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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Combination of repeated single-session percutaneous ethanol injection and transarterial chemoembolisation compared to repeated single-session percutaneous ethanol injection in patients with non-resectable hepatocellular carcinoma显示文摘瞄准:为病人评估经皮的乙醇注射(PEI ) 的治疗效果与先进, non-resectable HCC 与 transarterial chemoembolisation 的联合相比(不作声) 并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。方法:在学习时期期间接受了 PEI 治疗的所有病人根据物理地位和肿瘤程度被包括并且成层到下列治疗形式之一:联合不作声并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。包括Okuda分类,门静脉血栓的存在,腹水的存在,肿瘤的数字,最大的肿瘤直径,和假胆硷酯酶( CHE )的临床的参数的预示的价值,以及孩子呸上演, alpha-fetoprotein (法新社),发烧,复杂并发症的发生在这些组之间被估计并且比较。幸存用 Kaplan-Meier 被决定,多,变量回归分析。结果:所有病人的 1 年、 3 年的幸存是 73% 和 47% 。在亚群分析,联合不作声, PEI (1 ) 与更长的幸存被联系(1- , 3- , 5 年的幸存:90% , 52% ,和 43%) 与 PEI 治疗相比独自一个(2 )(1- , 3- , 5 年的幸存:65% , 50% ,和 37%) 。(3 ) 在起始的层化以后的第二等的 PEI 产出可比较的结果不作声(1- , 3- , 5 年的幸存:91% , 40% ,和 30%) 当在到最好的支持的照顾(4 ) 的层化以后的 PEI 与减少的幸存被联系时(1- , 3- , 5 年的幸存:50% , 23% , 12%) 。除了选择治疗形式,为更好的幸存的预言者是肿瘤数字(n <
5 ) ,肿瘤尺寸(<
5 厘米) ,在 PEI 前的没有腹水,和在 PEI 以后的稳定的假胆硷酯酶(P <
0.05 ) 。在在 PEI 以后的 2 wk 以内的死亡是 2.8%(n = 3 ) 。有 24 (8.9%) 主修在包括部分肝梗塞,焦点的肝坏死,和肝脓肿的 PEI 以后的复杂并发症。所有复杂并发症能非通过手术被管理。结论:重复单个会议的 PEI 在有以可接受、可管理的复杂并发症率的先进 HCC 的病人是有效的。病人们成层到联合不作声, PEI 能比那些独自成层到重复 PEI 期望更长的幸存。而且,有在好临床的地位的大或多重的肿瘤的病人可以也从联合获利不作声并且为第二等的 PEI 的再考虑。 | Arne Dettmer Timm D Kirchhoff Michael Gebel Lars Zender Nisar P Malek Bernhard Panning Ajay Chavan Herbert Rosenthal Stefan Kubicka Susanne Krusche Sonja Merkesdal Michael Galanski Michael P Manns Joerg S Bleck | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 3 | 卵巢癌与宫颈癌合并血栓栓塞性疾病临床特点分析显示文摘目的:对比分析上皮性卵巢癌患者与宫颈鳞状细胞癌患者发生静脉血栓栓塞(VTE)的临床特征,分析其高危因素,为其临床预防及诊治提供参考。方法:回顾性分析我院收治的上皮性卵巢癌患者(n=147例)及宫颈鳞状细胞癌患者(n=149例)的临床资料,对比分析两组患者VTE发生临床特点的差异,尤其是化疗及围手术期对VTE发生的影响,单因素回归分析VTE发生的高危因素。结果:卵巢癌患者的VTE发生率高于宫颈癌患者(13.6%vs 7.4%,P=0.08),但无统计学意义。卵巢癌患者与宫颈癌患者VTE的发生具有不同特点,卵巢癌患者VTE多发生于初步诊断时(65% vs 9.1%,P=0.003),而宫颈癌患者VTE多发生于手术后(81.8%vs 25%,P=0.006)。两组患者新辅助化疗期间VTE发生率(10% vs 0%,P=0.53)以及术后辅助化疗期间VTE发生率(0%vs 9.1%,P=0.354)均无显著差异。多数患者合并的VTE均为下肢静脉血栓,仅1例卵巢癌患者发生肺栓塞。单因素分析发现卵巢癌患者绝经后状态(17.9% vs 5.8%,P=0.045)为VTE发生的高危因素。结论:卵巢癌患者与宫颈癌患者VTE发生特点存在显著差异。卵巢癌患者易自发发生VTE,宫颈癌患者VTE多于手术后发生。卵巢癌患者与宫颈癌患者合并VTE的总发病率无统计学差异。化疗不增加两组患者VTE的发生率。 | Chavan Devendra 黄珍 孙丽萍 姚舒 宋坤 | 2016 | 现代妇产科进展2016，25，2： | 11 |
| 4 | Cellulose based polymers in development of amorphous solid dispersions显示文摘Cellulose derivatives have gained immense popularity as stabilizers for amorphous solid dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid dispersion-based products that have been approved for marketing consist of cellulose derivatives as stabilizers, thus highlighting their importance in generation of amorphous solid dispersions. These polymers offer numerous advantages like drug solubilization, crystallization inhibition and improvement in release patterns of drugs. Exploring their potential and exploiting their chemistry and p H responsive behaviour have led to the synthesis of new derivatives that has broadened the scope of the use of cellulose derivatives in amorphous formulation development. The present review aims to provide an overview of different mechanisms by which these cellulose derivatives inhibit the crystallization of drugs in the solid state and from supersaturated solution. A summary of different categories of cellulose derivatives along with the newly explored polymers has been provided. A special segment on strengths, weaknesses, opportunities, and threats(SWOT) analysis and critical quality attributes(CQAs) which affect the performance of the cellulose based amorphous solid dispersion will aid the researchers in identifying the major challenges in the development of cellulose based solid dispersion and serve as a guide for further formulation development. | Rahul B Chavan Sneha Rathi Vaskuri G S Sainaga Jyothi Nalini R Shastri | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 5 |
