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    题名 作者 年代 出处 被引量
1Laparoscopic Partial Nephrectomy With Segmental Renal Artery Clamping:Technique and Clinical Outcomes显示文摘Background:Warm ischemic injury is one of the most important factors affecting renal function in partial nephrectomy(PN).The technique of segmental renal artery clamping emerges as an alternative to conventional renal artery clamping for renal hilar control.Objective:To evaluate the feasibility and efficiency of laparoscopic PN(LPN) with segmental renal artery clamping in comparison with the conventional technique.Design,setting,and participants:A total of 75 patients underwent LPN from June 2007 to November 2009.All patients had T1a or T1b tumor in one kidney and a normal contralateral kidney.Thirty-seven patients underwent surgeries with main renal artery clamping,and 38 underwent surgeries with segmental artery clamping.Intervention:All procedures were performed by the same laparoscopic surgeon.Measurements:Blood loss,operation time,warm ischemia(WI) time,and complications affected renal function before and after operation were recorded.Results and limitations:All LPNs were completed without conversion to open surgery or nephrectomy.The novel technique slightly increased WI time(p < 0.001) and intraoperative blood loss(p = 0.006),while it provided better postoperative affected renal function(p < 0.001) compared with the conventional technique.The total complication rate was 12%.Among the 38 cases where segmental renal artery clamping was performed,7 had to convert to the conventional method.Tumor size and location influenced the number of clamped segmental arteries.Long-term postoperative renal function is still awaited.Conclusions:LPN with segmental artery clamping is safe and feasible in clinical practice.It minimizes the intraoperative WI injury and improves early postoperative affected renal function compared with main renal artery clamping.(C) 2010 European Association of Urology.Published by Elsevier B.V.All rights reserved.Shao,P.F. Qin,C. Yin,C.J. Meng,X.X. Ju,X.B. Li,J. Lü,Q.A. Zhang,W. Xu,Z.Q.Shao,Pengfei Qin,Chao Yin,Changjun Meng,Xiaoxin Ju,Xiaobing Li,Jie Lü,Qiang Zhang,Wei Xu,Zhengquan] Nanjing Med Univ,Affiliated Hosp 1,Dept Urol,Nanjing,Peoples R China.Guangzhou Rd 300,Nanjing 210029,Peoples R China. 2011南京医科大学学报(自然科学版)2011,31,7:123
2H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen 2017Cell Research2017,27,12:70
3Evolution of planetary boundary layer under different weather conditions,and its impact on aerosol concentrations显示文摘一个领域实验在天津被进行,从 2010 年 9 月 930 日的中国,在表面空气污染物质上集中了于行星的边界层(PBL ) 和它的影响的进化。实验使用了三台遥感仪器,风侧面雷达( WPR ),微波辐射计( MWR )和微脉搏的激光雷达( MPL ),到检测风,温度,和喷雾器 backscattering 系数并且到的垂直侧面测量表面污染物质的垂直侧面(喷雾器,公司, SO2 , NOx ),并且也从 255-m 收集了声音的风速表数据气象学的塔。把大小基于这些, PBL 的进化被估计。平均 PBL 高度在夜间期间在 noon/afternoon-time,和 200300 m 期间是大约 10001300 m。PBL 高度和喷雾器集中是相关反的在期间清楚并且薄雾条件。当平均喷雾器集中分别地是在薄雾和晴朗天空条件下面的 52 和 17 g/m3 时,平均最大的 PBL 高度是 1.08 和 1.70 km。太阳的放射上的喷雾器和云的影响基于从 255-m 收集的声音的风速表数据被观察气象学的塔。当 PBL 的镇压结构进一步削弱了污染物质的散开时,热流动被发现被薄雾(重污染) 或云显著地减少了,它趋于压抑 PBL 的发展,导致重污染。这个可能的积极反馈周期(更多的喷雾器降低 PBL 高度更多的喷雾器) 将在大城市为重地面污染导致一个加速过程。Jiannong Quan Yang Gao Qiang Zhang Xuexi Tie Junji Cao Suqin Han Junwang Meng Pengfei Chen Delong Zhao 2013Particuology2013,11,1:51
4Key technologies and equipment for a fully mechanized top-coal caving operation with a large mining height at ultra-thick coal seams显示文摘Jinhua Wang Bin Yu Hongpu Kang Guofa Wang Debing Mao Yuntao Liang Pengfei Jiang 2015International Journal of Coal Science & Technology2015,2,2:57
