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| 1 | AZF microdeletions associated with idiopathic and non idiopathic cases with cryptorchidism and varicocele显示文摘Aim:To identify submicroscopic interstitital deletions in azoospermia factor (AZF) loci in idiopathic and non-idiopathic cases of male infertility in Indians.Methos:One hundred and twenty two infertile males with oligozoospermia or azoospermia were included in this study.Semen analysis was done to determine the sperm density,i.e.,normospermia(>20million/mL),oligozoospermia(<20million/mL) or azoospermia.They were subjected to detailed clinical examination and endocrinological and cytogenetic study.Thirty G-banded metaphases were analyzed in the 122 cases and polymerase chain reaction (PCR) microdeletion analysis was done in 70 cytogenetically normal subjects.For this genomic DNA was extracted using peripheral blood.The STS primers tested in each case were sY84,sY86(AZFa);sY127,sY134(AZFb);sY254,sY255(AZFc).PCR amplifications found to be negative were repeated at least 3 times to confirm the deletion of a given marker.The PCR products were analyzed on a 1.8% agarose gel.Results:Eight of the 70 cades(11.4%) showed deletion of at least one of the STS markers.Deletions were detected in cases with known and unknown aetiology with bilateral severe testiculopathy and also in cryptorchid and varicocele subjects.Conclusion.AZF microdeletions were seen in both idiopathic and non-idiopathic cases with cryptorchidism and varicocele.The finding of a genetic aetiology in infertile men with varicocele and cryptorchidism suggests the need for molecular screening in non-idiopathic cases. | Rima Dada N.P. Gupta K. Kucheria | 2002 | Asian Journal of Andrology2002，4，4： | 22 |
| 2 | Applying terahertz time-domain spectroscopy to probe the evolution of kerogen in close pyrolysis systems显示文摘Terahertz time-domain spectroscopy (THz-TDS) has been used to probe the evolutionary paths of kerogen in selected black mudstone. The evolutionary regime of kerogens (for instance, the immaturity, early maturity, middle maturity, late maturity, and catagenesis stages) can be indicated by the absorption coefficient in the THz region. The present study of identification based on THz-TDS was in good agreement with programmed pyrolysis experiments and suggests that THz technology can act as a nondestructive, contact-free tool for probing the ability to generate hydrocarbons from kerogens. | BAO RiMa WU ShiXiang ZHAO Kun ZHENG LunJu XU ChangHong | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，8： | 19 |
| 3 | Less than 6 GHz resolution THz spectroscopy of water vapor显示文摘在许多的技术象石油工业一样回答的兆兆赫(THz ) 的申请要求高分辨率和多功能认识到不同材料的精确察觉。在这学习水里,在空气的蒸汽与 shortand 被扫描有不同扫描范围的长路径的 THz 分光计。在在长路径的系统的 THz 典型的线的半最大值的完整的宽度到达了不到 7 GHz 和那在突然完成了 5.5 GHz,显示水蒸汽的 THz 光谱学能被用来校准 THz 设备。有正确扫描范围的 THz 系统能是为有由于高分辨率的很类似的结构的固体,液体和气体的材料的鉴定的一种有希望的选择。研究证明多功能的 THz 测试能在许多领域里通过分辨率和采样空格的平衡被认识到,例如油气体工业。 | ZHAN HongLei SUN ShiNing ZHAO Kun LENG WenXiu BAO RiMa XIAO LiZhi ZHANG ZhenWei | 2015 | Science China(Technological Sciences)2015，58，12： | 10 |
| 4 | 菊粉对Labneh浓缩酸乳微观结构和质构的影响显示文摘研究了添加菊粉对脱脂乳制备的Labneh(一种浓缩酸乳)物理和感官性质的影响.将市售菊粉按不同比例(1%、3%、5%和7%)加入至复配脱脂乳粉(reconstituted skimmilk powder,RSMP)制作Labneh样品.通过对酸乳宏观和微观结构的分析发现,添加菊粉后,Labneh凝胶结构和凝胶强度都有所改善.实验表明,与未加菊粉的酸乳相比,含有脂肪替代品的酸乳的微观结构比较均匀、疏松且开放度较高.感官评定的结果表明,5%菊粉复配脱脂乳粉制作的酸乳与全脂牛乳制作的Labneh相比具有相似的特征,对全脂牛乳制作的样品和添加3%、5%、7%菊粉的样品的统计分析结果没有显著的差别. | Consolate N 江波 Rima K | 2005 | 食品与发酵工业2005，31，4： | 9 |
