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| 1 | Serum Urate as an Independent Predictor of Poor Outcome and Future Vascular Events After Acute Stroke显示文摘 | Christopher J. Weir Scott W. Muir Matthew R. Walters Kennedy R. Lees | 2003 | Stroke: Journal of the American Heart Association2003，，8： | 5 |
| 2 | Acute kidney injury and hepatorenal syndrome in cirrhosis显示文摘Acute kidney injury(AKI)in cirrhosis,including hepatorenal syndrome(HRS),is a common and serious complication in cirrhotic patients,leading to significant morbidity and mortality.AKI is separated into two categories,non-HRS AKI and HRS-AKI.The most recent definition and diagnostic criteria of AKI in cirrhosis and HRS have helped diagnose and prognosticate the disease.The pathophysiology behind non-HRS-AKI and HRS is more complicated than once theorized and involves more processes than just splanchnic vasodilation.The common biomarkers clinicians use to assess kidney injury have significant limitations in cirrhosis patients;novel biomarkers being studied have shown promise but require further studies in clinical settings and animal models.The overall management of non-HRS AKI and HRS-AKI requires a systematic approach.Although pharmacological treatments have shown mortality benefit,the ideal HRS treatment option is liver transplantation with or without simultaneous kidney transplantation.Further research is required to optimize pharmacologic and nonpharmacologic approaches to treatment.This article reviews the current guidelines and recommendations of AKI in cirrhosis. | Kapil Gupta Abhishek Bhurwal Cindy Law Scott Ventre Carlos D Minacapelli Savan Kabaria You Li Christopher Tait Carolyn Catalano Vinod K Rustgi | 2021 | World Journal of Gastroenterology2021，27，26： | 5 |
| 3 | Natural-orifice transgastric endoscopic peritoneoscopy in humans: Initial clinical trial显示文摘 | Jeffrey W. Hazey Vimal K. Narula David B. Renton Kevin M. Reavis Christopher M. Paul Kristen E. Hinshaw Peter Muscarella E. Christopher Ellison W. Scott Melvin | 2008 | Surgical Endoscopy2008，，1： | 4 |
| 4 | The Cost-Effectiveness of Neoadjuvant Chemoradiation is Superior to a Surgery-First Approach in the Treatment of Pancreatic Head Adenocarcinoma显示文摘 | Daniel E. Abbott Ching-Wei David Tzeng Ryan P. Merkow Scott B. Cantor George J. Chang Matthew Harold Katz David J. Bentrem Karl Y. Bilimoria Christopher H. Crane Gauri R. Varadhachary James L. Abbruzzese Robert A. Wolff Jeffrey E. Lee Douglas B. Evans Jas | 2013 | Annals of Surgical Oncology2013，，3： | 3 |
| 5 | Chemical and biological transformations for detoxification of trichothecene mycotoxins in human and animal food chains: a review显示文摘 | Jianwei He Ting Zhou J. Christopher Young Greg J. Boland Peter M. Scott | 2009 | Trends in Food Science & Technology2009，，2： | 3 |
| 6 | Holographic planar lightwave circuit for on-chip spectroscopy显示文摘Computer-generated planar holograms are a powerful approach for designing planar lightwave circuits with unique properties.Digital planar holograms in particular can encode any optical transfer function with high customizability and is compatible with semiconductor lithography techniques and nanoimprint lithography.Here,we demonstrate that the integration of multiple holograms on a single device increases the overall spectral range of the spectrometer and offsets any performance decrement resulting from miniaturization.The validation of a high-resolution spectrometer-on-chip based on digital planar holograms shows performance comparable with that of a macrospectrometer.While maintaining the total device footprint below 2 cm2,the newly developed spectrometer achieved a spectral resolution of 0.15 nm in the red and near infrared range,over a 148 nm spectral range and 926 channels.This approach lays the groundwork for future on-chip spectroscopy and lab-on-chip sensing. | Giuseppe Calafiore Alexander Koshelev Scott Dhuey Alexander Goltsov Pavel Sasorov Sergey Babin Vladimir Yankov Stefano Cabrini Christophe Peroz | 2014 | Light(Science & Applications)2014，3，1： | 3 |
| 7 | Entrepreneurial motivation显示文摘 | Scott Shane Edwin A. Locke Christopher J. Collins | 2003 | Human Resource Management Review2003，，2： | 3 |
| 8 | The Diagnostic Approach to Monogenic Very Early Onset Inflammatory Bowel Disease显示文摘 | Holm H. Uhlig Tobias Schwerd Sibylle Koletzko Neil Shah Jochen Kammermeier Abdul Elkadri Jodie Ouahed David C. Wilson Simon P. Travis Dan Turner Christoph Klein Scott B. Snapper Aleixo M. Muise | 2014 | Gastroenterology2014，，： | 3 |
| 9 | Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy显示文摘 | Sinha Rohit Anthony You Seo-Hee Zhou Jin Siddique Mobin M Bay Boon-Huat Zhu Xuguang Privalsky Martin L Cheng Sheue-Yann Stevens Robert D Summers Scott A Newgard Christopher B Lazar Mitchell A Yen Paul M | 2012 | EN2012，，7： | 2 |