5Mercury removal from coal combustion flue gas by modified fly ash显示文摘Fly ash is a potential alternative to activated carbon for mercury adsorption. The effects of physicochemical properties on the mercury adsorption performance of three fly ash samples were investigated. X-ray fluorescence spectroscopy, X-ray photoelectron spectroscopy, and other methods were used to characterize the samples. Results indicate that mercury adsorption on fly ash is primarily physisorption and chemisorption. High specific surface areas and small pore diameters are beneficial to efficient mercury removal. Incompletely burned carbon is also an important factor for the improvement of mercury removal efficiency, in particular. The C-M bond, which is formed by the reaction of C and Ti, Si and other elements, may improve mercury oxidation. The samples modified with CuBr2 , CuCl 2 and FeCl3 showed excellent performance for Hg removal, because the chlorine in metal chlorides acts as an oxidant that promotes the conversion of elemental mercury (Hg0) into its oxidized form (Hg2+). Cu2+ and Fe3+ can also promote Hg 0 oxidation as catalysts. HCl and O2 promote the adsorption of Hg by modified fly ash, whereas SO2 inhibits the Hg adsorption because of competitive adsorption for active sites. Fly ash samples modified with CuBr2 , CuCl2 and FeCl3 are therefore promising materials for controlling mercury emissions.Wenqing Xu Hairui Wang Tingyu Zhu Junyan Kuang Pengfei Jing 2013Journal of Environmental Sciences2013,25,2:39
6Measurement and Interpretation of Connectivity of Chinese Cities in World City Network,2010显示文摘This is an empirical paper that measures and interprets the position of Chinese cities in the world city network in 2010. Building on a specification of the world city network as a′interlocking network′in which business services firms play the crucial role in city network formation, information is gathered about the presence of global service firms in cities. This information is converted into data to provide the′service value′of a city for a firm′s provision of corporate services in a 526(cities)×175(firms) matrix. These data are then used as the input to the interlocking network model in order to measure cities′connectivity and its predominant geographical orientation. Here we focus on the position of some key Chinese cities in this regard, and discuss and interpret results in the context of the urban dimensions of the′opening up′of the Chinese economy.Ben DERUDDER Peter J TAYLOR Michael HOYLER NI Pengfei LIU Xingjian ZHAO Miaoxi SHEN Wei Frank WITLOX 2013Chinese Geographical Science2013,23,3:40
7环境友好型绿色道路研究进展与展望显示文摘交通运输行业作为经济建设的先行者,是中国绿色高质量发展的重点研究对象。为进一步推进我国道路领域绿色、高效发展,对国内外绿色道路相关技术研究进展、热点前沿、存在问题及其对策进行综述,并对绿色道路的发展前景进行展望。从多学科交叉以提高道路性能入手,系统归纳现阶段不同类型功能型道路的材料组成、生产工艺和应用技术,着重阐述自调温道路、自愈合道路以及自俘能道路的应用机理、方式和现状;基于再循环利用理念,介绍再生沥青混合料(RAP)、建筑固废和废塑料等材料在道路中的应用技术及方式方法,阐述大宗工业固废在道路应用中的影响因素,针对目前大宗工业固废路用利用中存在的问题,提出合理的改善方法和建议;对冷补、温拌和清洁化等绿色道路施工工艺与技术从工艺、实施角度等方面进行总结与评估。本综述可为绿色道路的设计与开发提供参考和借鉴,促进道路工程绿色化的创新与发展。王海成 金娇 刘帅 高玉超 李锐 冯明珠 熊剑平 LIU Pengfei 2021中南大学学报(自然科学版)2021,52,7:39
8Progress and recent trend in MILD combustion显示文摘Moderate or intense low oxygen dilution(MILD)combustion plays a significant role in the mitigation of combustion-generated pollutants and greenhouse gases whilst meeting thermal efficiency needs.However,due to the lack of the fundamental knowledge on this combustion,there is a misconception that MILD combustion should be established by high preheating of the air,which has limited its application.Our research and development on this combustion has been performed for several years. We have found that the requirements for establishing the MILD combustion are more relaxed than previously.It is also revealed that this combustion of different type,i.e.,non-premixed,partially premixed and fully premixed,can be achieved by firing various fuels(i.e.,gaseous,liquid and solid fuels).It is suggested that the application of the MILD combustion can be expanded significantly.The present review summarizes the progress and recent trend made in the R&D of this combustion and recommends further fundamental studies for improving our knowledge and widening its applications.LI PengFei MI JianChun DALLY B B WANG FeiFei WANG Lin LIU ZhaoHui CHEN Sheng ZHENG ChuGuang 2011Science China(Technological Sciences)2011,54,2:31