| 5 | Estimating steatosis and fibrosis: Comparison of acoustic structure quantification with established techniques显示文摘AIM:To compare ultrasound-based acoustic structure quantification(ASQ) with established non-invasive techniques for grading and staging fatty liver disease.METHODS:Type 2 diabetic patients at risk of nonalcoholic fatty liver disease(n = 50) and healthy volunteers(n = 20) were evaluated using laboratory analysis and anthropometric measurements, transient elastography(TE), controlled attenuation parameter(CAP), proton magnetic resonance spectroscopy(1H-MRS; only available for the diabetic cohort), and ASQ.ASQ parameters mode, average and focal disturbance(FD) ratio were compared with:(1) the extent of liver fibrosis estimated from TE and nonalcoholic fatty liver disease(NAFLD) fibrosis scores; and(2) the amount of steatosis, which was classified according to CAP values.RESULTS:Forty-seven diabetic patients(age 67.0±8.6 years;body mass index 29.4±4.5 kg/m2)with reliable CAP measurements and all controls(age 26.5±3.2 years;body mass index 22.0±2.7 kg/m2)were included in the analysis.All ASQ parameters showed differences between healthy controls and diabetic patients(P<0.001,respectively).The ASQ FD ratio(logarithmic)correlated with the CAP(r=-0.81,P<0.001)and 1H-MRS(r=-0.43,P=0.004)results.The FD ratio[CAP<250 d B/m:107(102-109),CAP between 250 and 300 d B/m:106(102-114);CAP between 300 and 350 d B/m:105(100-112),CAP≥350 d B/m:102(99-108)]as well as mode and average parameters,were reduced in cases with advanced steatosis(ANOVA P<0.05).However,none of the ASQ parameters showed a significant difference in patients with advanced fibrosis,as determined by TE and the NAFLD fibrosis score(P>0.08,respectively).CONCLUSION:ASQ parameters correlate with steatosis,but not with fibrosis in fatty liver disease.Steatosis estimation with ASQ should be further evaluated in biopsy-controlled studies. | Thomas Karlas Joachim Berger Nikita Garnov Franziska Lindner Harald Busse Nicolas Linder Alexander Schaudinn Bettina Relke Rima Chakaroun Michael Trltzsch Johannes Wiegand Volker Keim | 2015 | World Journal of Gastroenterology2015，21，16： | 9 |
| 6 | Y chromosome microdeletions in azoospermic patients with Klinefelter's syndrome显示文摘瞄准:与 Klinefelter 的症候群(KFS ) 在 azoospermic 病人学习 Y 微删除的出现。方法:血和精液样品与 KFS 从 azoospermic 病人被收集(n = 14 ) 并且证明富饶的人的一个控制组(n = 13 ) 。精液分析根据世界卫生组织被做() 指南。血样品为 karyotyping,荧光灯的原位杂交(鱼) 和由放射性免疫测定刺激荷尔蒙(FSH ) 的血浆滤泡的测量被处理。决定 Y 微删除, 16 顺序的聚合酶链反应(PCR ) 标注了地点(圣) ,三基因(DFFRY, XKRY 和 RBM1Y ) 在孤立的 genomic DNA 上被执行。阴囊的好针渴望细胞学(FNAC ) 在选择情况中被做。结果:跨越一个 and AZFb 部位与 KFS 在 14 个 azoospermic 病人中的四个被发现的精子缺乏因素(AZF ) 的 Y 微删除。染色质组型和鱼分析表明显示出 Y 微删除的四个盒子,三个盒子有一 47, XXY/46, XY 染色体的模式和一个盒子有一 46, XY/47, XXY/48, XXXY/48, XXYY 染色体的模式。有 Y 微删除的一件样品的阴囊的 FNAC 揭示了形态学的 Sertoli 房间唯一的类型。然而,没有 Y 微删除在任何 13 个肥沃的人被观察。有 KFS 的所有病人提高了血浆 FSH 层次。结论:有 KFS 的病人可以怀有 Y 微删除并且为这些屏蔽应该是他们的诊断病情的检查的部分,特别地在那些考虑帮助了繁殖技术。 | Anurag Mitra Rima Dada Rajeev Kumar Narmada Prasad Gupta Kiran Kucheria Satish Kumar Gupta | 2006 | Asian Journal of Andrology2006，8，1： | 8 |
