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| 1 | Inflammation and colorectal cancer, when microbiota-host mutualism breaks显示文摘Structural changes in the gut microbial community have been shown to accompany the progressive development of colorectal cancer.In this review we discuss recent hypotheses on the mechanisms involved in the bacteria-mediated carcinogenesis,as well as the triggering factors favoring the shift of the gut microbiota from a mutualistic to a pro-carcinogenic configuration.The possible role of inflammation,bacterial toxins and toxic microbiota metabolites in colorectal cancer onset is specifically discussed.On the other hand,the strategic role of inflammation as the keystone factor in driving microbiota to become carcinogenic is suggested.As a common outcome of different environmental and endogenous triggers,such as diet,aging,pathogen infection or genetic predisposition,inflammation can compromise the microbiota-host mutualism,forcing the increase of pathobionts at the expense of health-promoting groups,and allowing the microbiota to acquire an overall pro-inflammatory configuration.Consolidating inflammation in the gut,and favoring the bloom of toxigenic bacterial drivers,these changes in the gut microbial ecosystem have been suggested as pivotal in promoting carcinogenesis.In this context,it will become of primary importance to implement dietary or probiotics-based interventions aimed at preserving the microbiota-host mutualism along aging,counteracting deviations that favor a pro-carcinogenic microbiota asset. | Marco Candela Silvia Turroni Elena Biagi Franck Carbonero Simone Rampelli Carla Fiorentini Patrizia Brigidi | 2014 | World Journal of Gastroenterology2014，20，4： | 13 |
| 2 | Lactobacilli,bifi dobacteria and E.coli nissle induce pro-and anti-inflammatory cytokines in peripheral blood mononuclear cells显示文摘AIM: To investigate whether the stimulation of peripher- al blood mononuclear cells (PBMNC) with the cell debris and cell extraction of different probiotic strains is similar or species specifi c. METHODS: Three strains of bifi dobacteria, 4 strains of lactobacilli, and E. coli nissle were sonicated and centri- fuged in order to divide them into cell extract and cell debris. PBMNC were separated by density gradient and incubated for 36 h with either the cell debris or the cell extract of single strains of probiotic bacteria in doses from 102 to 108 CFU/mL. Cell supernatants were taken and interleukin (IL)-10, IL-1β, and tumor necosis factor (TNF)-α were determined by ELISA. RESULTS: Depending on the species super-family, the strains had different stimulation patterns. Except for both L. casei strains, the cell extract of bifidobacteriaand lactobacilli had less stimulating capacity than cell debris, whereas the cell extract of E. coli nissle had simi- lar stimulating properties to that of the cell debris of the strain and significantly more stimulating capacity than that of bifi dobacteria and lactobacilli. The cell debris of bifi dobacteria stimulated more cytokine release than the cell debris of lactobacilli. The cell debris of lactobacilli did not have a stimulating capacity when lower concentra- tions were used. Neither cell extraction nor cell debris had an inhibitory effect on the production of the tested cytokines by stimulated PBMNC. CONCLUSION: The incubation of probiotic strains, which have been used in clinical trials for inflammatory diseases, with immunocompetent cells leads to different species specifi c reactions. High IL-10 response to cell de- bris of bifi dobacteria and E. coli nissle can be found. This corresponds to positive effects of bifi dobacteria and E. coli nissle in clinical trials for inflammatory bowel disease compared to negative outcomes obtained with lactoba- cilli. | Ulf Helwig Karen M Lammers Fernando Rizzello Patricia Brigidi Verena Rohleder Elisabetta Caramelli Paolo Giochetti Juergen Schrezenmeir Ulrich R Foelsch Stefan Schreiber Massimo Campieri | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 3 | Effects of probiotic bacteria