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| 1 | Autophagy: for better or for worse显示文摘Autophagy 是降级的降级小径损坏了的 lysosomal 或过剩房间部件进基本 biomolecules,它然后回来被再循环进 cytosol。在这个方面, autophagy 在一个连续降级新生周期驾驶 biomolecules 的流动。Autophagy 通常被认为在应力或差的滋养的条件下面保护房间的支持幸存的机制。当前的研究清楚地证明 autophagy 在重要生物过程完成众多的功能。它在开发被含有,区别,天生、适应的免疫,变老并且房间死亡。另外,积累证据表明在 autophagy 和几人的疾病和肿瘤开发之间的有趣的连接。因此, autophagy 似乎是在细胞和有机体的生活和死亡的一个重要播放器。尽管有 autophagy 的增长知识, autophagic 机械通过调整这些多样的过程的机制完全没被理解。在这评论,我们给表明小径的 autophagic 的全面概述,它的角色一般来说细胞的过程和它的连接到房间死亡。另外,我们在场发信号到疾病的有缺点的 autophagic 的可能的贡献的简短概述。 | Ellen Wirawan Tom Vanden Berghe Saskia Lippens Patrizia Agostinis Peter Vandenabeele | 2012 | Cell Research2012，22，1： | 70 |
| 2 | 干辣椒风味物质气相色谱及质谱方法的研究显示文摘用嗅觉测量法-气相色谱联用(GC-O),火焰离子检测器-气相色谱联用(GC-FID),质谱-气相色谱联用(GC-MS)三种气相色谱检测方法和常压化学离子化飞行时间质谱(APCI-TOFMS),质子传递反应质谱(PTR-MS)两种直接质谱检测方法来比较测定干辣椒中的挥发性香味成分。干辣椒的挥发性香味成分的大体描述最后由感官评定来确定。三种较显著的风味分别是:辣椒味、煮熟蔬菜味和青草味。用气质联用顶空分析法共有63种挥发性香味成分被分离出来。而嗅觉测量法-气相色谱联用(GC-O)认为其中的11种成分决定了辣椒的香味活跃程度。在所有的方法中普遍认为:3-甲基正丁醛是最活跃的香味成份,其次是2-甲基正丁醛。确定挥发性香味成分的多少主要是受测定方法的影响。色谱方法之间有很强的相关性(ρ=0.946)。直接质谱法相关性不显著(ρ=0.613)。经过不同方法的分析,我们发现,用GC-MS,GC-FID和PTR-MS三种方法检测出的挥发性香味成分并没有显著的不同,显著性的差异主要存在于PCI-TOFMS法和其工艺的不同(P<0.01).(Int J Mass Spectrom223-224(2003)55-65) | Saskia van Ruth Elena Boscaini Dagmar Mayr Jonathan Pugh Maarten Posthumus 刘蓉 刘志敏 | 2007 | 辣椒杂志2007，，1： | 15 |
| 3 | The treatment of Parkinson's disease with deep brain stimulation: current issues显示文摘Deep brain stimulation has become a well-established symptomatic treatment for Parkinson's disease during the last 25 years. Besides improving motor symptoms and long-term motor complications, positive effects on patients' mobility, activities of daily living, emotional well-being and health-related quality of life have been recognized. Apart from that, numerous clinical trials analyzed effects on non-motor symptoms and side effects of deep brain stimulation. Several technical issues and stimulation paradigms have been and are still being developed to optimize the therapeutic effects, minimize the side effects and facilitate handling. This review summarizes current therapeutic issues, i.e., patient and target selection, surgical procedure and programming paradigms. In addition it focuses on neuropsychological effects and side effects of deep brain stimulation. | Alexia-Sabine Moldovan Stefan Jun Groiss Saskia Elben Martin Südmeyer Alfons Schnitzler Lars Wojtecki | 2015 | Neural Regeneration Research2015，10，7： | 8 |
| 4 | 提供免费眼镜对中国学龄儿童学习成绩的影响:整群随机对照试验显示文摘目的探讨免费眼镜对中国农村近视儿童学习成绩的影响。设计仅对研究者进行设盲的整群随机对照研究。地点2012-2013年,中国西部的两个市的252所学校。研究对象在19934名小学四、五年级儿童中的、任一眼裸眼视力〈6/12且戴镜视力可提高至〉6/12的3177名(平均龄10.5岁)儿童,其中的3052名(96.0%)儿童完成了整个研究。干预措施纳入研究的儿童在学年开始时,以学校为单位(平均每组84所学校)随机分为3组,分别接受以下干预:仅获得配镜处方(此组为本研究的对照组),获得项目指定眼镜店换取眼镜的凭证,或现场获取免费眼镜。主要结果指标末次检查(研究结束)时的戴镜率和研究结束时用专门设计的数学测试考核的成绩(用研究开始的成绩进行调整,以标准差的改变来度量)。结果3177名纳入的儿童被随机分配到对照组(1036名,占32.6%)、凭证组(988名,占31.1%)和免费眼镜组(1153名,占36.3%)。虽然所有儿童戴镜后视力均有提高,但在研究开始时,仅15%的儿童配戴了眼镜。研究结束时免费眼镜组观察到的戴镜率为41%,儿童自诉的戴镜率为68%;对照组观察到的戴镜率为26%,儿童自诉的戴镜率为37%。相对于对照组,免费眼镜组对学习成绩影响为0.11标准差(SD)[95%可信区间(CI)0.01—0.21,P=0.03]。调整后的免费眼镜的效应(0.10SD,95%CI0.002~0.19;P=0.04)也远远大于父母的受教育程度(0.03,95%CI-0.04~0.09)及家庭的富裕程度(0.01,95%CI-0.06~0.08)。虽然组间有统计学差异,但差异的幅度还是比用于样本量计算的幅度,即0.20SD小。结论尽管儿童的依从性并不是非常好,向儿童提供免费眼镜对于提高儿童的数学成绩有统计学意义,但各组间差异小于预期。本研究中,儿童的近视患病率较高但戴镜率却很低。 | 马晓晨 周钟强 易红梅 庞晓鹏 史耀疆 陈倩韵 Mirjam E. Meltzer Saskia le Cessie 何明光 Scott Rozelle 刘奕志 Nathan Congdon | 2014 | 英国医学杂志中文版2014，17，6： | 7 |
