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| 1 | The dependences of osteocyte network on bone compartment, age, and disease显示文摘Osteocytes, the most abundant bone cells, form an interconnected network in the lacunar-canalicular pore system(LCS) buried within the mineralized matrix, which allows osteocytes to obtain nutrients from the blood supply, sense external mechanical signals, and communicate among themselves and with other cells on bone surfaces. In this study, we examined key features of the LCS network including the topological parameter and the detailed structure of individual connections and their variations in cortical and cancellous compartments, at different ages, and in two disease conditions with altered mechanosensing(perlecan deficiency and diabetes).LCS network showed both topological stability, in terms of conservation of connectivity among osteocyte lacunae(similar to the ‘‘nodes' ' in a computer network), and considerable variability the pericellular annular fluid gap surrounding lacunae and canaliculi(similar to the ‘‘bandwidth'' of individual links in a computer network). Age, in the range of our study(15–32 weeks), affected only the pericellular fluid annulus in cortical bone but not in cancellous bone. Diabetes impacted the spacing of the lacunae, while the perlecan deficiency had a profound influence on the pericellular fluid annulus. The LCS network features play important roles in osteocyte signaling and regulation of bone growth and adaptation. | Xiaohan Lai Christopher Price Shannon Modla William R Thompson Jeffrey Caplan Catherine B Kirn-Safran Liyun Wang | 2015 | Bone Research2015，3，2： | 6 |
| 2 | Heparin resistance in severe thermal injury:a prospective cohort study显示文摘Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for thromboprophylaxis.Some studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically studied.We hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa activity.Methods:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and 14.Peak anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were measured.Mixed effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and AFXa.Results:A total of 30 patients with severe burns were included.Mean TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin resistant.Nucleosome levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the hypothesis.The final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of sample.Conclusions:Heparin resistance is a prevalent issue in severe burns.Nucleosome levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they may interfere with the anticoagulant effect of heparin in vivo and contribute to heparin resistance.Accurate monitoring of AFXa activity with appropriate therapy escalation plans are recommended with dose adjustment following severe burn injury. | Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian Lowe Christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison | 2021 | Burns & Trauma2021，9，1： | 3 |
| 3 | Immunodominance and functional alterations of tumor‐associated antigen‐specific CD8+ T‐cell responses in hepatocellular carcinoma显示文摘 | Tobias Flecken Nathalie Schmidt Sandra Hild Emma Gostick Oliver Drognitz Robert Zeiser Peter Schemmer Helge Bruns Thomas Eiermann David A. Price Hubert E. Blum Christoph Neumann‐Haefelin Robert Thimme | 2014 | Hepatology2014，，： | 2 |
| 4 | Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis显示文摘 | Matthew Rutter Brian Saunders Kay Wilkinson Steve Rumbles Gillian Schofield Michael Kamm Christopher Williams Ashley Price Ian Talbot Alastair Forbes | 2004 | Gastroenterology2004，，： | 2 |
| 5 | Thirty-Year Analysis of a Colonoscopic Surveillance Program for Neoplasia in Ulcerative Colitis显示文摘 | Matthew D. Rutter Brian P. Saunders Kay H. Wilkinson Steve Rumbles Gillian Schofield Michael A. Kamm Christopher B. Williams Ashley B. Price Ian C. Talbot Alastair Forbes | 2006 | Gastroenterology2006，，： | 2 |
| 6 | Role of metastable phases in the spontaneous precipitation of calcium carbonate显示文摘 | John R Clarkson Timothy J Price Christopher J Adms | 1992 | Chem Soc Faraday Trans1992，88，2： | 1 |
| 7 | Clonal plants and environmental heterogeneity显示文摘 | Elizabeth A C Price Christopher Marshall | 1999 | Plant Ecology1999，141，12： | 1 |
| 8 | Platelet Reactivity and Cardiovascular Outcomes After Percutaneous Coronary Intervention: A Time-Dependent Analysis of the Gauging Responsiveness With a VerifyNow P2Y12 Assay: Impact on Thrombosis and Safety (GRAVITAS) Trial显示文摘 | Matthew J. Price Dominick J. Angiolillo Paul S. Teirstein Elizabeth Lillie Steven V. Manoukian Peter B. Berger Jean-Fran?ois Tanguay Christopher P. Cannon Eric J. Topol | 2011 | Circulation2011，，10： | 1 |
