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| 1 | 心腔内超声在卵圆孔未闭封堵术中的应用显示文摘目的 探讨心腔内超声 (ICE)在经导管卵圆孔未闭 (PFO)封堵术中的应用价值。方法 应用ICE观察 86例PFO的解剖形态及周围结构 ,测量PFO通道的直径和长度 ,监测与引导封堵过程、伞释放后位置 ,并通过彩色血流显像和超声造影判断有无残余分流。结果 ICE清晰地观察到各种形态的PFO ,86例中有 85例封堵成功 ,1例失败。结论 ICE指导经导管封堵PFO是一种安全、有效。 | 刘政 张萍 Daniel McCormick Timothy Puri Amy Loyd Mani Vannan | 2004 | 中华超声影像学杂志2004，13，10： | 4 |
| 2 | 心腔内超声引导下经导管卵圆孔未闭封堵术显示文摘目的探讨心腔内超声(ICE)在经导管卵圆孔未闭(PFO)封堵术中的初步应用经验及其与X线的比较.方法应用ICE监测与引导86例PFO的封堵过程,在ICE上测量基础状态PFO通道的直径和长度,分别用ICE和X线透视测量PFO球囊伸展径(BSD).ICE观察封堵器释放后的位置,并通过彩色血流显像和声学造影判断有无残余分流.结果 ICE清晰地显示PFO解剖形态及周围结构,在ICE上测量基础状态PFO通道长度和直径分别为3.6~22 mm(11±4 mm),0~9 mm(4±2 mm).ICE上测量的PFO球囊伸展径为5~16 mm(9.2±2.6 mm),经X线透视测量的PFO球囊伸展径为5~17 mm(9.7±2.8 mm),二者相关非常显著(r=0.90,P<0.0001),86例中有85例封堵成功,1例失败.结论 ICE不仅能提供PFO的解剖和血流动力学信息,而且能准确提供PFO各种测量值. | 刘政 张萍 Daniel McCormick Timothy Puri Amy Loyd Mani Vannan | 2005 | 中国介入心脏病学杂志2005，13，3： | 4 |
| 3 | Whole Exome Sequencing to Identify a Novel Gene (Caveolin-1) Associated With Human Pulmonary Arterial Hypertension显示文摘 | Eric D. Austin Lijiang Ma Charles LeDuc Erika Berman Rosenzweig Alain Borczuk John A. Phillips Teresa Palomero Pavel Sumazin Hyunjae R. Kim Megha H. Talati James West James E. Loyd Wendy K. Chung | 2012 | Circulation: Cardiovascular Genetics2012，，3： | 2 |
| 4 | Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation显示文摘AIM: To study the genesis of neointima formation in pulmonary hypertension(PH), we investigated the role of caveolin-1 and related proteins. METHODS: Male Sprague Dawley rats were given monocrotaline(M, 40 mg/kg) or subjected to hypobaric hypoxia(H) to induce PH. Another group was given M and subjected to H to accelerate the disease process(M + H). Right ventricular systolic pressure, right ventricular hypertrophy, lung histology for medial hypertrophy and the presence of neointimal lesions were examined at 2 and 4 wk. The expression of caveolin-1 and its regulatory protein peroxisome proliferator-activated receptor(PPAR) γ, caveolin-2, proliferative and antiapoptotic factors(PY-STAT3, p-Erk, Bcl-x L), endothelial nitric oxide synthase(e NOS) and heat shock protein(HSP) 90 in the lungs were analyzed, and the results from M + H group were compared with the controls, M and H groups. Double immunofluorescence technique was used to identify the localization of caveolin-1 in pulmonary arteries in rat lungs and in human PH lung tissue. RESULTS: In the M + H group, PH was more severe compared with M or H group. In the 4 wk M+H group, several arteries with reduced caveolin-1 expression in endothelial layer coupled with an increased expression in smooth muscle cells(SMC), exhibited neointimal lesions. Neointima was present only in the arteries exhibiting enhanced caveolin-1 expression in SMC. Lung tissue obtained from patients with PH also revealed neointimal lesions only in the arteries exhibiting endothelial caveolin-1 loss accompanied by an increased caveolin-1 expression in SMC. Reduction in e NOS and HSP90 expression was present in the M groups(2 and 4 wk), but not in the M + H groups. In both M groups and in the M + H group at 2 wk, endothelial caveolin-1 loss was accompanied by an increase in PPARγ expression. In the M + H group at 4 wk, increase in caveolin-1 expression was