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| 1 | Benefit of combination β-blocker and endoscopic treatment to prevent variceal rebleeding: A meta-analysis显示文摘AIM: To determine whether the association of β-blockers with endoscopic treatment is superior to endoscopic treatment alone for the secondary prophylaxis of oesophageal variceal bleeding. METHODS: Randomised controlled trials comparing sclerotherapy (SCL) with SCL plus β-blockers (BB) or banding ligation (BL) with BL plus BB were identif ied.Main outcomes were overall and 6, 12 and 24 mo rebleeding rates, as well as overall and 6, 12 and 24 mo mortality. Two statistical methods were used: Yusuf-Peto, and Der Simonian and Laird. Inter-trial heterogeneity was systematically taken into account. RESULTS: Seventeen randomised controlled trials were included, 14 with SCL and 3 with BL. Combination β-blocker and endoscopic treatment signif icantly reduced rebleeding rates at 6, 12 and 24 mo and overall [odds ratio (OR): 2.20, 95% conf idence interval (CI): 1.69-2.85, P<0.0001] compared to endoscopic treatment alone. Mortality at 24 mo was signif icantly lower for the combined treatment group (OR: 1.83, 95% CI:1.16-2.90, P= 0.009), as well as overall mortality (OR: 1.43, 95% CI:1.03-1.98, P= 0.03). CONCLUSION: Combination therapy should thus be recommended as the fi rst line treatment for secondary prophylaxis of oesophageal variceal bleeding. | Natalie Funakoshi Frédérique Ségalas-Largey Yohan Duny Frédéric Oberti Jean-Christophe Valats Michael Bismuth Jean-Pierre Daurès Pierre Blanc | 2010 | World Journal of Gastroenterology2010，16，47： | 24 |
| 2 | Management of digestive bleeding related to portal hypertension in cirrhotic patients:A French multicenter cross-sectional practice survey显示文摘AIM: To investigate the conformity of management practices of gastrointestinal hemorrhage in cirrhotic patients with relevant guidelines. METHODS: A questionnaire on the management of digestive bleeding was completed for all consecutive cirrhotic patients admitted to 31 French hospitals. RESULTS: One hundred and twenty-six bleeding events were recorded. It was the first bleeding episode in 79 patients (63%), of whom 40 (51%) had a prior diagnosis of cirrhosis and 25 (32%) had previously undergone an endoscopy. The bleeding episode was a recurrence in 46 patients (37%). The median time between onset and admission was 4 h, but exceeded 12 h in 42% of cases. There was an agreement between centers forearly vasoactive drug administration (87% of cases), association with ligation (42%) more often than sclerosis (21%) at initial endoscopy, and antibiotic prophylaxis (64%). By contrast, prescription of beta-blockade alone or in combination (0 to 100%, P = 0.003) for secondary prophylaxis and lactulose (26% to 86%, P = 0.04), differed among centers. CONCLUSION: In French hospitals, management of bleeding related to portal hypertension in cirrhotic patients is generally in keeping with the consensus. Broad variability still remains concerning beta-blockade use for secondary prophylaxis. Screening for esophageal varices, the use of antibiotic prophylaxis and patients information need to be improved. | Pierre Ingrand Jérme Gournay Pierre Bernard Frédéric Oberti Brigitte Bernard-Chabert Arnault Pauwels Philippe Renard Eric Bartoli Jean-Franois Cadranel Jean-Claude Barbare Isabelle Ingrand Michel Beauchant | 2006 | World Journal of Gastroenterology2006，12，48： | 4 |
