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| 1 | MicroRNAs in the Human Heart: A Clue to Fetal Gene Reprogramming in Heart Failure显示文摘 | Thomas Thum Paolo Galuppo Christian Wolf Jan Fiedler Susanne Kneitz Linda W. van Laake Pieter A. Doevendans Christine L. Mummery Jürgen Borlak Axel Haverich Carina Gross Stefan Engelhardt Georg Ertl Johann Bauersachs | 2007 | Circulation2007，，3： | 3 |
| 2 | Acquired von Willebrand Syndrome in Patients With a Centrifugal or Axial Continuous Flow Left Ventricular Assist Device显示文摘 | Anna L. Meyer Doris Malehsa Ulrich Budde Christoph Bara Axel Haverich Martin Strueber | 2014 | JACC: Heart Failure2014，，2： | 2 |
| 3 | Indications for and Outcomes After Combined Lung and Liver Transplantation: A Single-Center Experience on 13 Consecutive Cases显示文摘 | Gerrit Grannas Michael Neipp Marius M. Hoeper Jens Gottlieb Rainer Lück Thomas Becker Andre Simon Christian P. Strassburg Michael P. Manns Tobias Welte Axel Haverich Jürgen Klempnauer Bj?rn Nashan Martin Strueber | 2008 | Transplantation2008，，4： | 1 |
| 4 | Plexiform Lesions in Pulmonary Arterial Hypertension显示文摘 | Danny Jonigk Heiko Golpon Clemens L. Bockmeyer Lavinia Maegel Marius M. Hoeper Jens Gottlieb Nils Nickel Kais Hussein Ulrich Maus Ulrich Lehmann Sabina Janciauskiene Tobias Welte Axel Haverich Johanna Rische Hans Kreipe Florian Laenger | 2011 | The American Journal of Pathology2011，，1： | 1 |
| 5 | Iloprost to improve surfactant function in porcine pulmonary grafts stored for twenty-four hours in low-potassium dextran solution显示文摘 | Bernhard Gohrbandt Sebastian P. Sommer Stefan Fischer Jens M. Hohlfeld Gregor Warnecke Axel Haverich Martin Strueber | 2005 | The Journal of Thoracic and Cardiovascular Surgery2005，，1： | 1 |
| 6 | Predictors of aneurysmal formation after surgical correction of aortic coarctation显示文摘 | Yskert von Kodolitsch Muhammet A Aydin Dietmar H Koschyk Roger Loose Ilka Schalwat Matthias Karck Jochen Cremer Axel Haverich Jürgen Berger Thomas Meinertz Christoph A Nienaber | 2002 | Journal of the American College of Cardiology2002，，： | 1 |
| 7 | Long-term results after aortic valve-sparing operation (David I) ? 显示文摘 | Malakh Shrestha Hassina Baraki Ilona Maeding Sebastian Fitzner Samir Sarikouch Nawid Khaladj Christian Hagl Axel Haverich | 2012 | European Journal of Cardio-Thoracic Surgery2012，，1： | 1 |
| 8 | Intramural Hemorrhage of the Thoracic Aorta: Diagnostic and Therapeutic Implications显示文摘 | Christoph A. Nienaber Yskert von Kodolitsch Ben Petersen Roger Loose Udo Helmchen Axel Haverich Rolf P. Spielmann | 1995 | Circulation1995，，6： | 1 |
| 9 | Intra-vital Fluorescence Microscopy for Intra-myocardial Graft Detection Following Cell Transplantation显示文摘 | Arjang Ruhparwar Theo Kofidis Nicole Ruebesamen Matthias Karck Axel Haverich Ulrich Martin | 2005 | The International Journal of Cardiovascular Imaging2005，，5： | 1 |
| 10 | Endoluminal treatment of aortic dissection显示文摘 | Ajay Chavan Joachim Lotz Frank Oelert Michael Galanski Axel Haverich Matthias Karck | 2003 | European Radiology2003，，11： | 1 |
| 11 | Antegrade versus retrograde perfusion of the donor lung: impact on the early reperfusion phase显示文摘 | Theo Kofidis Martin Strüber Gregor Warnecke Sebastian Sommer Rainer G. Leyh Leora B. Balsam Robert C. Robbins Axel Haverich | 2003 | Transplant International2003，，11： | 1 |
| 12 | Noncompliance with Diet and Fluid Restriction Among Restrictions Among Having Hemo- dialysis显示文摘 | Christianc Kugler Hans Vlaminck Axel Haverich | 2005 | Journal of Nurs Scholarship2005，37，1： | 1 |