| 7 | Narrow line between benefit and harm: Additivity of hyperthermia to cisplatin cytotoxicity in different gastrointestinal cancer cells显示文摘AIM To investigate the response to hyperthermia and chemotherapy, analyzing apoptosis, cytotoxicity, and cisplatin concentration in different digestive system cancer cells.METHODS AGS(gastric cancer cell line), Caco-2(colon cancer cell line) and T3M4(pancreatic cancer cell line) were treated by cisplatin and different temperature setting(37 ℃ to 45 ℃) either in isolation, or in combination. Treatment lasted for one hour. 48 h after the treatment viability was evaluated by MTT, cell apoptosis by Annexin V-PE and 7 ADD flow cytometry. Intracellular cisplatin concentration was measured immediately after the treatment, using mass spectrometry. Isobologram analysis was performed to evaluate the mathematical combined effect of temperature and cisplatin.RESULTS AGS cells were the most sensitive to isolated application of hyperthermia. Hyperthermia, in addition to cisplatin treatment, did not provoke a synergistic effect at intervals from 37 ℃ to 41 ℃ in neither cancer cell line. However, a temperature of 43 ℃ enhanced cisplatin cytotoxicity for Caco-2 cells. Moreover, isobologram analysis revealed mathematical antagonistic effects of cisplatin and temperature combined treatment in AGS cells; variations between synergistic, additive, and antagonistic effects in Caco-2 cells; and additive and antagonistic effects in T3 M4 cells. Combined treatment enhanced initiation of cell apoptosis in AGS, Caco-2, and T3 M4 cells by 61%, 20%, and 19% respectively. The increase of intracellular cisplatin concentration was observed at 43 ℃ by 30%, 20%, and 18% in AGS, Caco-2, and T3 M4 cells, respectively.CONCLUSION In addition to cisplatin, hyperthermia up to 43 ℃ does not affect the viability of cancer cells in a synergistic manner. | Vaidotas Cesna Arturas Sukovas Aldona Jasukaitiene Rima Naginiene Giedrius Barauskas Zilvinas Dambrauskas Saulius Paskauskas Antanas Gulbinas | 2018 | World Journal of Gastroenterology2018，24，10： | 6 |
| 8 | Higher frequency of Yq microdeletions in sperm DNA as compared to DNA isolated from blood显示文摘瞄准:决定删除的 Yq 微删除频率和 loci 是否在不同胚胎学的起源的二纸巾(血和精子) 是类似的。方法:现在的学习包括了 52 个不肥沃的 oligozoospermic 盒子。在每种情况中, DNA 从血和精子被孤立,微删除分析从 genomic DNA 被做的聚合酶链反应(PCR ) 从两个孤立纸巾。PCR 产品在 1.8% 统帅玫瑰胶化上被分析。发现否定的 PCR 扩大被重复至少三次证实一个给定的标记的删除。结果:仅仅 1 个盒子在血 DNA 怀有微删除,而 4 个盒子在精子 DNA 怀有微删除。结论:Yq 微删除的频率作为与血相比在细菌房间是更高的。为帮助繁殖生产技术(艺术) 作为不肥沃的夫妇的多数抉择, Yq 微删除从细菌房间屏蔽是重要的理解不孕的基因基础,提供全面建议和大多数改编治疗学给不肥沃的夫妇。 | Rima Dada Rakesh Kumar M. B. Shamsi Rajeev Kumar Kiran Kucheria Raj K. Sharma Satish K. Gupta Narmada P. Gupta | 2007 | Asian Journal of Andrology2007，9，5： | 6 |
| 9 | Discovery of YB-1 as a new immunological target in neuroblastoma by vaccination in the context of regulatory T cell blockade显示文摘Neuroblastoma 是在幼年期和早童年的最普通的稳固的肿瘤之一。用 A/J 老鼠和 syngeneic neuroblastoma 房间线 AGN2a,我们导致了强壮的 anti-neuroblastoma 细胞的有免疫力的反应当表示 costimulatory 分子(CD80/CD86/CD54/CD137L ) 的 AGN2a transfected 在规章的 T 房间的上下文被用作一支疫苗时,封锁。强壮的体液的免疫被 AGN2a-4p 免疫与规章的 T 房间封锁在上下文导致。从对待的鼠标的浆液被用来屏蔽与精力快车向量被构造以便由 SEREX 识别联系肿瘤的抗原的一个 AGN2a cDNA 表达式图书馆。21 克隆被定序和基因水池的比较分析识别。大多数抄本在 neuronal 区别起一些作用,房间新陈代谢,或以前作为抄本被识别了在另外的恶意是过去表示的。用从有 Treg 封锁老鼠的 AGN2a-4p 免疫的浆液,最通常识别的联系肿瘤的抗原是也导致了 T 房间回答的 YB-1 蛋白质。这些结果显示潜在的联系 neuroblastoma 的抗原被 sera 从与与规章的 T 房间功能封锁表示 costimulatory 分子的肿瘤房间使免疫的老鼠发现。能够得到 T 房间回答的 YB-1 同样联系肿瘤的抗原的鉴定验证我们的试验性的途径并且为我们这里识别了作为受动器免疫的目标并且作为疫苗的候选人被评估的抗原争论。 | Jin Zheng Weiqing Jing Rimas J. Orentas | 2009 | Acta Biochimica et Biophysica Sinica2009，41，12： | 5 |