| 9 | SubSift web services and workflows for profiling and comparing scientists and their published works显示文摘 | Simon Price Peter A. Flach Sebastian Spiegler Christopher Bailey Nikki Rogers | 2013 | Future Generation Computer Systems2013，，2： | 1 |
| 10 | First international reference preparation for individual proteins in urine显示文摘 | Christopher P. Price David J. Newman Sorin Blirup-Jensen Walter G. Guder Anders Grubb Yoshi Itoh Myron Johnson Manfred Lammers Simon Packer Daniel Seymour | 1998 | Clinical Biochemistry1998，，6： | 1 |
| 11 | Epidemiological evidence for a relationship between life events, coping style, and personality factors in the development of breast cancer显示文摘 | Phyllis N Butow Janet E Hiller Melanie A Price Sarah V Thackway Anne Kricker Christopher C Tennant | 2000 | Journal of Psychosomatic Research2000，，3： | 1 |
| 12 | Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis显示文摘 | Matthew Rutter Brian Saunders Kay Wilkinson Steve Rumbles Gillian Schofield Michael Kamm Christopher Williams Ashley Price Ian Talbot Alastair Forbes | 2004 | Gastroenterology2004，，2： | 1 |
| 13 | Human TEN1 Maintains Telomere Integrity and Functions in Genome-wide Replication Restart显示文摘 | Christopher Kasbek Feng Wang Carolyn M. Price | 2013 | Journal of Biological Chemistry2013，，42： | 1 |
| 14 | Human CST Has Independent Functions during Telomere Duplex Replication and C-Strand Fill-In显示文摘 | Feng Wang Jason A. Stewart Christopher Kasbek Yong Zhao Woodring E. Wright Carolyn M. Price | 2012 | Cell Reports2012，，5： | 1 |
| 15 | Efficient evaluation of performance-based earthquake engineering equations显示文摘 | Brendon A. Bradley Dominic S. Lee Robert Broughton Christopher Price | 2008 | Structural Safety2008，，1： | 1 |
| 16 | The effect of high intensity ultrasound on the synthesis of some polyurethanes 显示文摘 | Gareth J Price Emma J Lenz Christopher W G Ansell | 2002 | European Polymer Journal2002，38，： | 1 |
| 17 | Crystalline polymorph selection and discovery with polymer heteronuclei显示文摘 | Christopher P Price Adam L Grzesiak Adam J Matzger | | 0，，： | 1 |
| 18 | An exploration of the relationship between recruitment communication and foraging in stingless bees显示文摘Social information is widely used in the animal kingdom and can be highly adaptive.In social insects,foragers can use social information to find food,avoid danger,or choose a new nest site.Copying others allows individuals to obtain information without having to sample the environment.When foragers communicate information they will often only advertise high-quality food sources,thereby filtering out less adaptive information.Stingless bees,a large pantropical group of highly eusocial bees,face intense inter-and intra-specific competition for limited resources,yet display disparate foraging strategies.Within the same environment there are species that communicate the location of food resources to nest-mates and species that do not.Our current understanding of why some species communicate foraging sites while others do not is limited.Studying freely foraging colonies of several co-existing stingless bee species in Brazil,we investigated if recruitment to specific food locations is linked to 1)the sugar content of forage,2)the duration of foraging trips,and 3)the variation in activity of a colony from 1 day to another and the variation in activity in a species over a day.We found that,contrary to our expectations,species with recruitment communication did not return with higher quality forage than species that do not recruit nestmates.Furthermore,foragers from recruiting species did not have shorter foraging trip durations than those from weakly recruiting species.Given the intense inter-and intraspecific competition for resources in these environments,it may be that recruiting species favor food resources that can be monopolized by the colony rather than food sources that offer high-quality rewards. | Robbie I’ANSON PRICE Francisca SEGERS Amelia BERGER Fabio S.NASCIMENTO Christoph GRUTER | 2021 | Current Zoology2021，67，5： | 1 |
| 19 | Cystatin C : an improved estimator of glomemlar filtration rate显示文摘 | Laterza Omar F Price Christopher P Scottn Mitchell G | 2002 | Clin Chem2002，48，5： | 1 |
| 20 | The effect of high intensity ultrasound on the synthesis of some polyurethanes 显示文摘 | Gareth J Price Emma J Lenz Christopher W G Ansell | 2002 | Eur Polym J2002，38，： | 1 |
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