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| 1 | Case of clear-cell hepatocellular carcinoma that developed in the normal liver of a middle-aged woman显示文摘A 36-year-old woman was admitted to our department for close examination of a liver tumor that was found during a medical checkup. Abdominal US, CT and MRI showed a tumor in segment 7 (S7) of the liver. Although imaging suggested hepatocellular carcinoma, laboratory tests showed no abnormality in liver function, hepatitis virus markers were negative, and tumor markers including protein induced by vitamin K absence or antagonist Ⅱ (PIVKA-Ⅱ), α-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA) were all within normal ranges. Upon aspiration biopsy of the liver, the histopathological diagnosis was moderately differentiated hepatocellular carcinoma. Therefore, right hepatectomy was performed. Although a part of the tumor was necrotic, about 60% of the viable part showed a clear-cell variant. Consequently, it was diagnosed as clear-cell hepatocellular carcinoma. It was noted that the background liver tissue was normal. This case is worthy of reporting because development of clear-cell hepatocellular carcinoma in the normal liver of a middle-aged woman is rarely seen. | Atsushi Takahashi Hironobu Saito Yukiko Kanno Kazumichi Abe Junko Yokokawa Atsushi Irisawa Akira Kenjo Takuro Saito Mitsukazu Gotoh Hiromasa Ohira | 2008 | World Journal of Gastroenterology2008，14，1： | 20 |
| 2 | Towards development of enhanced fully-Lagrangian mesh-free computational methods for fluid-structure interaction显示文摘Simulation of incompressible fluid flow-elastic structure interactions is targeted by using fully-Lagrangian mesh-free computational methods. A projection-based fluid model(moving particle semi-implicit(MPS)) is coupled with either a Newtonian or a Hamiltonian Lagrangian structure model(MPS or HMPS) in a mathematically-physically consistent manner. The fluid model is founded on the solution of Navier-Stokes and continuity equations. The structure models are configured either in the framework of Newtonian mechanics on the basis of conservation of linear and angular momenta, or Hamiltonian mechanics on the basis of variational principle for incompressible elastodynamics. A set of enhanced schemes are incorporated for projection-based fluid model(Enhanced MPS), thus, the developed coupled solvers for fluid structure interaction(FSI) are referred to as Enhanced MPS-MPS and Enhanced MPS-HMPS. Besides, two smoothed particle hydrodynamics(SPH)-based FSI solvers, being developed by the authors, are considered and their potential applicability and comparable performance are briefly discussed in comparison with MPS-based FSI solvers. The SPH-based FSI solvers are established through coupling of projection-based incompressible SPH(ISPH) fluid model and SPH-based Newtonian/Hamiltonian structure models, leading to Enhanced ISPH-SPH and Enhanced ISPH-HSPH. A comparative study is carried out on the performances of the FSI solvers through a set of benchmark tests, including hydrostatic water column on an elastic plate,high speed impact of an elastic aluminum beam, hydroelastic slamming of a marine panel and dam break with elastic gate. | Abbas Khayyer Hitoshi Gotoh Hosein Falahaty Yuma Shimizu | 2018 | Journal of Hydrodynamics2018，30，1： | 8 |