9Neuroprotective effects of Buyang Huanwu decoction on cerebral ischemia-induced neuronal damage显示文摘Among the various treatment methods for stroke, increasing attention has been paid to traditional Chinese medicines. Buyang Huanwu decoction is a commonly used traditional Chinese medicine for the treatment of stroke. This paper summarizes the active components of the Chinese herb, which is composed of Huangqi(Radix Astragali seu Hedysari), Danggui(Radix Angelica sinensis), Chishao(Radix Paeoniae Rubra), Chuanxiong(Rhizoma Ligustici Chuanxiong), Honghua(Flos Carthami), Taoren(Semen Persicae) and Dilong(Pheretima), and identifies the therapeutic targets and underlying mechanisms that contribute to the neuroprotective properties of Buyang Huanwu decoction.Qingchun Mu Pengfei Liu Xitong Hu Haijun Gao Xu Zheng Haiyan Huang 2014Neural Regeneration Research2014,9,17:32
10Litterfall production and nutrient return in different-aged Chinese fir(Cunninghamia lanceolata) plantations in South China显示文摘The amounts of litter produced and nutrients returned play a fundamental role in the productivity and biogeochemical and nutrient cycling of forest ecosystems.We monitored annual litterfall production, nutrient return,and monthly dynamics over a one-year period in Chinese fir plantations aged 10, 22, and 34 years. Our objective was to quantify litterfall and nutrient return over a complete harvest rotation of Chinese fir. Annual litterfall production increased with stand age and was recorded as(3,294.6 ± 360.4),(3,733.9 ± 211.2), and(4,876.1 ± 212.8) kg ha-1a-1in stands aged 10, 22 and 34 years, respectively. Total litter production was significantly greater in the stand aged34 years than in the stand aged 10 years(p \ 0.05). With the exception of miscellaneous components, needle litterfall constituted the highest proportion(27.5–43.6 %), followed by branches/twigs(9.5–16.6 %). In all three plantations,annual total nutrient return to soil was in the order of C(1,119.95–2,709.05 kg ha-1a-1) [ N(39.32–62.04 kg ha-1a-1) [ K(15.95–22.44 kg ha-1a-1) [ P(1.30–1.63 kg ha-1a-1). C, N, K and P input to soil was significantly lower in the 10-year-old stand in comparison to the 22- and34-year-old stands(p \ 0.05). Litterfall production and nutrient return(C, N and K) followed similar patterns, and C and N input to soil was significantly related to litterfall production(needle, branch and total litterfall). C, N, P and K input to soil and total litterfall production were mainly driven by needle litterfall.Lili Zhou Addo-Danso Daniel Shalom Pengfei Wu Shubin Li Yayun Jia Xiangqing Ma 2015Journal of Forestry Research2015,26,1:32
11Hybrid optimization algorithm based on chaos,cloud and particle swarm optimization algorithm显示文摘As for the drop of particle diversity and the slow convergent speed of particle in the late evolution period when particle swarm optimization(PSO) is applied to solve high-dimensional multi-modal functions,a hybrid optimization algorithm based on the cat mapping,the cloud model and PSO is proposed.While the PSO algorithm evolves a certain of generations,this algorithm applies the cat mapping to implement global disturbance of the poorer individuals,and employs the cloud model to execute local search of the better individuals;accordingly,the obtained best