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| 1 | 水泥基复合材料集料与浆体界面研究综述(二):界面微观结构的形成、劣化机理及其影响因素显示文摘首先概括介绍了目前国际上存在的几种界面过渡区微观结构的模型。然后分新拌混凝土阶段和水化早期、材料硬化过程中以及材料使用过程中3个阶段描述了界面微观结构的形成以及劣化机理。在第1阶段.界面过渡区形成的可能机理为:边壁效应,絮凝成团作用,微区泌水效应,离子的迁移、沉积与成核生长,水化产物的单边生长效应以及脱水收缩效应。在第2阶段,界面过渡区可能的形成与劣化机理为:自身收缩、化学收缩和自干燥收缩、干缩,集料与浆体膨胀系数的差别,浆体的进一步水化以及水化产物的重结晶。在第3阶段,界面过渡区的形成与劣化机理为:荷载的作用.环境介质的侵蚀,冻融的破坏,碱集料反应以及胶凝材料的进一步水化。同时给出了几种常规的以及可能成为界面过渡区微观结构的表征方法。最后,从原材料的物理、化学组成,配合比以及材料制备工艺角度分析了影响界面过渡区微观结构的因素。 | 陈惠苏 孙伟 Stroeven Piet | 2004 | 硅酸盐学报2004，32，1： | 99 |
| 2 | 水泥基复合材料界面对材料宏观性能的影响显示文摘从力学性能、传输性能和收缩性能3个角度阐述了界面过渡区(ITZ)对混凝土宏观性能的影响.其中力学性能主要从强度、刚度以及断裂力学性能3个方面,传输性能主要从扩散性能与渗透性能2个方面进行考虑.探讨了在多因素交互作用下,有关界面研究方面存在的不足. | 陈惠苏 孙伟 Stroeven Piet | 2005 | 建筑材料学报2005，8，1： | 43 |
| 3 | 水泥基复合材料集料与浆体界面研究综述(一):实验技术显示文摘关于界面研究,概括起来主要可以从以下5个方面考虑:(1)界面研究的相关技术手段;(2)界面微观结构特征的研究;(3)界面微观结构的形成及劣化机理;(4)影响界面微观结构因素的研究;(5)界面过渡区的性能对材料宏观性能(包括:力学性能和耐久性)影响的研究。对这些问题的研究是为了回答以下2个问题:(1)各种层次的界面过渡区到底在多大程度上影响着整个材料的力学性能和耐久性;(2)通过改善界面来达到改善水泥基复合材料的性能这一措施是否可行。由于界面研究的技术手段与方法随着其它相关技术与设备的引入而不断取得新的进展,促进了水泥基复合材料集料与浆体界面相关研究也不断取得新的成果。关于界面研究的新实验技术和方法,从如下4个方面进行了描述:(1)与界面过渡区微观结构表征相关的实验技术;(2)与界面过渡区力学性能(包括:粘结强度、刚度和断裂力学性能)相关的技术和方法;(3)与界面过渡区传输性能相关的技术和方法;(4)与界面过渡区收缩性能相关的技术和方法。 | 陈惠苏 孙伟 Stroeven Piet | 2004 | 硅酸盐学报2004，32，1： | 33 |
| 4 | GRADE指南:Ⅷ.证据质量评价--间接性显示文摘直接证据来自直接比较我们关注的干预措施用于我们关注的患者人群,并测量患者重要结局的研究。间接证据可由以下4种方式之一产生。第一,患者可能与我们关注的患者不同(适用性一词常用于这类间接性)。第二,所检验的干预措施可能与我们关注的干预措施不同。有关患者和干预措施间接性的决策取决于对生物或社会因素差异是否大到可能使效应尺度出现预期的较大差异的考虑。第三,结果可能有别于最初设定的结局指标——如替代结果本身不重要,但测量之是基于替代结果的变化反映患者重要结局变化这一假设。第四类间接性在概念上与前三类不同,发生于临床医生必须在未经直接比较的两种干预措施间做出选择时。这种情况下比较治疗方案需要特定的统计方法,并根据患者人群、联合干预措施、结局测量指标及备选干预措施试验方法的差异程度,将证据级别降低1或2级。 | Gordon Guyatt Andrew D.Oxman Regina Kunz James Woodcock Jan Brozek Mark Helfand Pablo Alonso-Coello Yngve Falck-Ytter Roman Jaeschke Gunn Vist Elie A.Akl Piet N Post Susan Norris Joerg Meerpohl Mona Nasser 代表GRADE工作组 李幼平 杨晓妍 李鸿浩 | 2011 | 中国循证医学杂志2011，11，12： | 30 |
| 5 | 水泥基复合材料界面过渡区体积分数的定量计算显示文摘借助邻近函数公式,给出了水泥基复合材料集料与浆体间界面过渡区体积分数的定量计算公式,并采用随机点采样方法验证采用该定量公式计算水泥基复合材料界面过渡区体积分数的可行性。在此基础上,预测了由符合Fuller分布的集料制备的混凝土中界面过渡区体积分数随集料体积分数和集料粒径范围的变化曲线。讨论了界面厚度变化、集料体积分数变化以及集料粒径分布变化对界面过渡区体积分数影响的差别,并给出了衡量界面过渡区重叠程度的定性和定量方法。结果表明:在常规集料体积分数下,三者中对界面过渡区体积分数以及界面过渡区重叠程度影响的主次顺序均为:界面过渡区厚度变化带来的影响>集料体积分数变化带来的影响>集料细度变化带来的影响。 | 陈惠苏 孙伟 STROEVEN Piet | 2006 | 复合材料学报2006，23，2： | 15 |
| 6 | 截面分析法对界面过渡区厚度的放大作用显示文摘在采用截面法分析研究截面过渡区厚度时,由于截平面并不一定正好垂直于集料的表面,导致得到的表观界面过渡区厚度与实际界面过渡区厚度是不同的。以3种规则形状(球形、椭圆形截面以及矩形截面)的集料为例,从几何概率角度研究了截面分析法对界面过渡区厚度的放大问题。研究结果表明,截面分析法得到的表观界面过渡区厚度都大于实际的界面过渡区厚度,平均放大倍数与集料的粒形有关。对正方体性集料而言,平均表观界面过渡区的厚度是实际界面厚度的1.12倍;对球形集料而言,实际界面过渡区厚度被放大了π/2倍。 | 陈惠苏 孙伟 赵庆新 Stroeven Piet | 2003 | 硅酸盐学报2003，31，11： | 12 |
