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| 1 | Herbal cardiotonic pills prevent gut ischemia/reperfusion-induced hepatic microvascular dysfunction in rats fed ethanol chronically显示文摘AIM: Cardiotonic Pill (CP), an oral herbal medicine that includes Danshen (Salviae Miltiorrhizae), Panax notoginseny and Dyroblanops aromatica gaertn, has been clinically used for vascular diseases such as occlusive vasculitis, coronary diseases, atherosclerosis, and cerebral infarction. The main component, SaMae Miltiorrhizae, has been reported to prevent cerebral and intestinal reperfusion injury. However, little is known about the effect of CP on hepatic microcirculation.Thus, this study aimed to determine whether CP could affect hepatic microvascular dysfunction elicited by gut ischemia/reperfusion (I/R) in rats fed ethanol chronically.METHODS: Male Wistar rats were pair-fed with a liquid diet containing ethanol or isocaloric control diet for 6 wk. After laparotomy, one lobe of the liver was examined through an inverted intravital microscope. The rats were exposed to 30 rain of gut ischemia followed by 60 rain of reperfusion.Rhodamine-6G-labeled leukocytes in the sinusoids were observed 90 rain after the onset of superior mesenteric artery ocdusion. Plasma tumor necrosis factor (TNF)-α and endotoxin levels were measured 1 h after the onset of reperfusion.Plasma alanine aminotransferase (ALT) activities were measured 6 h after the onset of reperfusion. In another set of experiments, CP (0.8 g/kg, intragastrically) was administered 1 and 24 h before the onset of ischemia.RESULTS: In control rats, gut I/R elicited increases in the number of stationary leukocytes, and plasma TNF-α and endotoxin levels and plasma ALT activities. These changes were mitigated by pretreatment with CP. In ethanol-fed rats,the gut I/R-induced increases in the number of stationary leukooltes, plasma endotoxin levels and ALT activities were enhanced. Pretreat^nent with CP attenuated the enhancement of gut I/R-induced responses by chronic ethanol consumption.CONCLUSION: These results suggest that CP prevents the gut I/R-induced hepatic microvascular dysfunction and hepatocellular injury. A reduction of inflammatory responses such as TNF-α production via reduction of blood endotoxin levels appears to be involved in the mechanisms. Chronic ethanol consumption enhances gut I/R-induced hepatic microvascular and hepatocellular injury. CP also attenuates an enhancement of gut I/R-induced responses by chronic ethanol consumption via the reduction of blood endotoxin levels. | Yoshinori Horie Shuka Mori Masahiro Konishi Mikio Kajihara Takehiko Kaneko Yoshiyuki Yamagishi Shinzo Kato Hiromasa Ishii Toshifumi Hibi | 2005 | World Journal of Gastroenterology2005，11，4： | 13 |
| 2 | SYNTHESIS OF STYRENIC TONER PARTICLES BY SPG EMULSIFICATION TECHNIQUE显示文摘This research studied the initiator efficiency for producing polymeric particles of poly(styrene-co-methylmethacrylate) copolymers by a Shirasu porous glass membrane (SPG) emulsification technique followed by suspensioncopolymerization. BPO, ADVN, and AIBN were used as initiators and we found that BPO is the most suitable initiator.Copolymers for various feed ratios of styrene/methyl methacrylate were thus synthesized by benzoyl peroxide, and theircopolymer particle size, molecular weight distribution and particle size distribution were characterized. Then n-BMA or 2-EHMA was added as the third monomer to decrease the terpolymer glass transition temperature. This article describes thepreparation technique, recipes and polymerization conditions for producing both copolymer and terpolymer panicles, particlesize changes, the corresponding particle morphologies and glass transition temperatures. | Suda Kiatkamjornwong Roongkan Nuisin Guang-HuiMa Shinzo Omi | 2000 | Chinese Journal of Polymer Science2000，18，4： | 2 |
