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| 1 | Progression of remnant gastric cancer is associated with duration of follow-up following distal gastrectomy显示文摘AIM: To re-evaluate the recent clinicopathological features of remnant gastric cancer (RGC) and to develop desirable surveillance programs. METHODS: Between 1997 and 2008, 1149 patients underwent gastrectomy for gastric cancer at the Department of Digestive Surgery, Kyoto Prefectural University of Medicine, Japan. Of these, 33 patients underwent gastrectomy with lymphadenectomy for RGC. Regarding the initial gastric disease, there were 19 patients with benign disease and 14 patients with gastric cancer. The hospital records of these patients were reviewed retrospectively. RESULTS: Concerning the initial gastric disease, the RGC group following gastric cancer had a shorter interval [P < 0.05; gastric cancer vs benign disease: 12 (2-22) vs 30 (4-51) years] and were more frequently reconstructed by Billroth-Ⅰ procedure than those following benign lesions (P < 0.001). Regarding reconstruction, RGC following Billroth-Ⅱ reconstruction showed a longer interval between surgical procedures [P < 0.001; Billroth-Ⅱ vs Billroth-Ⅰ: 32 (5-51) vs 12 (2-36) years] and tumors were more frequently associated with benign disease (P < 0.001) than those following Billroth-Ⅰ reconstruction. In tumor location of RGC, after Billroth-Ⅰ reconstruction, RGC occurred more frequently near the suture line and remnant gastric wall. After Billroth-Ⅱ reconstruction, RGC occurred more frequently at the anastomotic site. The duration of follow-up was significantly associated with the stage of RGC (P < 0.05). Patients diagnosed with early stage RGC such as stage Ⅰ-Ⅱ tended to have been followed up almost every second year. CONCLUSION: Meticulous follow-up examination and early detection of RGC might lead to a better prognosis. Based on the initial gastric disease and the procedure of reconstruction, an appropriate follow-up interval and programs might enable early detection of RGC. | Shuhei Komatsu Daisuke Ichikawa Kazuma Okamoto Daito Ikoma Masahiro Tsujiura Yukihisa Nishimura Yasutoshi Murayama Atsushi Shiozaki Hisashi Ikoma Yoshiaki Kuriu Masayoshi Nakanishi Hitoshi Fujiwara Toshiya Ochiai Yukihito Kokuba Eigo Otsuji | 2012 | World Journal of Gastroenterology2012，18，22： | 25 |
| 2 | Endoscopic submucosal dissection for early esophageal neoplasms using the stag beetle knife显示文摘AIM To determine short-and long-term outcomes of endoscopic submucosal dissection(ESD) using the stag beetle(SB) knife, a scissor-shaped device.METHODS Seventy consecutive patients with 96 early esophageal neoplasms, who underwent ESD using a SB knife at Kure Medical Center and Chugoku Cancer Center, Japan, between April 2010 and August 2016, were retrospectively evaluated. Clinicopathological characteristics of lesions and procedural adverse events were assessed. Therapeutic success was evaluated on the basis of en bloc, histologically complete, and curative or non-curative resection rates. Overall and tumor-specific survival, local or distant recurrence, and 3-and 5-year cumulative overall metachronous cancer rates were also assessed.RESULTS Eligible patients had dysplasia/intraepithelial neoplasia(22%) or early cancers(squamous cell carcinoma, 78%). The median procedural time was 60 min