individuals form a new swarm.For this new swarm,the evolution operation is maintained with the PSO algorithm,using the parameter of pop distr to balance the global and local search capacity of the algorithm,as well as,adopting the parameter of mix gen to control mixing times of the algorithm.The comparative analysis is carried out on the basis of 4 functions and other algorithms.It indicates that this algorithm shows faster convergent speed and better solving precision for solving functions particularly those high-dimensional multi-modal functions.Finally,the suggested values are proposed for parameters pop distr and mix gen applied to different dimension functions via the comparative analysis of parameters.Mingwei Li Haigui Kang Pengfei Zhou Weichiang Hong 2013Journal of Systems Engineering and Electronics2013,24,2:29
12Control of a Quadruped Robot with Bionic Springy Legs in Trotting Gait显示文摘Mantian Li Zhenyu Jiang Pengfei Wang Lining Sun Shuzhi Sam Ge 2014Journal of Bionic Engineering2014,11,2:25
13Activated carbon adsorption of quinolone antibiotics in water:Performance,mechanism,and modeling显示文摘The extensive use of antibiotics has led to their presence in the aquatic environment, and introduces potential impacts on human and ecological health. The capability of powdered activated carbon(PAC) to remove six frequently used quinolone(QN) antibiotics during water treatment was evaluated to improve drinking water safety. The kinetics of QN adsorption by PAC was best described by a pseudo second-order equation, and the adsorption capacity was well described by the Freundlich isotherm equation. Isotherms measured at different p H showed that hydrophobic interaction, electrostatic interaction,and π–π dispersion force were the main mechanisms for adsorption of QNs by PAC. A p H-dependent isotherm model based on the Freundlich equation was developed to predict the adsorption capacity of QNs by PAC at different p H values. This model had excellent prediction capabilities under different laboratory scenarios. Small relative standard derivations(RSDs), i.e., 0.59%–0.92% for ciprofloxacin and 0.09%–3.89% for enrofloxacin,were observed for equilibrium concentrations above the 0.3 mg/L level. The RSDs increased to 11.9% for ciprofloxacin and 32.1% for enrofloxacin at μg/L equilibrium levels, which is still acceptable. This model could be applied to predict the adsorption of other chemicals having different ionized forms.Hao Fu Xuebing Li Jun Wang Pengfei Lin Chao Chen Xiaojian Zhang I.H.(Mel)Suffet 2017Journal of Environmental Sciences2017,29,6:25
14A Combination of N2 and CO2 Adsorption to Characterize Nanopore Structure of Organic-Rich Lower Silurian Shale in the Upper Yangtze Platform, South China: Implications for Shale Gas Sorption Capacity显示文摘The pores in shales are mainly of nanometer-scale,and their pore size distribution is very important for the preservation and exploitation of shale gas.This study focused on the organic-rich Lower Silurian black shale from four wells in the Upper Yangtze Platform,and their TOC,mineralogical composition and pore characterization were investigated.Low pressure N_2 and CO_2 adsorption were conducted at 77.35 K and 273.15 K,respectively,and the pore structures were characterized by modified Brunauer-Emmett-Teller(BET),Dubinin-Radushkevich(DR),t-plot,BarrettJoyner-Halenda(BJH) and density functional theory(DFT) methods and then the relationship between pore structure and shale gas sorption capacity was discussed.The results indicate that(1) The Lower Silurian shale has high TOC content of 0.92%-4.96%,high quartz content of 30.6%-69.5%,and high clays content of 24.1%-51.2%.The total specific surface area varies from 7.56 m^2/g to 25.86 m^2/g.Both the total specific surface area and quartz content are positively associated with the TOC content.