| 3 | Early effects of oral administration of omeprazole and roxatidine on intragastric pH显示文摘Objective:The ideal medication for the treatment of acid-related diseases,e.g.,peptic ulcers,stress-related gastric bleeding,functional dyspepsia,and gastroesophageal reflux disease,should have a rapid onset of action to promote hemostasis and relieve the symptoms.The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor,omeprazole 20 mg,and an H2-receptor antagonist,roxatidine 75 mg.Methods:Ten Helicobacter pylori-negative male subjects participated in this randomized,two-way crossover study.Intragastric pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 mg.Each administration was separated by a 7-d washout period.Results:During the 6-h study period,the average pH after administration of roxatidine was higher than that after administration of omeprazole(median:4.45 vs.2.65;P=0.0367).Also during the 6-h study period,a longer duration of maintenance at pH above 2,5,and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg(median:90.6% vs.55.2%,P=0.0284;43.7% vs.10.6%,P=0.0125;40.3% vs.3.3%,P=0.0125;respectively).Conclusions:In Helicobacter pylori-negative healthy male subjects,oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg. | Hiroshi IIDA Shingo KATO Yusuke SEKINO Eiji SAKAI Takashi UCHIYAMA Hiroki ENDO Kunihiro HOSONO Yasunari SAKAMOTO Koji FUJITA Masato YONEDA Tomoko KOIDE Hirokazu TAKAHASHI Chikako TOKORO Ayumu GOTO Yasunobu ABE Noritoshi KOBAYASHI Kensuke KUBOTA Eiji GOTOH Shin MAEDA Atsushi NAKAJIMA Masahiko INAMORI | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 6 |
| 4 | 超低频地磁异常与2000年日本伊豆诸岛震群的关系显示文摘通过研究电磁现象与大地震的联系有助于建立监测地壳运动(如地震、火山喷发)的电磁方法.在地震的紧急预报中,超低频(ULF)地磁的方法是最有前途的方法之一.本文将一种主要分量分析的新方法应用在了与2000年日本伊豆诸岛震群有关的ULF地磁资料的研究中.这次震群活动始于2000年6月26日,同年9月结束.在这次地震活动中,观测到5次震级超过6级的大地震(分别发生在7月1日、8日、15日、30日和8月18日).在此期间,我们的超低频地磁观测站幸运地记录下了数据,其中有三个观测站相距很近(大约5 km的距离),距地震中心大约80~100 km.因为我们可以在正交分解的基础上,用主要分量分析法将一些噪声分辨出来,所以我们把主要分量分析法用在了超低频地磁水平方向的NS分量中.我们研究了主要分量分析法结果中本征值和本征矢量的临时变化,这些结果总结如下.第一主要分量是源于日地交互作用影响的信号,如:地磁脉动.第一主要分量的本征矢量的变化说明这种信号在整个分析过程中非常稳定.第二主要分量中混有当地的人为的噪音.而最小的第三分量出现在伊豆半岛当地的子夜,在大地震前几天,第三本征值明显地增加.大约在震群活动开始前三个月,第三本征值的水平有微小增强.相应地,在信号的子空间中本征矢量方向的模式同时改变,在震群活动后又恢复到了其原来的水平.这些特征可能与大地震有关.最后我们强调主要分量分析的方法是目前监测地壳活动最有前途的方法. | Katsumi Hattori Aya Serita Kaoru Gotoh Chie Yoshino Makoto Harada Nobuhiro Isezaki Masashi Hayakawa 辛长江 | 2005 | 国际地震动态2005，，11： | 4 |
| 5 | 超声波在纺织品水溶液洗涤中的应用显示文摘本论文探讨了超声波作为机械去污应用在纺织品的清洗。本实验将被炭黑或油酸污染的涤纶布(后面文章中称之为脏织物)与没有被污染的涤纶布(后面文章中称之为原织物)在有碱或者表面活性剂的水溶液中和没有碱或者表面活性剂的水溶液中一起用超声波、震荡和搅拌等三种去污方式来洗涤。三种去污方式的清洁度和污垢再沉积的现象用脏织物和原织物的表面折射率的变化来进行评价。实验发现超声波和震荡、搅拌相比能在较短的时间内和较低的浴比下有效地去除颗粒和油污。随着超声功率的增加,超声波去污的效果更好,超过了常用的Wascator洗衣机(一种横轴滚筒式洗衣机)。实验中还使用三种标准织物确定洗涤中机械作用对织物造成的损伤大小,结果显示超声波对织物几乎没有造成损伤。然而,超声波清洗中污垢再沉积的现象经常被观察到,尤其是在低浴比条件下。 | Keiko Gotoh KokoroHarayama 杨杰 | 2013 | 中国洗涤用品工业2013，，7： | 4 |
| 6 | Preoperative Gemcitabine-Based Chemoradiation Therapy for Resectable and Borderline Resectable Pancreatic Cancer显示文摘 | Hidenori Takahashi Hiroaki Ohigashi Kunihito Gotoh Shigeru Marubashi Terumasa Yamada Masayuki Murata Tatsuya Ioka Hiroyuki Uehara Masahiko Yano Osamu Ishikawa | 2013 | Annals of Surgery2013，，6： | 3 |
| 7 | characteristics of intestinal pseudo-obstruction in patients with mitochondrial diseases显示文摘AIM: To reveal the frequency, characteristics and prognosis of chronic intestinal pseudo-obstruction (CIP) in mitochondrial disease patients. METHODS: Between January 2000 and December 2010, 31 patients (13 males and 18 females) were di-agnosed with mitochondrial diseases at our hospital. We conducted a retrospective review of the patients' sex, subclass of mitochondrial disease, age at onset of mitochondrial disease, frequency of CIP and the age at its onset, and the duration of survival. The age at onset or at the first diagnosis of the disorder that led to the clinical suspicion of mitochondrial disease was also examined. RESULTS: Twenty patients were sub-classified with mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS), 8 with chronic progressive external ophthalmoplegia (CPEO), and 3 with myoclonus epilepsy associated with ragged-red fibers (MERRF). Nine patients were diagnosed with CIP, 8 of the 20 (40.0%) patients with MELAS, 0 of the 8 (0.0%) patients with CPEO, and 1 of the 3 (33.3%) patients with MERRF. The median age (range) at the diagnosis and the median age at onset of mitochondrial disease were 40 (17-69) and 25 (12-63) years in patients with CIP, and 49 (17-81) and 40 (11-71) years in patients without CIP. During the survey period, 5 patients (4 patients with MELAS and 1 with CPEO) died. The cause of death was cardiomyopathy in 2 patients with MELAS, cerebral infarction in 1 patient with MELAS, epilepsy and aspiration pneumonia in 1 patient with MELAS, and multiple metastases from gastric cancer and aspiration pneumonia in 1 patient with CPEO. CONCLUSION: Patients with CIP tend to have disorders that are suspected to be related to mitochondrial diseases at younger ages than are patients without CIP. | Yusuke Sekino Masahiko Inamori Eiji Yamada Hidenori Ohkubo Eiji Sakai Takuma Higurashi Hiroshi Iida Kunihiro Hosono Hiroki Endo Takashi Nonaka Hirokazu Takahashi Tomoko Koide Yasunobu Abe Eiji Gotoh Shigeru Koyano Yoshiyuki Kuroiwa Shin Maeda Atsushi Nakajima | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 8 | Efficacy and adverse events of cold vs hot polypectomy: A meta-analysis显示文摘AIM: To compare previously reported randomized controlled studies(RCTs) of cold and hot polypectomy, we systematically reviewed and clarify the utility of cold polypectomy over hot with respect to efficacy and adverse events.METHODS: A meta-analysis was conducted to evaluate the predominance of cold and hot polypectomy for removing colon polyps. Published articles and abstracts from worldwide conferences were searched using the keywords 'cold polypectomy'. RCTs that compared either or both the effects or adverse events of cold polypectomy with those of hot polypectomy were collected. The patients' demographics, endoscopic procedures, No. of examined lesions, lesion size, macroscopic and histologic findings, rates of incomplete resection, bleeding amount, perforation, and length of procedure were extracted from each study. A forest plot analysis was used to verify the relative strength of the effects and adverse events of each procedure. A funnel plot was generated to assess the possibility of publication bias.RESULTS: Ultimately, six RCTs were selected. No significant differences were noted in the average lesion size(less than 10 mm) between the cold and hot polypectomy groups in each study. Further, the rates of complete resection and adverse events, including delayed bleeding, did not differ markedly between cold and hot polypectomy. The average procedural time in the cold polypectomy group was significantly shorter than in the hot polypectomy group.CONCLUSION: Cold polypectomy is a time-saving procedure for removing small polyps with markedly similar curability and safety to hot polypectomy. | Mikihiro Fujiya Hiroki Sato Nobuhiro Ueno Aki Sakatani Kazuyuki Tanaka Tatsuya Dokoshi Shugo Fujibayashi Yoshiki Nomura Shin Kashima Takuma Gotoh Junpei Sasajima Kentaro Moriichi Jiro Watari Yutaka Kohgo | 2016 | World Journal of Gastroenterology2016，22，23： | 3 |
| 9 | Cobalt(Ⅲ) Complex [CoL3] Derived from an Asymmetric Bidentate Schiff Base Ligand L (L=(5-Bromo-2- hydroxybenzyl-2-furylmethyl)-imine): Synthesis, Characterization and Crystal Structure显示文摘 | Khalaji, Aliakbar D. Maghsodlou Rad, Sepideh Grivani, Gholamhossein Rezaei, Morteza Gotoh, Kazuma Ishida, Hiroyuki | 2011 | Chinese Journal of Chemistry2011，29，8： | 3 |