on gastrointestinal motility in guinea-pig isolated tissue显示文摘AIM: To evaluate the intestinal motility changes evoked by 8 bacterial strains belonging to Bifidobacterium , Lactobacillus and Streptococcus genera within the probiotic preparation VSL#3. METHODS: Ileum and proximal colon segments isolated from guinea-pigs were used as a study model. Entire cells and cell fractions (cell debris, cell wall fraction, cytoplasmatic fraction, proteinaceous and non- proteinaceous cytoplasmatic components) of VSL#3 strains and, as controls, Escherichia coli, Salmonella aboni and Bacillus licheniformis were tested in this in vitro model. RESULTS: Among the bacterial cell fractions tested, only the cytoplasmatic fraction modified intestinal motility. Lactobacillus strains stimulated the contraction of ileum segment, whereas all probiotic strains tested induced proximal colon relaxation response. The non-proteinaceous cytoplasmatic components were responsible for the colon relaxation. CONCLUSION: The results obtained in this study suggest that the proximal colon relaxation activity showed by the probiotic bacteria could be one of the possible mechanisms of action by which probiotics exert their positive effects in regulating intestinal motility. | Matteo Massi Pierfranco Ioan Roberta Budriesi Alberto Chiarini Beatrice Vitali Karen M Lammers Paolo Gionchetti Massimo Campieri Anthony Lembo Patrizia Brigidi | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 4 | Antibiotics and probiotics in chronic pouchitis:A comparative proteomic approach显示文摘AIM:To profile protein expression in mucosal biopsies from patients with chronic refractory pouchitis following antibiotic or probiotic treatment,using a comparative proteomic approach. METHODS:Two-dimensional polyacrylamide gel electrophoresis and matrix-assisted laser desorption/ ionization-time of flight mass spectrometry were used to characterize the changes related to antibiotic therapy in the protein expression profiles of biopsy samples from patients with chronic refractory pouchitis.The same proteomic approach was applied to identify differentially expressed proteins in the non-inflamed pouch before and after probiotic administration. RESULTS:In the first set of 2D gels,26 different proteins with at least 2-fold changes in their expression levels between the pouchitis condition and antibiotic-induced remission were identified.In the second set of analysis,the comparison between mucosal biopsy proteomes in the normal and probiotic-treated pouch resulted in 17 significantly differently expressed proteins.Of these,8 exhibited the same pattern of deregulation as in the pouchitis/pouch remission group. CONCLUSION:For the first time,2D protein maps of mucosal biopsies from patients with ileal pouch-anal anastomosis were provided,and differentially expressed proteins following antibiotic/probiotic treatment were identified. | Silvia Turroni Beatrice Vitali Marco Candela Paolo Gionchetti Fernando Rizzello Massimo Campieri Patrizia Brigidi | 2010 | World Journal of Gastroenterology2010，16，1： | 3 |
| 5 | Ageing and gut microbes: Perspectives for health maintenance and longevity显示文摘 | Elena Biagi Marco Candela Silvia Turroni Paolo Garagnani Claudio Franceschi Patrizia Brigidi | 2012 | Pharmacological Research2012，，： | 2 |
| 6 | Microbes Central to Human Reproduction显示文摘 | Gregor Reid Patrizia Brigidi Jeremy P. Burton Nikhat Contractor Sylvia Duncan Emilie Fargier Colin Hill Sarah Lebeer Rocio Martín Andrew J. McBain Gil Mor Catherine O’Neill Juan Miguel Rodríguez Jonathan Swann Saskia Hemert Juliett Ansell | 2015 | Am J Reprod Immunol2015，，1： | 1 |
| 7 | hnmunomodulatory effects of probiotic bacteria DNA: IL-1 and IL-10 response in human peripheral blood mononuclear cells 显示文摘 | Lammers KM Brigidi P Vitali B | 2003 | FEMS Immunol Med Mierobiol2003，38，2： | 1 |
| 8 | Genetic transformation of intact ceils of Bacillus subtilis by electroporation 显示文摘 | Brigidi P Rossi E D Bertarini M L | 1990 | FEMS Microbiology Letters1990，67，12： | 1 |