accompanied by a reduction in the PPARγ expression. In the H group, there was neither a loss of endothelial caveolin-1, eNOS or HSP 90, nor an increase in SMC caveolin-1 expression; or any alteration in PPARγ expression. Proliferative pathways were activated in all experimental groups. CONCLUSION: Enhanced caveolin-1 expression in SMC follows extensive endothelial caveolin-1 loss with subsequent neointima formation. Increased caveolin-1 expression in SMC, thus, may be a prelude to neointima formation. | Jing Huang John H Wolk Michael H Gewitz James E Loyd James West Eric D Austin Rajamma Mathew | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 5 | The origin of the millimeter-scale lamination in the Neoproterozoic lower beck spring dolomite: implications for widespread, fine-scale, layer-parallel diagenesis in Precambrian carbonates显示文摘 | Loyd S J Corsetti F A | 2010 | Society for Sedimentary Geology2010，80，10： | 1 |
| 6 | Depletion of antigen-presen- ting ceils by clodronate liposomes reverses the psoriatic skin phenotype in KC-Tie2 mice显示文摘 | Ward NL Loyd CM Wolfram 3A | 2011 | Br J Dermatol2011，164，4： | 1 |
| 7 | Primary pulmonary hypertension显示文摘 | Runo JR Loyd JE | | 0，，： | 1 |
| 8 | 查看详情显示文摘 | Wilson SE He YG Loyds SA | | 0，，： | 1 |
| 9 | Long term variation in beam symmetry as a function of gantry angle for a computer-controlled linear accelerator 显示文摘 | Lane RG Laxton J | 1989 | Med Phys1989，6，4： | 1 |
| 10 | Primary pulmonary hypertension显示文摘 | Loyd JE | 2003 | Lancet2003，361，： | 1 |
| 11 | Oxidative DNA damage mediated by copper(Ⅱ),iron(Ⅱ),and nickel(Ⅱ) Fenton reactions:Evidence for site specific mechanisms in the formation of double-strand breaks,8-hydroxydeoxyguanosine,and putative intrastrand cross-links显示文摘 | Loyd D R Phillips D H 1999 | 1999 | Mutat Res1999，424，： | 1 |
| 12 | The genetics of pulmonary arterial hypertension显示文摘 | Austin ED Loyd JE | 2014 | Circ Res2014，115，： | 1 |
| 13 | Primary pulmonary hypertension显示文摘 | Runo J R Loyd J E | 2003 | Lancet2003，361，： | 1 |
| 14 | Socioeconomic disadvantage and child development显示文摘 | Mc Loyd V | 2008 | American Psychologist2008，53，2： | 1 |
| 15 | Application and opportunities for ultrasound assisted extraction in the food industry-A review显示文摘 | KAMALJIT V RAYMOND M LOYD S | 2008 | Innovative Food Science and Emerging Technologies2008，9，2： | 1 |
| 16 | Preparation and evaluation of potassium ferrate as anoxidant and coagulant for potable water treatment 显示文摘 | Jiang J QL Loyd B Grigore L | 2001 | Environment Engineer Science2001，18，5： | 1 |
| 17 | Histoplasmosis in normal hosts显示文摘 | Goodwin R A Loyd J E Des Prez R M | 1981 | Medicine (Baltimore)1981，60，： | 1 |
| 18 | N2,N2O and O2profiles in a tagus estuary salt marsh estuarine显示文摘 | Cartaxana P Loyd D | 1999 | Coastal and Shelf Science1999，48，6： | 1 |
| 19 | Occult breast cancer显示文摘 | Loyd MS Nash AG | 2001 | Ann R Coll Surg Engl2001，83，6： | 1 |
| 20 | The origin of the millimeter scale lamination in the Neoproterozoic lower beck spring dolomite:Implications for widespread, fine-scale, layer-parallel diagenesis in Precambrian carbonates显示文摘 | Loyd S J Corsetti F A | 2010 | Society for Sedimentary Geology2010，80，10： | 1 |
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