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您的检索式：作者名="Simone Rampelli"
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| 1 | Inflammation and colorectal cancer, when microbiota-host mutualism breaks显示文摘Structural changes in the gut microbial community have been shown to accompany the progressive development of colorectal cancer.In this review we discuss recent hypotheses on the mechanisms involved in the bacteria-mediated carcinogenesis,as well as the triggering factors favoring the shift of the gut microbiota from a mutualistic to a pro-carcinogenic configuration.The possible role of inflammation,bacterial toxins and toxic microbiota metabolites in colorectal cancer onset is specifically discussed.On the other hand,the strategic role of inflammation as the keystone factor in driving microbiota to become carcinogenic is suggested.As a common outcome of different environmental and endogenous triggers,such as diet,aging,pathogen infection or genetic predisposition,inflammation can compromise the microbiota-host mutualism,forcing the increase of pathobionts at the expense of health-promoting groups,and allowing the microbiota to acquire an overall pro-inflammatory configuration.Consolidating inflammation in the gut,and favoring the bloom of toxigenic bacterial drivers,these changes in the gut microbial ecosystem have been suggested as pivotal in promoting carcinogenesis.In this context,it will become of primary importance to implement dietary or probiotics-based interventions aimed at preserving the microbiota-host mutualism along aging,counteracting deviations that favor a pro-carcinogenic microbiota asset. | Marco Candela Silvia Turroni Elena Biagi Franck Carbonero Simone Rampelli Carla Fiorentini Patrizia Brigidi | 2014 | World Journal of Gastroenterology2014，20，4： | 13 |
| 2 | Over-feeding the gut microbiome: A scoping review on health implications and therapeutic perspectives显示文摘The human gut microbiome has gained increasing attention over the past two decades.Several findings have shown that this complex and dynamic microbial ecosystem can contribute to the maintenance of host health or,when subject to imbalances,to the pathogenesis of various enteric and non-enteric diseases.This scoping review summarizes the current knowledge on how the gut microbiota and microbially-derived compounds affect host metabolism,especially in the context of obesity and related disorders.Examples of microbiome-based targeted intervention strategies that aim to restore and maintain an eubiotic layout are then discussed.Adjuvant therapeutic interventions to alleviate obesity and associated comorbidities are traditionally based on diet modulation and the supplementation of prebiotics,probiotics and synbiotics.However,these approaches have shown only moderate ability to induce sustained changes in the gut microbial ecosystem,making the development of innovative and tailored microbiome-based intervention strategies of utmost importance in clinical practice.In this regard,the administration of next-generation probiotics and engineered microbiomes has shown promising results,together with more radical intervention strategies based on the replacement of the dysbiotic ecosystem by means of fecal microbiota transplantation from healthy donors or with the introduction of synthetic communities specifically designed to achieve the desired therapeutic outcome.Finally,we provide a perspective for future translational investigations through the implementation of bioinformatics approaches,including machine and deep learning,to predict health risks and therapeutic outcomes. | Monica Barone Federica D'Amico Marco Fabbrini Simone Rampelli Patrizia Brigidi Silvia Turroni | 2021 | World Journal of Gastroenterology2021，27，41： | 1 |
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