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| 1 | Plasma matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 as biomarkers of ulcerative colitis activity显示文摘AIM: Overexpression of mucosal metalloproteinases (MMP)has been demonstrated recently in inflammatory boweldisease. Their activity can be counterbalanced by the tissueinhibitor of metalloproteinases (TIMP). The aim of this studywas to evaluate the effect of ulcerative colitis (UC) on MMP-1 and TTMP-1 plasma concentrations, as two possiblebiomarkers of the disease activity.METHODS: MMP-1 and TIMP-1 plasma concentrations weremeasured with an enzyme immunoassay in 16 patients withendoscopically confirmed active UC.RESULTS: Plasma concentrations of both MMP-11 (13.7±0.2ng/ml) and TIMP-L (799±140 ng/ml) were significantlyelevated in UC patients in comparison to healthy controls(11.9±0.9 ng/ml and 220±7 ng/ml respectively). There wasno correlation between TIMP-1 and MMP-1 concentrations(r=-0.02). TIMP-1 levels revealed significant positivecorrelations with scored endoscopic degree of mucosai injury,disease activity index and clinical activity index values aswell as C-reactive protein concentration. There was nocorrelation between MMP-1 and laboratory, clinical orendoscopic indices of the disease activity.CONCLUSION: These results confirm the role of both MMP-1 and TIMP-1 in the pathogenesis of ulcerative colitis.However only TIMP-1 can be useful as a biomarker of thedisease activity, demonstrating association with clinical andendoscopic pictures. | Alicja Wiercinska-Drapalo Jerzy Jaroszewicz Robert Flisiak Danuta Prokopowicz | 2003 | World Journal of Gastroenterology2003，9，12： | 21 |
| 2 | Plasma interleukin-18 reflects severity of ulcerative colitis显示文摘AIM: The aim of this study was to evaluate the association between ulcerative colitis activity and plasma or mucosal concentrations of interleukin (IL)-18.METHODS:Il-18 concentrations were measured in plasma and mucosal samples from 15 patients with active ulcerative colitis (UC).RESULTS: The mean plasma concentration of IL-18 measured in all patients (422±88 pg/mL) doubled the mean value in healthy controls (206±32 pg/mL); however,the difference was not statistically significant. Plasma IL-18 levels revealed a significant positive correlation with scored endoscopic degree of mucosal injury, disease activity index, clinical activity index and C-reactive protein concentration. The mean concentration of plasma IL-18 was significantly higher in patients with severe ulcerative colitis (535±115 pg/mL) than in patients with mild ulcerative colitis (195±41 pg/mL), and in healthy controls.Although the mucosal mean IL-18 concentration in severe ulcerative colitis (2 523±618 pg/mg protein) doubled values observed in mild one (1 347±308 pg/mg protein), there was no statistically significant difference.CONCLUSION: Plasma IL-18 can be considered as a surrogate marker helpful in evaluation of ulcerative colitis activity. | Alicja Wiercinska-Drapalo Flobert Flisiak Jerzy Jaroszewicz Danuta Prokopowicz | 2005 | World Journal of Gastroenterology2005，11，4： | 16 |
