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| 1 | Intensive phototherapy vs.exchange transfusion for the treatment of neonatal hyperbilirubinemia:a multicenter retrospective cohort study显示文摘Background:Intensive phototherapy(IPT)and exchange transfusion(ET)are the main treatments for extreme hyperbilirubinemia.However,there is no reliable evidence on determining the thresholds for these treatments.This multicenter study compared the effectiveness and complications of IPT and ET in the treatment of extreme hyperbilirubinemia.Methods:This retrospective cohort study was conducted in seven centers from January 2015 to January 2018.Patients with extreme hyperbilirubinemia that met the criteria of ET were included.Patients were divided into three subgroups(low-,medium-,and high-risk)according to gestational week and risk factors.Propensity score matching(PSM)was performed to balance the data before treatment.Study outcomes included the development of bilirubin encephalopathy,duration of hospitalization,expenses,and complications.Mortality,auditory complications,seizures,enamel dysplasia,ocular motility disorders,athetosis,motor,and language development were evaluated during follow-up at age of 3 years.Results:A total of 1164 patients were included in this study.After PSM,296 patients in the IPT only group and 296 patients in the IPT plus ET group were further divided into the low-,medium-,and high-risk subgroups with 188,364,and 40 matched patients,respectively.No significant differences were found between the IPT only and IPT plus ET groups in terms of morbidity,complications,and sequelae.Hospitalization duration and expenses were lower in the low-and medium-risk subgroups in the IPT only group.Conclusions:In this study,our results suggest that IPT is a safe and effective treatment for extreme hyperbilirubinemia.The indication of ET for patients with hyperbilirubinemia could be stricter.However,it is necessary to have a contingency plan for emergency ET as soon as IPT is commenced especially for infants with risk factors.If IPT can be guaranteed and proved to be therapeutic,ET should be avoided as much as possible. | Meng Zhang Yang He Jun Tang Wenbin Dong Yong Zhang Benjin Zhang Hong Wan Quanmin Deng Lirong Guan Bin Xia Zhong Chen Min Ge Jing Zhao Wenxing Li Jingjun Pei Yi Qu Dezhi Mu | 2022 | Chinese Medical Journal2022，，5： | 7 |
| 2 | 7,8-Dihydroxyflavone suppresses proliferation and induces apoptosis of human osteosarcoma cells显示文摘Recent studies suggest that 7,8-dihydroxyflavone(7,8-DHF)inhibits the development of several tumors.However,its role in osteosarcoma(OS)remains unknown.This study was designed to investigate the effects and underlying mechanisms of 7,8-DHF that may influence OS development.Human OS cell lines(U2OS and 143B)were treated with 7,8-DHF;cell viability and cell migration were assessed by methylthiazolyldiphenyl-tetrazolium bromide(MTT)assay and wound-healing assay,respectively;and cell death and apoptosis were evaluated by LIVE/DEAD staining and terminal deoxynucleotidyl transferase(TdT)dUTP nick-end labeling(TUNEL)assay,respectively.Reactive oxygen species production was measured using 2,7-dichlorodihydrofluorescein diacetate probe.Akt,Bcl-xL/Bcl-2 asociated death promoter(Bad),p38 mitogen-activated protein kinase(MAPK),extracellular regulated protein kinase(ERK),and c-Jun N-terminal kinase(JNK)expression and their respective phosphorylation levels were detected by western blot analysis.We found that 7,8-DHF reduced cell viability in a dose-dependent manner and also promoted apoptosis,inhibited migration,and induced oxidative stress in OS cells.Moreover,7,8-DHF inhibited Akt,Bad,and p38MAPK,but activated ERK and JNK signals.In summary,our results suggest that 7,8-DHF inhibits OS progression,possibly by regulating Akt/Bad and MAPK signaling.These findings provide new evidence for the pharmacological effects of 7,8-DHF that may improve drug therapy for OS patients. | Jing Zhao Peifeng Li Hua Zhu Fengqin Ge Jie Liu Jingjun Xia Pengzhou Hang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 3 |
| 3 | An intermedi- ate view for data integration, management in cloud compu- ting 显示文摘 | Ge Jingjun Hu Changjun Li Yang | 2013 | Journal of Computational Information Systems2013，9，9： | 1 |
| 4 | An Intermediate View for Data Integration,M anagement in Cloud Computing显示文摘 | Ge Jingjun | 2013 | Journal of Computational Information Systems2013，9，9： | 1 |
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