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| 1 | 饮水微量元素与老年人群认知能力关系研究显示文摘在中国山东与河南两省农村研究了饮水中微量元素与老年人群认知能力 (CognitiveFunction)之间的关系。采用中国国标方法分析了饮水中氟、钙、硒、铝、铁、锌、镉、铅、砷微量元素和pH值 ;用老年性痴呆症 (Dementia)调查表 ,进行了≥ 6 5岁老年暴露人群认知能力的测定。调整年龄、性别和文化水平后 ,对微量元素与老年认知能力之间的关系进行直线模型、二次方模型和联合作用模型的统计分析 ,评价饮水中每种微量元素浓度对老年认知能力的影响。结果表明 ,单因素分析时发现几种微量元素对老年认知能力有明显作用。然而 ,在调整其它元素水平后 ,其中一些元素的作用消失。饮水中钙浓度对老年认知能力呈现一作用曲线 ,即随着饮水钙水平升高而认知能力增加 ;到某一点高峰后 ,又随钙水平增加而认知能力降低。而锌与镉之间存在一种相互作用 ,即在低饮水镉水平时 ,锌浓度与认知能力呈正相关 ,但在高饮水镉水平时 。 | 梁超轲 吉荣娣 曹静祥 姜玉亭 余波 马凤 吴云鹏 应波 张妍 孙淑庄 Li Yiming Christine L Emsley Gao Sujuan Kathleen S Hall Hugh C Hendrie | 2003 | 卫生研究2003，32，5： | 12 |
| 2 | IPAI: a direct target of SL signaling显示文摘 | Stephanie C Kerr Christine A Beveridge | 2017 | Cell Research2017，27，10： | 5 |
| 3 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 4 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 5 | 扁桃体鳞癌中HPV感染与EGFR、VEGF表达的相关性研究显示文摘目的:研究扁桃体鳞癌(squamous cell carcinomas of the tonsil tonsillar,SCCs)中人乳头瘤病毒(human papillomavirus,HPV)感染与血管内皮生长因子(vascular endothelial growth factor,VEGF)和表皮生长因子受体(epidermal growth factor,EGFR)表达的关系,探讨HPV与EGFR和VEGF在扁桃体鳞癌发生中的交互效应。方法:采用多重实时荧光定量聚合酶链反应(multiplex real-time polymerase chain reaction,MT-PCR)检测85例扁桃体鳞癌HPV DNA及型别,通过HPV DNA分析进行HPV感染状况的测定;同时采用半定量免疫组化检测HPV(+)组和HPV(-)组中VEGF、EGFR蛋白表达情况。结果:扁桃体鳞癌中HPV感染率为49.4%(42/85),HPV-16型占所有感染者的比例为90.5%(38/42),明显高于其他型别;HPV(+)组EGFR蛋白表达明显低于HPV(-)组(P值均<0.01);HPV(+)组与HPV(-)组VEGF蛋白表达无明显差异;此外,VEGF表达与EGFR、患者的年龄、性别、TNM分期、组织学分级均无明显相关性。结论:HPV感染与扁桃体鳞癌的发生存在相关性,HPV相关的扁桃体鳞癌中,HPV基因可能通过改变EGFR表达致癌,为HPV致癌机理进一步研究提供一个新的视角,具有重要的理论意义。 | 费继敏 Timothy A Dobbins Deanna Jones C Soon Lee Christine Loo Jonathan Clark Barbara Rose | 2015 | 现代肿瘤医学2015，23，4： | 3 |
| 6 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 7 | Stock market volatility, excess returns, and the role of investor sentiment显示文摘 | Wayne Y Lee Christine X Jiang Daniel C Indro | 2002 | Journal of Banking and Finance2002，，12： | 2 |
| 8 | Safety and efficacy of sofosbuvir/velpatasvir/voxilaprevir in postliver transplant patients with previous direct-acting antiviral failure:Six case reports显示文摘BACKGROUND Direct-acting antiviral(DAA)therapy regimens are highly effective at eliminating hepatitis C virus(HCV)infection but rates of sustained virologic response(SVR)are lower in patients with decompensated cirrhosis or hepatocellular carcinoma.Since many of these patients will be referred for liver transplant,they will require retreatment after transplantation.Sofosbuvir/velpatasvir/voxilaprevir(SOF/VEL/VOX)is recommended by guidelines as the preferred regimen to treat HCV in DAA-experienced patients following liver transplant however there is limited data.CASE SUMMARY We present the cases of six liver transplant recipients who had previous treatment failure with sofosbuvir-based DAA therapy prior to transplantation and who then received SOF/VEL/VOX after transplant.CONCLUSION This case series demonstrate the real-world efficacy and safety of SOF/VEL/VOX in the post liver transplant setting.Treatment was successful with all patients achieving SVR,it was well tolerated,and there were minimal drug-drug interactions with their immunosuppressants. | Cory Higley Christine C Hsu Coleman Smith Sandeep Nadella Alexander T.Lalos | 2020 | World Journal of Hepatology2020，12，12： | 2 |
| 9 | Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis显示文摘 | Christophe Aubé Frédéric Oberti Nouri Korali Marc-Antoine Namour Didier Loisel Jean-Yves Tanguy Emmanuelle Valsesia Christophe Pilette Marie Christine Rousselet Pierre Bedossa Hervé Rifflet Moussa Y Ma?ga Dominique Penneau-Fontbonne Christine Caron Paul C | 1999 | Journal of Hepatology1999，，3： | 2 |
