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| 1 | Clinical significance of type V_I pit pattern subclassification in determining the depth of invasion of colorectal neoplasms显示文摘AIM: To clarify whether subclassification of the type VI pit pattern on the basis of magnifying colonoscopy findings is useful in determining the type and depth of invasion of colorectal neoplasms.METHODS: We retrospectively analyzed 272 colorectal neoplasms (117 dysplasias and 155 submucosal invasive carcinomas; 228 patients) with a type V pit pattern [type VI, n = 202; type VN, n = 70 (Kudo and Tsuruta classification system)]. We divided lesions with a type VI pit pattern into two subclasses, mildly irregular lesions and severely irregular lesions, according to the prominent and detailed magnifying colonoscopy findings. We examined the relation between these two subclasses and histology/invasion depth.RESULTS: One hundred and four lesions (51.5%) were judged to be mildly irregular, and 98 lesions (48.5%) were judged to be severely irregular. Ninety-seven (93.3%) mildly irregular lesions showed dysplasias or submucosal invasion of less than 1000 μm (SM < 1000 μm). Fifty-five (56.1%) severely irregular lesions showed submucosal invasion equal to or deeper than 1000 μm (SM ≥ 1000 μm). Mild irregularity was found significantly more often in dysplasias or lesions with SM < 1000 μm than in lesions with SM ≥ 1000 μm (P < 0.01).CONCLUSION: Subclassification of the type VI pit pattern is useful for identifying dysplasias or lesions with SM < 1000 μm. | Hiroyuki Kanao Shinji Tanaka Shiro Oka Iwao Kaneko Shigeto Yoshida Koji Arihiro Masaharu Yoshihara Kazuaki Chayama | 2008 | World Journal of Gastroenterology2008，14，2： | 15 |
| 2 | Blood glucose control in patients with severe sepsis and septic shock显示文摘The main pathophysiological feature of sepsis is the uncontrollable activation of both pro-and anti-inflammatory responses arising from the overwhelming pro-duction of mediators such as pro-and anti-inflammatory cytokines. Such an uncontrollable inflammatory response would cause many kinds of metabolic derangements. One such metabolic derangement is hyperglycemia. Accordingly, control of hyperglycemia in sepsis is considered to be a very effective therapeutic approach. However, despite the initial enthusiasm, recent studies reported that tight glycemic control with intensive insulin therapy failed to show a beneficial effect on mortality of patients with severe sepsis and septic shock. One of the main reasons for this disappointing result is the incidence of harmful hypoglycemia during intensive insulin therapy. Therefore, avoidance of hypoglycemia during intensive insulin therapy may be a key issue in effective tight glycemic control. It is generally accepted that glycemic control aimed at a blood glucose level of 80-100 mg/dL, as initially proposed by van den Berghe, seems to be too tight and that such a level of tight glycemic control puts septic patients at increased risk of hypoglycemia. Therefore, now many researchers suggest less strict glycemic control with a target blood glucose level of 140-180 mg/dL. Also specific targeting of glycemic control in diabetic patients should be considered. Since there is a significantcorrelation between success rate of glycemic control and the degree of hypercytokinemia in septic patients, some countermeasures to hypercytokinemia may be an important aspect of successful glycemic control. Thus, in future, use of an artificial pancreas to avoid hypoglycemia during insulin therapy, special consideration of septic diabetic patients, and control of hypercytokinemia should be considered for more effective glycemic control in patients with severe sepsis and septic shock. | Hiroyuki Hirasawa Shigeto Oda Masataka Nakamura | 2009 | World Journal of Gastroenterology2009，15，33： | 13 |
