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| 1 | 不同氮源对海洋微藻氮同位素分馏作用的影响显示文摘以海链藻 (Thalassiosirapseudonana)为研究对象 ,分别考察了以硝酸盐、铵盐和尿素为氮源的氮同位素分馏作用。在建立相应理论模型基础上 ,分别计算出各个实验体系的ε值。结果表明 ,在藻类生长初期 ,δ1 5N均较低 ,其δ1 5N的积累主要发生在指数增长期 ,在稳定期达到最高 ,与氮源的初始δ1 5N相同 ;不同氮源的氮同位素分馏作用也不相同 ,其中以铵盐最强 ,硝酸盐次之 ,尿素最弱。考虑到实际情况下氮化合物并非单一存在 ,作者还进一步考察了上述3种氮源混合后对其同位素分馏作用的影响 ,发现混合氮源体系的表观ε值介于单一氮源时的最大与最小ε值之间 ,该结果较好地解释了Montoya等 ( 1 991 )在Chesapeak湾的现场实验结果。 | 俞志明 Waser N A D Harrison P J | 2004 | 海洋与湖沼2004，35，6： | 13 |
| 2 | Pathogenesis of hepatocarcinogenesis in non-cirrhotic nonalcoholic fatty liver disease:Potential mechanistic pathways显示文摘Although hepatocellular carcinoma(HCC) primarily arises in the background of liver cirrhosis,the development of HCC in nonalcoholic fatty liver disease(NAFLD) without cirrhosis is increasingly recognized. The pathogenesis of NAFLD associated non-cirrhotic HCC is distinct from that of cirrhotic HCC because the metabolic syndrome(MS) along with obesity and insulin resistance(IR) underlie several unique mechanisms that promote tumorigenesis. IR associated with MS,NAFLD,and type 2 diabetes mellitus lead to the release of multiple pro-inflammatory cytokines,including tumor necrosis factor alpha,interleukin-6,leptin and resistin,as well as decreased amounts of adiponectin. These processes favor the development of hepatic steatosis and inflammation within the liver,which precede HCC development. Nevertheless,further investigation is necessary to elucidate the determinants for development of HCC in patients with NAFLD in the absence of cirrhosis. | Ryan B Perumpail Andy Liu Robert J Wong Aijaz Ahmed Stephen A Harrison | 2015 | World Journal of Hepatology2015，7，22： | 6 |
| 3 | 乙肝病毒A1762、G1764双突变是筛选男性HBsAg携带者肝癌最高危人群的生物学标记显示文摘目的探讨乙肝病毒A1762、G1764双突变是否可作为筛选HBsAg携带者肝癌最高危人群的生物学标记。方法对2 258名乙肝病毒无症状携带者进行前瞻性队列研究,其中HBV A1762、G1764双突变株组1 261人,野毒株组997人,跟踪随访队列,每6个月1次对观察对象抽血进行甲胎蛋白(AFP)检测及B超体检以检查肝癌发病情况。结果观察48个月,2 258名乙肝病毒无症状携带者中,共发生肝癌72例,突变株组64例,野毒株组8例,发病率分别为932.2/10万人年和203.5/10万人年,两组发病率差异有统计学意义(P<0.001),相对危险度(RR)为4.58。突变株组男性发病率1 827.8/10万人年,明显高于野毒株组的180.5/10万人年,两者比较差异有统计学意义(P<0.001),相对危险度为10.13。92.5%的男性病例有双突变;突变株组女性发病率为686.6/10万人年,高于野毒株组的233.3/10万人年,两组比较差异有统计学意义(P<0.05),但相对危险度仅为2.94。结论双突变是筛选男性HBsAg携带者中肝癌最高危人群的很好生物学标记,但对女性筛选肝癌高危人群的意义不如男性。 | 王学燕 李国坚 董柏青 杨进业 陈钦艳 方孔雄 黄坚 韦少超 方钟燎 Caroline A Sabin Tim J Harrison | 2011 | 广西医学2011，33，2： | 5 |
| 4 | Comparison of two remote sensing models for estimating evapotranspiration: algorithm evaluation and application in seasonally arid ecosystems in South Africa显示文摘Remote sensing tools are becoming increasingly important for providing spatial information on water use by different ecosystems. Despite significant advances in remote sensing based evapotranspiration(ET) models in recent years, important information gaps still exist on the accuracy of the models particularly in arid and semi-arid environments. In this study, we evaluated the Penman-Monteith based MOD16 and the modified Priestley-Taylor(PT-JPL) models at the daily time step against three measured ET datasets. We used data from two summer and one winter rainfall sites