| 3 | 云南常见牛肝菌属真菌中汞含量及食用安全评价显示文摘汞(Hg)是危害人类健康的主要重金属元素之一,多数食用菌对Hg有很强的富集能力,测定食用菌中Hg含量,并对其进行食用安全性评价具有重要意义。采用冷原子吸收直接测汞仪系统测定85份云南常见牛肝菌属真菌菌盖、菌柄中总Hg含量;以同一牛肝菌子实体菌盖与菌柄总Hg含量比(Q(C/S))分析牛肝菌属真菌对Hg的富集特征;根据联合国粮农组织和世界卫生组织(FAO/WHO)现行每周Hg允许摄入量(provisional tolerable week—lyintake,PTWI)标准和中国GB2762—2012规定的食用菌中Hg限量标准评价样品的食用安全性。结果表明,菌盖和菌柄中总Hg含量分别在0.13—22.00、0.20~8.40mg·kg^-1DW,不同产地、种类及不同采集年份的样品中总Hg含量存在明显差异;同一牛肝菌菌盖、菌柄总Hg含量比(Q(C/S))在0.28~4.08,92%的样品Q((C/S))〉1,表明多数样品中菌盖对Hg的富集能力强于菌柄。根据GB2762-2012规定的食用菌及其制品中总Hg含量限量标准(≤0.1mg·kg^-1),发现所有测试样品的总Hg含量均超标;根据PTWI标准,假设成年人(60kg)每周食用300g新鲜牛肝菌,则多数样品Hg摄入量低于允许摄入量,无安全风险,而少数样品Hg摄入量高于允许摄入量,食用有一定的潜在风险。同时,牛肝菌总Hg含量与种类、产地、采集时间等因素密切相关,采食及安全评价需综合考虑这些因素。 | 杨天伟 张霁 Jerzy FALANDYSZ Grazyna KRASIИSKA Martyna SABA 王元忠 刘鸿高 | 2015 | 生态学杂志2015，34，12： | 12 |
| 4 | 植物甾醇和植物甾烷醇:来源、安全性以及在保健食品中的应用显示文摘包括植物甾醇和植物甾烷醇在内的植物固醇天然存在于植物细胞中,作为构成细胞膜的组成成分。在植物油和松科树木的树油中含有丰富的植物固醇,特别是β-谷甾醇、菜油甾醇和豆甾醇。在动物实验和人体临床实验中发现植物固醇具有降低总胆固醇和LDL胆固醇的作用。临床实验的结果表明,每日摄入1—2g的植物固醇可以达到降低州10%—15%的血清胆固醇的作用。其作用机制与植物固醇同胆固醇的结构类似性及其在乳糜微粒中的溶解度有关,从而降低胆固醇在肠道中的吸收。一般认为植物固醇是安全的,它本身是正常膳食中的一部份。临床毒理学研究发现有效剂量之内的植物固醇不仅能降低胆固醇而且对人和动物没有毒性,虽然有对于食物中的植物固醇影响类胡萝卜素吸收的担心,但从临床研究的结果中证明只要在膳食中增加一份的富含类胡萝卜素的水果和蔬菜就可以轻易解决这一问题。 | Jerzy Zawistowski 胡春 David D Kitts | 2002 | 中国食品学报2002，2，2： | 12 |
| 5 | Cholesky分解递归算法与改进显示文摘递归算法是计算稠密线性代数的一种新的有效方法 .递归产生自动、变化的矩阵分块 ,能充分发挥当今分级存储高性能计算机的效率 .对 Cholesky分解递归算法进行了研究 ,给出了算法的详细推导过程 ,用具有递归功能的 Fortran 90实现了算法 ,并通过矩阵元素顺序重排的方法 ,进一步提高了递归算法的运算速度 .研究产生的算法比目前常用的分块算法快 15 %~ 2 5 % . | 陈建平 Jerzy Wasniew ski | 2001 | 计算机研究与发展2001，38，8： | 11 |
| 6 | 项目组合管理:关键概念、过程与工具显示文摘项目组合管理概述在当前的经济环境下,公司实施的项目越来越多,这些项目的实施结果成为重要的竞争因素。即使是在银行、保险公司或生产型公司等以运营业务为主的公司中,项目所扮演的角色也变得越来越重要。如今,项目已成为实施公司战略的业务工具。 | Jerzy Stawicki 李志民 | 2008 | 项目管理技术2008，，11： | 10 |
| 7 | Metallic Functionally Graded Materials:A Specific Class of Advanced Composites显示文摘Functionally graded materials,including their characterization,properties and production methods are a new rapidly developing field of materials science.The aims of this review are to systematize the basic production techniques for manufacturing functionally graded materials.Attention is paid to the principles for obtaining graded structure mainly in the metal based functionally graded materials.Several unpublished results obtained by the authors have been discussed briefly.Experimental methods and theoretical analysis for qualitative and quantitative estimation of graded properties have also been presented.The article can be useful for people who work in the field of functionally graded structures and materials,and who need a compact informative review of recent experimental and theoretical activity in this area. | Jerzy J.Sobczak Ludmil Drenchev | 2013 | Journal of Materials Science & Technology2013，29，4： | 10 |