| 7 | 猪配合饲料中铜和锌的需要量的最新研究进展显示文摘铜、锌是猪微量元素营养中重要的组成部分,它与猪体内许多代谢活动密切相关。日粮中铜、锌缺乏或不足,会对仔猪的食欲、体质、生产性能以及健康状况等产生不同程度的影响。研究表明,高铜、高锌能够促进仔猪的增重,提高生长速度,防止腹泻的发生。但是猪日粮中如果长期使用高铜、高锌导致猪机体慢性中毒、组织残留增多和资源浪费,更重要的是动物残留和大量排泄会对人类及整个生态链健康造成不可忽视的影响和危害。随着人们对自身健康意识的加强及对生活质量要求的提高,畜产品药物残留及其所带来的一系列不良后果,引起人们的广泛关注,并积极采取有效的避免措施。本文是由荷兰SFR饲料研究所所长、首席专家Piet van der Aar博士和美瑞泰科/美瑞康生物科技有限公司的金立志博士以'猪配合饲料中铜和锌的需要量的最新研究进展'为题,介绍了欧盟在猪饲料中铜和锌的允许添加量,并通过试验探讨了如何在猪日粮中进一步降低铜、锌的含量的可能性,希望能给业界的同仁以启迪。 | Piet van der Aar 金立志 | 2013 | 饲料工业2013，34，12： | 12 |
| 8 | Primary prevention and treatment of venous thromboembolic events in patients with gastrointestinal cancers- Review显示文摘Venous thromboembolism event(VTE) is a common and morbid complication in cancer patients. Patients with gastrointestinal cancers often suffer from symptomatic or incidental splanchnic vein thrombosis, impaired liver function and/or thrombocytopenia. These characteristics require a thorough risk/benefit evaluation for individual patients. Considering the risk factors for the development of VTE and bleeding events in addition to recent study results may be helpful for correct initiation of primary pharmacological prevention and treatment of cancer-associated thrombosis(CAT), preferably with low molecular weight heparins(LMWH). Whereas thromboprophylaxis is most often recommended in hospitalized surgical and non-surgical patients with malignancy, there is less agreement as to its duration. With regard to ambulatory cancer patients, the lack of robust data results in low grade recommendations against routine use of anticoagulant drugs. Anticoagulation with LMWH for the first months is the evidence-based treatment for acute CAT, but duration of secondary prevention and the drug of choice are unclear. Based on published guidelines and literature, this review will focus on prevention and treatment strategies of VTE in patients with gastrointestinal cancers. | Hanno Riess Piet Habbel Anja Jühling Marianne Sinn Uwe Pelzer | 2016 | World Journal of Gastrointestinal Oncology2016，8，3： | 9 |
| 9 | 计算混凝土中平均最邻近集料表面间距的正十二面体模型显示文摘带状模型是以解析解的方式研究混凝土中集料尺寸分布和集料体积分数对平均最邻近集料表面间距影响的模型。但是,由带状模型的计算公式计算浆体的体积无法得到正确的结果。鉴于上述缺点,提出采用单一粒径球形粒子体系的正十二面体模型。以符合Fuller分布集料为例,结合数量基平均粒径方法,采用正十二面体模型研究了集料尺寸分布和集料体积分数对平均最邻近集料表面间距的影响。研究结果表明:随着集料体积分数的增加和集料细度的提高,平均最邻近集料表面间距减小;对所研究的集料体积分数(60%~75%)和集料尺度分布(Fuller分布)而言,平均最邻近集料表面间距值在90~232μm之间变化;在给定的集料分布下,集料体积分数在55%~75%范围内,平均邻近集料表面间距与集料体积分数之间近似呈线性关系。 | 陈惠苏 孙伟 Stroeven Piet | 2003 | 硅酸盐学报2003，31，11： | 8 |
