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| 1 | Enhanced microfracture techniques in cartilage knee surgery: Fact or fiction?显示文摘The limited intrinsic healing potential of human articular cartilage is a well-known problem in orthopedic surgery. Thus a variety of surgical techniques have been developed to reduce joint pain, improve joint function and delay the onset of osteoarthritis. Microfractures as a bone marrow stimulation technique present the most common applied articular cartilage repair procedure today. Unfortunately the deficiencies of fibrocartilaginous repair tissue inevitably lead to breakdown under normal joint loading and clinical results deteriorate with time. To overcome the shortcomings of microfracture, an enhanced microfracture technique was developed with an additional collagen Ⅰ/Ⅲ membrane(Autologous, Matrix-Induced Chondrogenesis, AMIC). This article reviews the pre-clinical rationale of microfractures and AMIC, presents clinical studies and shows the advantages and disadvantages of these widely usedtechniques. PubM ed and the Cochrane database were searched to identify relevant studies. We used a comprehensive search strategy with no date or language restrictions to locate studies that examined the AMIC technique and microfracture. Search keywords included cartilage, microfracture, AMIC, knee, ChondroGide. Besides this, we included our own experiences and study authors were contacted if more and non published data were needed. Both cartilage repair techniques represent an effective and safe method of treating full-thickness chondral defects of the knee in selected cases. While results after microfracture deteriorate with time, mid-term results after AMIC seem to be enduring. Randomized studies with long-term followup are needed whether the grafted area will maintain functional improvement and structural integrity over time. | Stefan Bark Tomasz Piontek Peter Behrens Sabiah Mkalaluh Deike Varoga Justus Gille | 2014 | World Journal of Orthopedics2014，5，4： | 3 |
| 2 | 白内障摘除术后的急性眼内炎文献的系统回顾显示文摘目的:确定白内障摘除术后随时间推移报道的急性眼内炎的发生率并探讨可能引起的因素,如白内障手术切口类型。
方法:以白内障摘除术、眼内炎及术后并发症为关键词,对1963—2003年PubMed上的英文文献进行广泛检索。并进行系统性回顾。附加的研究确认为与其相切题的文献和已发表的会议记录。在可能提供的情况下。记录手术方式。对用不同手术切口技术导致眼内炎发展的累计发生率和相关危险度进行评估。用不同切口的技术评估累计眼内炎的发生率与发展眼内炎的相对危险因素。
结果:从4916篇特定且具潜在相关性的引文中对其中215篇涉及眼内炎且符合入选标准的研究进行分析。总共3140650例白内障手术后,累计0.128%发生眼内炎。然而,急性眼内炎的发生率随着时代不同而改变。与过去lO年相比。2000年以来发生率明显升高(相对危险度,2.44;95%可信区间,2.27—2.61)。2000—2003年眼内炎发生率为0.265%。20世纪90年代为0.087%,80年代为0.158%,70年代为0.327%。并且,与1991年及以前相比,1992年以来发生率有上升趋势。手术切口类型似乎是产生显著影响的危险因素,因为1992—2003年中,经透明角膜切口白内障手术后眼内炎发生率为0.189%。与经巩膜切口0.074%(相对危险度,2.55;95%可信区间,1.75—3.71)及经角巩膜缘切口0.062%(相对危险度,3.06;95%可信区间,2.48—3.76)的发生率相比较,手术切口类型似乎是产生显著影响的危险因素。
结论:这一系统回顾显示,与白内障摘除术相关眼内炎的发生率在过去10年中有所上升。其发生频率的上升趋势与当前无缝线透明角膜白内障摘除术的进展相一致。 | Mehran Taban Ashley Behrens Robert L. Newcomb Matthew Y. Nobe Golnaz Saedi Paula M. Sweet Peter J. McDonnell 胡妙妙(译) 蒋幼芹(校) | 2006 | 美国医学会眼科杂志(中文版)2006，18，1： | 2 |
| 3 | Composites of perylene chromophores and layered double hydroxides: Direct synthesis, characterization and photo-and chemical stability 显示文摘 | Johann Bauer Peter Behrens Markus Speekbacher | 2003 | Adv Funct Mater2003，13，3： | 1 |