| 8 | 实施项目群和项目组合管理——从标准到执行显示文摘如今,人们再也不会将项目视为特殊的活动而将其置于组织真空中来执行。经过多年研究、传播及行业应用,项目群和项目组合管理的相关概念最终被诸多标准化机构采用,并形成了自己的知识体系。 | Jerzy Stawicki 李志民 | 2008 | 项目管理技术2008，6，2： | 9 |
| 9 | 应用有限元法(FEM)验证在直齿轮和斜齿轮内采用ISO和AGMA标准的齿根强度的比较分析显示文摘在工程界现在普遍的趋势是要求重新研究各不同的标准以确是其在工业内最好的实践。本文介绍采用在ISO和AGMA标准对齿根强度估算方法的比较分析,并用开发的有限元和模型仿真进行证实。本分析(1)介绍了采用齿条和齿轮刀具制造的广大范围的直齿和斜齿轮,而(2)是齿轮主要几何学(齿轮设计),制造(齿条和齿轮刀具)和性能参数的不同组合,以及对每个齿轮进行齿根强度分析的有限元方法(FEM)。FEM的结果与用ISO和AGMA标准计算的相比较。对不同的设计、制造和性能参数组合的比较分析用图解说明和简要讨论。该结果将许可在现代工程实际中应用标准所存在的限制有一个很好的了解,并为改进和统一标准提供一个基础。 | Andrzej kawalec Jerzy Wiktor Dariusz Ceglarek | 2007 | 传动技术2007，21，2： | 8 |
| 10 | Gastrointestinal stromal tumors – definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis显示文摘 | Markku Miettinen Jerzy Lasota | 2001 | Virchows Archiv2001，，1： | 8 |
| 11 | 植酸酶对肉仔鸡不同锌源生物利用率的影响显示文摘为评定植酸酶添加对不同锌源生物利用率的影响 ,选用 5 6 0只 4日龄肉用公鸡进行为期 2 4d的饲养试验。结果表明 :不管日粮添加植酸酶与否 ,ZnAA的生物利用率均高于ZnSO4 。日粮添加植酸酶ZnAA的相对生物利用率(ZnSO4 为 10 0 )分别为 :10 3(体增重 ) ,10 3.7(饲料转化率 ) ,114 .4 (脱脂胫骨锌含量 ) ,114 .5 (胫骨灰分锌含量 )和 10 8.9(胫骨总锌含量 )。日粮不加植酸酶组这些值相应为 12 0 .8,116 .0 ,139.1,14 1.6和 116 .9。 | 戴求仲 Sylwester Swiatkiewicz Jerzy Koreleski | 2004 | 中国畜牧杂志2004，40，8： | 8 |
| 12 | Effect of lamivudine treatment on plasma levels of transforming growth factor β_1,tissue inhibitor of metalloproteinases-1 and metalloproteinase-1 in patients with chronic hepatitis B显示文摘AIM: Transforming growth factor (TGF)-β1, metalloproteinase (MMP)-1 and its tissue inhibitor (TIMP)-I are considered predictive biomarkers of chronic hepatitis activity and fibrosis.The aim of this study was to evaluate the effect of lamivudine treatment on the plasma levels of these peptides in patients with chronic hepatitis B.METHODS: TGF-β1, MMP-1 and TIMP-1 plasma concentrations were measured with an enzyme immunoassay in 40 patients treated with lamivudine for 48 wk. Elimination of HBV-DNA and HBV antigens was evaluated 24 wk after treatment completion.RESULTS: Baseline TGF-β1(29.6±2.2 ng/mL) and TIMP-1(1 578±93 ng/mL) significantly exceeded normal values(18.3±1.6 ng/mL and 1 102±67 ng/mL respectively). Lamivudine treatment resulted in a significant decrease of TGF-β1 and TIMP-1 during treatment with an increase after 24 wk of treatment. Pretreatment MMP-1 levels (6.7±0.7 ng/mL) were significantly lower than normal values (11.9±0.9 ng/mL) and increased during treatment and follow-up. A significant correlation was noted between TGF-β1 or TIMP-1 and aminotransferases as well as fibrosis scored in liver biopsy