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| 1 | Utility of magnetic resonance imaging in anorectal disease显示文摘Imaging of both benign and malignant anorectal diseases has traditionally posed a challenge to clinicians, and as a result history and physical exam have been relied on heavily. CT scanning and endorectal ultrasound have become popular in assessment of anatomy and staging of tumors, but have limitations. Magnetic resonance imaging (MRI) has the capability to fill in the gaps left open by more conventional imaging modalities and continues to be promising as the definitive imaging technique in the pelvis, especially with advancement of emerging technologies in this field. A comprehensive review of this topic has been undertaken. Anorectal disease is divided into three broad categories: cancer, fistula/abscess, and pelvic floor disorders. A review of the literature is performed to evaluate the use of MRI and other imaging modalities in these three areas. Preoperative imaging is useful in the evaluation of all three areas of anorectal disease. MRI is an effective tool in delineating anatomy and, when correlating with the specific clinical scenario, is an effective adjunct in clinical decision-making in order to optimize outcome. MRI continues to be a promising and novel approach to imaging various afflictions of the anorectum and the pelvic floor. Its role is more well-established in some areas than in others, and there are still signif icant limitations. As technology advances, MRI will shed more light on a complex anatomical area. | Loren Berman Gary M Israel Shirley M McCarthy Jeffrey C Weinreb Walter E Longo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Key factors in developing the trinitrobenzene sulfonic acid-induced post-inflammatory irritable bowel syndrome model in rats显示文摘AIM:To investigate the key factors in developing the trinitrobenzene sulfonic acid(TNBS)-induced postinflammatory irritable bowel syndrome(PI-IBS)model in rats. METHODS:TNBS was administered to rats at the following conditions:(1)with different doses(20,10,5 mg/0.8 mL per rat);(2)with same dose in different concentrations(20 mg/rat,25,50 mg/mL);(3)in different ethanol percentage(25%,50%);and(4)at depth either 4 cm or 8 cm from anus.At 5 d and 4 wk after TNBS administration,inflammation severity and inflammation resolution were evaluated.At 4 and 8 wk after TNBS application,visceral hyperalgesia and enterochromaffin(EC)cell hyperplasia were assayed by abdominal withdrawal reflex test,silver staining and capillary electrophoresis. RESULTS:Our results showed that:(1)TNBS induced dose-dependent acute inflammation and inflammation resolution.At 5 d post TNBS,the pathological score and myeloperoxidase(MPO)activity in all TNBS treated rats were significantly elevated compared to that of the control(9.48±1.86,8.18±0.67,5.78± 0.77 vs 0,and 3.55±1.11,1.80±0.82,0.97±0.08 unit/mg vs 0.14±0.01 unit/mg,P<0.05).At 4 wk post TNBS,the pathological score in high and median dose TNBS-treated rats were still significantly higher than that of the control(1.52±0.38 and 0.80±0.35 vs 0,P<0.05);(2)Intracolonic TNBS administration position affected the persistence of visceral hyperalgesia.At 4 wk post TNBS,abdominal withdrawal reflex (AWR)threshold pressure in all TNBS-treated groups were decreased compared to that of the control(21.52 ±1.73 and 27.10±1.94 mmHg vs 34.44±1.89 mmHg,P<0.05).At 8 wk post TNBS,AWR threshold pressure in 8 cm administration group was still significantly decreased(23.33±1.33 mmHg vs 36.79±2.29 mmHg,P<0.05);(3)Ethanol percentage affected the TNBS-induced inflammation