| 10 | High frequency of the c.3207C>A (p.H1069Q) mutation in ATP7B gene of Lithuanian patients with hepatic presentation of Wilson's disease显示文摘AIM: To investigate the prevalence of the ATP7B gene mutation in patients with hepatic presentation of Wilson's disease (WD) in Lithuania. METHODS: Eleven unrelated Lithuanian families, including 13 WD patients were tested. Clinically WD diagnosis was established in accordance to the Leipzig scoring system. Genomic DNA was extracted fromwhole venous blood using a salt precipitation method. Firstly, the semi-nested polymerase chain reaction (PCR) technique was used to detect the c.3207C>A (p.H1069Q) mutation. Patients not homozygous for the c.3207C>A (p.H1069Q) mutation were further analyzed. The 21 exons of the WD gene were amplified in a thermal cycler (Biometra T3 Thermocycler, G?ttingen, Germany). Direct sequencing of the amplified PCR products was performed by cycle sequencing using fluorescent dye terminators in an automatic sequencer (Applied Biosystems, Darmstadt, Germany). RESULTS: Total of 13 WD patients (mean age 26.4 years; range 17-40; male/female 3/10) presented with hepatic disorders and 16 their first degree relatives (including 12 siblings) were studied. Some of WD patients, in addition to hepatic symptoms, have had extrahepatic disorders (hemolytic anemia 3; Fanconi syndrome 1; neurophsychiatric and behavioural disorder 2). Liver biopsy specimens were available in all of 13 WD patients (8 had cirrhosis; 1-chronic hepatitis; 3-acute liver failure, 1-liver steatosis). Twelve of 13 (92.3%) WD patients had the c.3207C>A (p.H1069Q) mutation, 6 of them in both chromosomes, 6 were presented as compound heterozygotes with additional c.3472-82delGGTTTAACCAT, c.3402delC, c.3121C>T (p.R1041W) or unknown mutations. For one patient with liver cirrhosis and psychiatric disorder (Leipzig score 6), no mutations were found. Out of 16 first degree WD relatives, 11 (68.7%) were heterozygous for the c.3207C>A (p.H1069Q) mutation. Two patients with fulminant WD died from acute liver failure and 11 are in full remission under penicillamine or zinc acetate treatment. Three women with WD successfully delivered healthy babies. CONCLUSION: The c.3207C>A (p.H1069Q) missense mutation is the most characteristic mutation for Lithuanian patients with WD. Even 92.3% of WD patients with hepatic presentation of the disease are homozygous or compound heterozygotes for the p.H1069Q mutation. | Laimutis Kucinskas Jolanta Jeroch Astra Vitkauskiene Raimundas Sakalauskas Vitalija Petrenkiene Vaidutis Kucinskas Rima Naginiene Hartmut Schmidt Limas Kupcinskas | 2008 | World Journal of Gastroenterology2008，14，38： | 5 |
| 11 | Defect of insulin signal in peripheral tissues: important role of ceramide显示文摘In healthy people,balance between glucose production and its utilization is precisely controlled.When circulating glucose reaches a critical threshold level,pancreaticβcells secrete insulin that has two major actions:to lower circulating glucose levels by facilitating its uptake mainly into skeletal muscle while inhibiting its production by the liver.Interestingly,dietary triglycerides are the main source of fatty acids to fulfill energy needs of oxidative tissues.Normally,the unconsumed fraction of excess of fatty acids is stored in lipid droplets that are localized in adipocytes to provide energy during fasting periods.Thus,adipose tissue acts as a trap for fatty acid excess liberated from plasma triglycerides.When the buffering action of adipose tissue to store fatty acids is impaired,fatty acids that build up in othertissues are metabolized as sphingolipid derivatives such as ceramides.Several studies suggest that ceramides are among the most active lipid second messengers to inhibit the insulin signaling pathway and this review describes the major role played by ceramide accumulation in the development of insulin resistance of peripherals tissues through the targeting of specific proteins of the insulin signaling pathway. | Rima Hage Hassan Olivier Bourron Eric Hajduch | 2014 | World Journal of Diabetes2014，5，3： | 5 |
