|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Inflammation and colorectal cancer, when microbiota-host mutualism breaks显示文摘Structural changes in the gut microbial community have been shown to accompany the progressive development of colorectal cancer.In this review we discuss recent hypotheses on the mechanisms involved in the bacteria-mediated carcinogenesis,as well as the triggering factors favoring the shift of the gut microbiota from a mutualistic to a pro-carcinogenic configuration.The possible role of inflammation,bacterial toxins and toxic microbiota metabolites in colorectal cancer onset is specifically discussed.On the other hand,the strategic role of inflammation as the keystone factor in driving microbiota to become carcinogenic is suggested.As a common outcome of different environmental and endogenous triggers,such as diet,aging,pathogen infection or genetic predisposition,inflammation can compromise the microbiota-host mutualism,forcing the increase of pathobionts at the expense of health-promoting groups,and allowing the microbiota to acquire an overall pro-inflammatory configuration.Consolidating inflammation in the gut,and favoring the bloom of toxigenic bacterial drivers,these changes in the gut microbial ecosystem have been suggested as pivotal in promoting carcinogenesis.In this context,it will become of primary importance to implement dietary or probiotics-based interventions aimed at preserving the microbiota-host mutualism along aging,counteracting deviations that favor a pro-carcinogenic microbiota asset. | Marco Candela Silvia Turroni Elena Biagi Franck Carbonero Simone Rampelli Carla Fiorentini Patrizia Brigidi | 2014 | World Journal of Gastroenterology2014，20，4： | 13 |
| 2 | Global and Deep Molecular Analysis of Microbiota Signatures in Fecal Samples From Patients With Irritable Bowel Syndrome显示文摘 | Mirjana Rajili?–Stojanovi? Elena Biagi Hans G.H.J. Heilig Kajsa Kajander Riina A. Kekkonen Sebastian Tims Willem M. de Vos | 2011 | Gastroenterology2011，，5： | 8 |
| 3 | Targeting of acute myeloid leukaemia by cytokine‐induced killer cells redirected with a novel CD 123‐specific chimeric antigen receptor显示文摘 | Sarah Tettamanti Virna Marin Irene Pizzitola Chiara F. Magnani Greta M. P. Giordano Attianese Elisabetta Cribioli Francesca Maltese Stefania Galimberti Angel F. Lopez Andrea Biondi Dominique Bonnet Ettore Biagi | 2013 | Br J Haematol2013，，3： | 3 |
| 4 | Failure of interferon-γ pre-treated mesenchymal stem cell treatment in a patient with crohn's disease显示文摘Mesenchymal stem cells(MSC) are cells of stromal origin which exhibit unlimited self-renewal capacity and pluripotency in vitro.It has recently been observed that MSC may also exert a profound immunosuppressive and anti-inflammatory effect both in vitro and in vivo with consequent potential use in autoimmune disorders.We present the case of a patient suffering from childhood-onset, multidrug resistant and steroiddependent Crohn's disease who underwent systemic infusions of MSC, which led to a temporary reduction in CCR4, CCR7 and CXCR4 expression by T-cells, and a temporary decrease in switched memory B-cells, In addition, following MSC infusion, lower doses of steroids were needed to inhibit proliferation of the patient's peripheral blood mononuclear cells.Despite these changes, no significant clinical benefit was observed, and the patient required rescue therapy with infliximab and subsequent autologous hematopoietic stem cell transplantation.The results of biological and in vitro observations after MSC use and the clinical effects of infusion are discussed, and a brief description is provided of previous data on MSC-based therapy in autoimmune disorders. | Andrea Taddio Alberto Tommasini Erica Valencic Ettore Biagi Giuliana Decorti Sara De Iudicibus Eva Cuzzoni Giuseppe Gaipa Raffaela Badolato Alberto Prandini Andrea Biondi Alessandro Ventura | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 5 | Ageing and gut microbes: Perspectives for health maintenance and longevity显示文摘 | Elena Biagi Marco Candela Silvia Turroni Paolo Garagnani Claudio Franceschi Patrizia Brigidi | 2012 | Pharmacological Research2012，，： | 2 |