| 10 | Effect of Microstructure of Cementite on Interphase Stress State in Carbon Steel显示文摘The experiments related to stress states of ferrite and cementite in carbon steels were carried out including in situ four-point bending and tensile test by X-ray diffraction technique.Stresses in the cementite phase can be measured by conventional X-ray diffraction instrument after a specific treatment on the specimen surface.In order to estimate the stress states in two phases,the X-ray elastic constants of two phases in single-phase state(PXEC)are determined by the experimental X-ray elastic constants of them in composite state(CXEC).The effects of volume fraction and particle size of spheroidal cementite on the interphase stress state are estimated.The experimental results are in good agreement with the theoretical relationships reported in the previous studies. | CHE Lei GOTOH Masahide HORIMOTO Yoshiaki HIROSE Yukio | 2007 | Journal of Iron and Steel Research(International)2007，14，4： | 3 |
| 11 | Development of High Temperature Materials Including CMCs for Space Application显示文摘 | Imuta M. Gotoh J | 1999 | Key Engineering Materials1999，，164： | 2 |
| 12 | Successful embolization assisted by covered stents for a pseudoaneurysm following pancreatic surgery显示文摘Delayed intra-abdominal hemorrhage after pancreatic surgery is a potentially lethal complication.Transarterial coil embolization and/or the placing of an endovascular stent are minimally invasive and effective procedures.An artery that is extensively eroded and rendered friable due to operative skeletonization or postoperative inflammation sometimes contributes to delayed intra-abdominal hemorrhage or rebleeding after coil embolization.This report presents a case of successful management of postoperative hemorrhage in a-74-year-old Japanese male.He experienced bleeding from a pseudoaneurysm of the brittle hepatic artery following total pancreatectomy.Initially the pseudoaneurysm was successfully treated with covered coronary stent-grafts,but rebleeding occurred 1 mo later due to the brittleness of the artery.Rebleeding was definitively managed by the complete packing of the stent by coil embolization.He remains stable at 18 mo following the f inal embolization.A stent graft can be used for protecting a brittle artery to avoid injury by coil embolization. | Koji Tanaka Hiroaki Ohigashi Hidenori Takahashi Kunihito Gotoh Terumasa Yamada Isao Miyashiro Masahiko Yano Osamu Ishikawa | 2010 | World Journal of Gastrointestinal Surgery2010，2，9： | 2 |
| 13 | Newsvendor solutions via conditional value-at-risk minimization显示文摘 | Jun-ya Gotoh Yuichi Takano | 2006 | European Journal of Operational Research2006，，1： | 2 |
| 14 | A study of high-rate shearing of commercially pure aluminum sheet显示文摘 | Gotoh Manabu Yamashita | 2001 | Journal of Materials Processing Technology2001，110，3： | 2 |
| 15 | Hepatocellular carcinoma arising from non-cirrhotic nonalcoholic steatohepatitis显示文摘 | Natsuko Kawada Kazuho Imanaka Tsukasa Kawaguchi Chie Tamai Ryu Ishihara Takashi Matsunaga Kunihito Gotoh Terumasa Yamada Yasuhiko Tomita | 2009 | Journal of Gastroenterology2009，，12： | 2 |
| 16 | A Pancreaticoduodenectomy Risk Model Derived From 8575 Cases From a National Single-Race Population (Japanese) Using a Web-Based Data Entry System: The 30-Day and In-hospital Mortality Rates for Pancreaticoduodenectomy显示文摘 | Wataru Kimura Hiroaki Miyata Mitsukazu Gotoh Ichiro Hirai Akira Kenjo Yuko Kitagawa Mitsuo Shimada Hideo Baba Naohiro Tomita Tohru Nakagoe Kenichi Sugihara Masaki Mori | 2014 | Annals of Surgery2014，，4： | 2 |
| 17 | Shearing strength of steel fiber reinforced concrete显示文摘 | KOHNO K HORII K YUKITOMO K GOTOH Y | 1983 | Transactions of the Japan Concrete Institute1983，5，4： | 2 |
| 18 | Pathogenesis of portal hyportensive gastropathy:a clinical and experimental review显示文摘 | Ohta M Yanmaguehi S Gotoh N | 2002 | Surgery2002，131，1： | 1 |
| 19 | Newsvendor solutions via conditional value-at-risk minimization显示文摘 | Gotoh J Takano Y | 2007 | European J Oper Res2007，179，1： | 1 |
| 20 | 显示文摘 | Gotoh Y Umemoto H | 1993 | J Appl Poly Sci: Appl Polym Sym1993，52，： | 1 |
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