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| 1 | Antibiotics and probiotics in treatment of inflammatory bowel disease显示文摘许多试验性、临床的观察建议肠的微植物群在煽动性的肠疾病(IBD ) 的致病起一个潜在的作用。用抗菌素或职业人员生命学的钠内容的操作代表一种潜在地有效的治疗学的选择。可得到的研究不在 ulcerative (UC ) 支持抗菌素的使用。抗菌素在对待是有效的腐败 Crohn 的疾病(CD ) 的复杂并发症但是他们主要治疗是更争论的使用,尽管这条途径经常并且成功地在临床的实践被采用。有证据关於生命的治疗可以是的那个职业人员在预防和处理有效对中等 UC 温和。相反,成功的学习数据的缺乏目前预防在 CD 的处理的专业版生命学的普遍使用。抗菌素和职业人员生命学看起来在 pouchitis 的处理和预防起一个有益的作用,进一步的审判被保证充分确定他们的临床的功效。 | Paolo Gionchetti Fernando Rizzello Karen M Lammers Claudia Morselli Lucia Sollazzi Samuel Davies Rosy Tambasco Carlo Calabrese Massimo Campieri | 2006 | World Journal of Gastroenterology2006，12，21： | 12 |
| 2 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 3 | Risk factors and outcomes of delayed graft function in renal transplant recipients receiving a steroid sparing immunosuppression protocol显示文摘AIM To analyse the risk factors and outcomes of delayed graft function(DGF) in patients receiving a steroid sparing protocol. METHODS Four hundred and twenty-seven recipients of deceased donor kidney transplants were studied of which 135(31.6%) experienced DGF. All patients received monoclonal antibody induction with a tacrolimus based, steroid sparing immunosuppression protocol.RESULTS Five year patient survival was 87.2% and 94.9% in the DGF and primary graft function(PGF) group respectively, P = 0.047. Allograft survival was 77.9% and 90.2% in the DGF and PGF group respectively, P < 0.001. Overall rejection free survival was no different between the DGF and PGF groups with a 1 and 5 year rejection free survival in the DGF group of 77.7% and 67.8% compared with 81.3% and 75.3% in the PGF group, P = 0.19. Patients with DGF who received IL2 receptor antibody induction were at significantly higher risk of rejection in the early post-transplant period than the group with DGF who received alemtuzumab induction. On multivariate analysis, risk factors for DGF were male recipients, recipients of black ethnicity, circulatory death donation, preformed DSA, increasing cold ischaemic time, older donor age and dialysis vintage.CONCLUSION Alemtuzumab induction may be of benefit in preventing early rejection episodes associated with DGF. Prospective trials are required to determine optimal immunotherapy protocols for patients at high risk of DGF. | Michelle Willicombe Anna Rizzello Dawn Goodall Vassilios Papalois Adam G Mc Lean David Taube | 2017 | World Journal of Transplantation2017，7，1： | 4 |
| 4 | Lactobacilli,bifi dobacteria and E.coli nissle induce pro-and anti-inflammatory cytokines in peripheral blood mononuclear cells显示文摘AIM: To investigate whether the stimulation of peripher- al blood mononuclear cells (PBMNC) with the cell debris and cell extraction of different probiotic strains is similar or species specifi c. METHODS: Three strains of bifi dobacteria, 4 strains of lactobacilli, and E. coli nissle were sonicated and centri- fuged in order to divide them into cell extract and cell debris. PBMNC were separated by density gradient and incubated for 36 h with either the cell debris or the cell extract of single strains of probiotic bacteria in doses from 102 to 108 CFU/mL. Cell supernatants were taken and interleukin (IL)-10, IL-1β, and tumor necosis factor (TNF)-α were determined by ELISA. RESULTS: Depending on the species super-family, the strains had different stimulation patterns. Except for both L. casei strains, the cell extract of bifidobacteriaand lactobacilli had less stimulating capacity than cell debris, whereas the cell extract of E. coli nissle had simi- lar stimulating properties to that of the cell debris of the strain and significantly more stimulating capacity than that of bifi dobacteria and lactobacilli. The cell debris of bifi dobacteria stimulated more cytokine release than the cell debris of lactobacilli. The cell debris of lactobacilli did not have a stimulating capacity when lower concentra- tions were used. Neither cell extraction nor