| 10 | Phlegmonous gastritis: case report and review显示文摘 | Gordon Y. Kim John Ward Bruce Henessey Joyce Peji Christopher Godell Hiwot Desta Scott Arlin John Tzagournis Fred Thomas | 2005 | Gastrointestinal Endoscopy2005，，1： | 2 |
| 11 | Discrete twinning dynamics and size-dependent dislocation-to twin transition in body-centred cubic tungsten显示文摘Body-centred cubic(BCC) metals are known to have unstable intrinsic stacking faults and high resistance to deformation twinning, which can strongly influence their twinning behaviour. Though twinning mechanisms of BCC metals have been investigated for more than 60 years, the atomistic level dynamics of twinning remains under debate, especially regarding its impact on competition between twinning and slip. Here, we investigate the atomistic level dynamics of twinning in BCC tungsten(W) nanowires using in situ nanomechanical testing. Quantitative experimental studies directly visualize that deformation twins in W nanowires have a minimum size of six-layers and grow in increments of approximately three-layers at a time, in contrast to the layer-by-layer growth of deformation twins in face-centred cubic metals. These unique twinning dynamics induces a strong competition with ordinary dislocation slip,as exhibited by a size-dependent dislocation-to-twin transition in W nanowires, with a transition size of ~40 nm. Our work provides physical insight into the dynamics of twinning at the atomic level, as well as a size-dependent dislocation-twinning competition, which have important implications for the plastic deformation in a broad class of BCC metals and alloys. | Jiangwei Wang Anik H.M.Faisal Xiyao Li Youran Hong Qi Zhu Hongbin Bei Ze Zhang Scott X Mao Christopher R.Weinberger | 2022 | Journal of Materials Science & Technology2022，，11： | 2 |
| 12 | 采用间接复位、钢板固定、不植骨的方法治疗稳定的股骨干髓内假体周围骨折显示文摘背景:间接复位技术相对于较早期的开放复位技术具有能够提高骨愈合率及减少植骨的优势,我们对以间接复位治疗股骨干假体周围骨折的结果进行了研究。
方法:连续对50例稳定的股骨干髓内假体周围骨折(Vancourvr B1型)进行治疗,根据病例记录包括切开复位、间接复位、外侧单钢板固定且不行同种异体或其他植骨。4例术后早期死亡,5例随访时间短,对其余41例(平均年龄72岁)进行了平均24个月的随访,并进行临床和影像学评估。
结果:所有骨折平均12周(7~23周)愈合,对位满意。1例有1根钢丝断裂,2例有1枚螺钉断裂,骨折最终愈合且无明显的内置物松动和对位不良。1例发生围手术期深部感染。41例中30例行走功能恢复到骨折前的状态。
结论:结果证实间接复位骨膜外侧单钢板固定且不进行植骨的方法对于稳定的股骨干髓内假体周围骨折的疗效是应该肯定的。
可信水平:治疗性研究,Ⅳ级,进一步可信度参见作者介绍。 | WILLIAM M. RICCI BRETT R. BOLHOFNER TIMOTHY LOFTUS CHRISTOPHER COX SCOTT MITCHELL JOSEPH BORRELLI JR 董强(译) 马宝通(译) | 2006 | 骨科动态2006，2，1： | 2 |
| 13 | Per-oral endoscopic myotomy white paper summary显示文摘 | Stavros N. Stavropoulos David J. Desilets Karl-Hermann Fuchs Christopher J. Gostout Gregory Haber Haruhiro Inoue Michael L. Kochman Rani Modayil Thomas Savides Daniel J. Scott Lee L. Swanstrom Melina C. Vassiliou | 2014 | Surgical Endoscopy2014，，7： | 2 |
| 14 | Transgastric endoscopic peritoneoscopy does not require decontamination of the stomach in humans显示文摘 | Vimal K. Narula Lynn C. Happel Kevin Volt Simon Bergman Jason C. Roland Rebecca Dettorre David B. Renton Kevin M. Reavis Bradley J. Needleman Dean J. Mikami E. Christopher Ellison W. Scott Melvin Jeffrey W. Hazey | 2009 | Surgical Endoscopy2009，，6： | 2 |
| 15 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 16 | Transgastric instrumentation and bacterial contamination of the peritoneal cavity显示文摘 | Vimal K. Narula Jeffrey W. Hazey David B. Renton Kevin M. Reavis Christopher M. Paul Kristen E. Hinshaw Bradley J. Needleman Dean J. Mikami E. Christopher Ellison W. Scott Melvin | 2008 | Surgical Endoscopy2008，，3： | 2 |
| 17 | ACCF/ACR/AHA/NASCI/SCMR 2010 Expert Consensus Document on Cardiovascular Magnetic Resonance显示文摘 | W. Gregory Hundley David A. Bluemke J. Paul Finn Scott D. Flamm Mark A. Fogel Matthias G. Friedrich Vincent B. Ho Michael Jerosch-Herold Christopher M. Kramer Warren J. Manning Manesh Patel Gerald M. Pohost Arthur E. Stillman Richard D. White Pamela K. Wo | 2010 | Journal of the American College of Cardiology2010，，23： | 1 |
| 18 | Total Thyroidectomy Is Superior to Subtotal Thyroidectomy for Management of Graves’ Disease in the United States显示文摘 | Scott M. Wilhelm Christopher R. McHenry | 2010 | World Journal of Surgery2010，，6： | 1 |
| 19 | Guidelines for Performing Ultrasound Guided Vascular Cannulation: Recommendations of the American Society of Echocardiography and the Society of Cardiovascular Anesthesiologists显示文摘 | Christopher A. Troianos Gregg S. Hartman Kathryn E. Glas Nikolaos J. Skubas Robert T. Eberhardt Jennifer D. Walker Scott T. Reeves | 2012 | Anesthesia & Analgesia2012，，1： | 1 |
| 20 | Total synthesis of(+)-papulacandin D显示文摘 | Scott E Denmark Tetsuya Kobayashi Christopher S Re-gens | 2010 | Tetra-hedron2010，，66： | 1 |
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