| 5 | Wireless Acoustic Sensor Networks and Edge Computing for Rapid Acoustic Monitoring显示文摘Passive acoustic monitoring is emerging as a promising solution to the urgent, global need for new biodiversity assessment methods. The ecological relevance of the soundscape is increasingly recognised, and the affordability of robust hardware for remote audio recording is stimulating international interest in the potential for acoustic methods for biodiversity monitoring.The scale of the data involved requires automated methods,however, the development of acoustic sensor networks capable of sampling the soundscape across time and space and relaying the data to an accessible storage location remains a significant technical challenge, with power management at its core. Recording and transmitting large quantities of audio data is power intensive,hampering long-term deployment in remote, off-grid locations of key ecological interest. Rather than transmitting heavy audio data, in this paper, we propose a low-cost and energy efficient wireless acoustic sensor network integrated with edge computing structure for remote acoustic monitoring and in situ analysis.Recording and computation of acoustic indices are carried out directly on edge devices built from low noise primo condenser microphones and Teensy microcontrollers, using internal FFT hardware support. Resultant indices are transmitted over a ZigBee-based wireless mesh network to a destination server.Benchmark tests of audio quality, indices computation and power consumption demonstrate acoustic equivalence and significant power savings over current solutions. | Zhengguo Sheng Saskia Pfersich Alice Eldridge Jianshan Zhou Daxin Tian Victor C.M.Leung | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，1： | 6 |
| 6 | Effect of soil management on soil erosion on sloping farmland during crop growth stages under a large-scale rainfall simulation experiment显示文摘Soil erosion on farmland is a critical environmental issue and the main source of sediment in the Yellow River, China. Thus, great efforts have been made to reduce runoff and soil loss by restoring vegetation on abandoned farmland. However, few studies have investigated runoff and soil loss from sloping farmland during crop growth season. The objective of this study was to investigate the effects of soil management on runoff and soil loss on sloping farmland during crop growth season. We tested different soybean growth stages (i.e., seedling stage (R1), initial blossoming stage (R2), full flowering stage (R3), pod bearing stage (R4), and initial filling stage (R5)) and soil management practice (one plot applied hoeing tillage (HT) before each rainfall event, whereas the other received no treatment (NH)) by applying simulated rainfall at an intensity of 80 mm/h. Results showed that runoff and soil loss both decreased and infiltration amount increased in successive soybean growth stages under both treatments. Compared with NH plot, there was less runoff and higher infiltration amount from HT plot. However, soil loss from HT plot was larger than that