(2)Shale samples with higher TOC content have more micropores,which results in more complex nanopore structure.Micropore volumes/surface areas and non-micropore surface areas all increase with the increasing TOC content.(3) A combination of N_2 and CO_2 adsorption provides the most suitable detection range(~0.3-60 nm) and has high reliability and accuracy for nanopore structure characterization.(4) The TOC content is the key factor to control the gas sorption capacity of the Lower Silurian shale in the Upper Yangtze Platform.CHEN Lei JIANG Zhenxue LIU Keyu GAO Fenglin WANG Pengfei 2017Acta Geologica Sinica(English Edition)2017,91,4:21
15Near-diffraction-limited linearly polarized narrow-linewidth random fiber laser with record kilowatt output显示文摘In this paper, we propose and experimentally investigate a linearly polarized narrow-linewidth random fiber laser(RFL) operating at 1080 nm and boost the output power to kilowatt level with near-diffraction-limited beam quality using a master oscillation power amplifier. The RFL based on a half-opened cavity, which is composed of a linearly polarized narrow-linewidth fiber Bragg grating and a 500 m piece of polarization-maintained Ge-doped fiber, generates a 0.71 W seed laser with an 88 pm full width at half-maximum(FWHM) linewidth and a 22.5 dB polarization extinction ratio(PER) for power scaling. A two-stage fiber amplifier enhances the seed laser to the maximal 1.01 k W with a PER value of 17 dB and a beam quality of M_x^2=1.15 and M_y^2=1.13. No stimulated Brillouin scattering effect is observed at the ultimate power level, and the FWHM linewidth of the amplified random laser broadens linearly as a function of the output power with a coefficient of about 0.1237 pm∕W.To the best of our knowledge, this is the first demonstration of a linearly polarized narrow-linewidth RFL with even kilowatt-level near-diffraction-limited output, and further performance scaling is ongoing.JIANGMING XU LONG HUANG MAN JIANG JUN YE PENGFEI MA JINYONG LENG JIAN WU HANWEI ZHANG PU ZHOU 2017Photonics Research2017,5,4:20
16Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic.Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan 2020National Science Review2020,7,9:20
17The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation.Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang 2022General Psychiatry2022,35,1:20
18Analysis of Dynamics and Driving Factors of Wetland Landscape in Zoige,Eastern Qinghai-Tibetan Plateau显示文摘Zoige Wetland is one of the largest plateau wetlands in the world.This paper provides a dynamic analysis of spatial and temporal patterns of the wetland in Zoige, Eastern Qinghai-Tibetan Plateau, supported by ERDAS8.7 and ArcGIS9.0.It is the first comparative analysis of a system of rapidly changing wetland with landscape patterns in Zoige, using 3 classified landsat Thematic Mapper images of 1977, 1994 and 2001.The classified images were used to generate wetland distributing maps, and shape index(S), diversity index(H), dominance index(D), evenness index(E), fragmentation index(F) and fractal dimension(Fd) were calculated and analyzed spatiotemporally across pure grazing area in Zoige for each landscape type and in different periods(before 1977, during 1977~1994 and 1994~2001), as well as the driving forces of natural and anthropogenic.The study shows that for a comprehensive understanding of the shapes and trajectories of the shrinking and desertificated land expansion of the wetland, a spatiotemporal landscape metrics analysis in different periods is an improvement than only with landscape changing rates.This type of analysis