cell debris had an inhibitory effect on the production of the tested cytokines by stimulated PBMNC. CONCLUSION: The incubation of probiotic strains, which have been used in clinical trials for inflammatory diseases, with immunocompetent cells leads to different species specifi c reactions. High IL-10 response to cell de- bris of bifi dobacteria and E. coli nissle can be found. This corresponds to positive effects of bifi dobacteria and E. coli nissle in clinical trials for inflammatory bowel disease compared to negative outcomes obtained with lactoba- cilli. | Ulf Helwig Karen M Lammers Fernando Rizzello Patricia Brigidi Verena Rohleder Elisabetta Caramelli Paolo Giochetti Juergen Schrezenmeir Ulrich R Foelsch Stefan Schreiber Massimo Campieri | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 5 | Antibiotics and probiotics in chronic pouchitis:A comparative proteomic approach显示文摘AIM:To profile protein expression in mucosal biopsies from patients with chronic refractory pouchitis following antibiotic or probiotic treatment,using a comparative proteomic approach. METHODS:Two-dimensional polyacrylamide gel electrophoresis and matrix-assisted laser desorption/ ionization-time of flight mass spectrometry were used to characterize the changes related to antibiotic therapy in the protein expression profiles of biopsy samples from patients with chronic refractory pouchitis.The same proteomic approach was applied to identify differentially expressed proteins in the non-inflamed pouch before and after probiotic administration. RESULTS:In the first set of 2D gels,26 different proteins with at least 2-fold changes in their expression levels between the pouchitis condition and antibiotic-induced remission were identified.In the second set of analysis,the comparison between mucosal biopsy proteomes in the normal and probiotic-treated pouch resulted in 17 significantly differently expressed proteins.Of these,8 exhibited the same pattern of deregulation as in the pouchitis/pouch remission group. CONCLUSION:For the first time,2D protein maps of mucosal biopsies from patients with ileal pouch-anal anastomosis were provided,and differentially expressed proteins following antibiotic/probiotic treatment were identified. | Silvia Turroni Beatrice Vitali Marco Candela Paolo Gionchetti Fernando Rizzello Massimo Campieri Patrizia Brigidi | 2010 | World Journal of Gastroenterology2010，16，1： | 3 |
| 6 | Persistent Activation of Nuclear Factor Kappa-B Signaling Pathway in Patients With Unstable Angina and Elevated Levels of C-Reactive Protein显示文摘 | Giovanna Liuzzo Matteo Santamaria Luigi M. Biasucci Michela Narducci Valeria Colafrancesco Annalisa Porto Salvatore Brugaletta Michela Pinnelli Vittoria Rizzello Attilio Maseri Filippo Crea | 2007 | Journal of the American College of Cardiology2007，，2： | 2 |
| 7 | New insights into the brain involvement in patients with Crohn’s disease: a voxel‐based morphometry study显示文摘 | A. Agostini F. Benuzzi N. Filippini A. Bertani A. Scarcelli V. Farinelli C. Marchetta C. Calabrese F. Rizzello P. Gionchetti M. Ercolani M. Campieri P. Nichelli | 2012 | Neurogastroenterology & Motility2012，，2： | 2 |
| 8 | Eviendep~ reduces number and size of duodenal polyps in familial adenomatous polyposis patients with ileal pouchanal anastomosis显示文摘AIM:To evaluate if 3 mo oral supplementation with Eviendep was able to reduce the number of duodenal polyps in familial adenomatous polyposis(FAP)patients with ileal pouch-anal anastomosis(IPAA).METHODS:Eleven FAP patients with IPAA and duodenal polyps were enrolled.They underwent upper gastrointestinal(GI)endoscopy at the baseline and after 3 mo of treatment.Each patient received 5 mg Eviendep twice a day,at breakfast and dinner time,for3 mo.Two endoscopists evaluated in a blinded manner the number and size of duodenal polyps.Upper GI endoscopies with biopsies were performed at the baseline(T0)with the assessment of the Spigelman score.Polyps>10 mm were removed during