severity and visceral hyperalgesia.In TNBS-25%ethanol-treated group,the pathological score and MPO activity were significantly lowered compared to that of the TNBS-50%ethanoltreated group,while AWR threshold pressure were significantly elevated(36.33±0.61 mmHg vs 23.33±1.33 mmHg,P<0.05);and(4)TNBS(5 mg/0.8 mL per rat, in 50%ethanol,8 cm from anus)-treated rats recovered completely from the inflammation with acquired visceral hyperalgesia and EC cell hyperplasia at 4 wk after TNBS administration.CONCLUSION:TNBS dosage,concentration,intraco-lonic administration position,and ethanol percentage play important roles in developing visceral hyperalgesia and EC cell hyperplasia of TNBS-induced PI-IBS rats. | Hong-Yan Qin Hai-Tao Xiao Justin CY Wu Brian M Berman Joseph JY Sung Zhao-Xiang Bian | 2012 | World Journal of Gastroenterology2012，18，20： | 10 |
| 3 | Assessing keloid recurrence following surgical excision and radiation显示文摘Keloids are a fibroproliferative disorder that can result from a cutaneous injury to the reticular dermis.Recurrence rates as high as 100%have been reported following surgical excision alone.Consequently,a variety of post-surgical techniques have been employed to prevent keloid recurrence,including the use of radiation.Although numerous studies have shown post-excisional X-rays,electron beam,lasers and brachytherapy can reduce the rate of keloid recurrence,numerous inconsistencies,including a wide range of definitions for keloid recurrence,make it difficult to compare study outcomes.The review aims to examine the various means for defining keloid recurrence in clinical trials involving the use of radiation therapy.Searches of the Cochrane Library and PubMed were performed to identify the available information for post-surgical keloid recurrence following radiation therapy.Each identified study was reviewed for patient followup and criteria used to define keloid recurrence.The search results included clinical studies with external beam radiation,brachytherapy and superficial radiation therapy.Many studies did not include a definition of keloid recurrence,or defined recurrence only as the return of scar tissue.Other studies defined keloid recurrence based on patient self-assessment questionnaires,symptoms and scar elevation and changes in Kyoto Scar Scale,Japan Scar Workshop Scale and Vancouver Scar Scale scores.The results of this review indicate keloidectomy followed by radiation therapy provide satisfactory recurrence rates;however,clinical studies evaluating these treatments do not describe treatment outcomes or use different definitions of keloid recurrence.Consequently,recurrence rates vary widely,making comparisons across studies difficult.Keloid recurrence should be clearly defined using both objective and subjective measures. | Michael H.Gold Mark S.Nestor Brian Berman David Goldberg | 2020 | Burns & Trauma2020，8，1： | 8 |
| 4 | Diagnosis of gastrointestinal stromal tumors: A consensus approach显示文摘 | Christopher D.M. Fletcher Jules J. Berman Christopher Corless Fred Gorstein Jerzy Lasota B.Jack Longley Markku Miettinen Timothy J. O’Leary Helen Remotti Brian P. Rubin Barry Shmookler Leslie H. Sobin Sharon W. Weiss | 2002 | Human Pathology2002，，5： | 7 |
| 5 | 黄山短尾猴的冬季产仔显示文摘动物的繁殖时间是动物在长期进化过程中对其栖息环境适应的结果。黄山的短尾猴属于季节性繁殖的动物,其产仔期一般在1~5月。但在2001年,记录了一例短尾猴在冬季产仔,产仔日期为11月29日。为分析其原因,依据1988~2001年连续14年的产仔数据及当地连续14年的气象资料(年平均气温、降水量及日照长度),统计学检验结果表明,黄山短尾猴产仔时间的推移与栖息地年平均气温显著相关(P<0 05),而与年平均降水量及日照长度无显著相关(P>0 05)。 | 尹华宝 李进华 周立志 葛继志 Consuel Ionica Carol M. Berman | 2004 | 兽类学报2004，24，1： | 4 |