| 3 | 儿茶酚胺介导的多形性室速患者家系CASQ2基因F189L突变的基因分析显示文摘目的在27例儿茶酚胺介导的多形性室速患者及家庭成员中寻找CASQ2基因突变。方法应用直接DNA序列分析对临床诊断为家族性多形性室速27例患者及家庭成员进行进行基因突变分析。应用Taqman基因分型检测在以1400名正常人群中确定CASQ2变异的频率。结果在一个多形性室速家系中发现了1个新的杂合子改变F189L。通过与多种生物比对,证实该改变发生于在第2结构域一个高度保守的氨基酸上,位于第5外显子的F189L的改变,使编码蛋白的第189位氨基酸由苯丙氨酸改变为亮氨酸。应用Taqman SNP genotyping assay分析方法证实正常人群1400名中未发现同样改变。在CASQ2基因中未发现其他引起疾病的基因突变。结论发现了CASQ2基因的1个新F189L突变。 | 刘茜蓓 Carlos Oberti 张贤钦 柯铁 张腾 Melvin Scheinman 胡大一 王擎 | 2008 | 中华医学遗传学杂志2008，25，3： | 4 |
| 4 | Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis显示文摘 | Christophe Aubé Frédéric Oberti Nouri Korali Marc-Antoine Namour Didier Loisel Jean-Yves Tanguy Emmanuelle Valsesia Christophe Pilette Marie Christine Rousselet Pierre Bedossa Hervé Rifflet Moussa Y Ma?ga Dominique Penneau-Fontbonne Christine Caron Paul C | 1999 | Journal of Hepatology1999，，3： | 2 |
| 5 | Noninvasive diagnosis of hepatic fibrosis or cirrhosis 显示文摘 | Oberti F Valsesia E Pilette C | 1997 | Gastroenterology1997，113，5： | 1 |
| 6 | Noninvasive diagnosis of hepatic fibrosis or cirrhosis显示文摘 | Oberti F Valsesia E Pilette C | 1997 | Gastroenterology1997，113，： | 1 |
| 7 | Noninvasive diagnosis of hepatic fibrosis or cirrhosis显示文摘 | Oberti F Vaisesid E Pilettec | 1997 | Gastenterology1997，113，： | 1 |
| 8 | New Doppler ultra- sound signs improve the non-invasive diagnosis of cirrhosis or severe liver fibrosis 显示文摘 | Aub6 C Wink_field B Oberti F | 2004 | Eur J Gastroenterol Hepatol2004，16，8： | 1 |
| 9 | Noninvasive diagnosis of hepatic fi-brosis or cirribosis 显示文摘 | Oberti F Valsesia E Pilette C | 1997 | Gastroenterology1997，113，5： | 1 |
| 10 | Trace-element incorpora- tion in titanite: constraints from experimentally determined solid/liquid partition coefficients 显示文摘 | Tiepolo M Oberti R Vannucci R | 2002 | Chem Geol2002，191，13： | 1 |
| 11 | The usefulness of ultrasonic microprobe imaging for endoscopic variceal ligation显示文摘 | Burtin P Cales P Oberti F | | 0，，03： | 1 |
| 12 | Susceptibility to leprosy is linked to the human NRAMPI gene显示文摘 | Abel L Sanchez F O Oberti J | 1998 | J Infect Dis1998，177，： | 1 |
| 13 | Noiuvasive diagnosis of hepatic fibrosis on cirrhosis显示文摘 | Oberti F Valsesia E Pilette C | 1997 | Gastroenterology1997，113，5： | 1 |
| 14 | Reproducibility of blood tests of liver fibrosis in clinical practice显示文摘 | Paul Calès Pascal Veillon Anselme Konaté Elisabeth Mathieu Catherine Ternisien Alain Chevailler Alban Godon Yves Gallois Fran?oise Joubaud Isabelle Hubert-Fouchard Frédéric Oberti Stéphane Réaud Gilles Hunault Fran?oise Mauriat Fran?oise Lunel-Fabiani | 2007 | Clinical Biochemistry2007，，1： | 1 |
| 15 | Arandomized controlled trial of high-dose ursodesoxycholicacid for nonalcoholic steatohepatitis 显示文摘 | Ratziu V de Ledinghen V Oberti F FRESGUN | 2011 | J Hepatol2011，54，5： | 1 |
| 16 | Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver‐prognosis in chronic hepatitis C显示文摘 | J. Boursier C. Brochard S. Bertrais S. Michalak Y. Gallois I. Fouchard‐Hubert F. Oberti M.‐C. Rousselet P. Calès | 2014 | Aliment Pharmacol Ther2014，，2： | 1 |
| 17 | Li-An important component in igneous alkali amphiboles显示文摘 | Hawthorne F C Ungaretti L Oberti R | 1993 | Amer Min1993，78，： | 1 |
| 18 | Noninvasive diagnosis of hepatic fibrosis or cirrgosis显示文摘 | Oberti F Valsesia E Pilette C et al | 1997 | Gastromenterology1997，113，5： | 1 |
| 19 | Relationship between vascular reactivity in vitro and blood flows in rats with cir- rhosis 显示文摘 | Pateron D Oberti F Lefilliatre P | 1999 | Clin Sci (Lond)1999，97，3： | 1 |
| 20 | Genome-wide linkage scan identifies a novel genetic locus on chromosmoe 5p13 for neonatal atrial fibrillation associated with sudden death and variable eardiomyopathy显示文摘 | Oberti C Wang L Li L | 2004 | Circulation2004，110，： | 1 |
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