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| 1 | 石羊河下游民勤绿洲变化的人文机制研究显示文摘本文根据社会调查资料分析了甘肃省河西地区石羊河下游民勤绿洲变化的趋势及其影响 ,进而从用水行为和水量均衡角度讨论了绿洲变化的人文作用机制 ,认为石羊河流域下游绿洲变化与传统农业外延式扩张机制密切相关 ,而传统农业扩张机制由于各种因素的制约在短时期内难以打破。而不打破导致绿洲环境恶化的人文机制 ,任何试图扭转此类地区绿洲环境恶化趋势的措施都可能是无效的。 | 杨永春 李吉均 陈发虎 Jacquie Burgess 李瑞成 李丁 常跟应 李忆春 | 2002 | 地理研究2002，21，4： | 59 |
| 2 | Distributional responses to climate change for alpine species of Cyananthus and Primula endemic to the Himalaya-Hengduan Mountains显示文摘Global warming increases the vulnerability of plants, especially alpine herbaceous species, to local extinction. In this study, we collected species distribution information from herbarium specimens for ten selected Cyananthus and Primula alpine species endemic to the Himalaya-Hengduan Mountains(HHM).Combined with climate data from WorldClim, we used Maximum Entropy Modeling(MaxEnt) to project distributional changes from the current time period to 2070. Our predictions indicate that, under a wide range of climate change scenarios, the distributions of all species will shift upward in elevation and northward in latitude; furthermore, under these scenarios, species will expand the size of their range. For the majority of the species in this study, habitats are available to mitigate upward and northward shifts that are projected to be induced by changing climate. If current climate projections, however, increase in magnitude or continue to increase past our projection dates, suitable habitat for future occupation by alpine species will be limited as we predict range contraction or less range expansion for some of the species under more intensified climate scenarios. Our study not only underscores the value of herbarium source information for future climate model projections but also suggests that future studies on the effects of climate change on alpine species should include additional biotic and abiotic factors to provide greater resolution of the local dynamics associated with species persistence under a warming climate. | Xie He Kevin S. Burgess Lian-Ming Gao De-Zhu Li | 2019 | Plant Diversity2019，41，1： | 7 |
| 3 | Novel fibrin-fibronectin matrix accelerates mice skin wound healing显示文摘Plasma fibrinogen(F1)and fibronectin(pFN)polymerize to form a fibrin clot that is both a hemostatic and provisional matrix for wound healing.About 90%of plasma F1 has a homodimeric pair ofγchains(γγF1),and 10%has a heterodimeric pair ofγand more acidicγ′chains(γγ′F1).We have synthesized a novel fibrin matrix exclusively from a 1:1(molar ratio)complex ofγγ′F1 and pFN in the presence of highly active thrombin and recombinant Factor XIII(rFXIIIa).In this matrix,the fibrin nanofibers were decorated with pFN nanoclusters(termedγγ′F1:pFN fibrin).In contrast,fibrin made from 1:1 mixture ofγγF1 and pFN formed a sporadic distribution of“pFN droplets”(termedγγF1+pFN fibrin).Theγγ′F1:pFN fibrin enhanced the adhesion of primary human umbilical vein endothelium cells(HUVECs)relative to theγγF1+FN fibrin.Three dimensional(3D)culturing showed that theγγ′F1:pFN complex fibrin matrix enhanced the proliferation of both HUVECs and primary human fibroblasts.HUVECs in the 3Dγγ′F1:pFN fibrin exhibited a starkly enhanced vascular morphogenesis while an apoptotic growth profile was observed in theγγF1+pFN fibrin.Relative toγγF1+pFN fibrin,mouse dermal wounds that were sealed byγγ′F1:pFN fibrin exhibited accelerated and enhanced healing.This study suggests that a 3D pFN presentation on a fibrin matrix promotes wound healing. | Carlos Poblete Jara Ou Wang Thais Paulino do Prado Ayman Ismail Frank Marco Fabian Han Li Licio A.Velloso Mark A.Carlson William Burgess Yuguo Lei William H.Velander Eliana P.Araújo | 2020 | Bioactive Materials2020，5，4： | 5 |
