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| 1 | Esophageal tuberculosis presenting with hematemesis显示文摘Esophageal tuberculosis is rare, constituting about 0.3% of gastrointestinal tuberculosis. It presents commonly with dysphagia, cough, chest pain in addition to fever and weight loss. Complications may include hemorrhage from the lesion, development of arterioesophageal fistula, esophagocutaneous fistula or tracheoesophageal fistula. There are very few reports of esophageal tuberculosis presenting with hematemesis due to ulceration. We report a patient with hematemesis that was due to the erosion of tuberculous subcarinal lymph nodes into the esophagus. A 15-year-old boy presented with hemetemesis as his only complaint. Esophagogastroduodenoscopy(EGD) revealed an eccentric ulcerative lesion involving 50% of circumference of the esophagus. Biopsy showed caseating epitheloid granulomas with lymphocytic infiltrates suggestive of tuberculosis. Computerised tomography of the thorax revealed thickening of the mid-esophagus with enlarged mediastinal lymph nodes in the subcarinal region compressing the esophagus along with moderate right sided pleural effusion. Patient was treated with anti-tuberculosis therapy(Rifampicin, Isoniazid, Pyrazinamide, Ethambutol) for 6 mo. Repeat EGD showed scarring and mucosal tags with complete resolution of the esophageal ulcer. | Samit S Jain Piyush O Somani Rajeshkumar C Mahey Dharmesh K Shah Qais Q Contractor Pravin M Rathi | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 6 |
| 2 | 《Science》杂志发表关于计算社会科学的文章:Computational Social Science显示文摘计算科学是一门正在兴起的综合性学科,它依赖于先进的计算机及计算技术对理论科学、大型实验、观测数据、应用科学、国防以及社会科学进行模型化、模拟与仿真、计算等。特别是对极复杂系统进行模型与程序化,然后利用计算机给出严格理论及实验无法达到的过程数据或者直接模拟出整个复杂过程的演变或者预测过程的发展趋势。对基础科学、应用科学、国防科学、社会科学以及工程技术等的发展有着不可估量的科学作用与经济效益。其中,随着信息化和网络化的不断普及与深入,社会动态变化的速度和规模已经提高到一个前所未有的水平,计算科学在社会科学中的深入应用,即计算社会科学也将成为科研信息化发展中一个新的热点。本刊对《Science》2009年2月发表的一篇关于计算社会科学的文章《Computational Social Science》进行了摘编,该文由美国多个大学及研究机构的共15名研究人员共同编写,文章从计算社会科学的数据获取、研究方法及其制约因素,以及人才的培养等几个方面,描述了计算社会科学的发展、讨论了社会科学研究的特点等。其主要目的是想借此文向广大读者介绍计算社会科学这一学科理念,推动这一对于提高社会科学研究水平和规范性的研究方法在国内的发展,并以此进一步繁荣我国社会科学研究工作。 | 张鉴 孔丽华 David Lazer Alex Pentland Lada Adamic Sinan Aral Albert-László Barabási Devon Brewer Nicholas Christakis Noshir Contractor James Fowler Myron Gutmann Tony Jebara Gary King Michael Macy Deb Roy Marshall Van Alstyne | 2010 | 科研信息化技术与应用2010，0，2： | 5 |
| 3 | Development of a sensitive and rapid method for quantitation of (S)-(-)- and (R)-(+)-metoprolol in human plasma by chiral LC–ESI–MS/MS显示文摘A selective, sensitive and high throughput liquid chromatography-tandem mass spectrometry(LC–ESI–MS/MS) method has been developed for separation and quantification of metoprolol enantiomers on a chiral Lux Amylose-2(250 mm 4.6 mm, 5 mm) column. Solid phase extraction of(S)-()- and(R)-(t)-metoprolol and rac-metoprolol-d6 as an internal standard(IS)was achieved on Lichrosep DVB HL cartridges employing 200 mL human plasma. Both the analytes were chromatographically separated with a resolution factor of 2.24 using 15 mM ammonium acetate in water, pH 5.0 and 0.1%(v/v) diethyl amine in acetonitrile(50:50, v/v) as the mobile phase within 7.0 min. The precursor-product ion transitions for the enantiomers and IS were monitored in the multiple reaction monitoring and positive ionization mode. The method was validated over the concentration range of 0.500–500 ng/mL for both the enantiomers. Matrix effect was assessed by post-column analyte infusion experiment and the mean extraction recovery was greater than 94.0% for both the enantiomers at all quality control levels. The stability of analytes was evaluated in plasma and whole blood under different storage conditions. The method was successfully applied to a clinical study in 14 healthy volunteers after oral administration of200 mg metoprolol tablet under fasting conditions. The assay reproducibility is shown by reanalysis of 68 incurred samples. The suitability of the developed method was assessed in comparison | Primal Sharma Pritesh Contractor Swati Guttikar Daxesh P.Patel Pranav S.Shrivastav | 2014 | Journal of Pharmaceutical Analysis2014，4，1： | 3 |
