显示文摘 | Finbarr H Charmagne C Daniela B | 2000 | Cancer Res2000，60，5： | 1 |
| 17 | Improved synthesis of graphene oxide显示文摘 | Daniela C Marcano Dmitry V Kosynkin | 2010 | ACS nano2010，4，8： | 1 |
| 18 | Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway显示文摘 | Peng J Daniela C Z P Stephanie C | 2004 | Nature neuroscience2004，7，2： | 1 |
| 19 | Effect of combining ACE inhibitor and statin in severe experimental nephropathy显示文摘 | Zoja C Coma D Rottoli Daniela | 2002 | Kidney Int2002，61，5： | 1 |
| 20 | Microwave Promoted Suzuki Reactions between Aroyl Chlorides and Boronic Acids Catalyzed by Het- erogeneous and Homogeneous Phosphine-free Palla- dium Catalysts 显示文摘 | DANIELA DE L M AGUIAR L C ANTUNES O A | 2011 | J of Organomet Chem2011，696，1516： | 1 |
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