and on average, the lesions measured 24 mm in diameter, yielding 33-mm tissue defects. The en bloc resection rate was 100%, with 95% and 81% of dissections deemed histologically complete and curative, respectively. All procedures were completed without accidental incisions/perforations or delayed bleeding. During follow-up(mean, 35 ± 23 mo), no local recurrences or metastases were observed. The 3-and 5-year survival rates were 83% and 70%, respectively, with corresponding rates of 85% and 75% for curative resections and 74% and 49% for noncurative resections. The 3-and 5-year cumulative rates of metachronous cancer in the patients with curative resections were 14% and 26%, respectively.CONCLUSION ESD procedures using the SB knife are feasible, safe, and effective for treating early esophageal neoplasms, yielding favorable short-and long-term outcomes. | Toshio Kuwai Toshiki Yamaguchi Hiroki Imagawa Ryoichi Miura Yuki Sumida Takeshi Takasago Yuki Miyasako Tomoyuki Nishimura Sumio Iio Atsushi Yamaguchi Hirotaka Kouno Hiroshi Kohno Sauid Ishaq | 2018 | World Journal of Gastroenterology2018，24，15： | 7 |
| 3 | 经自然腔道取标本手术(NOSES)治疗结直肠癌的国际共识显示文摘近年来,经自然腔道取标本手术(NOSES)治疗结直肠癌已引起了广泛关注。NOSES应用于结直肠手术的潜在优势包括减轻术后疼痛,减少伤口并发症,减少对术后镇痛的需求,加快肠道功能的恢复,缩短住院时间,更好的美容效果,以及给患者带来了更佳的心理状态。尽管NOSES的手术创伤显著减轻,然而该技术也存在一些潜在问题。尤其随着这项新技术的兴起,人们对其无菌的把控、肿瘤学结果和病例选择等问题表示出关切。因此,迫切需要一部操作指南来规范NOSES手术在结直肠癌中的开展。经过国际NOSES联盟全体成员的三轮讨论,最终形成了该部共识。这一共识有助于NOSES在全球范围内的长远发展。 | Xu Guan Zheng Liu Antonio Longo Jian-Chun Cai William Tzu-Liang Chen Lu-Chuan Chen Ho-Kyung Chun Joaquim Manuel da Costa Pereira Sergey Efetov Ricardo Escalante Qing-Si He Jun-Hong Hu Cuneyt Kayaalp Seon-Hahn Kim Jim S.Khan Li-Jen Kuo Atsushi Nishimura Fernanda Nogueira Junji Okuda Avanish Saklani Ali A.Shafik Ming-Yin Shen Jung-Tack Son Jun-Min Song Dong-Hui Sun Keisuke Uehara Gui-Yu Wang Ye Wei Zhi-Guo Xiong Hong-Liang Yao Gang Yu Shao-Jun Yu Hai-Tao Zhou Suk-Hwan Lee Petr V.Tsarkov Chuan-Gang Fu Xi-Shan Wang The International Alliance of NOSES | 2019 | Gastroenterology Report2019，7，1： | 3 |
| 4 | Disease proteomics toward bedside reality显示文摘 | Toshihide Nishimura Atsushi Ogiwara Kiyonaga Fujii Takao Kawakami Takeshi Kawamura Hisae Anyouji Harubumi Kato | 2005 | Journal of Gastroenterology2005，，16： | 1 |
| 5 | Preference Toward a T-Helper Type 1 Response in Patients With Coronary Spastic Angina显示文摘 | Hirofumi Soejima Atsushi Irie Shinzo Miyamoto Ichiro Kajiwara Sunao Kojima Jun Hokamaki Tomohiro Sakamoto Tomoko Tanaka Michihiro Yoshimura Yasuharu Nishimura Hisao Ogawa | 2003 | Circulation: Journal of the American Heart Association2003，，17： | 1 |
| 6 | Degradation of a bitter peptide derived from casein by lactic acid bacterial peptidase显示文摘 | Tomoko Shimamura Taiehi Nishimura Atsushi Iwasaki | 2009 | Food Science and Technology Research2009，15，2： | 1 |
| 7 | Removal of formaldehyde from indoor air by passive type air-cleaning materials显示文摘 | YOSHIKA SEKINE ATSUSHI NISHIMURA | 2001 | Atmospheric Environment2001，，35： | 1 |
| 8 | Totally laparoscopic anterior resection with transvaginal assistance and transvaginal specimen extraction: a technique for natural orifice surgery combined with reduced-port surgery显示文摘 | Atsushi Nishimura Mikako Kawahara Keisuke Honda Takahiro Ootani Tomoyuki Kakuta Chie Kitami Shigeto Makino Yasuyuki Kawachi Keiya Nikkuni | 2013 | Surgical Endoscopy2013，，12： | 1 |