| 5 | Co-gasification of coal and biomass an emerging clean energy technology: Status and prospects of development in Indian context显示文摘Co-gasification of coal and biomass is emerging as potential clean fuel technology to achieve high thermodynamic efficiency with relatively low CO2 emission. The coal and biomass have been exclusively gasified more than a century to obtain gas–liquid fuels and the production of chemicals. Co-gasification has higher efficiency than the solitary coal gasification because the cellulose, hemicellulose and lignin content of biomass help to ignite and enhance the rate of gasification. It is suggested that the extensive research on carbon reactivity pattern, heat release, reaction kinetics, etc. may support to reduce the uncertainties in the co-gasification performance of coal and biomass blends, particularly in India. The prospects of co-gasification technology in Indian context have been discussed considering the abundance of varieties of coal and biomass. The suitability of existing gasifier procedures and their limitations with operating parameters like temperature, residence time, density optimisation, feed rate, agglomeration intensity, the tar formation and techno-economics involved are described. Also, this paper reviews the research highlights of the history of co-gasification and the advancement in upcoming challenges like a design of gasifier, access and preparation of biomass, disposal of residue, environmental concerns and reassurance to the operators for execution of large and small-scale projects. | Alka D.Kamble Vinod Kumar Saxena Prakash Dhondiram Chavan Vinod Atmaram Mendhe | 2019 | International Journal of Mining Science and Technology2019，29，2： | 5 |
| 6 | Revisiting the morphology of pelvicalyceal system in human cadaveric kidneys with a systematic review of literature显示文摘Objective:Renal collecting system macroscopically consists of minor calyx,major calyx,renal pelvis and ureter.Stone in renal collecting system is a common presentation in everyday urological practice.The prevalence of renal calculi ranges from 4%to 20%in different geographical distribution.Anatomical variation in renal collecting system plays a significant role in formation of calculi in its parts.The large extra renal pelvis leads to stagnation of urine for longer durations and formation of stones.The stone free rate after percutaneous nephrolithotomy and extra corporeal shock wave lithotomy is significantly related to anatomical factors,particularly the type of renal pelvis and dimensions(length and width)of lower infundibulum.Previous authors described the morphology of pelvicalyceal system in a highly variable manner and the available anatomical description of pelvicalyceal system is contradictory and incomplete.Hence an attempt has been made to provide the precise anatomy of pelvicalyceal system in adult human kidneys.Methods:We studied 196 formalin embalmed kidneys to note the number of infundibulum,major and minor calyces.The location