can also be used to infer underlying social, economic, and political processes that drive the observed wetland forms.The results indicate that wetland patterns can be changed over relatively short periods of time.Thetotal area of lake reduced by 164.86 km2,grassland extended by 141.74 km2,semi-marsh extended by 105.94 km2 , marsh reduced by 86.00 km2;the number of landscape patches reduced by 56, and their average area decreased by 2.68 km2;the successions within lake, marsh, semi-marsh and grassland were found obviously;S decreased stepwise;D and F increased but H decreased;The changing rate after 1994 was 2.3 to 2.9 times greater than that before.The change of the wetland landscape patterns resulted in the interaction between socio-economic and natural forces of positive and negative aspects;and natural factors affected as assistant aspect.Some important human activities in this period led to the change of the landscape patterns in this region directly.Some measurements made by government and NGO delayed the converting process partly.QIU Pengfei WU Ning LUO Peng WANG Zuyuan LI Maihe 2009Journal of Mountain Science2009,6,1:19
19Numerical simulation of dust distribution at a fully mechanized face under the isolation effect of an air curtain显示文摘在是的一个煤矿的一张充分使机械化的工作的脸建原型,我们调查了由在它由空气的一个窗帘的隔离的过程期间的模拟,流动地和灰尘分发,使用 CFD 软件,流畅。结果证明有效地在 shearer 罐头上安装的空气窗帘阻止灰尘(特别能呼吸的灰尘) 扩散进操作员的工作区域,减少操作员并且极大地的方面上的灰尘集中改进他的工作环境。空气窗帘的地应用程序证明一个空气窗帘的灰尘隔离效果是相当显著的。为呼吸灰尘的隔离效率是超过 70% ,也,它为非呼吸的灰尘有好灰尘隔离效果。空气窗帘是在一张充分使机械化的工作的脸解决灰尘隔离的问题的一个有用方法。它用更广泛的应用程序在其它地方有一个实际背景。Wang Pengfei Feng Tao Liu Ronghua 2011Mining Science and Technology2011,21,1:19
20Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis显示文摘Objective:Neutrophil extracellular traps(NETs)produced by tumor-infiltrating neutrophils(TINs)are associated with poor prognosis in patients with several types of cancer.However,the mechanisms underlying the involvement of NETs in glioma progression remain largely unknown.This study aimed to elucidate the roles of NETs in biological processes that drive the crosstalk between glioma progression and the tumor microenvironment.Methods:Neutrophil infiltration and NETs formation were investigated in glioma tissue through immunohistochemistry,and their relationships with clinicopathological features and outcomes were statistically evaluated.The effects of NETs on glioma cell progression were studied in a co-culture system.In vivo and in vitro experiments validated the reactive oxygen species activity and cytokine production of TINs,as well as the ERK signaling pathway activation and the metastasis of gliomas.Results:Neutrophil infiltration and NETs formation were induced in high-grade glioma compared with low-grade glioma.NETs induced by TINs were determined to be an oncogenic marker of high-grade gliomas and to be involved in cell proliferation and invasion.NETs overproduction promoted glioma cell proliferation,migration,and invasion.Furthermore,HMGB1 was found to bind to RAGE and activate the NF-κB signaling pathway in vitro.In addition,NETs stimulated the NF-κB signaling pathway,thus promoting IL-8 secretion in glioblastoma.Subsequently,IL-8 recruited neutrophils which in turn mediated NETs formation via the PI3 K/AKT/ROS axis in TINs.Conclusions:Our results suggest that NETs produced by TINs mediate the crosstalk between glioma progression and the tumor microenvironment by regulating the HMGB1/RAGE/IL-8 axis.Targeting NETs formation or IL-8 secretion may be an effective approach to inhibit glioma progression.Caijun Zha Xiangqi Meng Lulu Li Shan Mi Da Qian Ziwei Li Pengfei Wu Shaoshan Hu Shihong Zhao Jinquan Cai Yanhong Liu 2020Cancer Biology & Medicine2020,17,1:19
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