| 3 | Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer显示文摘AIM: To clarify the usefulness of immunohistochemical molecular markers in predicting lymph node metastasis of submucosal colorectal cancer. METHODS: We examined microvessel density, lymphatic vessel density, the Ki-67 labeling index, expression of MUC1 and Matrix metalloproteinase-7 (MMP-7) in tumor cells, and expression of cathepsin D in stromal cells at the invasive front by immunostaining of samples resected from 214 patients with submucosal colorectal cancer. Pathologic features were assessed on hematoxylin-eosin- stained samples. We evaluated the relations between clinicopathologic/immunohistochemical features and lymph node metastasis. RESULTS: Lesions of the superficial type, with an unfavorable histologic grade, budding, lymphatic involvement, high microvessel density (≥ 40), high lymphatic vessel density (≥ 9), high Ki-67 labeling index (≥ 42), and positivity of MUC1, cathepsin D, and MMP-7 showed a significantly high incidence of lymph node metastasis. Multivariate analysis revealed that high microvessel density, unfavorable histologic grade, cathepsin D positivity, high lymphatic vessel density, superficial type, budding, and MUC1 positivity were independent risk factors for lymph node metastasis.A combined examination with four independent immunohistochemical markers (microvessel density, cathepsin D, lymphatic vessel density, and MUC1) revealed that all lesions that were negative for all markers or positive for only one marker were negative for lymph node metastasis. CONCLUSION: Analysis of a combination of immuno- histochemical molecular markers in endoscopically resected specimens of submucosal colorectal cancer allows prediction of curability regardless of the pathologic features visible of hematoxylin-eosin-stained sections. | Iwao Kaneko Shinji Tanaka Shiro Oka Shigeto Yoshida Toru Hiyama Koji Arihiro Fumio Shimamoto Kazuaki Chayama | 2007 | World Journal of Gastroenterology2007，13，28： | 12 |
| 4 | Safety of immediate endoscopic sphincterotomy in acutesuppurative cholangitis caused by choledocholithiasis显示文摘AIM: To examine the safety of immediate endoscopic sphincterotomy(EST) in patients with acute suppurative cholangitis(ASC) caused by choledocholithiasis, as compared with elective EST.METHODS: Patients with ASC due to choledocholithiasis were allocated to two groups: Those who underwent EST immediately and those who underwent EBD followed by EST 1 wk later because they were under anticoagulant therapy, had a coagulopathy(international normalized ratio > 1.3, partial thromboplastin time greater than twice that of control), or had a platelet count < 50000 × 103/μL. One of four trainees [200-400 cases of endoscopic retrograde cholangiopancreatography(ERCP)] supervised by a specialist(> 10000 cases of ERCP) performed the procedures. The success and complication rates associated with EST in each group were examined.RESULTS: Of the 87 patients with ASC, 59 were in the immediate EST group and 28 in the elective EST group. EST was successful in all patients in both groups. There were no complications associated with EST in either group of patients, although white blood cell count, C-reactiveprotein, total bilirubin, and serum concentrations of liver enzymes just before EST were significantly higher in the immediate EST group than in the elective EST group.CONCLUSION: Immediate EST can be as safe as elective EST for patients with ASC associated with choledocholithiasis provided they are not under anticoagulant therapy, or do not have a coagulopathy or a platelet count < 50000 × 103/μL. Moreover, the procedure was safely performed by a trainee under the supervision of an experienced specialist. | Tomoyasu Ito Jin Kan Sai Hironao Okubo Hiroaki Saito Shigeto Ishii Ryo Kanazawa Ko Tomishima SumioWatanabe Shuichiro Shiina | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，3： | 10 |