| 6 | RANKL/RANK control Brca1 mutation-driven mammary tumors显示文摘 | Verena Sig Kwadwo Owusu-Boaitey Puma A Joshi Anoop Kavirayani Gerald Wimsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujaaa for CIMBA Holger Heyn Enrique Vidal Jennifer Cru. ickshank Hal Berman Renu Sarao Melita Tieevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva YHP Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha LaundeRe P Jones Josef M Penninger | 2016 | Cell Research2016，26，7： | 3 |
| 7 | 冠状动脉钙化在高血压患者心血管病风险分层中的作用显示文摘研究者研究了冠状动脉钙化(coronary artery calcium,CAC)在成人高血压心血管病风险分层中的作用,包括符合收缩压干预试验(systolic blood pressure intervention trial,SPRINT)标准的患者。此外,研究者使用CAC来确定心血管病死亡率与SPRINT中标准降压组心血管病死亡率('SPRINT水平')相当的高血压成年患者,其可能受益于强化降压治疗。研究人群包括来自CAC研究联盟的高血压患者16 167例,其中6375例患者构成'SPRINT类似人群'。研究者按CAC分类(0,1~99,100~399,≥400)比较了多因素校正后的冠状动脉粥样硬化性心脏病(冠心病)和心血管病死亡风险比。 | 刘青(译) 叶鹏(摘、审校) Uddin SMI Mirbolouk M Kianoush S Orimoloye OA Dardari Z Whelton SP Miedema MD Nasir K Rumberger JA Shaw LJ Berman DS Budoff MJ McEvoy JW Matsushita K Blaha MJ Graham G | 2019 | 中华高血压杂志2019，27，5： | 3 |
| 8 | The ubiquitin conjugating enzyme UBE2L3 regulates TNFa-induced linear ubiquitination显示文摘 | Bishi Fu Shitao Li Lingyan Wang Michael A Berman Martin E Dorf | 2014 | Cell Research2014，24，3： | 3 |
| 9 | Evidence for alterations in central noradrenergic signaling in irritable bowel syndrome显示文摘 | Steven Berman Brandall Suyenobu Bruce D. Naliboff Joshua Bueller Jean Stains Heng Wong Mark Mandelkern Leah Fitzgerald Gordon Ohning Arpana Gupta Jennifer S. Labus Kirsten Tillisch Emeran A. Mayer | 2012 | Neuroimage2012，，4： | 3 |
| 10 | Which Research Is Needed to Support Clinical Decision-Making on Integrative Medicine?——Can Comparative Effectiveness Research Close the Gap?显示文摘在关于互补、综合的药的临床的研究,尽管有终端用户的需要的不完全的理解,专家和科学家经常追求了一个研究议程。因而,以前的临床的试用的多数主要估计了干预的功效。欠缺的数据在他们的有效性上是可得到的。由产生比较最好的好处和伤害的证据支持决定制造者的比较有效性研究(CER ) 诺言在乎选择。这条证据,比证据可推广的更多由传统的使随机化的控制审判(RCT ) 产生了,更好被适合通知真实世界的照顾决定。CER 上的一个重音支持证据底的发展为临床并且政策决策。而在互补、综合的药的大多数区域比较有效性上的数据是少见的,可得到的针灸研究已经贡献 CER 证据。这篇论文将介绍 CER 并且为未来研究做建议。 | Claudia M.Witt 黄文静 Lixing Lao Berman BM | 2012 | Chinese Journal of Integrative Medicine2012，18，10： | 2 |
| 11 | Clinical laboratory and imaging evidence for effectiveness of agarose-agarose macrobeads containing stem-like cells derived from a mouse renal adenocarcinoma cell population (RMBs) in treatment-resistant, advanced metastatic colorectal cancer:Evaluation of显示文摘Objective: The complexity, heterogeneity and capacity of malignant neoplastic cells and tumors for rapid change and evolution suggest that living-cell-based biological-systems approaches to cancer treatment are merited. Testing this hypothesis, the tumor marker, metabolic activity, and overall survival(OS) responses, to the use of one such system, implantable macrobeads [RENCA macrobeads(RMBs)], in phase I and IIa clinical trials in advanced,treatment-resistant metastatic colorectal cancer(m CRC) are described here.Methods: Forty-eight m CRC patients(30 females; 18 males), who had failed all available, approved treatments,underwent RMB implantation(8 RMB/kg body weight) up to 4 times in phase I and phase IIa open-label trials.Physicals, labs [tumor and inflammation markers, lactate dehydrogenase(LDH)] and positron emission tomography-computed tomography(PET-CT) imaging to measure number/volume and metabolic activity of the tumors were performed pre-and 3-month-post-implantation to evaluate safety and initial efficacy(as defined by biological responses). PET-CT maximum standard uptake value(SUVmax)(baseline and d 90; SUVmax ≥2.5), LDH,and carcinoembryonic antigen(CEA) and/or cancer antigen 19-9(CA 19-9) response(baseline, d 30 and/or d 60)were assessed and