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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | MiR-182 is up-regulated and targeting Cebpa in hepatocellular carcinoma显示文摘MicroRNAs(miRNAs) are endogenous small non-coding RNAs that repress their targets at post transcriptional level.Existing studies have shown that miRNAs are important regulatory genes in hepatocellular carcinoma(HCC),as either tumor suppressors or oncogenes.MiR-122 is normally downregulated in HCC and regarded as a tumor suppressor.Recently miR-122 has been reported to be regulated by CEBPA,which is then involved in a novel pathway to influence proliferation of tumor cells.However it is unknown whether CEBPA is regulated by miRNAs in HCC.In this study,we find that miR-182 is upregulated in HCC model rat,and represses CEBPA in both rat and human.This further improves the current CEBPA/miR-122 pathway that controls the proliferation of tumor cells.These results suggest that miR-182 is a potential oncogene in HCC and could be used as a diagnostic marker and drug target of HCC. | Chenggang Wang Ren Ren Haolin Hu Changjun Tan Miao Han Xiaolin Wang Yun Zheng | 2014 | Chinese Journal of Cancer Research2014，26，1： | 13 |
| 3 | New innovations in pavement materials and engineering:A review on pavement engineering research 2021显示文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of'New innovations in pavement materials and engineering:A review on pavement engineering research 2021'.Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering. | JTTE Editorial Office Jiaqi Chen Hancheng Dan Yongjie Ding Yangming Gao Meng Guo Shuaicheng Guo Bingye Han Bin Hong Yue Hou Chichun Hu Jing Hu Ju Huyan Jiwang Jiang Wei Jiang Cheng Li Pengfei Liu Yu Liu Zhuangzhuang Liu Guoyang Lu Jian Ouyang Xin Qu Dongya Ren Chao Wang Chaohui Wang Dawei Wang Di Wang Hainian Wang Haopeng Wang Yue Xiao Chao Xing Huining Xu Yu Yan Xu Yang Lingyun You Zhanping You Bin Yu Huayang Yu Huanan Yu Henglong Zhang Jizhe Zhang Changhong Zhou Changjun Zhou Xingyi Zhu | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 7 |
| 4 | Automatic tuning of sparse matrix-vector multiplication on multicore clusters显示文摘To have good performance and scalability, parallel applications should be sophisticatedly optimized to exploit intra-node parallelism and reduce inter-node communication on multicore clusters. This paper investigates the automatic tuning of the sparse matrix-vector(Sp MV) multiplication kernel implemented in a partitioned global address space language, which supports a hybrid thread- and process-based communication layer for multicore systems. One-sided communication is used for inter-node data exchange, while intra-node communication uses a mix of process shared memory and multithreading. We develop performance models to facilitate selecting the best configuration of threads and processes hybridization as well as the best communication pattern for Sp MV. As a result, our tuned Sp MV in the hybrid runtime environment consumes less memory and reduces inter-node communication volume, without damaging the data locality. Experiments are conducted on 12 real sparse matrices. On 16-node Xeon and 8-node Opteron clusters, our tuned Sp MV kernel gets on average 1.4X and 1.5X improvement in performance over the well-optimized process-based message-passing implementation, respectively. | LI ShiGang HU ChangJun ZHANG JunChao ZHANG YunQuan | 2015 | Science China(Information Sciences)2015，58，9： | 3 |
| 5 | Effect of cerium on microstructure,mechanical properties and corrosion properties of Al-Zn-Mg alloy显示文摘The effects of trace Ce on the microstructure,mechanical properties and corrosion resistance of Al-Zn-Mg alloy were studied by means of metallographic analysis,scanning electron microscopy(SEM),mechanical tensile test,slow strain rate tensile test,cyclic polarization curve test,electrochemical impedance spectroscopy test and anodic oxidation test.The results show that the addition of trace Ce has little effect on the strength of Al-Zn-Mg alloy,but can significantly improve the corrosion resistance of the alloy;The mechanical properties and corrosion resistance of the alloys decrease significantly with the addition of excessive Ce;the addition of 0.04 wt%Ce can reduce significantly the self-corrosive current density of AlZn-Mg alloy and increase obviously passivation film resistance of the alloy.The stress corrosion sensitivity index decreases from 0.612 to 0.219,which improves the corrosion resistance properties significantly. | Guiyun Hu Changjun Zhu Daofen Xu Pengxuan Dong Kanghua Chen | 2021 | Journal of Rare Earths2021，39，2： | 2 |
| 6 | Fenofibrate down-regulates the expressions of androgen receptor (AR) and AR target genes and induces oxidative stress in the prostate cancer cell line LNCaP显示文摘 | Hu Zhao Chen Zhu Chao Qin Tao Tao Jie Li Gong Cheng Pu Li Qiang Cao Xiaoxin Meng Xiaobing Ju Pengfei Shao Lixin Hua Min Gu Changjun Yin | 2013 | Biochemical and Biophysical Research Communications2013，，： | 2 |
| 7 | β-Cyclodextrin-functionalized hydrophobically associating acrylamide copolymer for enhanced oil recovery显示文摘 | Zou Changjun Zhao Pinwen Hu Xuze | 2013 | Energy Fuels2013，27，： | 1 |
| 8 | Equations of state for copolymer systems based on different perturbation terms显示文摘 | Peng Changjun Liu Honglai Hu Ying | 2003 | Fluid Phase Equilibria2003，206，： | 1 |
| 9 | An intermedi- ate view for data integration, management in cloud compu- ting 显示文摘 | Ge Jingjun Hu Changjun Li Yang | 2013 | Journal of Computational Information Systems2013，9，9： | 1 |