| 5 | Clinical outcomes of ampullary neoplasms in resected margin positive or uncertain cases after endoscopic papillectomy显示文摘BACKGROUND Endoscopic papillectomy(EP) for benign ampullary neoplasms could be a lessinvasive alternative to pancreatoduodenectomy(PD). There are some problems and limitations with EP. The post-EP resection margins of ampullary tumors are often positive or uncertain because of the burning effect of EP. The clinical outcomes of resected margin positive or uncertain cases after EP remain unknown.AIM To investigate the clinical outcomes of resected margin positive or uncertain cases after EP.METHODS Between January 2007 and October 2018, all patients with ampullary tumors who underwent EP at Kobe University Hospital were included in this study. The indications for EP were as follows: adenoma, as determined by preoperative endoscopic biopsy, without bile/pancreatic duct extension, according to endoscopic ultrasound or intraductal ultrasound. The clinical outcomes of resected margin positive or uncertain cases after EP were retrospectively investigated.RESULTS Of the 45 patients, 29 were male, and 16 were female. The mean age of the patients was 65 years old. Forty-one patients(89.5%) underwent en bloc resection,and 4 patients(10.5%) underwent piecemeal resection. After EP, 33 tumors were histopathologically diagnosed as adenoma, and 12 were diagnosed as adenocarcinoma. The resected margins were positive or uncertain in 24 patients(53.3%). Of these cases, 15 and 9 were diagnosed as adenoma and adenocarcinoma, respectively. Follow-up observation was selected for all adenomas and 5 adenocarcinomas. In the remaining 4 adenocarcinoma cases,additional PD was performed. Additional PD was performed in 4 cases, and residual carcinoma was found after the additional PD in 1 of these cases. In the follow-up period, local tumor recurrence was detected in 3 cases. Two of these cases involved primary EP-diagnosed adenoma. The recurrent tumors were also adenomas detected by biopsy. The remaining case involved primary EPdiagnosed adenocarcinoma. The recurrent tumor was also an adenocarcinoma.All of the recurrent tumors were successfully treated with argon plasma coagulation(APC). There was no local or lymph node recurrence after the APC.The post-APC follow-up periods lasted for 57.1 to 133.8 mo. No ampullary tumor-related deaths occurred in all patients.CONCLUSION Resected margin positive or uncertain cases after EP could be managed by endoscopic treatment including APC, even in cases of adenocarcinoma. EP could become an effective less-invasive first-line treatment for early stage ampullary tumors. | Arata Sakai Masahiro Tsujimae Atsuhiro Masuda Takao Iemoto Shigeto Ashina Kohei Yamakawa Takeshi Tanaka Shunta Tanaka Yasutaka Yamada Ryota Nakano Yu Sato Manabu Kurosawa Takuya Ikegawa Seiji Fujigaki Takashi Kobayashi Hideyuki Shiomi Yoshifumi Arisaka Tomoo Itoh Yuzo Kodama | 2019 | World Journal of Gastroenterology2019，25，11： | 9 |
| 6 | Simultaneously disrupting AtPrx2,AtPrx25 and AtPrx71 alters lignin content and structure in Arabidopsis stem显示文摘Plant class III heme peroxidases catalyze lignin polymerization. Previous reports have shown that at least three Arabidopsis thaliana peroxidases, At Prx2, At Prx25 and At Prx71,are involved in stem lignification using T-DNA insertion mutants,atprx2, atprx25, and atprx71. Here, we generated three double mutants, atprx2/atprx25, atprx2/atprx71, and atprx25/atprx71,and investigated the impact of the simultaneous de ficiency of these peroxidases on lignins and plant growth. Stem tissue analysis using the acetyl bromide method and derivatization