compared to OS.Results: Responses after implantation were characterized by an at least 20% decrease in CEA and/or CA 19-9 in75% of patients. Fluorodeoxyglucose(FDG)-positive lesions(phase I, 39; 2 a, 82) were detected in 37/48 evaluable patients, with 35% stable volume and stable or decreased SUV(10) plus four with necrosis; 10, increased tumor volume, SUV. LDH levels remained stable and low in Responders(R)(d 0–60, 290.4–333.9), but increased steadily in Non-responders(NR)(d 0–60, 382.8–1,278.5)(d 60, P=0.050). Responders to RMBs, indicated by the changes in the above markers, correlated with OS(R mean OS=10.76 months; NR mean OS=4.9 months; P=0.0006).Conclusions: The correlations of the tumor marker, tumor volume and SUV changes on PET-CT, and LDH levels themselves, and with OS, support the concept of a biological response to RMB implantation and the validity of the biological-systems approach to m CRC. A phase III clinical trial is planned. | Barry H.Smith Lawrence S.Gazda Thomas J.Fahey Angelica Nazarian Melissa A.Laramore Prithy Martis Zoe P.Andrada Joanne Thomas Tapan Parikh Sudipta Sureshbabu Nathaniel Berman Allyson J.Ocean Richard D.Hall David J.Wolf | 2018 | Chinese Journal of Cancer Research2018，30，1： | 2 |
| 12 | Silymarin Ascending Multiple Oral Dosing Phase I Study in Noncirrhotic Patients With Chronic Hepatitis C显示文摘 | Roy L. Hawke Sarah J. Schrieber Tedi A. Soule Zhiming Wen Philip C. Smith Rajender K. Reddy Abdus S. Wahed Steven H. Belle Nezam H. Afdhal Victor J. Navarro Josh Berman Qi-Ying Liu Edward Doo Michael W. Fried | 2010 | Journal of Clinical Pharmacology2010，，4： | 2 |
| 13 | ACCF/ACR/AHA/NASCI/SAIP/SCAI/SCCT 2010 Expert Consensus Document on Coronary Computed Tomographic Angiography显示文摘 | Daniel B. Mark Daniel S. Berman Matthew J. Budoff J. Jeffrey Carr Thomas C. Gerber Harvey S. Hecht Mark A. Hlatky John McB. Hodgson Michael S. Lauer Julie M. Miller Richard L. Morin Debabrata Mukherjee Michael Poon Geoffrey D. Rubin Robert S. Schwartz | 2010 | Journal of the American College of Cardiology2010，，23： | 2 |
| 14 | Whole Exome Sequencing to Identify a Novel Gene (Caveolin-1) Associated With Human Pulmonary Arterial Hypertension显示文摘 | Eric D. Austin Lijiang Ma Charles LeDuc Erika Berman Rosenzweig Alain Borczuk John A. Phillips Teresa Palomero Pavel Sumazin Hyunjae R. Kim Megha H. Talati James West James E. Loyd Wendy K. Chung | 2012 | Circulation: Cardiovascular Genetics2012，，3： | 2 |
| 15 | Incremental Prognostic Value of Myocardial Perfusion Single Photon Emission Computed Tomography for the Prediction of Cardiac Death: Differential Stratification for Risk of Cardiac Death and Myocardial Infarction显示文摘 | Rory Hachamovitch Daniel S. Berman Leslee J. Shaw Hosen Kiat Ishac Cohen J. Arthur Cabico John Friedman George A. Diamond | 1998 | Circulation1998，，6： | 2 |
| 16 | Improvement of a large analytical model using test data显示文摘 | Berman A Nagy E J | 1983 | AIAA J1983，21，8： | 2 |
| 17 | Three ways to successfully innovate your business model显示文摘 | Edward Giesen Saul J. Berman Ragna Bell Amy Blitz | 2007 | Strategy & Leadership2007，，6： | 2 |
| 18 | Few layer graphene to reduce wear and friction on sliding steel surfaces显示文摘 | Diana Berman Ali Erdemir Anirudha V. Sumant | 2012 | Carbon2012，，： | 2 |
| 19 | 3-D printing: The new industrial revolution显示文摘 | Barry Berman | 2011 | Business Horizons2011，，： | 2 |
| 20 | Dry period heat stress relief effects on prepartum progesterone, calf birth weight, and milk production 显示文摘 | Wolfenson D Flamenbaum I Berman A | 1988 | J Dairy Sci1988，71，3： | 1 |
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