from NH plot in R1–R3, but lower in R4 and R5. In the early growth stages, hoeing tillage was effective for reducing runoff and enhancing rainfall infiltration. By contrast, hoeing tillage enhanced soil and water conservation during the late growth stages. The total soil loss from HT plot (509.0 g/m^2) was 11.1% higher than that from NH plot (457.9 g/m^2) in R1–R5. However, the infiltration amount from HT plot (313.9 mm) was 18.4% higher than that from NH plot (265.0 mm) and the total runoff volume from HT plot was 49.7% less than that from NH plot. These results indicated that crop vegetation can also act as a type of vegetation cover and play an important role on sloping farmland. Thus, adopting rational soil management in crop planting on sloping farmland can effectively reduce runoff and soil loss, as well as maximize rainwater infiltration during crop growth period. | WANG Linhua WANG Yafeng Keesstra SASKIA Cerdà ARTEMI MA Bo WU Faqi | 2018 | Journal of Arid Land2018，10，6： | 5 |
| 7 | Soil Physical Quality of Citrus Orchards Under Tillage, Herbicide, and Organic Managements显示文摘Soil capacity to support life and to produce economic goods and services is strongly linked to the maintenance of good soil physical quality(SPQ). In this study, the SPQ of citrus orchards was assessed under three different soil managements, namely no-tillage using herbicides, tillage under chemical farming, and no-tillage under organic farming. Commonly used indicators, such as soil bulk density,organic carbon content, and structural stability index, were considered in conjunction with capacitive indicators estimated by the Beerkan estimation of soil transfer parameter(BEST) method. The measurements taken at the L'Alcoleja Experimental Station in Spain yielded optimal values for soil bulk density and organic carbon content in 100% and 70% of cases for organic farming. The values of structural stability index indicated that the soil was stable in 90% of cases. Differences between the soil management practices were particularly clear in terms of plant-available water capacity and saturated hydraulic conductivity. Under organic farming, the soil had the greatest ability to store and provide water to plant roots, and to quickly drain excess water and facilitate root proliferation.Management practices adopted under organic farming(such as vegetation cover between the trees, chipping after pruning, and spreading the chips on the soil surface) improved the SPQ. Conversely, the conventional management strategies unequivocally led to soil degradation owing to the loss of organic matter, soil compaction, and reduced structural stability. The results in this study show that organic farming has a clear positive impact on the SPQ, suggesting that tillage and herbicide treatments should be avoided. | Simone DI PRIMA Jesus RODRIGO-COMINO Agata NOVARA Massimo IOVINO Mario PIRASTRU Saskia KEESSTRA Artemi CERDA | 2018 | Pedosphere2018，28，3： | 4 |
