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| 1 | Fatty liver disease in severe obese patients:Diagnostic value of abdominal ultrasound显示文摘AIM:To evaluate the sensitivity and specificity of abdominal ultrasound (US) for the diagnosis of hepatic steatosis in severe obese subjects and its relation to histological grade of steatosis. METHODS: A consecutive series of obese patients, who underwent bariatric surgery from October 2004 to May 2005, was selected. Ultrasonography was performed in all patients as part of routine preoperative time and an intraoperative wedge biopsy was obtained at the beginning of the bariatric surgery. The US and histological findings of steatosis were compared, considering histology as the gold standard. RESULTS: The study included 105 patients. The mean age was 37.2 ± 10.6 years and 75.2% were female. The histological prevalence of steatosis was 89.5%. The sensitivity and specificity of US in the diagnosis of hepatic steatosis were, respectively, 64.9% (95% CI: 54.9-74.3) and 90.9% (95% CI: 57.1-99.5). The positive predictive value and negative predictive value were, respectively, 98.4% (95% CI: 90.2-99.9) and 23.3% (95% CI: 12.3-39.0). The presence of steatosis onUS was associated to advanced grades of steatosis on histology (P = 0.016). CONCLUSION: Preoperative abdominal US in our series has not shown to be an accurate method for the diagnosis of hepatic steatosis in severe obese patients. Until another non-invasive method demonstrates better sensitivity and specificity values, histological evaluation may be recommended to these patients undergoing bariatric surgery. | Alessandro de Moura Almeida Helma Pinchemel Cotrim Daniel Batista Valente Barbosa Luciana Gordilho Matteoni de Athayde Adimeia Souza Santos Almir Galvo Vieira Bitencourt Luiz Antonio Rodrigues de Freitas Adriano Rios Erivaldo Alves | 2008 | World Journal of Gastroenterology2008，14，9： | 10 |
| 2 | Anthropometric indicators of visceral adiposity as predictors of non-alcoholic fatty liver disease: A review显示文摘The objective was to critically analyze studies that evaluated the predictive capacity of indicators of visceral adiposity in non-alcoholic fatty liver disease(NAFLD). The bibliographic research was carried out using the electronic database PubMed, LILACS and SciELO, references of selected articles. Although we found few studies, they have already used several indicators of visceral adiposity as waist circumference, waist-to-hip ratio, waist-to-height ratio, Lipid accumulation product, Body Shape Index, Body Roundness Index and most them were good predictors of NAFLD. Thus, the anthropometric indicators may contribute for the diagnosis of NAFLD in a simple, low-cost and noninvasive way, allowing early therapeutic measures to prevent the evolution to non-alcoholic steatohepatitis. | Naiade Silveira Almeida Raquel Rocha Helma Pinchemel Cotrim Carla Daltro | 2018 | World Journal of Hepatology2018，10，10： | 5 |
| 3 | Nonalcoholic fatty liver disease in asymptomatic Brazilian adolescents显示文摘AIM:To evaluate the prevalence and clinical characteristics of Nonalcoholic fatty liver disease(NAFLD) among asymptomatic Brazilian adolescents. METHODS:Transversal observational study included asymptomatic adolescents with central obesity from private and public schools in Salvador-Bahia,northeastern Brazil.The children answered a questionnaire that included age,gender,race,and medical history,and were submitted to a complete physical exam and abdominal ultrasound.Biochemical exams included:ALT,AST,GGT,C reactive protein(CRP),fasting glucose,insulin,cholesterol and triglycerides.Criteria for NAFLD included:the presence of steatosis in ultrasound and/or high level of ALT,negative or occasional historic of intake of alcohol(≤140 g/wk),negative investigation for hepatitis A,B,C,auto-immune hepatitis,Wilson disease and hemochromatosis.RESULTS:From October,2005 to October,2006,the study included 1801 subjects between 11 and 18 years of age and a mean age of 13.7±2.0 years.One hundred ninety-nine had central obesity.The prevalence of NAFLD was 2.3%,most of whom were