endoscopy and at the end of the procedure a new Spigelman score was determined(T1).The procedure was repeated 3 mo after the baseline(T2).Four photograms were examined for each patient,at T1 and T2.The examined area was divided into 3 segments:duodenal bulb,second and third portion duodenum.Biopsy specimens were taken from all polyps>10 mm and from all suspicious ones,defined by the presence of a central depression,irregular surface,or irregular vascular pattern.Histology was classified according to the updated Vienna criteria.RESULTS:At baseline the mean number of duodenal detected polyps was 27.7 and mean sizes were 15.8mm;the mean Spigelman score was 7.1.After polypectomy the mean number of duodenal detected polyps was 25.7 and mean sizes were 7.6 mm;the mean Spigelman score was 6.4.After 3 mo of Eviendep bid,all patients showed a reduction of number and size of duodenal polyps.The mean number of duodenal polyps was 8(P=0.021)and mean size was 4.4 mm;the mean Spigelman score was 6.6.Interrater agreement was measured.Lesions>1 cm found a very good degree of concordance(kappa 0.851)and a good concordance was as well encountered for smaller lesions(kappa 0.641).CONCLUSION:Our study demonstrated that shortterm(90 d)supplementation with Eviendep in FAP patients with IPAA and with recurrent adenomas in the duodenal mucosa,resulted effective in reducing polyps number of 32%and size of 51%. | Carlo Calabrese Chiara Praticò Andrea Calafiore Maurizio Coscia Lorenzo Gentilini Gilberto Poggioli Paolo Gionchetti Massimo Campieri Fernando Rizzello | 2013 | World Journal of Gastroenterology2013，19，34： | 2 |
| 9 | Role of inflammation in the pathogenesis of unstable coronary artery disease显示文摘 | BIASUCCI L M COLIZZI C RIZZELLO V | 1999 | Scand J Clin Invest1999，59，230： | 1 |
| 10 | Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis : a double-blind, placebo-controlled trial 显示文摘 | Gionchetti P Rizzello F Venturi A | 2000 | Gastroenterology2000，119，： | 1 |
| 11 | Effect of sour dough fermentation on stabilization and chemical and nutritional characteristics of wheat germ 显示文摘 | C G Rizzello L Nionelli R Coda | 2010 | Food Chemistry2010，119，3： | 1 |
| 12 | Prophylaxis of pouchitis onset with probiotic therapy : a double-blind, placebo-controlled trial 显示文摘 | GIONCHETTI P RIZZELLO F HELWlG U | 2003 | Gastroenter- ology2003，124，5： | 1 |
| 13 | Bran bioprocessing for enhanced functional properties 显示文摘 | Rossana Coda Kati Katina Carlo G Rizzello | 2015 | Food Science2015，1，： | 1 |
| 14 | Endometriosis and infertility Surgery and ART : An integrated approach for successful management 显示文摘 | Coccia ME Rizzello F Cammilli F | 2008 | Eur J Obstet Gynecol Reprod Biol2008，138，1： | 1 |
| 15 | Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis:a double-blind,placebo-controlled trial显示文摘 | GIONCHETTI P RIZZELLO F VENTURI A | 2000 | Gastroenterology2000，119，2： | 1 |
| 16 | Manufacture and characterization of functional emmet beverages fermented by selected lactic acid bacteria显示文摘 | CODA P RIZZELLO C G TRANI A | | Food Microbiology0，28，： | 1 |
| 17 | Antifungal activity of sourdough fermented wheat germ used as an Ingredient for bread making显示文摘 | RIZZELLO C G CASSONE A CODA R | 2011 | Food Chemistry2011，127，3： | 1 |
| 18 | Endometriosis and in- fertility surgery and ART an integrated approach for successful management 显示文摘 | Elisabetta MC Rizzello F Cammilli F | 2008 | European Journal of Obstetrics and Gynecology and Reproductive Biology2008，138，1： | 1 |
| 19 | Individual prediction of functional recovery after coronary revascularization in patients with ischemic cardiomyopthy:the scar-to-biphasic model显示文摘 | Rizzello V Schinkel AF Bax J J | 2003 | Am J Cardiol2003，91，12： | 1 |
| 20 | Long-term effects of laparoscopic sleeve gastrectomy, gastric bypass, and adjustable gastric banding on type 2 diabetes 显示文摘 | Abbatini F Rizzello M Casella G | 2010 | Surg Endosc2010，24，5： | 1 |
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