specimens. There were no statistically significant differences of TGF-β1, TIMP-1 and MMP-1 between four groups at baseline, 24 and 48 wk of treatment. TGF-β1 and TIMP-1 levels increased significantly in non-responders and normalized in responders at wk 72. MMP-1 also normalized in responders and decreased to values significantly lower than normal in non-responders.CONCLUSION: These findings support the role of TGF-β1,TIMP-1 and MMP-1 in the pathogenesis of chronic hepatitis B.Because of their association with hepatic injury and antiviral treatment efficacy, determination of these peptides may be useful in disease management. | Robert Flisiak Haza Al-Kadasi Jerzy Jaroszewicz Danuta Prokopowicz Iwona Flisiak | 2004 | World Journal of Gastroenterology2004，10，18： | 7 |
| 13 | Effect of pegylated interferon alpha 2b plus ribavirin treatment on plasma transforming growth factor-β1,metalloproteinase-1,and tissue metalloproteinase inhibitor-1 in patients with chronic hepatitis C显示文摘AIM: To evaluate the effect of antiviral treatment on plasma levels of transforming growth factor-β1 (TGF-β1),metalloproteinase 1 (MMP-1), and tissue inhibitor of metalloproteinase-1 (TIMP-1) in patients with chronic hepatitis C.METHODS: TGF-β1, MMP-1, and TIMP-1 plasma concentrations were measured by an enzyme immunoassay in 28 patients, during 48 wk of treatment with pegylated interferon-alpha 2b (PEG-IFN-α2b) plus ribavirin (RBV)and after 24 wk of follow-up. Patients were divided into two groups: responders (R) and non-responders (NR)related to achieved sustained virologic response. Normal values were evaluated in plasma samples of 13 healthy volunteers.RESULTS: Baseline plasma concentrations of TGF-β1and TIMP-1 (30.9±3.7 and 1506±61 ng/mL respectively)measured in all subjects significantly exceeded the normal values (TGF-β1:18.3±1.6 ng/mL and TIMP-1:1102±67 ng/mL). In contrast, pretreatment MMP-1mean level (6.5±0.9 ng/mL) was significantly lower than normal values (11.9±0.9 ng/mL). Response to the treatment was observed in 12 patients (43%). TGF-β1mean concentration measured during the treatment phase decreased to the control level in both groups.However at wk 72, values of NR patients increased and became significantly higher than in R group.TIMP-1 concentrations in R group decreased during the treatment to the level similar to normal. In NR group,TIMP-1 remained significantly elevated during treatment and follow-up phase and significant difference between both groups was demonstrated at wk 48 and 72. MMP-1levels were significantly decreased in both groups at baseline. Treatment caused rise of its concentration only in the R group, whereas values in NR group remained on the level similar to baseline. Statistically significant difference between groups was noted at wk 48 and 72.CONCLUSION: These findings support the usefulness of TGF-β1, TIMP-1, and MMP-1 in the management of chronic hepatitis C. Elevated TIMP-1 and low MMP-1plasma concentrations during antiviral therapy may indicate medication failure. | Robert Flisiak Jerzy Jaroszewicz Tadeusz W Lapiski Iwona Flisiak Danuta Prokopowiczi | 2005 | World Journal of Gastroenterology2005，11，43： | 7 |