male and white.Insulin resistance(IR)was observed in 22.9% of them and had positive correlations with ALT and GGT(P<0.05).Elevated CRP was observed in 6.9% of the cases;however,it was not associated with WC,IR or liver enzymes. CONCLUSION:The prevalence of NAFLD in Brazilian adolescents was low.The ethnicity may have influence this frequency in the population studied,which had a large proportion of African descendents. | Raquel Rocha Helma Pinchemel Cotrim Almir Galvo Vieira Bitencourt Daniel Batista Valente Barbosa Adméia Souza Santos Alessandro de Moura Almeida Bruno Cunha Isabel Guimares | 2009 | World Journal of Gastroenterology2009，15，4： | 2 |
| 4 | Sonographic hepatorenal ratio: A noninvasive method to diagnose nonalcoholic steatosis显示文摘 | Valéria Ferreira de Almeida e Borges Angélica L. D. Diniz Helma P. Cotrim Haroldo L. O. G. Rocha Nestor Barbosa Andrade | 2012 | J Clin Ultrasound2012，，1： | 2 |
| 5 | Chlorogenic Acidsin Coffee Substitutes显示文摘 | Helma Haffke Ulrich H Engelhardt | 1986 | Z Lebensm-Unters Forsh1986，183，1： | 1 |
| 6 | Genetic diversity among Botulinum Neurotoxin producing clostridial strains 显示文摘 | Hill K K Smith T J Helma C H | 2007 | Journal of bacteriology2007，189，3： | 1 |
| 7 | Comparative Evaluation of four bacterial assays for the detection of genotoxie effects in the dissolved water phases of aqueous matrices显示文摘 | Helma C Sundermann V M Houk V S | 1996 | Environmental Science Technology1996，30，89： | 1 |
| 8 | A public domain image analysis program for the single cell electrophoresis (comet) assay 显示文摘 | Helma C Uhl M | 2000 | Mutat Res2000，466，： | 1 |
| 9 | Topography of the inferior rectal artery: A possible cause of chronic, primary anal fissure显示文摘 | Bernd Klosterhalfen Peter Vogel Helma Rixen Christian Mittermayer | 1989 | Diseases of the Colon & Rectum1989，，1： | 1 |
| 10 | Modulation of protein properties in living cells using nanobodies 显示文摘 | Kirchhofer A Helma J Schmidthals K | 2009 | Nat Struct Mol Biol2009，17，： | 1 |
| 11 | Plasma Membrane Alterations and Cytoskeletal Changes in Apoptosis显示文摘 | Manon van Engeland Helma J.H. Kuijpers Frans C.S. Ramaekers Chris P.M. Reutelingsperger Bert Schutte | 1997 | Experimental Cell Research1997，，： | 1 |
| 12 | Genetic diversity among botulinum neurotoxin-producing clostridial strains显示文摘 | Hill KK Smith T J Helma CH | 2007 | J Bact2007，189，3： | 1 |
| 13 | Low birth weight in Silo Luis, northeastern Brazil, trends and associated factors 显示文摘 | Helma Jane Ferreira Veloso Ant6nio Augusto Moura da Silva Helolsa Bettiol Marcelo Zubarin Goldani Fernando Lamy Filho Vanda Maria Ferreira Sim6es Rosgmgela Fernandes Lucena Batista Marco Ant6nio Barbieri | 2014 | BMC Pre Child2014，14，1： | 1 |
| 14 | Evaluation of the single cell gel electrophoresis assay with human hepatoma cells显示文摘 | UHL M HELMA C KNASMULLER S | 2000 | Mutat Res2000，468，2： | 1 |
| 15 | Direct and dynamic detection of HIV-1 in living cells显示文摘 | Helma J Schmidthals K Lux V | 2012 | PLoS One2012，7，50： | 1 |
| 16 | The limits of European-ness:Immigrant Women inFortress Europe显示文摘 | Helma Lutz | 1997 | Feminist Review1997，，57： | 1 |
| 17 | Young children’s perceptions of teacher–child relationships: An evaluation of two instruments and the role of child gender in kindergarten显示文摘 | Jantine L. Spilt Helma M.Y. Koomen Panayota Y. Mantzicopoulos | 2010 | Journal of Applied Developmental Psychology2010，，： | 1 |
| 18 | Effectiveness of a back pain prevention program:A cluster randomized controlled trial in an occupational setting 显示文摘 | Helma IJzelenberg Willem-Jan Meerding Alex Burdorf | 2007 | Spine2007，32，7： | 1 |
| 19 | Evaluation of the single cell gel electrophoresis assay with human hepatoma(Hep G2)cells显示文摘 | Helma C Knasmuller S | 2000 | Murat Res2000，468，2： | 1 |
| 20 | Internalizing Behaviors Among Kindergarten Children: Measuring Dimensions of Social Withdrawal With a Checklist显示文摘 | Jochem T. Thijs Helma M. Y. Koomen Peter F. de Jong Aryan van der Leij Mirella G. P. van Leeuwen | 2004 | Journal of Clinical Child & Adolescent Psychology2004，，4： | 1 |
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