| 12 | Human herpesvirus 6 infections after liver transplantation显示文摘Human herpesvirus 6(HHV-6) infections occur in > 95% of humans.Primary infection,which occurs in early childhood as an asymptomatic illness or manifested clinically as roseola infantum,leads to a state of subclinical viral persistence and latency.Reactivation of latent HHV-6 is common after liver transplantation,possibly induced and facilitated by allograft rejection and immunosuppressive therapy.Since the vast majority of humans harbor the virus in a latent state,HHV-6 infections after liver transplantation are believed to be mostly due to endogenous reactivation or superinfection(reactivation in the transplanted organ).In a minority of cases,however,primary HHV-6 infection may occur when an HHV-6 negative individual receives a liver allograft from an HHV-6 positive donor.The vast majority of documented HHV-6 infections after liver transplantation are asymptomatic.In a minority of cases,HHV-6 has been implicated as a cause of febrile illness with rash and myelosuppression,hepatitis,pneumonitis,and encephalitis after liver transplantation.In addition,HHV-6 has been associated with a variety of indirect effects such as allograft rejection,and increased predisposition and severity of other infections including cytomegalovirus(CMV),hepatitis C virus,and opportunistic fungi.Because of the uncommon nature of the clinical illnesses directly attributed to HHV-6,there is currently no recommended HHV-6-specific approach to prevention.However,ganciclovir and valganciclovir,which are primarily intended for the prevention of CMV disease,are also active against HHV-6 and may prevent its reactivation after transplantation.The treatment of established HHV-6 disease is usually with intravenous ganciclovir,cidofovir,or foscarnet,complemented by reduction in the degree of immunosuppression.This article reviews the current advances in the pathogenesis,clinical diagnosis,and therapeutic modalities against HHV6 in the setting of liver transplantation. | Rima Camille Abdel Massih Raymund R Razonable | 2009 | World Journal of Gastroenterology2009，15，21： | 5 |
| 13 | Protective action of NADPH oxidase inhibitors and role of NADPH oxidase in pathogenesis of colon inflammation in mice显示文摘AIM:To investigate the role of nicotinamide adenine dinucleotide phosphate(NADPH) oxidase in colon epithelial cells in the pathogenesis of acute and chronic colon inflammation in a mouse model of dextran sulphate sodium(DSS)-induced colitis.METHODS:Balb/c mice were divided into three groups:8 mice with acute DSS-induced colitis(3.5% DSS solution;7 d),8 mice with chronic DSS-induced colitis(3.5% DSS solution for 5 d + water for 6 d;4 cycles;total:44 d) and 12 mice without DSS supplementation as a control group.Primary colonic epithelial cells were isolated using chelation method.The cells were cultivated in the presence of mediators(lipopolysaccharide(LPS),apocynin or diphenyleneiodonium).Viability of cells was assessed by fluorescent microscopy.Production of reactive oxygen species(ROS) by the cells was measured fluorometrically using Amplex Red.Production of tumour