and shape of pelvis were also studied.Results:The intra-renal pelvis was narrow and had funnel shaped appearance in 95 of total 196(48.5%)specimens,and the extra-renal pelvis was dilated as balloon shaped in 43 of 196(21.9%)specimens.In 41(20.9%)specimens,the renal pelvis was having partially intra-and extra-renal in location.Bilateral symmetry was found in only 27.1%of 196 renal collecting systems.The length of lower infundibulum was more than 22 mm in 19(9.7%)of 196 cases which directly affects the stone clearance rate during open and endoscopic surgeries on pelvicalyceal system.Conclusion:This study provides the accurate morphological details of the shape and dimensions of renal pelvicalyceal system to help the urologists and nephrologists. | Kusum Rajendra Gandhi Sushama Chavan | 2019 | Asian Journal of Urology2019，6，3： | 5 |
| 7 | Mapping of dwarfing gene Rht14 in durum wheat and its effect on seedling vigor, internode length and plant height显示文摘Short coleoptiles associated with GA-insensitive Rht-1 alleles in wheat reduces yield due to poor seedling establishment under dry, or stubble-retained conditions. Hence there is a need for alternative dwarfing genes for wheat improvement programs. GA-sensitive dwarfing gene Rht14 confers semidwarf stature in wheat while retaining longer coleoptiles and early seedling vigor. Two RIL populations were used to identify the map position of Rht14 and to estimate its effect on plant height, coleoptile length, seedling shoot length,spike length and internode length. Rht14 on chromosome 6 A was mapped in the genomic region 383–422 Mbp flanked by GA2oxA9 and wmc753 in a Bijaga Yellow/Castelporziano RIL population. Recombination events between Rht14 and GA2oxA9 in the RIL population indicated that Rht14 might not be allelic to GA2oxA9. The conserved DNA sequence of GA2oxA9 and its flanking region in Castelporziano also suggested that the point of mutation responsible for the Rht14 allele must be a few Mbp away from GA2oxA9. The dwarfing effects of Rht14 on plant height, internode length and seedling vigor were compared with those of Rht-B1 b in an HI 8498/Castelporziano RIL population. Both genes significantly reduced plant height and internode length. Rht-B1 b conferred a significant reduction in coleoptile length and seedling shoot length, whereas Rht14 reduced plant height, but not coleoptile and seedling shoot length. Therefore, Rht14 can be a used as an alternative to Rht-B1 b for development of cultivars suitable for deeper sowing in dry environments and in conditions of conservation agriculture where crop residues are retained. | Parimal Vikhe Suhasini Venkatesan Ajit Chavan Shubhada Tamhankar Ravindra Patil | 2019 | The Crop Journal2019，7，2： | 4 |
| 8 | Initial experience from a combination of systemic and regional chemotherapy in the treatment of patients with nonresectable cholangiocellular carcinoma in the liver显示文摘AIM: In nonresectable cholangiocellular carcinoma (CCC)therapeutic options are limited. Recently, systemic chemotherapy has shown response rates of up to 30%.Additional regional therapy of the arterially hyper vascularized hepatic tumors might represent a rational approach in an attempt to further improve response and palliation. Hence, a protocol combining transarterial chemoembolization and systemic chemotherapy was applied in patients with CCC limited to the liver.METHODS: Eight patients (6 women, 2 men, mean age 62 years) with nonresectable CCC received systemic