| 14 | Diagnosis of gastrointestinal stromal tumors: A consensus approach显示文摘 | Christopher D.M. Fletcher Jules J. Berman Christopher Corless Fred Gorstein Jerzy Lasota B.Jack Longley Markku Miettinen Timothy J. O’Leary Helen Remotti Brian P. Rubin Barry Shmookler Leslie H. Sobin Sharon W. Weiss | 2002 | Human Pathology2002，，5： | 7 |
| 15 | Hepatitis B surface antigen (HBsAg) levels in the natural history of hepatitis B virus (HBV)-infection: A European perspective显示文摘 | Jerzy Jaroszewicz Beatriz Calle Serrano Karsten Wursthorn Katja Deterding Jerome Schlue Regina Raupach Robert Flisiak C.-Thomas Bock Michael P. Manns Heiner Wedemeyer Markus Cornberg | 2010 | Journal of Hepatology2010，，4： | 6 |
| 16 | SAP实施项目案例研究显示文摘引言
SAP开发并不断改进的管理系统能够为各种公司的管理提供支持,因而在全世界范围内获得了广泛应用。这一系统在不同时期有不同的名称,如R/3(20世纪90年代中期)、mySAP.com(2000年前后)以及mySAP ERP,在本文中统称为SAP系统。 | Jerzy Stawicki 李志民 | 2008 | 项目管理技术2008，6，9： | 5 |
| 17 | Gastrointestinal stromal tumors: Pathology and prognosis at different sites显示文摘 | Markku Miettinen Jerzy Lasota | 2006 | Seminars in Diagnostic Pathology2006，，2： | 5 |
| 18 | Laparoscopy-assisted percutaneous endoscopic gastrostomy enables enteral nutrition even in patients with distorted anatomy显示文摘AIM:To analyzed whether laparoscopy-assisted percutaneous endoscopic gastrostomy(PEG)could be a valuable option for patients with complicated anatomy.METHODS:A retrospective analysis of twelve patients(seven females,five males;six children,six young adults;mean age 19.2 years)with cerebral palsy,spastic quadriparesis,severe kyphoscoliosis and interposed organs and who required enteral nutrition(EN)due to starvation was performed.For all patients,standard PEG placement was impossible due to distorted anatomy.All the patients qualified for the laparoscopyassisted PEG procedure.RESULTS:In all twelve patients,the laparoscopy-assisted PEG was successful,and EN was introduced four to six hours after the PEG placement.There were no complications in the perioperative period,either technical or metabolic.All the patients were discharged from the hospital and were then effectively fed using bolus methods.CONCLUSION:Laparoscopy-assisted PEG should become the method of choice for gastrostomy tube placement and subsequent EN if PEG placement cannot be performed safely. | Adam Hermanowicz Ewa Matuszczak Marta Komarowska Elzbieta Jarocka-Cyrta Jerzy Wojnar Wojciech Debek Konrad Matysiak Stanislaw Klek | 2013 | World Journal of Gastroenterology2013，19，43： | 5 |