necrosis factor-alpha(TNF-α) by the colonic epithelial cells was analysed by ELISA.Nox1 gene expression was assessed by real-time PCR.RESULTS:Our study showed that TNF-α level was increased in unstimulated primary colonic cells both in the acute and chronic colitis groups,whereas decreased viability,increased ROS production,and expression of Nox1 was characteristic only for chronic DSS colitis mice when compared to the controls.The stimulation by LPS increased ROS generation via NADPH oxidase and decreased cell viability in mice with acute colitis.Treatment with NADPH oxidase inhibitors increased cell viability and decreased the levels of ROS and TNF-α in the LPS-treated cells isolated from mice of both acute and chronic colitis groups.CONCLUSION:Our study revealed the importance of NADPH oxidase in the pathogenesis of both acute and chronic inflammation of the colon. | Rima Ramonaite Jurgita Skieceviciene Simonas Juzenas Violeta Salteniene Juozas Kupcinskas Paulius Matusevicius Vilmante Borutaite Limas Kupcinskas | 2014 | World Journal of Gastroenterology2014，20，35： | 4 |
| 14 | Mild oxidative stress is beneficial for sperm telomere length maintenance显示文摘AIM:To evaluate telomere length in sperm DNA and its correlation with oxidative stress(normal,mild,severe).METHODS:The study included infertile men(n=112)and age matched fertile controls(n=102).The average telomere length from the sperm DNA was measured using a quantitative real time PCR based assay.Seminal reactive oxygen species(ROS)and 8-Isoprostane(8-IP)levels were measured by chemiluminescence assay and ELISA respectively.RESULTS:Average sperm telomere length in infertile men and controls was 0.609±0.15 and 0.789±0.060,respectively(P<0.0001).Seminal ROS levels in infertile was higher[66.61±28.32 relative light units(RLU)/s/million sperm]than in controls(14.04±10.67RLU/s/million sperm)(P<0.0001).The 8-IP level in infertile men was significantly higher(421.55±131.29pg/mL)than in controls(275.94±48.13 pg/mL)(P<0.001).When correlated to oxidative stress,in normal range of oxidative stress(ROS,0-21.3 RLU/s/million sperm)the average telomere length in cases was 0.663±0.14,in mild oxidative stress(ROS,21.3-35 RLU/s/million sperm)it was elevated(0.684±0.12)and in severe oxidative stress(ROS>35 RLU/s/million sperm)average telomere length was decreased to 0.595±0.15.CONCLUSION:Mild oxidative stress results in lengthening of telomere length,but severe oxidative stress results in shorter telomeres.Although telomere maintenance is a complex trait,the study shows that mild oxidative stress is beneficial in telomere length maintenance and thus a delicate balance needs to be established to maximize the beneficial effects of free radicals and prevent harmful effects of supra physiological levels.Detailed molecular evaluation of telomere structure,its correlation with oxidative stress would aid in elucidating the cause of accelerated telomere length attrition. | Swetasmita Mishra Rajeev Kumar Neena Malhotra Neeta Singh Rima Dada | 2016 | World Journal of Methodology2016，6，2： | 4 |
| 15 | An NF90/NF110-mediated feedback amplification loop regulates dicer expression and controls ovarian carcinoma progression显示文摘 | Jerome Barbier Xin Chen Gabriel Sanchez Muyan Cai Marion Helsmoortel Takuma Higuchi Pierre Giraud Xavier Contreras Gangjun Yuan Zihao Feng Rima Nait-Saidi Olivier Deas Lisa Bluy Jean-Gabriel Judde Sylvie Rouquier William Ritchie Shuji Sakamoto Dan Xie Rosemary Kiernan | 2018 | Cell Research2018，28，5： | 3 |