| 4 | Questions about NgAgo显示文摘 | Shawn Burgess Linzhao Cheng Feng Gu Zhiwei Huang Shuo Lin Jinsong Li Wei Li Wei Qin Yujie Sun Zhou Songyang Wensheng Wei Qiang Wu Haoyi Wang Xiaoqun Wang Jing-Wei Xiong Jianzhong Xi Hui Yang Bin Zhou Bo Zhang Junjiu Huang | 2016 | Protein & Cell2016，7，12： | 5 |
| 5 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 6 | Deciphering the epitranscriptome: A green perspective显示文摘The advent of high-throughput sequencing technologies coupled with new detection methods of RNA modifications has enabled investigation of a new layer of gene regulation the epitranscriptome. With over 100 known RNA modifications, understanding the repertoire of RNA modifications is a huge undertaking. This review summarizes what is known about RNA modifications with an emphasis on discoveries in plants. RNA ribose modifications, base methylations and pseudouridylation are required for normal development in Arabidopsis, as mutations in the enzymes modifying them have diverse effects on plant development and stress responses. These modifications can regulate RNA structure,turnover and translation. Transfer RNA and ribosomal RNA modifications have been mapped extensively and theirfunctions investigated in many organisms, including plants.Recent work exploring the locations, functions and targeting of N^6-methyladenosine(m^6A), 5-methylcytosine(m^5C), pseudouridine(Ψ), and additional modifications in mRNAs and nc RNAs are highlighted, as well as those previously known on t RNAs and r RNAs. Many questions remain as to the exact mechanisms of targeting and functions of specific modified sites and whether these modifications have distinct functions in the different classes of RNAs. | Alice Burgess | 2016 | Journal of Integrative Plant Biology2016，58，10： | 4 |
| 7 | LSTM RNN:detecting exploit kits using redirection chain sequences显示文摘While consumers use the web to perform routine activities,they are under the constant threat of attack from malicious websites.Even when visiting‘trusted’sites,there is always a risk that site is compromised,and,hosting a malicious script.In this scenario,the injected script would typically force the victim’s browser to undergo a series of redirects before reaching an attacker-controlled domain,which,delivers the actual malware.Although these malicious redirection chains aim to frustrate detection and analysis efforts,they could be used to help identify web-based attacks.Building upon previous work,this paper presents the first known application of a Long Short-Term Memory(LSTM)network to detect Exploit Kit(EK)traffic,utilising the structure of HTTP redirects.Samples are processed as sequences,where each timestep represents a redirect and contains a unique combination of 48 features.The experiment is conducted using a ground-truth dataset of 1279 EK and 5910 benign redirection chains.Hyper-parameters are tuned via K-fold cross-validation(5f-CV),with the optimal configuration achieving an F1 score of 0.9878 against the unseen test set.Furthermore,we compare the results of isolated feature categories to assess their importance. | Jonah Burgess Philip O’Kane Sakir Sezer Domhnall Carlin | 2021 | Cybersecurity2021，4，1： | 4 |