| 10 | 计算混凝土中邻近集料表面间距平均值的体视学方法显示文摘借助于体视学中的平均自由程公式,给出了计算水泥基复合材料平均邻近集料表面间距平均值的方法,并给出了两种计算集料的表面积的方法:基于集料表面积近似计算的解析解法和混凝土样品截面的线采样分析法.结果表明:采用截面线采样分析法能够很好地近似计算混凝土中邻近集料表面间距的平均值,也提供了一种计算不规则形状集料粒子体系表面积的思路,混凝土中邻近集料表面间距的平均值大小只与混凝土中集料的体积分数、集料的密度以及集料的比表面积有关,而与集料的粒径分布(或粒径范围)无关. | 陈惠苏 孙伟 STROEVEN Piet STROEVEN Martijn | 2005 | 哈尔滨工业大学学报2005，37，11： | 8 |
| 11 | 水泥基复合材料浆体厚度分布的定量表达显示文摘依据统计物理学领域中的弦长密度函数,提出了水泥基复合材料邻近集料间浆体厚度分布的定量估计方法。借助计算机模拟方法生成的模型结构验证该理论方法的可靠性。通过浆体厚度的数量基概率密度曲线和累计概率曲线的比较发现,理论解和模拟结果之间能较好吻合。在常用集料体积分数下,用该解析解预测了集料符合Fuller分布的砂浆和混凝土中浆体厚度分布及其平均值随集料体积分数和集料细度的变化关系。结果发现:邻近集料间浆体厚度平均值的变化范围为190~860μm。 | 陈惠苏 孙伟 SLUYS Lambertus Johannes STORVEN Piet | 2007 | 硅酸盐学报2007，35，12： | 5 |
| 12 | How to assess intestinal viability during surgery: A review of techniques显示文摘Objective and quantitative intraoperative methods of bowel viability assessment are essential in gastrointestinal surgery. Exact determination of the borderline of the viable bowel with the help of an objective test could result in a decrease of postoperative ischemic complications. An accurate, reproducible and cost effective method is desirable in every operating theater dealing with abdominal operations. Numerous techniques assessing various parameters of intestinal viability are described by the studies. However, there is no consensus about their clinical use. To evaluate the available methods, a systematic search of the English literature was performed. Virtues and drawbacks of the techniques and possibilities of clinical application are reviewed. Valuable parameters related to postoperative intestinal anastomotic or stoma complications are analyzed. Important issues in the measurement and interpretation of bowel viability are discussed. To date, only a few methods are applicable in surgical practice.Further studies are needed to determine the limiting values of intestinal tissue oxygenation and flow indicative of ischemic complications and to standardize the methods. | Linas Urbanaviius Piet Pattyn Dirk Van de Putte Donatas Venskutonis | 2011 | World Journal of Gastrointestinal Surgery2011，3，5： | 4 |
| 13 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 14 | 1100kV/1200kV断路器大功率试验(英文)显示文摘特高压(UHV)断路器试验本身就是一项挑战,当前,KEMA已开发了用于超高压和特高压开关设备大功率测试装置。鉴于特高压断路器一般至少由双断口灭弧室组成,需要做验证其正常电流(或故障电流)开断能力的局部试验,可以只针对断路器单断口(即断路器的1/2或1/4)来进行。例如,装有均压电容的瓷柱式断路器的情形就是这样。然而,为满足对金属封闭式开关设备的试验要求(见IEC61633),在带电部件和外壳之间以及在分闸过程应具备正确的电介质应力,不做断路器整极试验在技术上是不正确的。这就要求开发新的UHV断路器试验电路。关键之处在于使用一种双级合成电路,其中一级电路放置在测试对象的附近。这种做法的好处是,测试对象的外壳可以保持地电位。各种800kV以及1100或1200kV断路器整极全面试验均证明这种方法是有效可行的。文章中展示了试验的例子。 | René Peter Paul Smeets Sander Kuivenhoven Piet Knol Adriaan Hofstee | 2009 | 南方电网技术2009，3，6： | 4 |