| 8 | 珠三角地区建设用地扩张与经济、人口变化之间相互作用的时空演变特征分析(英文)显示文摘Since 1979,the Pearl River Delta(PRD) of China has experienced rapid socioeconomic development along with a fast expansion of construction area. Affected by both natural and human factors,a complex interdependency is found among the regional changes in construction area,GDP and population. A quantitative analysis of the four phases of the regional land use data extracted from remote sensing images and socioeconomic statistics spanning 1979 to 2009 demonstrates that the proportion of construction area in the PRD increased from 0.5% in 1979 to 10.8% in 2009,accompanied with a rapid loss of agricultural land. An increase of one million residents was associated with an increase of GDP of approximately 32 billion yuan before 2000 and approximately 162 billion yuan after 2000. Because the expansion of construction area has approached the limits of land resource in some cities of the PRD,a power function is found more suitable than a linear one in describing the relationship between GDP and construction area. Consequently,the Logistic model is shown to provide more accurate predictions of population growth than the Malthus model,particularly in some cities where a very large proportion of land resource has been urbanized,such as Shenzhen and Dongguan. | 刘志佳 黄河清 Saskia E.WERNERS 闫丹 | 2016 | Journal of Geographical Sciences2016，26，2： | 4 |
| 9 | Human immune cells' behavior and survival under bioenergetically restricted conditions in an in vitro fracture hematoma model显示文摘骨头骨折愈合的起始的煽动性的阶段为愈合的过程的结果代表关键步。然而,开始这个煽动性的阶段的机制和在破裂地点在场的有免疫力的房间的功能糟糕被理解。以便在破裂 hematoma 以内学习早事件,我们建立了一在里面 vitro 破裂 hematoma 模型:我们有教养的 hematomas 在 bioenergetically 控制的条件下面在 vitro 在全部的新潮的关节造形术(THA ) 期间在腿节的截骨术(人工的骨头破裂) 期间形成。这个模型允许我们在跟随破裂的早阶段期间监视有免疫力的房间人口,房间幸存和 cytokine 表示。而且,这个模型使我们能改变 bioenergetical 条件以便模仿在里面 vivo 状况,它被假定被组织缺氧描绘并且限制了营养素的数量。用这个模型,我们发现有免疫力的房间经由 angiogenic 因素, chemoattractants 和支持 inflammatory 分子的表示适应组织缺氧。另外,联合了氧的限制,滋养的供应与 myeloid 的比较提高了淋巴细胞的选择幸存导出的房间(即, neutrophils ) 。笔记,非限制的 bioenergetical 条件没关于 cytokine 表示或有免疫力的房间子集的不同幸存率显示出任何类似的效果。在结论,我们发现 bioenergetical 条件在导致骨折愈合的起始的煽动性的阶段的关键因素之中并且因此是为在早破裂 hematoma 影响有免疫力的房间的幸存和功能的一个关键步骤。 | Paula Hoff Patrick Maschmeyer Timo Gaber Tabea Schiitze Tobias Raue Katharina Schmidt-Bleek Rene Dziurla Saskia Schellmann Ferenz Leonard Lohanatha Eric Rohner Andrea Ode Gerd-Riidiger Burmester Georg N Duda Carsten Perka Frank Buttgereit | 2013 | Cellular & Molecular Immunology2013，10，2： | 3 |
| 10 | CRM1-mediated nuclear export: to the pore and beyond显示文摘 | Saskia Hutten Ralph H. Kehlenbach | 2007 | Trends in Cell Biology2007，，4： | 2 |
| 11 | 抗凝剂治疗非抗磷脂综合征妇女复发性流产(英文)显示文摘目的评价采用抗凝剂(如阿司匹林和肝素)治疗有两次自然流产史或一次近期不明原因(非遗传性血栓形成倾向)宫内胎死妇女的有效性和安全性.方法我们检索了Cochrane妊娠和分娩组临床试验注册库(2004年3月),Cochrane临床对照试验中心注册库(Cochrane图书馆2004年第1期), MEDLINE(1966.1~2004.3)及EMBASE(1980~2004.3). 我们查阅了所有检索到研究的参考文献以避免漏检.纳入对有两次自然流产史或一次近期不明原因(非遗传性血栓形成倾向)宫内胎死妇女,评估抗凝制剂治疗提高活产率效果的随机或半随机临床对照试验.干预措施包括用于预防流产的阿司匹林、未分馏肝素及低分子肝素,与安慰剂比较或互相比较.由两名作者进行文献质量评价和数据提取,数据录入RevMan并交叉核对.结果共纳入两个试验(242例患者)并均对符合评价纳入标准的妇女亚组进行了数据提取.1个试验中,54例抗心肌磷脂抗体阴性的复发性自然流产妊娠妇女随机分入低剂量阿司匹林治疗组和安慰剂组,两组活产率相似[RR=1.00, 95%CI (0.78,1.29)].另一个试验中,一个之前曾有孕20周后流产史的血栓缺陷妇女亚组共20例,随机分入依诺肝素组和阿司匹林组.与低剂量阿司匹林治疗比较,依诺肝素治疗能提高活产率[RR=10.00, 95%CI (1.56,64.20)].结论现有关于使用阿司匹林和肝素治疗该类妇女流产的有效性和安全性证据不足,现有条件下不推荐使用抗凝剂治疗.急需进行大样本安慰剂对照的随机试验. | arcello Di Nisio Louisette W.Peters Saskia Middeldorp 姚巡 | 2005 | 中国循证医学杂志2005，5，9： | 2 |