in South Africa. One site was dominated by native broad leaf and the other by fine leafed deciduous savanna tree species and C4 grasses. The third site was in the winter rainfall Cape region and had shrubby fynbos vegetation. Actual ET was measured using open-path eddy covariance systems at the summer rainfall sites while a surface energy balance system utilizing the large aperture boundary layer scintillometer was used in the Cape. Model performance varied between sites and between years with the worst estimates(R2<0.50 and RMSE>0.80 mm/d) observed during years with prolonged mid-summer dry spells in the summer rainfall areas. Sensitivity tests on MOD16 showed that the leaf area index, surface conductance and radiation budget parameters had the largest effect on simulated ET. MOD16 ET predictions were improved by:(1) reformulating the emissivity expressions in the net radiation equation;(2) incorporating representative surface conductance values;and(3) including a soil moisture stress function in the transpiration sub-model. Implementing these changes increased the accuracy of MOD16 daily ET predictions at all sites. However, similar adjustments to the PT-JPL model yielded minimal improvements. We conclude that the MOD16 ET model has the potential to accurately predict water use in arid environments provided soil water stress and accurate biome-specific parameters are incorporated. | Sebinasi DZIKITI Nebo Z JOVANOVIC Richard DH BUGAN Abel RAMOELO Nobuhle P MAJOZI Alecia NICKLESS Moses A CHO David C LE MAITRE Zanele NTSHIDI Harrison H PIENAAR | 2019 | Journal of Arid Land2019，11，4： | 4 |
| 5 | 隆安县乙肝病毒无症状携带者HBV前S基因缺失突变的研究显示文摘目的了解肝癌高发区隆安县乙型肝炎病毒(HBV)前S基因缺失突变株的流行情况。方法HBV表面抗原(HBsAg)无症状携带者从我们隆安县研究队列中选择,用套式聚合酶链反应对研究对象血清HBV前S基因扩增和序列分析。结果在66例标本中9例出现前S基因缺失突变,占13.6%(9/66)。9例缺失突变均为框内突变,其中7例突变发生在或涉及前S2区的5'末端。男6例、女3例出现前S基因缺失突变,但男女间突变率(12.0%,6/50与18.8%,3/16)差异无统计学意义(χ2=0.709,P>0.10);前S基因缺失突变率在基因型B、基因型C和重组基因型之间差异无统计学意义(χ2=0.002,P>0.95)。结论肝癌高发区隆安县居民HBV无症状携带者前S基因缺失突变率较高,这种突变与肝癌的关系值得进一步探讨。 | 王学燕 李国坚 董柏青 陈钦艳 方孔雄 杨进业 黄坚 韦少超 方钟燎 Caroline A Sabin Tim J Harrison | 2010 | 广西医学2010，32，2： | 4 |
| 6 | The natural history of nonalcoholic fatty liver disease: a clinical histopathological study显示文摘 | Stephen A Harrison Sigurd Torgerson Paul H Hayashi | 2003 | The American Journal of Gastroenterology2003，，9： | 4 |
| 7 | Barrett’s metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor显示文摘 | Anna M Nicholson Trevor A Graham Ashley Simpson Adam Humphries Nicola Burch Manuel Rodriguez-Justo Marco Novelli Rebecca Harrison Nicholas A Wright Stuart A C McDonald Janusz A Jankowski | 2012 | Gut2012，，10： | 3 |
| 8 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 9 | HBsAg携带者配偶乙型肝炎病毒感染状况调查显示文摘目的了解广西乙型肝炎病毒(HBV)性传播状况。方法对我们2004年建立的隆安研究队列HBsAg无症状携带者的配偶采静脉血收集血清,用酶联免疫吸附试验检测HBV血清学标志物。结果 217名研究对象中,96.8%(210/217)有过去或目前感染乙肝病毒的标记,其中32例HBsAg阳性,阳性率为14.7%(32/217),男、女阳性率分别为15.4%(14/91)和14.3%(18/126),差异无统计学意义(χ2=0.051,P>0.05);107例HBsAb阳性,阳性率为49.3%(107/217);一名男性HBsAg和HBsAb同时阳性;有79例HBsAg,anti-HBs and HBeAg阴性,这79例要么抗-HBc和抗-HBe同时阳性,要么单项阳性,但都是HBVDNA阴性;有7人(包括男性3人、女性4人)没有任何乙肝感染标记,包括HBVDNA阴性。另外,122名HBVDNA阳性的HBsAg携带者其配偶(研究对象)有14人HBsAg阳性;95名HBVDNA阴性的HBsAg携带者其配偶有18人HBsAg阳性,两者阳性率无统计学差异(χ2=2.372,P>0.05)。HBeAg阴、阳性的HBsAg携带者其配偶的HBsAg阳性率分别为15.61%(27/173)和11.76%(4/34),两者也无统计学差异(χ2=0.093,P>0.05)。结论配偶因密切接触HBsAg携带者而受HBV感染的机会比一般人群大,但性别、病毒量和HBeAg不影响其配偶感染HBV的机会。 | 王学燕 李国坚 杨进业 陈钦艳 黄坚 方孔雄 方钟燎 Caroline A Sabin Tim J Harrison | 2010 | 应用预防医学2010，16，6： | 2 |