chemotherapy (gemcitabine 1 000 mg/m2) and additional transarterial chemoembolization procedures (50 mg/m2cisplatin, 50 mg/m2 doxorubicin, up to 600 mg degradable starch microspheres). Clinical follow-up of patients, tumor markers, CT and ultrasound were performed to evaluate maximum response and toxicity.RESULTS: Both systemic and regional therapies were tolerated well; no severe toxicity (WHO Ⅲ/Ⅳ) was encountered. Nausea and fever were the most commonly observed side effects. A progressive rarefication of the intrahepatic arteries limited the maximum number of chemoembolization procedures in 4 patients. A median of 2 chemoembolization cycles (range, 1-3) and a median of 6.5 gemcitabine cycles (range, 4-11) were administered.Complete responses were not achieved. As maximum response, partial responses were achieved in 3 cases,stable diseases in 5 cases. Two patients died from progressive disease after 9 and 10 mo. Six patients are still alive. The current median survival is 12 mo (range, 9-18); the median time to tumor progression is 7 mo (range, 3-18). Seven patients suffered from tumor-related symptoms prior to therapy, 3 of these experienced a treatment-related clinical relief. In one patient the tumor became resectable under therapy and was successfully removed after 10 mo.CONCLUSION: The present results indicate that a combination of systemic gemcitabine therapy and repeated regional chemoembolizations is well tolerated and may enhance the effect of palliation in a selected group of patients with intrahepatic nonresectable CCC. | Timm Kirchhoff Lars Zender Sonja Merkesdal Bernd Frericks Nisar Malek Joerg Bleck Stefan Kubicka Stefan Baus Ajay Chavan Michael P.Manns Michael Galanski | 2005 | World Journal of Gastroenterology2005，11，8： | 3 |
| 9 | Effect of Downward Seepage on Turbulent Flow Characteristics and Bed Morphology around Bridge Piers显示文摘在这个工作,试验性的调查被追求了分析影响向下在在在冲积隧道的圆形的桥码头附近的旋涡结构的流动和相应变化的狂暴的特征上的渗出物。实验为没有渗出物, 10% 渗出物和 20% 渗出物盒子与不同尺寸的圆形的墩在沙床隧道被进行。象速度和雷纳兹压力那样的狂暴的流动统计的测量被发现在 scour 洞在以内否定墩在上游而申请向下,渗出物延迟在速度和雷纳兹引起减少的流动的颠倒强调。更高级的雷纳兹砍因为生产,应力在下游的方面占优势弄醒旋涡。到彻底的雷纳兹的所有爆炸事件的贡献砍压力生产被观察了增加与向下渗出物。不可分的规模的分析建议旋涡的那种尺寸与渗出物增加,它为粒子活动性的增加负责。开始搜索评价是消退逐渐地象与一样与膨胀预定的更多增加了向下渗出物。存在向下,渗出物向墩的下游的方面减少旋涡和移动的深度和长度。 | Rutuja Chavan Anurag Sharma Bimlesh Kumar | 2017 | Journal of Marine Science and Application2017，16，1： | 3 |
| 10 | Experimental Investigation on Flow and Scour Characteristics Around Tandem Piers in Sandy Channel With Downward Seepage显示文摘Experimental investigations have been carried out to study morpho-hydraulic characteristics such as scour geometry and turbulent flow properties around tandem piers in alluvial channels. Experiments were carried out in a plane sand bed with two circular piers of same diameter arranged in tandem manner under no seepage, 10% seepage and 20% seepage conditions. Downward seepage minimizes the scour depth around piers and restrains the development of scour depth with time. Strong reversal flow is found near the bed at upstream of piers and near free surface at downstream of piers where velocity and Reynolds shear stress are found to be negative which reduce in magnitude with downward seepage. The flow is more critical within the gap between two piers where velocity is lesser near free surface and gradually increasing towards bed. Quadrant analysis shows that contribution of each event to the total Reynolds shear stress increases with downward seepage. Sedimentation effect prevails within the scour hole whereas outside the scour hole erosive forces become more dominant. Reduced reversal flow at upstream of pier because of downward seepage results in decreasing higher order moments and turbulent kinetic energy. At downstream of piers, secondary currents are dominant due to wake vortices. Strouhal number decreases in case of seepage runs than no seepage condition. | Rutuja Chavan Bimlesh Kumar | 2017 | Journal of Marine Science and Application2017，16，3： | 3 |