| 12 | Nanostructure in energy conversion显示文摘Nanostructured and nanosized materials are widely applied to tackle the pressing challenges associated with energy conversion. In this conceptual review, rather than highlighting separate examples, we aim to give a general overview about where and how nanostructure design can be beneficial in the three major research fields(photo)thermal chemical energy conversion, electrochemical energy conversion, and solar energy conversion. It will be shown that in many cases the design of catalytically active nanostructures is the main task and that especially for catalysts nanostructure and activity are inseparably linked to each other. Moreover, electrochemical and photochemical processes are complicated by the overlap of multiple processes that all need to be optimized, including in particular light absorption, charge migration,recombination and trapping events and surface processes. It will also be shown how the development of materials for new challenges can often be based on our knowledge on existing materials for related applications. | Saskia Buller Jennifer Strunk | 2016 | Journal of Energy Chemistry2016，25，2： | 2 |
| 13 | Can pure play internet banking survive the credit crisis?显示文摘 | Ivo J.M. Arnold Saskia E. van Ewijk | 2010 | Journal of Banking and Finance2010，，4： | 2 |
| 14 | Best Practices in Managing Investor Relations Websites: Directions for Future Research显示文摘 | Bollen Laury H Hassink Harold F de Lange Rindert K Buijl Saskia D | 2008 | Journal of Information Systems2008，，2： | 2 |
| 15 | Inflammatory Markers and Loss of Muscle Mass (Sarcopenia) and Strength显示文摘 | Laura A. Schaap Saskia M.F. Pluijm Dorly J.H. Deeg Marjolein Visser | 2006 | The American Journal of Medicine2006，，6： | 2 |
| 16 | Carbon nanotubes as conducting support for potential Mn-oxide electrocatalysts: Influences of pre-treatment procedures显示文摘Different oxygen and nitrogen containing functional groups were created on the surface of the multiwalled carbon nanotubes. The multi-walled carbon nanotubes were treated in ultrasonic bath with sulfuric or nitric acid. Furthermore the surface texture was modified by increase of the roughness. In particular after treatment with the oxidizing nitric acid, in comparison to the H_2SO_4 or ultra-sonic treated samples,craters and edges are dominating the surface structures. Manganese oxide was deposited on the multiwalled carbon nanotubes by precipitation mechanism. Various manganese oxides are formed during the deposition process. The samples were characterized by elemental analysis, microscopy, thermal analysis,Raman spectroscopy, and by the zeta potential as well as X-ray diffraction measurements. It was shown that the deposited manganese oxides are stabilized rather by surface texture of the multi-walled carbon nanotubes than by created functional groups. | Saskia Buller Marius Heise-Podleska Norbert Pfander Marc Willinger Robert Schlogl | 2016 | Journal of Energy Chemistry2016，25，2： | 2 |