| 13 | Intramural Hematoma of the Aorta: Predictors of Progression to Dissection and Rupture显示文摘 | Yskert von Kodolitsch Susanne K. Cs?sz Dietmar H. Koschyk Ilka Schalwat Roger Loose Matthias Karck Christoph Dieckmann Rossella Fattori Axel Haverich Jürgen Berger Thomas Meinertz Christoph A. Nienaber | 2003 | Circulation: Journal of the American Heart Association2003，，8： | 1 |
| 14 | Enrichment of cardiac pacemaker-like cells: neuregulin-1 and cyclic AMP increase I f -current density and connexin 40 mRNA levels in fetal cardiomyocytes显示文摘 | Arjang Ruhparwar Fikret Er Ulrich Martin Kristin Radke Ina Gruh Michael Niehaus Matthias Karck Axel Haverich Uta C. Hoppe | 2007 | Medical & Biological Engineering & Computing2007，，2： | 1 |
| 15 | 显示文摘 | Augustinus Bader Loredana De Bartolo Axel Haverich | 2000 | Journal of Biotechnology2000，81，： | 1 |
| 16 | Evaluation of different minimally invasive technique in pediatric cardiac surgery:Is a full sternotomy always a nessessity?显示文摘 | Christian Hagl Ulrich Stock Axel Haverich | 2001 | Chest2001，1，19： | 1 |
| 17 | Monophasic action potential mapping in human subjects with normal electrocardiograms: direct evidence for the genesis of the T wave显示文摘 | MICHAEL R. FRANZ KLAUS BARGHEER WOLF RAFFLENBEUL AXEL HAVERICH PAUL R. LICHTLEN | 1987 | Circulation1987，，： | 1 |
| 18 | Immunological and functional features of decellularized xenogeneic heart valves after transplantation into GGTA1-KO pigs显示文摘Decellularization of xenogeneic heart valves might lead to excellent regenerative implants,from which many patients could benefit.However,this material carries various xenogeneic epitopes and thus bears a considerable inherent immunological risk.Here,we investigated the regenerative and immunogenic potential of xenogeneic decellularized heart valve implants using pigs deficient for the galactosyltransferase gene(GGTA1-KO)as novel large animal model.Decellularized aortic and pulmonary heart valves obtained from sheep,wild-type pigs or GGTA1-KO pigs were implanted into GGTA1-KO pigs for 3,or 6 months,respectively.Explants were analyzed histologically,immunhistologically(CD3,CD21 and CD172a)and anti-aGal antibody serum titers were determined by ELISA.Xenogeneic sheep derived implants exhibited a strong immune reaction upon implantation into GGTA1-KO pigs,characterized by massive inflammatory cells infiltrates,presence of foreign body giant cells,a dramatic increase of anti-aGal antibody titers and ultimately destruction of the graft,whereas wild-type porcine grafts induced only a mild reaction in GGTA1-KO pigs.Allogeneic implants,wild-type/wild-type and GGTA1-KO/GGTA1-KO valves did not induce a measurable immune reaction.Thus,GGTA1-KO pigs developed a‘human-like’immune response toward decellularized xenogeneic implants showing that immunogenicity of xenogeneic implants is not sufficiently reduced by decellularization,which detracts from their regenerative potential. | Robert Ramm Tobias Goecke Peter Kohler Igor Tudorache Serghei Cebotari Anatol Ciubotaru Samir Sarikouch Klaus Hoffler Friederike Bothe Bjorn Petersen Axel Haverich Heiner Niemann Andres Hilfiker | 2021 | Regenerative Biomaterials2021，8，5： | 0 |