| 9 | Hyperinsulinemiadrives diet-induced obesity independently of brain insulin produc-tion 显示文摘 | Mehran AE Templeman NM Brigidi GS | 2012 | Cell Metab2012，16，6： | 1 |
| 10 | Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial显示文摘 | Paolo Gionchetti Fernando Rizzello Ulf Helwig Alessandro Venturi Karen Manon Lammers Patrizia Brigidi Beatrice Vitali Gilberto Poggioli Mario Miglioli Massimo Campieri | 2003 | Gastroenterology2003，，5： | 1 |
| 11 | PCR detection of Bifidobacterium strains and Streptococcus thermophilus in feces of human subjects after oral bacteriotherapy and yogurt consumption显示文摘 | Patrizia Brigidi Erwin Swennen Beatrice Vitali Maddalena Rossi Diego Matteuzzi | 2002 | International Journal of Food Microbiology2002，，3： | 1 |
| 12 | Intestinal microbiota is a plastic factor responding to environmental changes显示文摘 | Marco Candela Elena Biagi Simone Maccaferri Silvia Turroni Patrizia Brigidi | 2012 | Trends in Microbiology2012，，8： | 1 |
| 13 | Immunomodulatory effects of probiotic bacteria DNA : IL-1 and IL-10 response in human peripheral blood mononuclear cells 显示文摘 | LAMMERS K M BRIGIDI P VITALI B | 2003 | FEMS Immunol Med Microbiol2003，38，2： | 1 |
| 14 | Characterization and molecular cloning of Bifidobacterium longum cryptic plasmid PMB1 显示文摘 | MATTEUZZI D BRIGIDI P | 1990 | Lett App Microbiol1990，，11： | 1 |
| 15 | Potential role of the gut microbiota in synthetic torpor and therapeutic hypothermia显示文摘Therapeutic hypothermia is today used in several clinical settings, among them the gut related diseases that are influenced by ischemia/reperfusion injury. This perspective paved the way to the study of hibernation physiology, in natural hibernators, highlighting an unexpected importance of the gut microbial ecosystem in hibernation and torpor. In natural hibernators, intestinal microbes adaptively reorganize their structural configuration during torpor, and maintain a mutualistic configuration regardless of long periods of fasting and cold temperatures. This allows the gut microbiome to provide the host with metabolites, which are essential to keep the host immunological and metabolic homeostasis during hibernation. The emerging role of the gut microbiota in the hibernation process suggests the importance of maintaining a mutualistic gut microbiota configuration in the application of therapeutic hypothermia as well as in the development of new strategy such as the use of synthetic torpor in humans. The possible utilization of tailored probiotics to mold the gut ecosystem during therapeutic hypothermia can also be taken into consideration as new therapeutic strategy. | Claudia Sisa Silvia Turroni Roberto Amici Patrizia Brigidi Marco Candela Matteo Cerri | 2017 | World Journal of Gastroenterology2017，23，3： | 1 |
| 16 | Cloning of the gene for cholesterol oxidase in Bacillus spp, Lactobacillus reuteri and its expression in Escheriehia coli显示文摘 | Brigidi P Bolognani F Rossi M | 1993 | Lett Appl Microbiol1993，17，2： | 1 |
| 17 | Antimicrobial susceptibility of Bifidobaeterium显示文摘 | Matteuzzi D Crociani F Brigidi P | 1983 | Annual of Institute Pasteur Microbiology1983，134，3： | 1 |
| 18 | Immunomodulatory effects of probiotic bacteria DNA: IL-1 and IL-10 response in human peripheral blood mononuclear cells显示文摘 | Karen Manon Lammers Patrizia Brigidi Beatrice Vitali Paolo Gionchetti Fernando Rizzello Elisabetta Caramelli Diego Matteuzzi Massimo Campieri | 2003 | FEMS Immunology and Medical Microbiology2003，，2： | 1 |
| 19 | Protocol for the use of PCR-denaturing gradient gel electrophotesis and quantitative PCR to determine vaginal microflora constitution and pathogens in bacterial vaginosis 显示文摘 | Vitali B Biagi E Brigidi P | 2012 | Methods Mol Biol2012，903，： | 1 |
| 20 | Effect of a new synbiotic supplement on symptoms, stool consistency, intestinal transit time and gut microbiota in patients with severe functional constipation: a pilot randomized double-blind, controlled trial显示文摘 | G. Bazzocchi T. Giovannini C. Giussani P. Brigidi S. Turroni | 2014 | Techniques in Coloproctology2014，，10： | 1 |
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