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| 1 | Current Alzheimer disease research highlights: evidence for novel risk factors显示文摘Alzheimer disease(AD)is the most common type of dementia characterized by the progressive cognitive and social decline.Clinical drug targets have heavily focused on the amyloid hypothesis,with amyloid beta(Aβ),and tau proteins as key pathophysiologic markers of AD.However,no effective treatment has been developed so far,which prompts researchers to focus on other aspects of AD beyond Aβ,and tau proteins.Additionally,there is a mounting epidemiologic evidence that various environmental factors influence the development of dementia and that dementia etiology is likely heterogenous.In the past decades,new risk factors or potential etiologies have been widely studied.Here,we review several novel epidemiologic and clinical research developments that focus on sleep,hypoxia,diet,gut microbiota,and hearing impairment and their links to AD published in recent years.At the frontiers of AD research,these findings and updates could be worthy of further attention. | Willa D.Brenowitz Yang Xiang Claire T.McEvoy Cui Yang Kristine Yaffe Wei-Dong Le Yue Leng | 2021 | Chinese Medical Journal2021，，18： | 3 |
| 2 | 抗病毒治疗对美沙酮门诊HIV感染者吸毒和高危性行为影响的定性研究显示文摘目的 了解美沙酮门诊HIV感染者参加抗病毒治疗(ART)后高危行为是否变化,探索变化及发生高危行为的原因.方法 对云南省美沙酮门诊参加ART的34名HIV感染者进行调查,包括一般情况,HIV感染情况,美沙酮维持治疗(MMT)情况,接受ART情况,ART前后性伴数量、性行为频率、安全套使用、毒品使用、针具共用情况.结果 受访者平均年龄38.5岁,男性居多(70.6%),均表示参加ART后不安全性行为和共用针具等行为未增加,主要原因是获得HIV相关知识培训、免费安全套、清洁针具并受到MMT影响,存在偷吸(12/34)和不坚持使用安全套(3/19)等高危行为,同时出现ART药物与美沙酮相互作用导致偷吸、对ART的态度乐观导致不安全性行为等新挑战.结论 参加ART未引起MMT门诊HIV感染者高危行为增加,但高危行为仍然存在,应重视ART高期望引起的新挑战. | 钱小爱 曹晓斌 赵燕 金莹莹 Willa Dong 罗巍 王常合 柔克明 张波 段松 唐仁海 吴尊友 | 2015 | 中华流行病学杂志2015，36，1： | 2 |
| 3 | Nuclear Factor (Erythroid-Derived 2)-Like-2 Factor (Nrf2), a Key Regulator of the Antioxidant Response to Protect Against Atherosclerosis and Nonalcoholic Steatohepatitis显示文摘 | Anisha A. Gupte Christopher J. Lyon Willa A. Hsueh | 2013 | Current Diabetes Reports2013，，3： | 2 |
| 4 | Control of vascular cell prolifelation and migration by PPAR-γ显示文摘 | Willa A Ronald E | 2001 | Diabetes Care2001，24，2： | 1 |
| 5 | Control of vascular cell pro- liferation and migration by PPAR-:/显示文摘 | Willa H Simon J Ronald EL | 2001 | Diabetes Care2001，24，2： | 1 |
| 6 | The role of water treatment显示文摘 | WILLA M J | 1986 | Agricultural Engineering1986，57，6： | 1 |
| 7 | Role of endothelial dysfunction in insulin resistance 显示文摘 | Willa A Hsueh L Manuel J | 2003 | American Journal of Cardiology2003，92，4： | 1 |
| 8 | Diabetes distress in type 1 diabetes--a new measurement fit for purpose 显示文摘 | Joensen LE Tapager I Willaing I | 2013 | Diabet Med2013，30，9： | 1 |
| 9 | TNFα induces expression of transcription factors c-fos, Egr-1, and Ets-1 in vascular lesions through extracellular signal-regulated kinases 1/2显示文摘 | Stephan Goetze Ulrich Kintscher Kristina Kaneshiro Woerner P. Meehan Alan Collins Eckart Fleck Willa A. Hsueh Ronald E. Law | 2001 | Atherosclerosis2001，，1： | 1 |
| 10 | A Nuclear Receptor Corepressor–Dependent Pathway Mediates Suppression of Cytokine-Induced C-Reactive Protein Gene Expression by Liver X Receptor显示文摘 | Florian Blaschke Yasunori Takata Evren Caglayan Alan Collins Peter Tontonoz Willa A. Hsueh Rajendra K. Tangirala | 2006 | Circulation Research2006，，12： | 1 |
| 11 | Hypertension, the endothelial cell, and the vascular complications of diabetes mellitus显示文摘 | Willa AH Pamela WA | 1992 | Hypertension1992，20，2： | 1 |
| 12 | Real-time PCRquantification of major Wilms’tumor gene 1(WT1)isoforms in acute myeloid leukemia,their characteristic expression patterns and possible functional consequences显示文摘 | Kramarzova K Stuchly J Willa sch A | 2012 | Leukemia2012，26，9： | 1 |
| 13 | Who Controls the Past显示文摘 | Helen Willa Samuels | 1986 | American Archivist1986，49，2： | 1 |
| 14 | Obesity and hypertension显示文摘 | Willa A H Thomas A B | 1999 | Endicrinol Meta Clin North Am1999，28，： | 1 |
| 15 | Trogtitazone inhibits angiotensin Ⅱ-induced DNA synthesis and migration in vascular smooth muscle ceils显示文摘 | Xiao-Ping Xi Willa A | 1997 | FEBS Letters1997，400，： | 1 |
| 16 | Smoking behavior among hospital staff still influences attitudes and counseling on smoking显示文摘 | Willaing I Ladelund S | 2004 | Nicotine Tobacco Research2004，6，2： | 1 |
| 17 | Data-mining: Improvement of university library services 显示文摘 | Nicole Willa | 2006 | Technological Forecasting and Social Change2006，，8： | 1 |
| 18 | Angiotensin II Has Multiple Profibrotic Effects in Human Cardiac Fibroblasts显示文摘 | Hiroaki Kawano Yung S. NA Yasuko Kawano Vaughn Starnes Mark Barr Ronald E. Law Willa A. Hsueh | 2000 | Circulation: Journal of the American Heart Association2000，，10： | 1 |
| 19 | Age-Accelerated Atherosclerosis Correlates With Failure to Upregulate Antioxidant Genes显示文摘 | Alan R. Collins Christopher J. Lyon Xuefeng Xia Joey Z. Liu Rajendra K. Tangirala Fen Yin Rima Boyadjian Alfiya Bikineyeva Domenico Praticò David G. Harrison Willa A. Hsueh | 2009 | Circulation Research2009，，6： | 1 |
| 20 | Insulin resistance and the endothelium显示文摘 | Willa A Hsueh Christopher J Lyon Manuel J Qui?ones | 2004 | The American Journal of Medicine2004，，2： | 1 |
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