followed by reductive cleavage revealed improved lignin characteristics, such as lowered lignin content and increased arylglycerolb-aryl(b-O-4) linkage type, especially b-O-4 linked syringyl units, in lignin, supporting the roles of these genes in lignin polymerization. In addition, none of the double mutants oexhibited severe growth defects, such as shorter plant stature, dwar fing, or sterility, and their stems had improved cell wall degradability. This study will contribute to progress in lignin bioengineering to improve lignocellulosic biomass. | Jun Shigeto Yoshitaka Itoh Sakie Hirao Kaori Ohira Koki Fujita Yuji Tsutsumi | 2015 | Journal of Integrative Plant Biology2015，57，4： | 7 |
| 7 | Parallel computing of discrete element method on multi-core processors显示文摘This paper describes parallel simulation techniques for the discrete element method (DEM) on multi-core processors. Recently, multicore CPU and GPU processors have attracted much attention in accelerating computer simulations in various flelds. We propose a new algorithm for multi-thread parallel computation of DEM, which makes effective use of the available memory and accelerates the computation. This study shows that memory usage is drastically reduced by using this algorithm. To show the practical use of DEM in industry, a large-scale powder system is simulated with a complicated drive unit. We compared the performance of the simulation between the latest GPU and CPU processors with optimized programs for each processor. The results show that the difference in performance is not substantial when using either GPUs or CPUs with a multithread parallel algorithm. In addition, DEM algorithm is shown to have high scalability in a multi-thread parallel computation on a CPU. | Yusuke Shigeto Mikio Sakai | 2011 | Particuology2011，9，4： | 6 |
| 8 | Endoscopic submucosal dissection for colorectal neoplasia: possibility of standardization显示文摘 | Shinji Tanaka Shiro Oka Iwao Kaneko Mayuko Hirata Ritsuo Mouri Hiroyuki Kanao Shigeto Yoshida Kazuaki Chayama | 2007 | Gastrointestinal Endoscopy2007，，1： | 5 |
| 9 | Differential Expression of Two Cytosolic Ascorbate Peroxidases and Two Superoxide Dismutase Genes in Response to Abiotic Stress in Rice显示文摘Superoxide dismutase (SOD) and ascorbate peroxidase (APX) play central roles in the pathway for scavenging reactive oxygen species in plants, thereby contributing to the tolerance against abiotic stress. Here we report the responses of cytosolic SOD (cSOD; sodCc1 and sodCc2) and cytosolic APX (cAPX; OsAPX1 and OsAPX2) genes to oxidative and abiotic stress in rice. RNA blot analyses revealed that methyl viologen treatment caused a more prominent induction of cAPXs compared with cSODs, and hydrogen peroxide treatment induced the expression of cAPXs whereas cSODs were not affected. These results suggest that cAPXs play more important roles in defense against oxidative stress compared with cSODs. It is noted that cSODs and cAPXs showed coordinate response to abscisic acid treatment which induced both sodCc1 and OsAPX2. However, cSODs and cAPXs responded differentially to drought, salt and chilling stress, which indicates that cSOD and cAPX genes are expressed differentially in response to oxidative and abiotic stress in rice. | Shigeto MORITA Shinya NAKATANI Tomokazu KOSHIBA Takehiro MASUMURA Yasunari OGIHARA Kunisuke TANAKA | 2011 | Rice science2011，18，3： | 3 |
| 10 | Post-stroke affective or apathetic depression and lesion location: left frontal lobe and bilateral basal ganglia显示文摘 | Seiji Hama Hidehisa Yamashita Masaya Shigenobu Atsuko Watanabe Kaoru Kurisu Shigeto Yamawaki Tamotsu Kitaoka | 2007 | European Archives of Psychiatry and Clinical Neuroscience2007，，3： | 3 |