| 9 | Clinicopathological features of stomach cancer with invasive micropapillary component显示文摘 | Takeo Fujita Naoto Gotohda Yuichiro Kato Takahiro Kinoshita Shinichiro Takahashi Masaru Konishi Hiroyuki Daiko Mitsuyo Nishimura Takeshi Kuwata Atsushi Ochiai Taira Kinoshita | 2012 | Gastric Cancer2012，，2： | 1 |
| 10 | Removal of formaldehyde from indoor air by passive type air - cleaning materials 显示文摘 | Y Sekine Atsushi Nishimura | 2000 | Atmospheric Environment2000，35，12： | 1 |
| 11 | Syntheses of 5-hydroxymethylfurfural and levoglucosan by selective dehy- dration of glucose using solid acid and base catalysts显示文摘 | Mika Ohara Atsushi Takagaki Shun Nishimura | 2010 | Applied Catalysis A:general2010，，383： | 1 |
| 12 | Diagnostic role of 18F-fluorodeoxyglucose positron emission tomography for follicular lymphoma with gastrointestinal involvement显示文摘AIM:To investigate the capacity for 18F-fluorodeoxyglucose(18F-FDG) positron emission tomography(PET) to evaluate patients with gastrointestinal lesions of follicular lymphoma.METHODS:This retrospective case series consisted of 41 patients with follicular lymphoma and gastrointestinal involvement who underwent 18F-FDG-PET and endoscopic evaluations at ten different institutions between November 1996 and October 2011.Data for endoscopic,radiological,and biological examinations performed were retrospectively reviewed from clinical records.A semi-quantitative analysis of 18F-FDG uptake was performed for each involved area by calculating the maximum standardized uptake value(SUVmax).Based on the positivity of 18F-FDG uptake in the gastrointestinal lesions analyzed,patients were subdivided into two groups.To identify potential predictive factors for 18F-FDG positivity,these two groups were compared with respect to gender,age at diagnosis of lymphoma,histopathological grade,pattern of follicular dendritic cells,mitotic rate,clinical stage,soluble interleukin-2 receptor levels detected by 18F-FDG-PET,lactate dehydrogenase(LDH) levels,hemoglobin levels,bone marrow involvement,detectability of gastrointestinal lesions by computed tomography(CT) scanning,and follicular lymphoma international prognostic index(FLIPI) risk.RESULTS:Involvement of follicular lymphoma in the stomach,duodenum,jejunum,ileum,cecum,colon,and rectum was identified in 1,34,6,3,2,3,and 6 patients,respectively.No patient had esophageal involvement.In total,19/41(46.3%) patients exhibited true-positive 18F-FDG uptake in the lesions present in their gastrointestinal tract.In contrast,false-negative 18F-FDG uptake was detected in 24 patients(58.5%),while false-positive 18F-FDG uptake was detected in 5 patients(12.2%).In the former case,2/19 patients had both 18F-FDG-positive lesions and 18F-FDGnegative lesions in the gastrointestinal tract.In patients with 18F-FDG avidity,the SUVmax value of the involved gastrointestinal tract ranged from 2.6 to 17.4(median:4.7).For the 18F-FDG-negative(n = 22) and-positive(n = 19) groups,there were no differences in the male to female ratios(10/12 vs 4/15,P = 0.186),patient age(63.6 ± 2.4 years vs 60.1 ± 2.6 years,P = 0.323),presence of histopathological grade 1 vs 2(20/2 and 17/2,P = 1.000),follicular dendritic cell pattern(duodenal/nodal:13/5 vs 10/3,P = 1.000),mitotic rate(low/partly high,14/1 vs 10/3,P = 0.311),clinical stage according to the Ann Arbor