| 10 | Modeling of Surface Tension and Viscosity for Non-electrolyte Systems by Means of the Equation of State for Square-well Chain Fluids with Variable Interaction Range显示文摘The equation of state(EOS)for square-well chain fluid with variable range(SWCF-VR) developed in our previous work based on statistical mechanical theory for chemical association is employed for the correlations of surface tension and viscosity of common fluids and ionic liquids(ILs).A model of surface tension for multi-component mixtures is presented by combining the SWCF-VR EOS and the scaled particle theory and used to produce the surface tension of binary and ternary mixtures.The predicted surface tensions are in excellent agreement with the experimental data with an overall average absolute relative deviation(AAD)of 0.36%.A method for the calculation of dynamic viscosity of common fluids and ILs at high pressure is presented by combining Eyring’s rate theory of viscosity and the SWCF-VR EOS.The calculated viscosities are in good agreement with the experimental data with the overall AAD of 1.44% for 14 fluids in 84 cases.The salient feature is that the molecular parameters used in these models are self-consistent and can be applied to calculate different thermodynamic properties such as pVT,vapor-liquid equilibrium,caloric properties,surface tension,and viscosity. | LI Jinlong HE Changchun MA Jun PENG Changjun LIU Honglai HU Ying | 2011 | Chinese Journal of Chemical Engineering2011，19，4： | 1 |
| 11 | Calculation of PVT and vapor-liquid equilibria of copolymer systems based on an equation of state显示文摘 | Peng Changjun Liu Honglai Hu Ying | 2002 | Fluid Phase Equilibria2002，202，： | 1 |
| 12 | Design and realization of materials service safety assessment system based on ontology显示文摘 | Ouyang Chunping Hu Changjun Liu Zhenyu | 2011 | Advance Material Research2011，186，： | 1 |
| 13 | Non-structured materials science data sharing based on semantic annotation显示文摘 | Hu Changjun Ouyang Chunping | | 0，，： | 1 |
| 14 | Apoptotic effect of sonodynamic therapy mediated by hematoporphyrin monomethyl ether on C6 glioma cells in vitro显示文摘 | Shaochun Dai Shaoshan Hu Changjun Wu | 2009 | Acta Neurochirurgica2009，，12： | 1 |
| 15 | Apoptotic effect of sonodynamic therapy mediated by hematoporphyrin monomethyl ether on C6 glioma cells in vitro 显示文摘 | Dai Shaochun Hu Shaoshan Wu Changjun | 2009 | Acta Neurochirurgica2009，151，12： | 1 |
| 16 | The involvement of sortase A in high virulence of STSS-causing Streptococcus suis serotype 2显示文摘 | Changjun Wang Ming Li Youjun Feng Feng Zheng Yaqing Dong Xiuzhen Pan Gong Cheng Ruiping Dong Dan Hu Xiaodan Feng Junchao Ge Di Liu Jing Wang Min Cao Fuquan Hu Jiaqi Tang | 2008 | Archives of Microbiology2008，，1： | 1 |
| 17 | Streptococcus suis infection显示文摘 | Youjun Feng Huimin Zhang Zuowei Wu Shihua Wang Min Cao Dan Hu Changjun Wang | 2014 | Virulence2014，，： | 1 |
| 18 | A fuzzy goal programming approach to multi-objective optimization problem with priorities 显示文摘 | Chaofang Hu Changjun Teng Shaoyuan Li | 2006 | European Journal of Operational Research (S0377-2217)2006，176，3： | 1 |
| 19 | Estimating the time interval between transmission generations and the presymptomatic period by contact tracing surveillance data from 31 provinces in the mainland of China显示文摘The global pandemic of 2019 coronavirus disease(COVID-19)is a great assault to public health.Presymptomatic transmission cannot be controlled with measures designed for symptomatic persons,such as isolation.This study aimed to estimate the interval of the transmission generation(TG)and the presymptomatic period of COVID-19,and compare the ftting effects of TG and serial interval(S)based on the SEIHR model incorporating the surveillance data of 3453 cases in 31 provinces.These data were allocated into three distributions and the value of AIC presented that the Weibull distribution fitted well.The mean of TG was 5.2 days(95%C:4.6-5.8).The mean of the presymptomatic period was 2.4 days(95%CI:1.5-3.2).The dynamic model using TG as the generation time performed well.Eight provinces exhibited a basic reproduction number from 2.16 to 3.14.Measures should be taken to control presymptomatic transmission in the COVID-19 pandemic. | Zhongxing Ding Kai Wang Mingwang Shen Kai Wang Shi Zhao Wenyu Song Rui Li Zhongjie Li Liping Wang Ganzhu Feng Zhiliang Hu Hongxia Wei Yanni Xiao Changjun Bao Jianli Hu Liguo Zhu Yong Li Xufeng Chen Yi Yin Weiming Wang Yongli Cai Zhihang Peng Hongbing Shen | 2021 | Fundamental Research2021，1，2： | 1 |
| 20 | Crystal MD:Molecular Dynamic Simulation Software for Metal with BCC Structure显示文摘Material irradiation effect plays an important role in material science.However,it is lack of high-throughput irradiation facility and process of evolution and development,which lead to lack of basic scientific theory about atomic scale materials design and development guidance.High-performance computing for simulation makes deeply understanding of micro-level-material possible.In this paper,a new data structure is proposed for the parallel simulation of metal materials evolution with crystal structure under irradiation defects.Compared with LAMMPS and IMD,which are two popular molecular dynamic simulation versions,our method takes much less memory on multi-core clusters. | He Bai Changjun Hu Xinfu He Boyao Zhang Jue Wang | 2015 | 国际计算机前沿大会会议论文集2015，，B12： | 0 |
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