| 15 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 16 | 砂浆中邻近集料表面最近间距分布的数值模拟显示文摘采用具有粒子动态混合密实功能的SPACE系统,实现了高集料体积分数模型砂浆结构的生成.从而,以3种细集料粒径分布的模型砂浆(其中一种的粒径范围为0.125~1.34 mm,另外两种的粒径范围为0.25~5.00mm)结构为例,研究了集料细度和集料体积分数(ψ=40%~70%)对邻近集料表面最近间距分布的影响.结果表明,集料细度增加和集料体积分数增大都会使大尺度邻近集料表面最近间距出现的概率减小、小尺度邻近集料表面最近间距出现的概率增加,且峰值概率的位置向小间距方向偏移.另外,邻近集料表面最近间距的分区段累计概率结果分析表明,3种模型砂浆结构的邻近集料表面最近间距分布的57%以上小于10μm.最后,邻近集料表面最近间距的平均值的分析结果显示,当集料体积分数在40%~70%之间变化时,邻近集料表面最近间距的平均值在54.6~1.1μm之间变化;当砂浆中集料的体积分数在50%~70%之间变化时,邻近集料表面最近间距的平均值与集料的体积分数基本上呈线性关系;单位砂浆体积下集料的表面积的变化对邻近集料表面最近间距的平均值有影响,但二者之间的比值并非常数. | 陈惠苏 孙伟 蒋金洋 STROEVEN Piet STROEVEN Martijn | 2005 | 复合材料学报2005，22，4： | 4 |
| 17 | Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain显示文摘AIM: To establish a novel, sensitive and high-throughput gelatinolytic assay to define new inhibitors and compare domain deletion mutants of gelatinase B/matrix metalloproteinase (MMP)-9. METHODS: Fluorogenic Dye-quenched (DQ)TM-gelatin was used as a substrate and biochemical parameters (substrate and enzyme concentrations, DMSO solvent concentrations) were optimized to establish a highthroughput assay system. Various small-sized libraries (ChemDiv, InterBioScreen and ChemBridge) of hetero-cyclic, drug-like substances were tested and compared with prototypic inhibitors. RESULTS: First, we designed a test system with gelatin as a natural substrate. Second, the assay was validated by selecting a novel pyrimidine-2,4,6-trione (barbitu- rate) inhibitor. Third, and in line with present structural data on collagenolysis, it was found that deletion of the O-glycosylated region significantly decreased gelatinolytic activity (kcat/kM ± 40% less than full-length MMP-9). CONCLUSION: The DQTM-gelatin assay is useful in high-throughput drug screening and exosite targeting. We demonstrate that flexibility between the catalytic and hemopexin domain is functionally critical for gelatinolysis. | Jennifer Vandooren Nathalie Geurts Erik Martens Philippe E Van den Steen Steven De Jonghe Piet Herdewijn Ghislain Opdenakker | 2011 | World Journal of Biological Chemistry2011，2，1： | 3 |
| 18 | 全新蜡质马铃薯淀粉给休闲食品带来创新显示文摘 | 罗永霞 陈正宏 Piet Buwalda | 2006 | 中外食品2006，，3： | 3 |