system(stages ⅠE and ⅡE/other,15/7 vs 15/4,P = 0.499),clinical stage according to the Lugano system(stages Ⅰ and Ⅱ-1/other,14/8 vs 14/5,P = 0.489),soluble interleukin-2 receptor levels(495 ± 78 vs 402 ± 83,P = 0.884),LDH levels(188 ± 7 vs 183 ± 8,P = 0.749),hemoglobin levels(13.5 ± 0.3 vs 12.8 ± 0.4,P = 0.197),bone marrow involvement(positive/negative,1/8 vs 1/10,P = 1.000),detectability by CT scanning(positive/negative,1/16 vs 4/13,P = 0.335),and FLIPI risk(low risk/other,16/6 vs 13/6,P = 0.763),respectively in each case.CONCLUSION:These findings indicate that it is not feasible to predict 18F-FDG-avidity.Therefore,18FFDG-PET scans represent a complementary modality for the detection of gastrointestinal involvements in follicular lymphoma patients,and surveillance of the entire gastrointestinal tract by endoscopic examinations is required. | Masaya Iwamuro Hiroyuki Okada Katsuyoshi Takata Katsuji Shinagawa Shigeatsu Fujiki Junji Shiode Atsushi Imagawa Masashi Araki Toshiaki Morito Mamoru Nishimura Motowo Mizuno Tomoki Inaba Seiyu Suzuki Yoshinari Kawai Tadashi Yoshino Yoshiro Kawahara Akinobu Takaki Kazuhide Yamamoto | 2012 | World Journal of Gastroenterology2012，18，44： | 1 |
| 13 | Guidelines for Diagnosis and Treatment of Carcinoma of the Esophagus April 2007 edition: part I Edited by the Japan Esophageal Society显示文摘 | Hiroyuki Kuwano Yasumasa Nishimura Atsushi Ohtsu Hiroyuki Kato Yuko Kitagawa Setsuo Tamai Yasushi Toh Hisahiro Matsubara | 2008 | Esophagus2008，，2： | 1 |
| 14 | Sodium sensitivity and cardiovascular events in patients with essential hypertension显示文摘 | Atsushi Morimoto Takashi Uzu Takashi Fujii Masataka Nishimura Setsuko Kuroda Satoko Nakamura Takashi Inenaga Genjiro Kimura | 1997 | The Lancet1997，，9093： | 1 |
| 15 | Comparison of Chinese and Japanese A1 isolates of Phytophthora infestans显示文摘 | Seishi Akino Kiyotaka Gotoh Ryo Nishimura Atsushi Maeda Shigeo Naito Akira Ogoshi | 2004 | Journal of General Plant Pathology2004，，4： | 1 |
| 16 | Syntheses of 5-hydroxymethylfurfural and levoglucosan by selective dehydration of glucose using solid acid and base catalysts显示文摘 | Mika Ohara Atsushi Takagaki Shun Nishimura | 2010 | Applied Catalysis A : General2010，383，12： | 1 |
| 17 | Sodium sensitivity and cardiovascular events in patients with essential hypertension显示文摘 | Atsushi Morimoto Takashi Uzu Takashi Fujii Masataka Nishimura Setsuko Kuroda Satoko Nakamura Takashi Inenaga Genjiro Kimura | 1997 | The Lancet1997，，9093： | 1 |
| 18 | Study of intra-abdominal fat distribution in sigmoid colon cancer in Japanese patients by use of MDCT data显示文摘 | Toshihiro Ogura Tomohiro Tachikawa Yoshiko Nishimura Satoshi Suda Younosuke Shimomura Masatoshi Oya Atsushi Kono | 2009 | Radiological Physics and Technology2009，，2： | 1 |
| 19 | Aberrant expression of EZH2 is associated with a poor outcome and P53alteration in squamous cell carcinoma of the esophagus显示文摘 | Atsushi Yamada Satoshi Fujii Hiroyuki Daiko Mitsuyo Nishimura Tsutomu Chiba Atsushi Ochiai | 2011 | International Journal of Oncology2011，，2： | 1 |
| 20 | Low-intensity fetal lungs on MRI may suggest the diagnosis of pulmonary hypoplasia显示文摘 | S. Kuwashima G. Nishimura Fumitoshi Iimura Tatsuo Kohno Hiroshi Watanabe Atsushi Kohno Mutsuhisa Fujioka | 2001 | Pediatric Radiology2001，，9： | 1 |
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