| 6 | Gastrointestinal manifestations in myotonic muscular dystrophy显示文摘Myotonic (MD ) 被肌强直的现象和进步肌肉发达的软弱描绘。胃肠道的参与是经常的并且可以发生在任何水平。临床的表明以前被归因于改变的平滑肌损坏,而是 histologic 证据引起的活动性混乱少见、冲突。一个神经因素也被假设了。,在更低的道在上面的消化道,咽下困难,心痛,流回和消化不良是最普通的抱怨,腹的疼痛,膨胀并且在肠习惯的变化经常被报导。消化症状可以是营养不良的疾病的第一症状并且可以先于肌与骨的特征。胃肠的功能的缺陷可能有时是那么渐渐的病人与症状的很少了解适应它。不在内视镜的如此的情况常规和 ultrasonographic 评估是足够、指向的技术(胃电描记法,测压法,肌电描记法,功能的 ultrasonography, scintigraphy,等等) 被需要。而与骨胳的肌肉疾病的持续时间的积极关联被报导了,在胃肠的骚乱的骨胳的肌肉参与和存在和严厉的度之间有低关联。这些药为对待象专业版那样的胃肠的抱怨推荐了运动的、反消化不良的药和 laxatives,主要针对改正活动性混乱。自从许多重要问题仍然是未解决的,在 MD 的胃肠的参与仍然是一个复杂、吸引人的条件。专注于基因方面,早诊断的技术和新治疗学的策略的发展的进一步的研究被需要改进我们 MD 的胃肠的表明的管理。 | Massimo Bellini Sonia Biagi Cristina Stasi Francesco Costa Maria Gloria Mumolo Angelo Ricchiuti Santino Marchi | 2006 | World Journal of Gastroenterology2006，12，12： | 2 |
| 7 | Antigen induced regulatory T cells显示文摘 | Vigouroux S Yvon E Biagi E | 2004 | Blood2004，104，1： | 1 |
| 8 | Reorganisation of the somatosensory system after early brain damage显示文摘 | Guzzetta A Bonanni P Biagi L | 2007 | Clinical Neurophysiology:Official Journal Of The International Federation Of Clinical Neurophysiology2007，118，5： | 1 |
| 9 | A phase Ⅱ study of dexamethasone, ifosfamide, cisplatin and etoposide(DICE) as salvage chemotherapy for patients with relapsed and refractory lymphoma显示文摘 | Biagi J J Herbert K E Smith C | 2005 | Leuk Lymphoma2005，46，2： | 1 |
| 10 | Extra-ordinary salmon growth 显示文摘 | Devlin R H Yesaki T Y Biagi C A | 1994 | Nature1994，371，： | 1 |
| 11 | Genetic mapping of Y-chormosomal DNA markersin Pacific salmon显示文摘 | Devlin R H Biagi C A Smailus D E | 2001 | Genetica2001，111，： | 1 |
| 12 | Temperature Variations Related to Earthquakes from Simultaneous Observation at the Ground Stations and by Satellites in Kamchatka area 显示文摘 | Tronin A A Biagi P F Molchanov 0 A | 2004 | Physics and Chemistry of the Earth2004，29，49： | 1 |
| 13 | Heart failure, oxidative stress, and allopurinol 显示文摘 | Biagi P Abate L | 2005 | Monaldi Arch Chest Dis2005，64，1： | 1 |
| 14 | Anti-goblet cell antibodies for the diagnosis of autoimmune enteropathy 显示文摘 | Biagi F Bianchi PI Trotta L | 2009 | Am J Gastroenterol2009，104，12： | 1 |
| 15 | Mesenchymal Stem/Stromal Cells: A New ’’Cells as Drugs’’ Paradigm. Efficacy and Critical Aspects in Cell Therapy显示文摘 | Laura de Girolamo Enrico Lucarelli Giulio Alessandri Maria Antonietta Avanzini Maria Ester Bernardo Ettore Biagi Anna Teresa Brini Giovanna D’Amico Franca Fagioli Ivana Ferrero Franco Locatelli Rita Maccario Mario Marazzi Ornella Parolini Augusto Pessina | 2013 | Current Pharmaceutical Design2013，，： | 1 |
| 16 | Gadolinium blocks low- and high- threshold calcium currents in pituitary cells 显示文摘 | Biagi BA Enyeart JJ | 1990 | Am Jounal of Physiol1990，259，： | 1 |
| 17 | Association be- tween time to initiation of adjuvant chemotherapy and surviv- al in colorectal cancer: a systematic review and meta-analy- sis显示文摘 | Biagi J J Raphael M J Maekillop WJ | 2011 | JAMA2011，305，22： | 1 |
| 18 | Is gliadin mispresented to the immune system in celiac disease? A hypothesis显示文摘 | BIAGI F ZIMMERL K THOMAS P | | 0，，： | 1 |
| 19 | Effect of gluconic acid on piglet growth performance,intestinal microflora,and intestinal wall morphology显示文摘 | BIAGI G PIVA A MOSCHIN! M | 2006 | J Anita Sci2006，，84： | 1 |
| 20 | Antigen-induced regulatory T cells显示文摘 | Vigouroux S Yvon E Biagi E | 2004 | Blood2004，104，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员