| 10 | Long-term stability of gentamicin sulfate-ethylenediaminetetraacetic acid disodium salt (EDTA-Na_2) solution for catheter locks显示文摘A lock solution composed of gentamicin sulfate(5 mg/mL) and ethylenediaminetetraacetic acid disodium salt(EDTA-Na2, 30 mg/mL) could fully eradicate in vivo bacterial biofilms in totally implantable venous access ports(TIVAP). In this study, fabrication, conditioning and sterilization processes of antimicrobial lock solution(ALS) were detailed and completed by a stability study. Stability of ALS was conducted for12 months in vial(25 °C 7 2 °C, 60% 7 5% relative humidity(RH), and at 40 °C 7 2 °C, RH 75% 7 5%)and for 24 h and 72 h in TIVAP(40 °C 7 2 °C, RH 75% 7 5%). A stability indicating HPLC assay with UV detection for simultaneous quantification of gentamicin sulfate and EDTA-Na2 was developed. ALS was assayed by ion-pairing high performance liquid chromatography(HPLC) needing gentamicin derivatization, EDTA-Na2 metallocomplexation of samples and gradient mobile phase. HPLC methods to separate four gentamicin components and EDTA-Na2 were validated. Efficiency of sterility procedure and conditioning of ALS was confirmed by bacterial endotoxins and sterility tests. Physicochemical stability of ALS was determined by visual inspection, osmolality, pH, and sub-visible particle counting. Results confirmed that the stability of ALS in vials was maintained for 12 months and 24 h and 72 h in TIVAP. | Anne-Sophie Fiolet Elise Jandot Pauline Doucey Coralie Crétet Célia Brunel Christine Pivot Jean-Marc Ghigo Christophe Beloin David Lebeaux Fabrice Pirot | 2018 | Journal of Pharmaceutical Analysis2018，8，6： | 2 |
| 11 | Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancercells显示文摘 | Myriam P Christine C Beatrice NR | 2005 | Cancer Res2005，65，： | 1 |
| 12 | Results from a phase I safety trial of hAADC gene therapy for Parkinson disease显示文摘 | EBERLING J L JAGUST W J CHRISTINE C W | 2008 | Neurology2008，70，21： | 1 |
| 13 | The effect of propranolol on free fatty acid mobilization and resting metabolic rate显示文摘 | Christin L Ravussin E Bogardus C | | 0，，05： | 1 |
| 14 | Experimental strategies to promote axonal regeneration after traumatic central nervous system injury显示文摘 | Hans W | 1998 | Prog Neurobiol1998，56，： | 1 |
| 15 | Enhancement of mechanical properties of TiN/AlN multilayers by modb lying the number and the quality of interfaces显示文摘 | ANNE T CHRISTOPHE R CHRISTINE C | 2000 | Surface and Coatings Technology2000，124，： | 1 |
| 16 | Experience with PICC at a U- niversity Medical Center 显示文摘 | Kathleen M D Christine D C | 1997 | Ioumal of Infusion Nursing1997，20，6： | 1 |
| 17 | The new market for federal judicial law clerks显示文摘 | Avery C Christine J Richard P and Alvin E R | 2007 | University of Chicago Law Review2007，，： | 1 |
| 18 | The Writing Assignments and Writing Problems of Doctoral Students:Faculty Perceptions, Pedagogical Issues,and Needed Research显示文摘 | Christine P C Philip H | 1992 | English for Specific Purposes1992，，11： | 1 |
| 19 | ANO1 amplifi cationand expression in HNSCC with a high propensity for futuredistant metastasis and its functions in HNSCC cell lines 显示文摘 | Ayoub C Christine Wasylyk Li Y | 2010 | BrJ Cancer2010，103，5： | 1 |
| 20 | Microbical contamination of stored hydrocarbon fuels and its control显示文摘 | CHRISTINE C G FATIMA M B JOAN K | 2003 | Journal of Microbiology2003，32，4： | 1 |
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