| 19 | Chemically induced hypoxia by dimethyloxalylglycine(DMOG)-loaded nanoporous silica nanoparticles supports endothelial tube formation by sustained VEGF release from adipose tissue-derived stem cells显示文摘Inadequate vascularization leading to insufficient oxygen and nutrient supply in deeper layers of bioartificial tissues remains a limitation in current tissue engineering approaches to which prevascularization offers a promising solution.Hypoxia triggering pre-vascularization by enhanced vascular endothelial growth factor(VEGF)expression can be induced chemically by dimethyloxalylglycine(DMOG).Nanoporous silica nanoparticles(NPSNPs,or mesoporous silica nanoparticles,MSNs)enable sustained delivery of molecules and potentially release DMOG allowing a durable capillarization of a construct.Here we evaluated the effects of soluble DMOG and DMOG-loaded NPSNPs on VEGF secretion of adipose tissue-derived stem cells(ASC)and on tube formation by human umbilical vein endothelial cells(HUVEC)-ASC co-cultures.Repeated doses of 100 mM and 500 mM soluble DMOG on ASC resulted in 3-to 7-fold increased VEGF levels on day 9(P<0.0001).Same doses of DMOG-NPSNPs enhanced VEGF secretion 7.7-fold(P<0.0001)which could be maintained until day 12 with 500 mM DMOG-NPSNPs.In fibrin-based tube formation assays,100 mM DMOG-NPSNPs had inhibitory effects whereas 50 mM significantly increased tube length,area and number of junctions transiently for 4 days.Thus,DMOG-NPSNPs supported endothelial tube formation by upregulated VEGF secretion from ASC and thus display a promising tool for prevascularization of tissue-engineered constructs.Further studies will evaluate their effect in hydrogels under perfusion. | Sarah Zippusch Karen FWBesecke Florian Helms Melanie Klingenberg Anne Lyons Peter Behrens Axel Haverich Mathias Wilhelmi Nina Ehlert Ulrike Boer | 2021 | Regenerative Biomaterials2021，8，5： | 0 |
| 20 | Non-intubated minimally-invasive lung surgery in Germany-current status and outlook显示文摘Lung surgery under spontaneous ventilation(non-intubated video-assisted thoracoscopic surgery,niVATS)picked up a lot of momentum during the past few years.Surgeons and anesthetists alike want to forgo known risks of orotracheal intubation and mechanical ventilation,ranging from local complications,like mucosal injury or even deleterious tracheal laceration and rupture,to increased release of pro-inflammatory cytokines and diaphragmatic dysfunction secondary to muscle relaxation.Despite initial adoption of VATS in Germany having been slow due to a general reticence towards it in smaller units,major thoracic centers nowadays have well-established minimally invasive programs and even perform minor non-intubated procedures on a regular basis.Experience with major niVATS cases still is sparse across Western Europe,and limited to specialized and highly trained centers,where exceptionally complex and often multimorbid patients can safely undergo lung surgery under spontaneous ventilation.Our group pioneered niVATS lobectomy in Germany back in 2018,and since then we tried to spread the technique by means of multidisciplinary Masterclass-courses held at our center,in which the participant’s initial reticence to perform niVATS often changed to enthusiasm for the procedure.This in turn led several visiting units to start with their own programs,and some of them even reported their initial experience.This article offers a short historic overview of VATS in general,gives an insight into how niVATS got pioneered in Germany and presents the current state of affairs. | Patrick Zardo Norman Zinne Alaa Selman Hayan Merhej Tobias Goecke Henning Starke Daniel Jaeger Jan Karsten Axel Haverich | 2021 | 中华胸部外科电子杂志2021，8，4： | 0 |
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