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| 1 | Pathological Changes to the Subcortical Visual System and its Relationship to Visual Hallucinations in Dementia with Lewy Bodies显示文摘Introduction Recurrent complex visual hallucinations are a core clinical feature of dementia with Lewy bodies(DLB)and are typically well-formed,often consisting of figures,such as people or animals(1)Despite the profound impact upon patients and caregivers in DLB,the aetiopathology of visual hallucinations remains largely unknown.In this article we discuss the anatomy of the human visual system,hypotheses of the genesis of visual hallucinations in DLB,and imaging and neuropathological studies that have attempted to understand visual hallucinations on a functional and anatomical basis. | Daniel Erskine John-Paul Taylor Alan Thomas Daniel Collerton Ian McKeith Ahmad Khundakar Johannes Attems Christopher Morris | 2019 | Neuroscience Bulletin2019，35，2： | 3 |
| 2 | Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring显示文摘现在有充分证据,对在使肥沃的后代显型的父亲的贡献多于公平 DNA。然而,这 nongenetic 继承的身份和机制糟糕被理解。在这个研究区域的更重要的问题之一是:在精子 DNA methylation 的变化为后代有 phenotypic 后果吗?我们以前报导了肥胖的雄的老鼠的后代与控制相比改变了葡萄糖新陈代谢并且这效果通过 nongenetic 工具被继承。这里,我们用一样的协议在一个新队描述调查进精子 DNA methylation。在高脂肪的节食的雄的老鼠是 30% 比喂控制的男性重在交配的时候(16-19 星期旧, n = 14/14 ) 。一小(0.25%) 在全部的 5-methyl-2 ’ 增加; -deoxycytidine 被液体层析双人脚踏车团 spectrometry 在肥胖的老鼠精子检测。那 retrotransposon DNA methylation 在精子说的有定序的充实蛋白质的染色体(MBD-Seq ) 和 pyrosequencing 揭示了的 methyl-CpG 绑定领域的染色体的重复部分的检查没被肥胖,而是 methylation 在整个染色体在卫星重复影响被增加。然而,从男 27-week-old 后代从的肌肉,肝,和精子的检查肥胖并且控制父亲(从 8 生的 n = 的两个组) 表明正常 DNA methylation 层次在后代开发期间被恢复。而且,没有变化在肥胖的老鼠精子在三个 genomic 印记被发现。我们的调查结果为 transgenerational epigenetic reprogramming 有含意。他们建议 postfertilization 机制为使导致 environmentally 的 DNA methylation 在精子房间改变的一些正常化存在。 | Neil A Youngson Virginie Lecomte Christopher A Maloney Preston Leung Jia Liu Luke B Hesson Fabio Luciani Lutz Krause Margaret J Morris | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 3 | Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma显示文摘 | Janel L. Kopp Guido von Figura Erin Mayes Fen-Fen Liu Claire L. Dubois John P. Morris Fong Cheng Pan Haruhiko Akiyama Christopher V.E. Wright Kristin Jensen Matthias Hebrok Maike Sander | 2012 | Cancer Cell2012，，6： | 2 |
| 4 | A Systematic Review and Meta-Analysis of Cytoreductive Surgery with Perioperative Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis of Colorectal Origin显示文摘 | Christopher Cao MBBS Tristan D. Yan PhD Deborah Black PhD David L. Morris PhD | 2009 | Annals of Surgical Oncology2009，，8： | 2 |
| 5 | Im- provements in Fixed-Valve micropump performance through shape optimization of valves 显示文摘 | Adrian R Gamboa Christopher J Morris and Fred K Forster | 2005 | Journal of Fluids Engineering2005，127，2： | 1 |
| 6 | International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT) 显示文摘 | Christopher RP Alain C | 2000 | Lancet2000，356，9277： | 1 |
| 7 | Feasibility of pancreatectomy following high-dose proton therapy for unresectable pancreatic cancer显示文摘AIM To review surgical outcomes for patients undergoing pancreatectomy after proton therapy with concomitant capecitabine for initially unresectable pancreatic adenocarcinoma.METHODS From April 2010 to September 2013,15 patients with initially unresectable pancreatic cancer were treated withproton therapy with concomitant capecitabine at 1000 mg orally twice daily. All patients received 59.40 Gy(RBE) to the gross disease and 1 patient received 50.40 Gy(RBE) to high-risk nodal targets. There were no treatment interruptions and no chemotherapy dose reductions. Six patients achieved a radiographic response sufficient to justify surgical exploration,of whom 1 was identified as having intraperitoneal dissemination at the time of surgery and the planned pancreatectomy was aborted. Five patients underwent resection. Procedures included:Laparoscopic standard pancreaticoduodenectomy(n = 3),open pyloris-sparing pancreaticoduodenectomy(n = 1),and open distal pancreatectomy with irreversible electroporation(IRE) of a pancreatic head mass(n = 1). RESULTS The median patient age was 60 years(range,51-67). The median duration of surgery was 419 min(range,290-484),with a median estimated blood loss of 850 cm^3(range,300-2000),median ICU stay of 1 d(range,0-2),and median hospital stay of 10 d(range,5-14). Three patients were