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| 1 | N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer显示文摘AIM:To investigate the possible association between meat intake,cigarette smoking and N-acetyltransferase 2 (NAT2) genetic polymorphisms on colorectal cancer (CRC) risk.METHODS:Patients with CRC were matched for gender and age to healthy controls.Meat intake and cigarette smoking were assessed using a specific frequency questionnaire.DNA was extracted from peripheral blood and the genotypes of the polymorphism were assessed by polymerase chain reaction-restriction fragment length polymorphism.Five NAT2 alleles were studied (WT,M1,M2,M3 and M4) using specific digestion enzymes.RESULTS:A total of 147 patients with colorectal cancer (76 women and 90 men with colon cancer) and 212 controls were studied.The mean age of the two groups was 62 years.More than half the subjects (59.8% in the case group and 51.9% in the control group) were NAT2 slow acetylators.The odds ratio for colorectal cancer was 1.38 (95% CI:0.90-2.12) in slow acetylators.Although the number of women was small (n=76 in the case group),the cancer risk was found to be lower in intermediate (W/Mx) acetylators [odds ratio (OR):0.55,95% confidence interval (95% CI):0.29-1.02].This difference was not observed in men (OR:0.56,95% CI:0.16-2.00).Among NAT2 fast acetylators (W/W or W/Mx),meat consumption more than 3 times a week increased the risk of colorectal cancer (OR:2.05,95% CI:1.01-4.16).In contrast,cigarette smoking increased the risk of CRC among slow acetylators (OR:1.97,95% CI:1.02-3.79).CONCLUSION:The risk of CRC was higher among fast acetylators who reported a higher meat intake.Slow NAT2 acetylation was associated with an increased risk of CRC. | Tiago Donizetti da Silva Aledson Vitor Felipe Jacqueline Miranda de Lima Celina Tizuko Fujiyama Oshima Nora Manoukian Forones | 2011 | World Journal of Gastroenterology2011，17，6： | 3 |
| 2 | Impact of major bleeding on 30-day mortality and clinical outcomes in patients with acute coronary syndromes: an analysis from the ACUITY Trial显示文摘 | Manoukian SV Feit F Mehran R | 2007 | J Am Coil Cardio]2007，49，： | 1 |
| 3 | The psycholog- ical impact of breast and ovarian cancer preventive options in BRCA1 and BRCA2 mutation earriers显示文摘 | Borreani C Manoukian S Bianchi E | 2014 | Clin Genet2014，85，1： | 1 |
| 4 | Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production显示文摘 | Kim MR Manoukian R Yeh R | 2002 | Blood2002，100，7： | 1 |
| 5 | Adenoidectomy: indiretct visualization of choanal adenoids 显示文摘 | Pearl AJ Manoukian JJ | 1994 | J Otolaryngol1994，23，： | 1 |
| 6 | Adenoidectomy:indirect visualization of choanal adenoids显示文摘 | Pearl AJ Manoukian JJ | 1994 | J Otolaryngol1994，23，3： | 1 |
| 7 | Evidence of aller- gic inflammation in the middle ear and nasopharynx in atopic children with otitis media with effusion显示文摘 | Nguyen LH Manoukian J J Tewfik TL | 2004 | J Otolaryngol2004，33，： | 1 |
| 8 | Similar allergic in- flammation in the middle ear and the upper airway: evidence linking otitis media with effusion to the united airways concept显示文摘 | Nguyen LH Manoukian J J Sobot SE | 2004 | J Allergy Clin Immunol2004，114，： | 1 |
| 9 | Trausgenie ovcrexpres sion of human IL-17E results in eosinophilia,B-lymphocyte hy perplasia,and altered antibody production显示文摘 | Kim MR Manoukian R Yeh R | 2002 | Blood2002，100，7： | 1 |
| 10 | Impact of major bleedingon 30-day mortality and clinical outcomes in patients with acutecoronary syndromes:an analysis from the ACUITY Trial显示文摘 | Manoukian SV Feit F Mehran R | 2007 | J AmColl Cardiol2007，49，12： | 1 |
| 11 | Platelet Reactivity and Cardiovascular Outcomes After Percutaneous Coronary Intervention: A Time-Dependent Analysis of the Gauging Responsiveness With a VerifyNow P2Y12 Assay: Impact on Thrombosis and Safety (GRAVITAS) Trial显示文摘 | Matthew J. Price Dominick J. Angiolillo Paul S. Teirstein Elizabeth Lillie Steven V. Manoukian Peter B. Berger Jean-Fran?ois Tanguay Christopher P. Cannon Eric J. Topol | 2011 | Circulation2011，，10： | 1 |
| 12 | Linking laryngopharyngeal reflux to otitis media with effusion:pepsinogen study of adenoid tissue and middle ear fluid显示文摘 | AL-SAAB F MANOUKIAN JJ AL-SABAH B | 2008 | J Otolaryngol Head Neck Surg2008，37，4： | 1 |
| 13 | Laterally hypertrophic adenoids as a contributing factor in otitis media 显示文摘 | Wright ED Pearl AJ Manoukian JJ | 1998 | Int J Pediatr Otorhinolaryugol1998，45，3： | 1 |
| 14 | Adenoi- dectomy:selection criteria for surgical cases of otitis media显示文摘 | Nguyen LH Manoukian JJ Voskovitch h | 2004 | Laryngoscope2004，114，5： | 1 |
| 15 | Ultrasonography and videobronchoscopy to assess the subglottic diameter inthe paediatric population: A first look显示文摘 | Husein M Manoukian JJ Platt R | 2002 | J Otolaryngol2002，31，4： | 1 |
| 16 | Adenoidectomy:in-direct visualization of choanal adenoids显示文摘 | Pearl AJ Manoukian JJ | 1994 | J Otolar-yngol1994，23，： | 1 |
| 17 | Epicardial coronary artery responses to acetylcholine are impaired in hypertensive patients 显示文摘 | Treasure CB Manoukian SV Klein JL | 1992 | Circ Res1992，71，4： | 1 |
| 18 | Adenoidectomy:indirect visualigationof choanal adenoids显示文摘 | Pearl AJ Manoukian JJ | 1994 | J Otolaryngol1994，23，3： | 1 |
| 19 | Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production 显示文摘 | Kim MR Manoukian R Yeh R | 2002 | Blood2002，100，： | 1 |
| 20 | Impact of femoral vascular closure devices and antithrombotic therapy on access site bleeding in acute cor- onary syndromes: the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial 显示文摘 | Sanborn TA Ebrahimi R Manoukian SV | 2010 | Circ Cardiovasc Interv2010，3，1： | 1 |
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