| 10 | Immunoplatelet counting: a proposed new reference procedure显示文摘 | Harrison P Horton A Grant D | 2000 | Brit J Heamat2000，108，： | 2 |
| 11 | Planar chips technology for miniaturization and integration of separation techniques into monitoring systems:capillary electrophoresis on a chip 显示文摘 | MANZ A HARRISON D J VERPOORTE E M J | 1992 | Chromatography1992，593，： | 2 |
| 12 | Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion显示文摘 | Philip N Newsome Ingolfur Johannessen Shelagh Boyle Evangelos Dalakas Karen A Mcaulay Kay Samuel Frances Rae Lesley Forrester Marc L Turner Peter C Hayes David J Harrison Wendy A Bickmore John N Plevris | 2003 | Gastroenterology2003，，7： | 2 |
| 13 | The role of endoscopy in the evaluation of suspected choledocholithiasis显示文摘 | John T. Maple Tamir Ben-Menachem Michelle A. Anderson Vasundhara Appalaneni Subhas Banerjee Brooks D. Cash Laurel Fisher M. Edwyn Harrison Robert D. Fanelli Norio Fukami Steven O. Ikenberry Rajeev Jain Khalid Khan Mary Lee Krinsky Laura Strohmeyer Jason A | 2010 | Gastrointestinal Endoscopy2010，，1： | 2 |
| 14 | 乙型肝炎病毒前S缺失突变与肝癌关系的巢式匹配病例对照研究显示文摘目的了解乙型肝炎病毒(HBV)前S基因缺失突变是否是肝癌的危险因素以及它的作用是否受HBV核心基因启动子双突变的混淆影响。方法按巢式匹配病例对照研究的方法,从隆安研究队列中选择33对病例(肝癌患者)和对照(HBsAg无症状携带者),配对的条件之一是病例和对照HBV核心基因启动子序列相同,用套式聚合酶链反应(nested PCR)对研究对象血清HBV前S基因扩增和序列分析。结果肝癌患者组前S基因缺失突变率(45.5%,15/33)显著高于对照组(6/33,18.2%)(χ2=7.364,P<0.01);男女间突变率无显著性差异(28%与43.8%,χ2=1.386,P>0.05)。多因素条件logistic回归分析结果显示,前S缺失突变是肝癌的危险因素(危险比为7,95%可信区:0.861-56.894),而HBeAg,抗-HBe及肝功能则与肝癌无关。核心基因启动子双突变组与核心基因启动子野毒株组之间的前S缺失突变率无显著性差异(χ2=0.597,P>0.05)。结论HBV前S缺失突变是肝癌的独立的危险因素,它的发生及作用与核心基因启动子双突变无关。 | 王学燕 李国坚 董柏青 陈钦艳 方孔雄 杨进业 黄坚 韦少超 方钟燎 黄志碧 Caroline A Sabin Tim J Harrison | 2010 | 应用预防医学2010，16，1： | 2 |
| 15 | Hepatitis delta virus显示文摘 | Sarah A Hughes Heiner Wedemeyer Phillip M Harrison | 2011 | The Lancet2011，，9785： | 2 |
| 16 | Impact of 'adverse selection' on managers project evaluation decisions 显示文摘 | HARRISON P D HARREL A | 1993 | Academy of Management Journal1993，36，3： | 1 |
| 17 | Evaluating distributed generation impacts with a multiobjective index显示文摘 | Ochoa L F Padilha-Feltrin A Harrison G | 2006 | IEEE Trans on Power Del2006，21，3： | 1 |
| 18 | Self-consistent tight-binding theory of elasticity in ionic solids显示文摘 | Straub G K Harrison W A | 1989 | Phys Rev B1989，39，10： | 1 |
| 19 | Utility of a rapid Brain natriuretic peptide assay in differentiating congestive heart failure from lung disease in patients presenting with dyspnea 显示文摘 | Morrison LK Harrison A Krishnaswamy P | 2002 | J Am Coll Cardiol2002，39，： | 1 |
| 20 | A general theory of acute and chronic heart {ailure显示文摘 | Maciver D H Dayer M J Harrison A J | 2013 | Int J Cardiol2013，165，1： | 1 |
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