| 8 | 甘肃中部地区禾谷镰孢的变异研究显示文摘为掌握禾谷镰孢在甘肃中部地区的分布及变异情况,从根部表现有坏死和叶鞘发褐的小麦幼苗的不同部位.小麦地土壤及玉米籽粒.玉米茎秆上分离禾谷镰孢,并以形态学为基础,参照Nelson分类系统进行鉴定.结果表明,在分离到的43个镰刀菌菌株中,有14 个菌株经鉴定为禾谷镰孢,均从玉米茎秆上分离到,小麦根部.小麦叶鞘.小麦地土壤.玉米籽粒中分离到的镰刀菌中未见禾谷镰孢.将禾谷镰孢在特定条件下培养后,发现14 个禾谷镰孢菌株产生子囊壳的数量不同,为2-90个.在以Fg16为引物的PCR 反应中,随机选取的11个禾谷镰孢菌株都产生0.41kb的PCR 产物,而6个对照菌株都产生0.50kb的片段,证明引物Fg16可以区分禾谷镰孢菌株群体的遗传多态性.以Tri13为引物的PCR 反应显示,11个禾谷镰孢菌株以及3 个中国对照菌株都产生脱氧雪腐镰刀菌烯醇(DON)毒素,而3个澳大利亚对照菌株产生雪腐镰刀菌烯醇(NIV)毒素. | 李金花 纪莉景 柴兆祥 Knight T E Burgess L W | 2009 | 草业学报2009，18，1： | 3 |
| 9 | 轮胎压力测试系统参考设计显示文摘 | Lett Burgess 钱炜坤 王志国 | 2004 | 今日电子2004，，5： | 3 |
| 10 | The role of MDM2 and MDM4 in breast cancer development and prevention显示文摘从乳癌的死亡的主要原因不是主要的瘤,而是 relapsing,药抵抗的、变形疾病。识别贡献好攻击的癌症的因素为治疗提供重要领先。对致癌物的固有的防卫取决于每个人的单个分子的组成。这些回答的重要分子的决定因素在鼠标的控制下面是两倍分钟(MDM ) 家庭:蛋白质 MDM2 和 MDM4 包括了。对应力和随后的恢复的在正常、健康成年房间,极其调整的 MDM 家庭功能测量的、细胞的回答。MDM 家庭的合适的功能为正常的胸开发,而且为保存 genomic 忠实是重要的。MDM 家庭成员最好被描绘让他们主要的瘤 suppressor p53 的否定规定调制压力回答。他们另外的细胞的管理者上的影响正在出现。MDM 家庭的不适当地提高的蛋白质层次高度与癌症发生的增加的风险被联系。是的 MDM 家庭成员的探索癌症治疗学的目标为设计定制的反癌症治疗是相关的,但是成功的途径必须战略上在目标癌症和邻近的健康房间和纸巾上考虑影响。这评论集中于在正常、恶意的胸房间与 MDM 家庭的角色相关的最近的调查结果。 | Sue Haupt Reshma Vijayakumaran Panimaya Jeffreena Miranda Andrew Burgess Elgene Lim Ygal Haup | 2017 | Journal of Molecular Cell Biology2017，9，1： | 3 |
| 11 | Microstructure and properties of Fe-based amorphous metallic coating produced by high velocity axial plasma spraying显示文摘 | X.Q. Liu Y.G. Zheng X.C. Chang W.L. Hou J.Q. Wang Z. Tang A. Burgess | 2009 | Journal of Alloys and Compounds2009，，： | 2 |
| 12 | 肝细胞(HepG2)表面apoE代谢与蛋白多糖的影响显示文摘目的 探讨肝细胞表面载脂蛋白E(apoE)的代谢及蛋白多糖对其的影响。方法 采用抗apoE单克隆抗体(7C9)特异性结合方法,分析肝素、硫酸软骨素和软骨素酶及xyloside 对HepG2细胞表面apoE结合与解离的影响。结果 HepG2细胞在含β-D-xyloside的培养液中生长,细胞表面apoE可减少45%,而apoE分泌则增加4.3倍;与肝素酶(3 U/ml)或肝素(l mg/ml)一起孵育可分别减少细胞表面apoE 25.0%和30.5%,而与软骨素ABC酶(1.5 U/ml)孵育可减少细胞表面apoE 40%;硫酸软骨素A和B可分别减少细胞表面apoE 23.6%和15.3%,硫酸软骨素C则没有影响作用;氨基多糖减少细胞表面apoE后,可增加LDL对HepG2细胞表面的结合1.8倍。结论 肝细胞表面apoE主要(约40%)通过硫酸软骨素蛋白多糖、小部分(约23%)通过硫酸乙酰肝素蛋白多糖与细胞表面连接;细胞表面apoE水平降低可增加LDL与细胞表面的结合。 | 梁平 Jim W. Burgess | 2001 | 中国医学科学院学报2001，23，4： | 2 |
| 13 | Colorectal cancer biomarkers: To be or not to be? Cautionary tales from a road well travelled显示文摘Colorectal cancer(CRC)is the second most common cause of cancer-related death worldwide and places a major economic burden on the global health care system.The time frame for development from premalignant to malignant disease typically spans 10-15 years,and this latent period provides an ideal opportunity for early detection and intervention to improve patient outcomes.Currently,early diagnosis of CRC is hampered by a lack of suitable non-invasive biomarkers that are clinically or economically acceptable for populationbased screening.New blood-based protein biomarkers for early detection of CRC are therefore urgently required.The success of clinical biomarker discovery and validation studies is critically dependent on