re-admitted to a hospital within 30 d after discharge for wound infection(n = 1),delayed gastric emptying(n = 1),and ischemic gastritis(n = 1). Two patients underwent R0 resections and demonstrated minimal residual disease in the final pathology specimen. One patient,after negative pancreatic head biopsies,underwent IRE followed by distal pancreatectomy with no tumor seen in the specimen. Two patients underwent R2 resections. Only 1 patient demonstrated ultimate local progression at the primary site. Median survival for the 5 resected patients was 24 mo(range,10-30).CONCLUSION Pancreatic resection for patients with initially unresectable cancers is feasible after high-dose [59.4 Gy(RBE)] proton radiotherapy with a high rate of local control,acceptable surgical morbidity,and a median survival of 24 mo. | Kathryn E Hitchcock R Charles Nichols Christopher G Morris Debashish Bose Steven J Hughes John A Stauffer Scott A Celinski Elizabeth A Johnson Robert A Zaiden Nancy P Mendenhall Michael S Rutenberg | 2017 | World Journal of Gastrointestinal Surgery2017，9，4： | 1 |
| 8 | The impact of heterogeneity correction on dosimetric parameters that predict for radiation pneumonitis显示文摘 | Daniel T. Chang Kenneth R. Olivier Christopher G. Morris Chihray Liu James F. Dempsey Rashmi K. Benda Jatinder R. Palta | 2006 | International Journal of Radiation Oncology Biology Physics2006，，1： | 1 |
| 9 | International nffedipine GITS study:intervention as a goal in hypertension treatment(INSI GHT)显示文摘 | Morris JB Christopher RP Alain C et a1 | 2000 | Lancet2000，356，9277： | 1 |
| 10 | Urban Heat Island Features of Southeast Australian Towns显示文摘 | Torok Simon J Christopher J G Morris Carol Skinner Neil Plummer | 2001 | Australian Meteorological Magazine2001，50，1： | 1 |
| 11 | Preoperative use of ultrasonography to localize an ingested foreign body显示文摘 | Lino Piotto Roger Gent Christopher P. Kirby Lloyd L. Morris | 2009 | Pediatric Radiology2009，，： | 1 |
| 12 | Inheritance and effect on ripening of antisense polygalacturonase genes in transgenic tomatoes显示文摘 | Christopher J. S. Smith Colin F. Watson Peter C. Morris Colin R. Bird Graham B. Seymour Julie E. Gray Christine Arnold Gregory A. Tucker Wolfgang Schuch Steven Harding Donald Grierson | 1990 | Plant Molecular Biology1990，，3： | 1 |
| 13 | Individual laboratory-measured discount rates predict field behavior显示文摘 | Christopher F. Chabris David Laibson Carrie L. Morris Jonathon P. Schuldt Dmitry Taubinsky | 2008 | Journal of Risk and Uncertainty (-)2008，，2： | 1 |
| 14 | Embolization of the left gastric artery in the absence of angiographic extravasation显示文摘 | D. Christopher Morris M.D. David M. Nichols Douglas G. Connell H. Joachim Burhenne | 1986 | Cardiovascular and Interventional Radiology1986，，4： | 1 |
| 15 | Proton therapy with concomitant capecitabine for pancreatic and ampullary cancers is associated with a low incidence of gastrointestinal toxicity显示文摘 | R. Charles Nichols Thomas J. George Robert A. Zaiden Ziad T. Awad Horacio J. Asbun Soon Huh Meng Wei Ho Nancy P. Mendenhall Christopher G. Morris bradford S. Hoppe | 2013 | Acta Oncologica2013，，3： | 1 |
| 16 | Validity and Reliability of the Alzheimer?s Disease Cooperative Study-Clinical Global Impression of Change显示文摘 | Lon S. Schneider Jason T. Olin Rachelle S. Doody Christopher M. Clark John C. Morris Barry Reisberg Frederick A. Schmitt Michael Grundman Ronald G. Thomas Steven H. Ferris | 1997 | Alzheimer Disease & Associated Disorders1997，，： | 1 |
| 17 | Preoperative use of ultrasonography to localize an ingested foreign body显示文摘 | Lino Piotto Roger Gent Christopher P. Kirby Lloyd L. Morris | 2009 | Pediatric Radiology2009，，3： | 1 |
| 18 | T1N0 to T2N0 Squamous Cell Carcinoma of the Glottic Larynx Treated With Definitive Radiotherapy显示文摘 | Bhishamjit S. Chera Robert J. Amdur Christopher G. Morris Jessica M. Kirwan William M. Mendenhall | 2010 | International Journal of Radiation Oncology Biology Physics2010，，2： | 1 |
| 19 | Osteoporosis and Vitumin D显示文摘 | CHRISTOPHER NORDIN BE MORRIS HA | 1992 | J Cellular Biochem1992，，49： | 1 |
| 20 | Brain oestradiol and testosterone levels in Alzheimer’s disease显示文摘 | Samantha J Twist Geoffrey A Taylor Ann Weddell David R Weightman James A Edwardson Christopher M Morris | 2000 | Neuroscience Letters2000，，1： | 1 |
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