| 19 | Near-infrared fluorescence guided esophageal reconstructive surgery: A systematic review显示文摘BACKGROUND After an esophagectomy, the stomach is most commonly used to restore continuity of the upper gastrointestinal tract. These esophago-gastric anastomoses are prone to serious complications such as leakage associated with high morbidity and mortality. Graft perfusion is considered to be an important predictor for anastomotic integrity. Based on the current literature we believe Indocyanine green fluorescence angiography(ICGA) is an easy assessment tool for gastric tube(GT) perfusion, and it might predict anastomotic leakage(AL).AIM To evaluate feasibility and effectiveness of ICGA in GT perfusion assessment and as a predictor of AL.METHODS This study was designed according to the PRISMA guidelines and registered in the PROSPERO database. PubMed and EMBASE were independently searched by 2 reviewers for studies presenting data on intraoperative ICGA GT perfusion assessment during esophago-gastric reconstruction after esophagectomy.Relevant outcomes such as feasibility, complications, intraoperative surgical changes based on ICGA findings, quantification attempts, anatomical data and the impact of ICGA on postoperative anastomotic complications, were collected by 2 independent researchers. The quality of the included articles was assessed based on the Methodological Index for Non-Randomized Studies. The 19 included studies presented data on 1192 esophagectomy patients, in 758 patients ICGA was used perioperative to guide esophageal reconstruction.RESULTS The 19 included studies for qualitative analyses all described ICGA as a safe and easy method to evaluate gastric graft perfusion. AL occurred in 13.8% of the entire cohort, 10% in the ICG guided group and 20.6% in the control group(P <0.001). When poorly perfused cases are excluded from the analyses, the difference in AL was even larger(AL well-perfused group 6.3% vs control group 20.5%, P <0.001). The AL rate in the group with an altered surgical plan based on the ICG image was 6.5%, similar to the well perfused group(6.3%) and significantly less than the poorly perfused group(47.8%)(P < 0.001), suggesting that the technique is able to identify and alter a potential bad outcome.CONCLUSION ICGA is a safe, feasible and promising method for perfusion assessment. The lower AL rate in the well perfused group suggest that a good fluorescent signal predicts a good outcome. | Elke Van Daele Yves Van Nieuwenhove Wim Ceelen Christian Vanhove Bart P Braeckman Anne Hoorens Jurgen Van Limmen Oswald Varin Dirk Van de Putte Wouter Willaert Piet Pattyn | 2019 | World Journal of Gastrointestinal Oncology2019，11，3： | 3 |
| 20 | 绿色工艺设计显示文摘用废弃物设计产品的概念已经不新鲜,但形成一系列体系完整、风格明显的设计却并不容易。荷兰工业设计师皮特·海因埃克(PIETHEINEEK)用废木料设计的家具,从1990年初开始至今已创造出了独特的美学风格,也为自己创造出了不同凡响的设计声望。 | Leeble Piet Hein Eek | 2013 | 设计2013，26，4： | 2 |
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