| 19 | 云南省野生牛肝菌总汞含量测定分析及健康风险评估显示文摘【目的】系统测定云南常见野生牛肝菌中总Hg含量,分析不同产地、种类及不同部位牛肝菌对Hg的富集规律和积累特征,评价野生牛肝菌的食用安全性,为野生食用菌产业的发展和食用安全评估提供数据依据。【方法】采用MA-2000直接测Hg仪—冷原子吸收光谱法测定牛肝菌菌盖、菌柄中总Hg含量,计算同一牛肝菌菌盖与菌柄总Hg含量比(QC/S),分析不同种类、部位牛肝菌中总Hg含量的差异和富集规律。根据中国《食品安全国家标准食品中污染物限量》(GB 2762—2012)规定的食用菌中Hg限量标准及联合国粮农组织和世界卫生组织(FAO/WHO)规定的每周Hg允许摄入量(provisional tolerable weekly intake,PTWI)现行标准,评价云南野生牛肝菌的食用安全性。【结果】同一子实体菌盖与菌柄的比值(QC/S)在0.3~8.8之间,95%牛肝菌样品菌盖、菌柄总Hg含量比(QC/S)≥1,表明多数牛肝菌菌盖对Hg的富集能力强于菌柄。本研究中多数野生牛肝菌菌盖、菌柄总Hg含量超过GB 2762—2012规定的食用菌中Hg含量限量标准(≤0.1 mg/kg);根据PTWI标准,假设成年人(60 kg)每周食用300 g新鲜牛肝菌,则多数样品Hg摄入量低于允许摄入量,无安全风险,而2013年采自玉溪大营街的美味牛肝菌,2012年采自楚雄永仁县的铜色牛肝菌及2014年采自玉溪新平的绒柄牛肝菌等少数样品Hg摄入量高于该标准。【结论】不同产地、种类牛肝菌菌盖、菌柄中总Hg含量存在明显差异,有少数牛肝菌总Hg含量超过相关标准,食用具有一定的潜在风险。 | 李杰庆 杨天伟 张霁 Jerzy FALANDYSZ Grazyna KRASINSKA Martyna SABA 王元忠 刘鸿高 | 2017 | 云南农业大学学报(自然科学版)2017，32，3： | 4 |
| 20 | Trace Elements in Leccinum scabrum Mushrooms and Topsoils from K odzka Dale in Sudety Mountains, Poland显示文摘In the current study, we determined concentrations and transfer rates of Ag, Al, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Pb, P, Rb, Sr and Zn to Brown Birch Scaber Stalks (Leccinum scabrum) mushrooms emerged in the area of Sudety Mountains (Sudetes) in Poland. Fruiting bodies and topsoil samples beneath L. scabrum were collected form the K odzka Dale. The trace elements were determined using validated method and inductively coupled plasma - atomic emission spectroscopy (ICP-AES) for final measurement. Mushrooms contained Ag, Cr, Hg, Co, Ni and Sr at < 1.0 μg/g dry weight; Ba and Pb at ~1.0 μg/g dw; Cd at < 5 μg/g dw; Cu and Mn at > 10 μg/g dw; Al and Ca at ~100 μg/g dw; Fe, Na, Rb and Zn at 100 to 500 μg/g dw, Mg at ~1,000 μg/g dw; P at ~5,000 μg/g dw and K at ~30,000 μg/g dw. Ca, Mn and Ni were nearly equally distributed between stipes and caps; stipes compared to caps were enriched in Ba, Na and Sr, while caps were enriched in Ag, Al, Cd, Co, Cr, Cu, Fe, K, P, Pb, Rb and Zn. The values of bioconcentration factor (BCF) varied highly depending on chemical element and were >1 for Ag, Cd, Cu, K, Mg, Na, P, Rb and Zn, while <1 for Al, Ba, Ca, Co, Cr, Fe, Mn, Ni, Pb and Sr. Topsoil showed elevated content of lead and mean concentration was 99 ± 32 μg/g dw, while cadmium was at 0.41 ± 0.15 and those two highly toxic to human elements occurred in edible caps of L. scabrum at 4.5 ± 2.2 and 2.9 ± 2.0 μg/g dw, respectively. | ZHANG Dan ZHANG Yu MORAWSKA Ewa BIELAWSKI Leszek KRASINSKA Grazyna DREWNOWSKA Ma gorzata PANKAVEC Sviatlana SZYMANSKA Karolina FALANDYSZ Jerzy | 2013 | Journal of Mountain Science2013，10，4： | 4 |
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