| 4 | Combination treatment of psoriasis with photochemotherapy and tazarotene gel, a receptor-selective topical retinoid显示文摘 | Behrens S Grundmann-Kollmann M Peter RU | 1999 | Br J Dermatol1999，141，1： | 1 |
| 5 | The Watson - Glaser critical thinking appraisal and academic performance of diploma schoal students显示文摘 | Peter J Behrens | 1996 | Journal of Nursing Education1996，35，1： | 1 |
| 6 | The Incidence of Endophthalmitis after Cataract Surgery among the U.S. Medicare Population Increased between 1994 and 2001显示文摘 | Emily S. West Ashley Behrens Peter J. McDonnell James M. Tielsch Oliver D. Schein | 2005 | Ophthalmology2005，，8： | 1 |
| 7 | Chemically induced hypoxia by dimethyloxalylglycine(DMOG)-loaded nanoporous silica nanoparticles supports endothelial tube formation by sustained VEGF release from adipose tissue-derived stem cells显示文摘Inadequate vascularization leading to insufficient oxygen and nutrient supply in deeper layers of bioartificial tissues remains a limitation in current tissue engineering approaches to which prevascularization offers a promising solution.Hypoxia triggering pre-vascularization by enhanced vascular endothelial growth factor(VEGF)expression can be induced chemically by dimethyloxalylglycine(DMOG).Nanoporous silica nanoparticles(NPSNPs,or mesoporous silica nanoparticles,MSNs)enable sustained delivery of molecules and potentially release DMOG allowing a durable capillarization of a construct.Here we evaluated the effects of soluble DMOG and DMOG-loaded NPSNPs on VEGF secretion of adipose tissue-derived stem cells(ASC)and on tube formation by human umbilical vein endothelial cells(HUVEC)-ASC co-cultures.Repeated doses of 100 mM and 500 mM soluble DMOG on ASC resulted in 3-to 7-fold increased VEGF levels on day 9(P<0.0001).Same doses of DMOG-NPSNPs enhanced VEGF secretion 7.7-fold(P<0.0001)which could be maintained until day 12 with 500 mM DMOG-NPSNPs.In fibrin-based tube formation assays,100 mM DMOG-NPSNPs had inhibitory effects whereas 50 mM significantly increased tube length,area and number of junctions transiently for 4 days.Thus,DMOG-NPSNPs supported endothelial tube formation by upregulated VEGF secretion from ASC and thus display a promising tool for prevascularization of tissue-engineered constructs.Further studies will evaluate their effect in hydrogels under perfusion. | Sarah Zippusch Karen FWBesecke Florian Helms Melanie Klingenberg Anne Lyons Peter Behrens Axel Haverich Mathias Wilhelmi Nina Ehlert Ulrike Boer | 2021 | Regenerative Biomaterials2021，8，5： | 0 |
| 8 | 穿透性角膜移植术后急性眼内炎的发病率系统评价显示文摘目的:确定穿透性角膜移植术(PK)后急性眼内炎随时间变化的发病率。
方法:以穿透性角膜移植术、眼内炎和术后并发症作为关键词在Pubmed数据库从1963年到2003年3月进行广泛的检索,然后对其中英文文献进行系统评价。从相关文章和发表汇编所列的文献目录中确定补充的资料。记录急性眼内炎作为术后并发症的患眼的比例,对随时间变化汇总的发病率进行评定。结果:1870篇有关主体的文章中,对其中66篇报道了眼内炎并符合选择标准的原文进行了分析。总共汇总了90549例PKs。术后发生眼内炎的总体估计值为0.382%。但是其中出现一个随时间发展的变化。眼内炎发病率在2000到2003年间为0.200%,20世纪90年代为0.453%。80年代为0.376%,70年代期间为0.142%。另外与1991年及以前相比。1992年以后眼内炎的发病率有下降的趋势。
结论:本系统评价表明近十年来与PK相关的眼内炎的发病率下降了。 | Mehran Taban Ashley Behrens Robert L. Newcomb Matthew Y. Nobe Peter J. McDonnell 张世杰(译) 任泽钦(校) | 2006 | 美国医学会眼科杂志(中文版)2006，18，1： | 0 |
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