| 17 | Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods显示文摘Neutralizing antibodies targeting the receptor-binding domain(RBD)of the SARS-CoV-2 spike(S)block severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)entry into cells via surface-expressed angiotensin-converting enzyme 2(ACE2).We used a surrogate virus neutralization test(sVNT)and SARS-CoV-2 S protein-pseudotyped vesicular stomatitis virus(VSV)vector-based neutralization assay(pVNT)to assess the degree to which serum antibodies from coronavirus disease 2019(COVID-19)convalescent patients interfere with the binding of SARS-CoV-2 S to ACE2.Both tests revealed neutralizing anti-SARS-CoV-2 S antibodies in the sera of ~90% of mildly and 100% of severely affected COVID-19 convalescent patients.Importantly,sVNT and pVNT results correlated strongly with each other and to the levels of anti-SARS-CoV-2 S1 IgG and IgA antibodies.Moreover,levels of neutralizing antibodies correlated with the duration and severity of clinical symptoms but not with patient age.Compared to pVNT,sVNT is less sophisticated and does not require any biosafety labs.Since this assay is also much faster and cheaper,sVNT will not only be important for evaluating the prevalence of neutralizing antibodies in a population but also for identifying promising plasma donors for successful passive antibody therapy. | Berislav Bosnjak Saskia Catherina Stein Stefanie Willenzon Anne Katrin Cordes Wolfram Puppe Gunter Bernhardt Inga Ravens Christiane Ritter Christian R.Schultze-Florey Nina Godecke Jorg Martens Hannah Kleine-Weber Markus Hoffmann Anne Cossmann Mustafa Yilmaz Isabelle Pink Marius M.Hoeper Georg M.N.Behrens Stefan Pohlm ann Rainer Blasczyk Thomas F.Schulz Reinhold Forster | 2021 | Cellular & Molecular Immunology2021，18，4： | 2 |
| 18 | A Stochastic Model Approach for Optimisation of Lowland River Restoration Works显示文摘Over the course of centuries, river systems have been heavily trained for the purpose of safe discharge of water, sediment and ice, and improves navigation. Traditionally, dikes are used to be reinforced and heightened to protect countries from ever higher flood levels. Other types of solutions than technical engineering solutions, such as measures to increase the flood conveyance capacity(e.g., lowering of groynes and floodplains, setting back dikes) become more popular. These solutions may however increase the river bed dynamics and thus impact negatively navigation, maintenance dredging and flood safety. A variety of numerical models are available to predict the impact of river restoration works on river processes. Often little attention is paid to the assessment of uncertainties. In this paper, we show how we can make uncertainty explicit using a stochastic approach. This approach helps identifying uncertainty sources and assessing their contribution to the overall uncertainty in river processes. The approach gives engineers a better understanding of system behaviour and enables them to intervene with the river system, so as to avoid undesired situations. We illustrate the merits of this stochastic approach for optimising lowland river restoration works in the Rhine in the Netherlands. | Saskia van Vuren Huib de Vriend Hermjan Barneveld | 2016 | Journal of Earth Science2016，27，1： | 2 |
| 19 | Barriers and needs in paediatric hospice home care in Germany:a qualitative inerview study with professsional experts显示文摘 | Tania Pastrana Martina Pestinger Saskia et al | 2010 | BMC hospice Care2010，9，10： | 1 |
| 20 | Microwave Chemistry显示文摘 | Saskia A Galema | 1997 | Chemical Society Reviews1997，26，3： | 1 |
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