| 11 | 基于神经科学的临床精神药理学命名系统显示文摘精神药物(psychotropic drug)也被称为精神治疗药物(psychotherapeutie drug),用于治疗各种精神障碍已有六十多年历史,传统上根据其治疗适应证进行命名分类,如治疗精神病性障碍的精神药物被命名为抗精神病药,治疗抑郁障碍的药物被命名为抗抑郁药,治疗躁狂发作的药物被命名为抗躁狂药或心境稳定剂,治疗焦虑障碍的药物被命名为抗焦虑药。这种命名系统在现代精神药理学发展初期,可帮助医生学习和认识不断上市的各种精神药物。但是随着近年来神经科学和精神药理学研究的进展,这种命名法常给使用者及患者带来诸多困惑和疑问,如患者常常质疑医生:我明明是抑郁障碍,医生为什么给我处方抗精神病药?甚至强化了患者的病耻感。 | 司天梅 于欣 Shigeto Yamawaki Joseph Zohar | 2017 | 中华精神科杂志2017，50，1： | 2 |
| 12 | Quest for the best endoscopic imaging modality for computer-assisted colonic polyp staging显示文摘BACKGROUND It was shown in previous studies that high definition endoscopy, high magnification endoscopy and image enhancement technologies, such as chromoendoscopy and digital chromoendoscopy [narrow-band imaging(NBI), iScan] facilitate the detection and classification of colonic polyps during endoscopic sessions. However, there are no comprehensive studies so far that analyze which endoscopic imaging modalities facilitate the automated classification of colonic polyps. In this work, we investigate the impact of endoscopic imaging modalities on the results of computer-assisted diagnosis systems for colonic polyp staging.AIM To assess which endoscopic imaging modalities are best suited for the computerassisted staging of colonic polyps.METHODS In our experiments, we apply twelve state-of-the-art feature extraction methods for the classification of colonic polyps to five endoscopic image databases of colonic lesions. For this purpose, we employ a specifically designed experimental setup to avoid biases in the outcomes caused by differing numbers of images per image database. The image databases were obtained using different imaging modalities. Two databases were obtained by high-definition endoscopy in combination with i-Scan technology(one with chromoendoscopy and one without chromoendoscopy). Three databases were obtained by highmagnification endoscopy(two databases using narrow band imaging and one using chromoendoscopy). The lesions are categorized into non-neoplastic and neoplastic according to the histological diagnosis.RESULTS Generally, it is feature-dependent which imaging modalities achieve high results and which do not. For the high-definition image databases, we achieved overall classification rates of up to 79.2% with chromoendoscopy and 88.9% without chromoendoscopy. In the case of the database obtained by high-magnification chromoendoscopy, the classification rates were up to 81.4%. For the combination of high-magnification endoscopy with NBI, results of up to 97.4% for one database and up to 84% for the other were achieved. Non-neoplastic lesions were classified more accurately in general than non-neoplastic lesions. It was shown that the image recording conditions highly affect the performance of automated diagnosis systems and partly contribute to a stronger effect on the staging results than the used imaging modality.CONCLUSION Chromoendoscopy has a negative impact on the results of the methods. NBI is better suited than chromoendoscopy. High-definition and high-magnification endoscopy are equally suited. | Georg Wimmer Michael Gadermayr Gernot Wolkersdorfer Roland Kwitt Toru Tamaki Jens Tischendorf Michael Hafner Shigeto Yoshida Shinji Tanaka Dorit Merhof Andreas Uhl | 2019 | World Journal of Gastroenterology2019，25，10： | 2 |
| 13 | Tin phosphide-carbon composite as a high-performance anode active material for sodium-ion batteries with high energy density显示文摘Tin phosphide(Sn_(4)P_(3))is a promising anode material for sodium-ion batteries because of its relatively large theoretical capacity,appropriate Na^(+) alloying potential,and good cyclic stability.Herein,the Sn_(4)P_(3) embedded into a carbon matrix with good rate performance and long cycle life is reported.The Sn_(4)P_(3)-C composite exhibits excellent rate performance(540 mAh g^(-1) at 5 A g^(-1))and the highest reversible capacity(844 mAh g^(-1) at 0.5 A ^(g-1))among Sn4P3-based anodes reported so far.Its reversible capacity is as high as 705 mAh g^(-1) even after 100 cycles at 0.5 A g^(-1).Besides,its initial Coulomb efficiency can reach 85.6%,with the average Coulomb efficiency exceeding 99.75%from the 3rd to 100th cycles.Na_(2)C_(6)O_(6) is firstly used as a cathode when Sn_(4)P_(3) acts as anode,and the Na-Sn_(4)P_(3)-C//Na_(2)C_(6)O_(6) full cell shows excellent electrochemical performance.These results demonstrate that the Sn_(4)P_(3)-C composite prepared in this work displays high-rate capability and superior cyclic performance,and thus is a potential anode for sodium ion batteries. | Zhiqiang Hao Nikolay Dimov Jeng-Kuei Chang Shigeto Okada | 2022 | Journal of Energy Chemistry2022，31，1： | 2 |
| 14 | Reduction in gastric cancer mortality by screening based on serum pepsinogen concentration: A case-control study显示文摘 | Masaharu Yoshihara Toru Hiyama Shigeto Yoshida Masanori Ito Shinji Tanaka Yoshiyuki Watanabe Ken Haruma | 2007 | Scandinavian Journal of Gastroenterology2007，，6： | 2 |
| 15 | Outcome of patients who have undergone total enteroscopy for obscure gastrointestinal bleeding显示文摘AIM:To assess the diagnostic success and outcome among patients with obscure gastrointestinal bleeding who underwent total enteroscopy with double-balloon endoscopy.METHODS:Total enteroscopy was attempted in 156 patients between August 2003 and June 2008 at Hiroshima University Hospital and achieved in 75 (48.1%).It is assessed whether sources of bleeding were identified,treatment methods,complications,and 1-year outcomes (including re-bleeding) after treatment,and we compared re-bleeding rates among patients.RESULTS:The source of small bowel bleeding was identified in 36 (48.0%) of the 75 total enteroscopy patients;the source was outside the small bowel in 11 patients (14.7%) and not identified in 28 patients (37.3%).Sixty-one of the 75 patients were followed up for more than 1 year (27.2 ± 13.3 mo).Four (6.6%) of these patients showed signs of re-bleeding during the first year,but bleeding did not recur after treatment.Although statistical significance was not reached,a marked difference was found in the re-bleeding rate between patients in whom total enteroscopy findings were positive (8.6%,3/35) and negative (3.8%,1/26) (3/35 vs 1/26,P=0.63).CONCLUSION:A good outcome can be expected for patients who undergo total enteroscopy and receive proper treatment for the source of bleeding in the small bowel. | Takayoshi Shishido Shiro Oka Shinji Tanaka Hiroki Imagawa Yoshito Takemura Shigeto Yoshida Kazuaki Chayama | 2012 | World Journal of Gastroenterology2012，18，7： | 2 |
| 16 | Narrow-band imaging magnification predicts the histology and invasion depth of colorectal tumors显示文摘 | Hiroyuki Kanao Shinji Tanaka Shiro Oka Mayuko Hirata Shigeto Yoshida Kazuaki Chayama | 2009 | Gastrointestinal Endoscopy2009，，3： | 2 |
| 17 | Relative effect of steroid hormone receptors on the prognosis of patients with operable breast cancer显示文摘 | Yasuo Nomura Shigeto Mintu Hiroki Koyama | 1992 | Cancer1992，69，2： | 2 |
| 18 | Helicobacter pylori Infection and Gastric Cancer (A Nested Case-Control Study in a Rural Area of Japan)显示文摘 | Yoshiyuki Watanabe John H. Kurata Shigeto Mizuno Masako Mukai Hideto Inokuchi Kazumasa Miki Kotaro Ozasa Keiichi Kawai | 1997 | Digestive Diseases and Sciences1997，，7： | 2 |
| 19 | Selective transport of ytterbium in the prensence of iron through liquid - membrane impregnating addle organ phosphor mobile carrier 显示文摘 | Kenichi A Masahim I Shigeto N | 1997 | J Membr Sci1997，129，： | 1 |
| 20 | The solubility of quartz in water at high temperatures and high pressures 显示文摘 | Shigeto Kitahara | 1960 | The Review of Physical Chemistry of Japan1960，30，2： | 1 |
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