| 3 | Synthesis of polymeric microspheres employing SPG emulsification technique显示文摘 | Omi Shinzo Kaneko Kazuyoshi Takesue Mariko | 1994 | J Appl Polym Sci1994，51，7： | 1 |
| 4 | Study on preparation of monodispersed poly ( styrene-CO-N-dimethylami-noethyl methacrylate ) composite microspheres by SPG (Shirasu Porous Glass)emulsification technique 显示文摘 | Guang-Hui Ma Masatoshi Nagai Shinzo Omi | 2001 | Journal of Applied Polymer Science2001，79，13： | 1 |
| 5 | Reaction of functional polymethacrylates grafted on phosphate-modified calcium carbonate 显示文摘 | TOKUO NAKATSUKA SHINZO YAMASHITA | 1983 | J Appl Polym Sci1983，28，11： | 1 |
| 6 | A convenient copper-catalyzed direct amination of nitroarenes with O-alkylhydroxylamines显示文摘 | Seko Shinzo Miyake Kunihito Kawamura Norio | 1999 | Organic and Bio-Organic Chemistry1999，，11： | 1 |
| 7 | Transpiration cooling using air as a coolant 显示文摘 | Kikkawa Shinzo Senda Mamoru Sakaguchi Katsuji | 1991 | Transactions of the Japan Society of Mechanical Engineers Part B1991，57，542： | 1 |
| 8 | Experimental investigation on transpiration cooling with water sprays and impinging air jets 显示文摘 | Kikkawa Shinzo Senda Mamoru Sakaguchi Katsuji | 1991 | Transactions of the Japan Society of Mechanical Engineers Part B1991，57，535： | 1 |
| 9 | In situ formed silica particles in rubber vulcanizate by the sol-gel method 显示文摘 | Yuko L Shinzo K | 1997 | Polymer1997，38，17： | 1 |
| 10 | Role of ICAM-1 in chronic ethanol consumption-enhanced liver injury after gut ischemia-reperfusion in rats显示文摘 | Yoshinori H Yoshiyuki Y Shinzo K | 2002 | Am J Physiol Gastrointest Liver Physiol2002，283，3： | 1 |
| 11 | 显示文摘 | Oshikawa Katsuhiko Nagai Masato Omi Shinzo | 2001 | Journal of Physical Chemistry B2001，105，38： | 1 |
| 12 | Alogliptin plus voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension 显示文摘 | Seino Y Fujita T Hiroi Shinzo | 2011 | Current Medical Research and Opinion2011，27，3： | 1 |
| 13 | Effect of pin fin arrangemnt on endwall heat transfer显示文摘 | Ryosuke M Shinzo K Mamoru S | 1997 | JSME International Journal1997，40，1： | 1 |
| 14 | PdO-AI203 in catalytic combustion of methane: stabilization and deactivation 显示文摘 | Yasushi Ozawa Yoshihisa Tochihara Masatoshi Nagai Shinzo Omi | 2003 | Chemical Engineering Science2003，58，： | 1 |
| 15 | Preparation of transparent conducting In4Sn3O12 thin films by DC magnetron sputtering显示文摘 | Tadatsugu Minami Yoshihiro Takeda Shinzo Takata | 1997 | Thin Solid Films1997，，13： | 1 |
| 16 | A Formation Mechanism of Transverse Cracks on CC Slab Surface显示文摘 | Shinzo Harada Shigenori Tanaka Hideyuki Misumi | 1990 | ISIJ International1990，30，4： | 1 |
| 17 | Effect of Thermal Annealing on Elec-trical degradation characteristics of Sb-Bi-Mn-Co-addedZnO varistors显示文摘 | Masayuk T Shinzo Y | 2010 | J Eur Ceram Soc2010，30，2： | 1 |
| 18 | Development of a sandwich enzyme-linked immunosorbent assay for the determination of human heart type fatty acid-binding protein in plasma and urine by using two different monoclonal antibodies specific for human heart fatty acid-binding protein 显示文摘 | Yasuhiko Ohkaru Kum ko Asayama Hiroo Ishii Shinzo Nishimura | 1995 | Journal of Immunological Methods1995，178，： | 1 |
| 19 | Angiotensin-converting enzyme inhibition reduces monocyte chemoattractant protein-1 and tissue factor levels in patients with myocardial infarction显示文摘 | Hirofumi Soejima Hisao Ogawa Hirofumi Yasue Koichi Kaikita Keiji Takazoe Koichi Nishiyama Kenji Misumi Shinzo Miyamoto Michihiro Yoshimura Kiyotaka Kugiyama Shin Nakamura Ichiro Tsuji | 1999 | Journal of the American College of Cardiology1999，，4： | 1 |
| 20 | Repeat Pulmonary Resection for Isolated Recurrent Lung Metastases Yields Results Comparable to Those after First Pulmonary Resection in Colorectal Cancer显示文摘 | Yutaka Ogata Keiko Matono Akihiro Hayashi Shinzo Takamor Keisuke Miwa Teruo Sasatomi Nobuya Ishibashi Seiichiro Shida Kazuo Shirouzu | 2005 | World Journal of Surgery2005，，3： | 1 |
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