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| 1 | Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study显示文摘 | Christopher D. Williams Joel Stengel Michael I. Asike Dawn M. Torres Janet Shaw Maricela Contreras Cristy L. Landt Stephen A. Harrison | 2011 | Gastroenterology2011，，1： | 20 |
| 2 | Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study显示文摘 | Christopher D. Williams Joel Stengel Michael I. Asike Dawn M. Torres Janet Shaw Maricela Contreras Cristy L. Landt Stephen A. Harrison | 2011 | Gastroenterology2011，，1： | 5 |
| 3 | Heparin resistance in severe thermal injury:a prospective cohort study显示文摘Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for thromboprophylaxis.Some studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically studied.We hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa activity.Methods:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and 14.Peak anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were measured.Mixed effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and AFXa.Results:A total of 30 patients with severe burns were included.Mean TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin resistant.Nucleosome levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the hypothesis.The final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of sample.Conclusions:Heparin resistance is a prevalent issue in severe burns.Nucleosome levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they may interfere with the anticoagulant effect of heparin in vivo and contribute to heparin resistance.Accurate monitoring of AFXa activity with appropriate therapy escalation plans are recommended with dose adjustment following severe burn injury. | Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian Lowe Christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison | 2021 | Burns & Trauma2021，9，1： | 3 |
| 4 | Features, Diagnosis, and Treatment of Nonalcoholic Fatty Liver Disease显示文摘 | Dawn M. Torres Christopher D. Williams Stephen A. Harrison | 2012 | Clinical Gastroenterology and Hepatology2012，，8： | 2 |
| 5 | Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection显示文摘 | Brad Q. Starley Christopher J. Calcagno Stephen A. Harrison | 2010 | Hepatology2010，，5： | 2 |
| 6 | SJES14121200034975显示文摘 | Kenneth Cusi Zhi Chang Steve Harrison Romina Lomonaco Fernando Bril Beverly Orsak Carolina Ortiz-Lopez Joan Hecht Ariel E. Feldstein Amy Webb Christopher Louden Martin Goros Fermin Tio | 2014 | Journal of Hepatology2014，，1： | 1 |
| 7 | Frenetic显示文摘 | Nate Foster Rob Harrison Michael J. Freedman Christopher Monsanto Jennifer Rexford Alec Story David Walker | 2011 | ACM SIGPLAN Notices2011，，： | 1 |
| 8 | Determination of zwitterionic and cationic surfactants by highperformance liquid chromatography with ch nitrogen detection显示文摘 | Christopher R Harrison Charles A Lucy | 2002 | Journal of Chromatography A2002，956，： | 1 |
| 9 | Measuring agile capabilities in the supply chain 显示文摘 | Van Hoek RI Harrison A Christopher MG | 2001 | International Journal of Operations and Production Management2001，21，12： | 1 |
| 10 | Age-Accelerated Atherosclerosis Correlates With Failure to Upregulate Antioxidant Genes显示文摘 | Alan R. Collins Christopher J. Lyon Xuefeng Xia Joey Z. Liu Rajendra K. Tangirala Fen Yin Rima Boyadjian Alfiya Bikineyeva Domenico Praticò David G. Harrison Willa A. Hsueh | 2009 | Circulation Research2009，，6： | 1 |
| 11 | Measuring agile capabilities in the supply chain显示文摘 | HOEK R I V HARRISON A CHRISTOPHER M | 2001 | International Journal of Operations &Production Management2001，21，12： | 1 |
| 12 | Features, Diagnosis, and Treatment of Nonalcoholic Fatty Liver Disease显示文摘 | Dawn M. Torres Christopher D. Williams Stephen A. Harrison | 2012 | Clinical Gastroenterology and Hepatology2012，，8： | 1 |
| 13 | Vascular Oxidative Stress and Endothelial Dysfunction in Patients With Chronic Heart Failure: Role of Xanthine-Oxidase and Extracellular Superoxide Dismutase显示文摘 | Ulf Landmesser Stephan Spiekermann Sergey Dikalov Helma Tatge Ragna Wilke Christoph Kohler David G. Harrison Burkhard Hornig Helmut Drexler | 2002 | Circulation: Journal of the American Heart Association2002，，24： | 1 |
| 14 | An Altemative picture of the geomagnetic field显示文摘 | CHRISTOPHER G A Harrison | 1994 | J Geomag Geoelectr1994，46，： | 1 |
| 15 | Hepatic Expression of Hepatocyte Growth Factor Gene mRNA in Acute Liver Failure显示文摘 | Phillip Harrison Christopher Gove Adrian Bomford | 2000 | Digestive Diseases and Sciences2000，45，10： | 1 |
| 16 | Endocarditis, Vegetation, and Perforation of the Pulmonary Valve显示文摘 | Melissa Vu Barry A. Harrison Christopher DeStephano John Odell | 2008 | Journal of Cardiothoracic and Vascular Anesthesia2008，，2： | 1 |
| 17 | Cephalosporins: A Re- view显示文摘 | Christopher J Harrison MD Denise B | 2008 | Pediatrics in Review2008，29，8： | 1 |
| 18 | Measuring agile capabilities in the supply chain显示文摘 | van Hoek R I Harrison A Christopher M | 2001 | International Journal of Operations and Production Management2001，，2： | 1 |
| 19 | A Pilot Study Using Simvastatin in the Treatment of Nonalcoholic Steatohepatitis: A Randomized Placebo-controlled Trial显示文摘 | Austin Nelson Dawn M. Torres Ana E. Morgan Christopher Fincke Stephen A. Harrison | 2009 | Journal of Clinical Gastroenterology2009，，10： | 1 |
| 20 | Transforming Growth Factor-β Receptor Mutations and Pulmonary Arterial Hypertension in Childhood显示文摘 | Rachel E. Harrison Rolf Berger Sheila G. Haworth Robert Tulloh Christoph J. Mache Nicholas W. Morrell Micheala A. Aldred Richard C. Trembath | 2005 | Circulation2005，，4： | 1 |
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