| 11 | Cytomegalovirus infection in the bone marrow transplant patient显示文摘Cytomegalovirus(CMV) infection is an important contributor to the morbidity and mortality associated with bone marrow transplantation(BMT). Infection may lead to CMV disease involving multiple organs such as pneumonia, gastroenteritis, retinitis, central nervus system involvement and others. CMV seropositivity is an important risk factor and approximately half of BMT recipients will develop clinically significant infection most commonly in the first 100 d post-transplant. The commonly used tests to diagnose CMV infection in these patients include the pp65 antigenemia test and the CMV DNA polymerase chain reaction(PCR) assay. Because of its greater sensitivity and lesser turnaround time, the CMV PCR is nowadays the preferred test and serves as a main guide for pre-emptive therapy. Methods of CMV prevention include use of blood products from seronegative donors or leukodepleted products. Prophylaxis or pre-emptive therapy strategies for CMV prevention may be used post-transplant with the latter becoming more common. The commonly used antivirals for pre-emptive therapy and CMV disease management include intravenous gancyclovir and foscarnet. The role of intravenous immunoglobulin, although used commonly in CMV pneumonia is not clear. | Vivek Bhat Amit Joshi Rahul Sarode Preeti Chavan | 2015 | World Journal of Transplantation2015，5，4： | 3 |
| 12 | Novel multistage solid-liquid circulating fluidized bed: Hydrodynamic characteristics显示文摘 | Prakash V. Chavan Manjusha A. Thombare Sandip B. Bankar Dinesh V. Kalaga Veena A. Patil-Shinde | 2018 | Particuology2018，16，3： | 2 |
| 13 | Functional propertics of protein isolates from beach pea显示文摘 | U D Chavan D B MeKenzie F Shahidi | 2001 | Food Chemistry2001，74，： | 1 |
| 14 | Zinc mediated transesterification of β-ketoesters and coumarin synthesis显示文摘 | Chavan S P Shivasankar K Sivappa R | 2002 | Tetrahedron Letters2002，43，： | 1 |
| 15 | Endolumin alteratment of aortic dissection显示文摘 | Chavan A Lotz J Oelert F | 2003 | Eur Radiol2003，13，11： | 1 |
| 16 | Regulation of melanogenesiscontroversies and newconcepts显示文摘 | Schallreuter KU Kothari S Chavan B | | Exp Dermatol0，17，5： | 1 |
| 17 | Design of an aluminium- based vehicle platform for front impact safety 显示文摘 | Deb A Mahendrakumar M S Chavan C | 2004 | International Journal of Impact Engineering2004，30，89： | 1 |
| 18 | Sweet syndrome : Clinical presentation, associations, and response to treatment in 77 patients显示文摘 | Rochet NM Chavan RN Cappel MA | 2013 | J Am Acad Dermatol2013，69，： | 1 |
| 19 | Functional properties of protein i-solates from beach pea显示文摘 | Chavan V D Mckenzie D B | 2001 | Food Chemistry2001，74，： | 1 |
| 20 | Chemokine recep- tors CCR5 and CCR2 genes in HIV positive, HIV exposed sero- negative and in HIV unexposed individuals: A study from Mum- bai显示文摘 | Chaudhari DV Kerkar SC Chavan V | 2015 | Indian J Dermatol Venereol Leprol2015，81，5： | 1 |
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