understanding and adjusting for potential experimental,analytical,and biological factors that can interfere with the robust interpretation of results.In this review we outline some important considerations for research groups undertaking biomarker research with exemplars from our studies.Implementation of experimental strategies to minimise the potential effects of these problems will facilitate the identification of panels of biomarkers with the sensitivity and specificity required for the development of successful tests for the early detection and surveillance of CRC. | Kim YC Fung Edouard Nice Ilka Priebe Damien Belobrajdic Aloke Phatak Leanne Purins Bruce Tabor Celine Pompeia Trevor Lockett Timothy E Adams Antony Burgess Leah Cosgrove | 2014 | World Journal of Gastroenterology2014，20，4： | 2 |
| 14 | 环境水样品中药物残留的潜在代谢物的鉴定显示文摘使用超高效液相色谱-串联四极杆飞行时间质谱(QTOF),对环境水样品中的药物和个人护理品(PPCPs)、滥用药物和农兽药等1000多种化合物进行高分辨质谱筛查,并对潜在代谢物进行结构鉴定.水样经过浓缩,使用ACQUITY UPLC HSS C18色谱柱分离后,进行UPLC-QTof分析.筛查出的潜在代谢物经UNIFI科学软件进行结构鉴定. | Gareth Cleland Mark Wrona Lauren Mullin Jennifer Burgess | 2015 | 环境化学2015，34，12： | 2 |
| 15 | Metabolic manifestations of insulin deficiency do not occur without glucagon action显示文摘 | Young Lee Eric D. Berglund May-yun Wang Xiaorong Fu Xinxin Yu Maureen J. Charron Shawn C. Burgess Roger H. Unger | 2012 | Proceedings of the National Academy of Sciences2012，，37： | 2 |
| 16 | Cell:癌基因“遗传平衡”或会影响患者对癌症疗法的反应显示文摘进行癌症疗法的选择越来越需要确定肿瘤细胞中是否含有一些特殊突变的癌基因会驱动癌细胞异常生长。并且确定是否癌细胞会对特殊药物耐受或敏感.近日来自加州大学旧金山分校的研究人员就通过研究发现。以常见的癌基因KRAs突变为例。患者对疗法的反应往往会随着肿瘤的不断进化而发生改变。相关研究刊登于国际杂志Cell上。 | Michael R. Burgess Eugene Hwang Rana Mroue Craig M. Bielski Anica M. Wandler Benjamin J. Huang Ari J. Firestone Amy Young Jennifer A. Lacap Lisa Crocker Saurabh Asthana Elizabeth M. Davis Jin Xu Keiko Akagi Michelle M. Le Beau Qing Li Benjamin Haley David Stokoe Deepak Sampath Barry S. Taylor Marie Evangelista Kevin Shannon | 2017 | 现代生物医学进展2017，17，18： | 2 |
| 17 | Dorsalis pedis arterial bypass: Durable limb salvage for foot ischemia in patients with diabetes mellitus显示文摘 | Frank B. Pomposelli Edward J. Marcaccio Gary W. Gibbons David R. Campbell Dorothy V. Freeman Anne M. Burgess Arnold Miller Frank W. LoGerfo | 1995 | Journal of Vascular Surgery1995，，： | 2 |
| 18 | Cytokine gene expression in splenic CD4 + and CD8 + T cell subsets of genetically resistant and susceptible chickens infected with Marek’s disease virus显示文摘 | P. Parvizi L.R. Read M.F. Abdul-Careem A.J. Sarson C. Lusty M. Lambourne N. Thanthrige-Don S.C. Burgess S. Sharif | 2009 | Veterinary Immunology and Immunopathology2009，，2： | 2 |
| 19 | 甘肃民勤盆地人类活动对生态环境的影响及其生态环境变化对人类的反作用研究——民勤盆地社会调查结果分析(英文)显示文摘主要根据民勤盆地的社会调查资料分析了甘肃省河西地区石羊河流域下游民勤盆地近5 0年来人类活动对生态环境的影响以及生态环境变化对人类的反作用 ,并着重分析了当地人对当地生态环境变化及其原因的理解与认识 .认为民勤盆地存在环境恶化趋势 .该地区地下水位迅速下降 ,沙漠化、土壤盐渍化、植被衰退过程加快 ,这些生态环境变化对人类的生产、生活造成了重大而深刻的影响 。 | 杨永春 Jacquie Burgess 陈发虎 Kevin Collins 李丁 常跟应 李忆春 韩艳梅 | 2002 | 兰州大学学报(自然科学版)2002，38，5： | 2 |
| 20 | 超高效液相色谱/三重四极杆质谱联用(ACQUITY UPLC/Xevo TQ-S)检测蜂花粉中吡虫啉残留量显示文摘在分析复杂环境样品中的痕量污染物时,通常会受到基质的严重干扰,使得在进行亚ng·g-1浓度水平检测时,所用仪器面临着必须满足灵敏度要求的挑战.杀虫剂暴露会对蜂群产生致死和亚致死效应,若要监控这些效应带来的影响则需要对蜜蜂和蜂产品中的杀虫剂水平进行可靠定量.某地区使用吡虫啉杀虫剂来应对昆虫的侵害, | Lauren Mullin Michael Young Jennifer Burgess | 2014 | 环境化学2014，33，6： | 2 |
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