| 16 | The prevalence of limited health literacy显示文摘 | Michael K. Paasche-Orlow Ruth M. Parker Julie A. Gazmararian Lynn T. Nielsen-Bohlman Rima R. Rudd | 2005 | Journal of General Internal Medicine2005，，2： | 3 |
| 17 | Laparoscopic versus open colorectal resection in the elderly population显示文摘 | Katherine Grailey Sheraz R. Markar Alan Karthikesalingam Rima Aboud Paul Ziprin Omar Faiz | 2013 | Surgical Endoscopy2013，，1： | 2 |
| 18 | Lighting preferences in office spaces concerning the indoor thermal environment显示文摘The accurate prediction of the visual comfort zone in an indoor environment is difficult as it depends on many parameters.This is especially the case for large compact urban areas in which the density and shadow from neighboring buildings can limit the accessible daylighting in indoor spaces.This paper investigates the satisfaction range for illuminance regarding indoor air temperature in office buildings and the significant parameters affecting this range in six office buildings in Tehran,Iran.Lighting comfort has been evaluated by a subjective survey(509 total responses)and field measurement.The questionnaires were filled out in 146 and 109 rooms in summer and winter,respectively.The results show that the illuminance should not be less than 550 lx,while illuminance between 600 and 650 lx provides the highest satisfaction level.The satisfaction with lighting level is affected by individual parameters such as age,type of activity,and environmental parameters such as window orientation,external obscurations,and season.A relationship was observed between lighting level satisfaction and thermal condition acceptance,and the overall comfort depends more on thermal conditions than the lighting level. | Maryam Fakhari Rima Fayaz Somayeh Asadi | 2021 | Frontiers of Architectural Research2021，10，3： | 2 |
| 19 | Characterizing the rock geological time by terahertz spectrum显示文摘In the field of geology,it is necessary to get the information about the rock geological time,which includes absolute geologic age and relative geologic age .Tracing the evolutionary history of the earth is one of the research tasks of earth science.Time,space,material and motivation are the basic elements for studying geological processes and enviromnental evolution,and time is the basis for studying geological problems.A clear understanding of the interaction between the above elements will be able to clearly make sure the evolution of the earth and the conditions of rock formation.Nowadays,it is urgent to get the geochronological data of rocks for wide range comparison,so as to study the evolution trend and development rule of the earth's crust . | WenXiu Leng QingYan Li RiMa Bao Kun Zhao XinYang Miao YiZhang Li | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，1： | 2 |
| 20 | 骨形态发生蛋白15基因多态性与复发性葡萄胎和习惯性流产的相关性研究显示文摘目的探讨骨形态发生蛋白15(BMP15)基因多态性与复发性葡萄胎(RHMs)和习惯性流产(RSAs)的相关性。方法收集2012年10月-2013年9月在加拿大麦吉尔大学人类健康中心妇产科治疗的77例不同种族的RHMs和习惯性流产妇女的血液标本,采用基因外显子测序分析患者BMP15基因的多态性,并采用蛋白功能预测软件预测各SNPs对BMP15蛋白功能的影响。结果在BMP15基因2个外显子中共检测到5个错义突变和1个插入突变。其中在外显子1中检测到2个错义突变(p.S5R和p.N103S);在外显子2中检测到3个错义突变(p.L148P,p.A180T,p.H200Y)和1个插入突变,(p.Leu263dup)。通过预测,p.L148P突变可能会严重影响BMP15蛋白的活性进而影响卵巢功能,而p.S5R突变的影响相对较小,其余SNPs对BMP15蛋白功能基本无影响。结论 BMP15基因突变除了可能与RHMs和习惯性流产妇女的卵泡生成障碍及卵巢功能早衰相关,还可能导致葡萄胎恶变。 | 王鹤 Ramesh Reddy Ngoc Minh Phuong Nguyen Seang L Tan Rima Slim | 2017 | 中国妇幼保健2017，32，11： | 2 |
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