| 4 | Upregulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide(FK228) and ATRA in acute promyelocytic leukemia cells显示文摘 | TABE Y KONOPLEVA M CONTRACTOR R | 2006 | Blood2006，107，4： | 1 |
| 5 | Majorcolorectal cancer resection should not be denied to the elderly显示文摘 | Smith JJ Lee J Burke C Contractor K B Dawson PM | 2002 | Eur J Surg Oncol2002，28，6： | 1 |
| 6 | mGluR5 has a critical role in inhibitory learning显示文摘 | Xu J Zhu Y Contractor A | | 0，，12： | 1 |
| 7 | Statins and the reduction of sudden cardiac death: antiarrbythmic or anti-isehemic effect? 显示文摘 | Beri A Contractor T Khasnis A | 2010 | Am J Cardiovasc Drugs2010，10，3： | 1 |
| 8 | Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia显示文摘 | Konopleva M Contractor R Tsao T | 2006 | Cancer Cell2006，10，5： | 1 |
| 9 | The growth of alliances in the knowledge-based economy 显示文摘 | Contractor F J Lorange P | 2002 | Intemational Business Re- view2002，，11： | 1 |
| 10 | Microbes Central to Human Reproduction显示文摘 | Gregor Reid Patrizia Brigidi Jeremy P. Burton Nikhat Contractor Sylvia Duncan Emilie Fargier Colin Hill Sarah Lebeer Rocio Martín Andrew J. McBain Gil Mor Catherine O’Neill Juan Miguel Rodríguez Jonathan Swann Saskia Hemert Juliett Ansell | 2015 | Am J Reprod Immunol2015，，1： | 1 |
| 11 | Up-regulation of MDRI and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells 显示文摘 | TABE Y KONOPLEVA M CONTRACTOR R | 2006 | Blood2006，107，4： | 1 |
| 12 | why should firms cooperate?The strategy and economics basis for cooperative ventures显示文摘 | Contractor FJ Lorange P | 1988 | Cooperative Strategies in International Business1988，，： | 1 |
| 13 | Intra-operative imprint cytology for assessing the sentinel node in breast cancer:results of its routine use over 8 years显示文摘 | Contractor K Gohel M AI-Salami E | 2009 | Eur J Surg Oncol2009，35，1： | 1 |
| 14 | The growth of alliances in the knowledgebased economy 显示文摘 | CONTRACTOR F J LORANGE P | 2002 | International Business Review2002，，11： | 1 |
| 15 | Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070(obatoclax)显示文摘 | Konopleva M Watt J Contractor R | | 0，，09： | 1 |
| 16 | A three-stage theory of international expansion: The link between multinationality and performance 显示文摘 | Contractor F J Kundu S K Hsu C C | 2003 | Journal of International Business Studies2003，34，1： | 1 |
| 17 | Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels显示文摘 | Smalley KS Contractor R Haass NK | 2007 | Br J Cancer2007，96，3： | 1 |
| 18 | Modal choice in a world of alliances: Analyzing organizational forms in the international hotel sector 显示文摘 | FAROK J CONTRACTOR SUMIT K KUNDU | 1998 | Journal of International Business Studies1998，，2： | 1 |
| 19 | Up-regulation of MDRI and induction of doxorubicin resistance by histone deacetylase inhibi- tor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells显示文摘 | Tabe Y Konopleva M Contractor R | 2006 | Blood2006，107，4： | 1 |
| 20 | How Knowledge Attributes Influence Alliance Governance Choices:A Theory Development Note显示文摘 | Contractor F J and Wonchan R | 2002 | Journal of International Management2002，8，1： | 1 |
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