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| 1 | Usefulness of noninvasive transient elastography for assessment of liver fibrosis stage in chronic hepatitis C显示文摘AIM:To evaluate the method of noninvasive transient elastography for assessment of histological stage of liver fibrosis in patients with chronic hepatitis C (CHC). METHODS: Two hundred and thirty-seven patients with CHC were included in this study. Liver biopsy was performed under ultrasonography on 217 of the patients, excluding twenty with clear clinical evidence of liver cirrhosis. Fifty subjects without liver disease were enrolled as a control group (stage 0). Twenty- five patients with sustained virological response (SVR) to interferon (IFN) therapy were also enrolled. These patients underwent liver biopsy before IFN therapy. Examination of liver stiffness (LS) was performed by elastography. RESULTS: Medians (50% levels) of LS were 4.1 (3.5-4.9), 6.3 (4.8-8.5), 8.8 (6.8-12.0), 14.6 (10.5-18.6), and 22.2 (15.4-28.0), respectively, in the fibrosis stages 0-4 (P < 0.001). LS was significantly correlated with four serum fibrosis markers. LS values in patients with SVR were 3.8 (3.5-5.6), 5.2 (4.4-6.8), 6.8 (6.1-7.6), and 6.1 (3.6-7.9), respectively, in the fibrosis stages 1-4. In all stages, LS for patients with SVR was significantly lower than that for patients who did not undergo IFN therapy. LS was significantly correlated with serum concentrations of hyaluronic acid, type Ⅳ collagen, type Ⅳ collagen 7S, and type Ⅲ procollagen N peptide. CONCLUSION: LS correlated well with the histologicalstage of fibrosis. Changes in liver fibrosis stage may thus be estimated noninvasively using transient elastography. | Tadashi Takeda Takahiro Yasuda Yuji Nakayama Mika Nakaya Megumi Kimura Mariko Yamashita Ayumi Sawada Koji Abo Setsuko Takeda Hiroki Sakaguchi Susumu Shiomi Hitoshi Asai Shuichi Seki | 2006 | World Journal of Gastroenterology2006，12，48： | 16 |
| 2 | Potato Responds to Salt Stress by Increased Activity of Antioxidant Enzymes显示文摘To understand the response of potato to salt stress, antioxidant enzyme activities and ion content were analyzed for a sensitive and a tolerant cultivar. Nodal cuttings of the tolerant cultivar, Kennebec, and the sensitive cultivar, Concord, were exposed to media without or with 30, 60, 90 or 120 mmol/L NaCl for 4 weeks. On exposure to NaCl, the length and fresh and dry weight of both shoots and roots of Concord showed greater decrease than those of Kennebec. The decrease in shoot growth was more severe than that of the root for both cultivars. The K+ content of shoots and roots of both cultivars was reduced in a dose-dependent manner by exposure to NaCl; the Na+ content increased. Activities of ascorbate peroxidase, catalase and glutathione reductase were increased in NaCl-exposed shoots of Kennebec; the corresponding activities in NaCl-exposed shoots of Concord were decreased. Roots of both cultivars showed similar changes in the activities of these enzymes on exposure to NaCl. These studies established that enzyme activities in Concord shoots are inversely related to the NaCl concentration, whereas those in Kennebec do not show a dose dependency, which is also the case for the roots of both cultivars. Our findings suggest that an increase in activity of antioxidant enzymes, such as ascorbate peroxidase, catalase and glutathione reductase, can contribute to salt tolerance in Kennebec, a salt resistant cultivar of potato. | Keyvan Aghaei Ali Akber Ehsanpour Setsuko Komatsu | 2009 | Journal of Integrative Plant Biology2009，51，12： | 10 |
| 3 | PROTEOME ANALYSIS OF RICE ROOT PROTEINS REGULATED BY GIBBERELLIN显示文摘To gain an enhanced understanding of the mechanism by which gibberellins (GAs) regulate the growth and development of plants, it is necessary to identify proteins regulated by GA. Proteome analysis techniques have been applied as a direct, e?ective, and reliable tool in di?erential protein expressions. In previous studies, sixteen proteins showed di?erences in accumulation levels as a result of treatment with GA3, uniconazole, or abscisic acid (ABA), and/or the di?erences between the GA-deficient semi-dwarf mutant, Tan-ginbozu, and normal cultivars. Among these proteins, aldolase increased in roots treated with GA3, was present at low levels in Tan-ginbozu roots, and decreased in roots treated with uniconazole or ABA. In a root elongation assay, the growth of aldolase-antisense transgenic rice was half of that of vector control transgenic rice. These results indicate that increases in aldolase activity stimulate the glycolytic pathway and may play an important role in the GA-induced growth of roots. In this review, we discuss the relationship among GA, aldolase, and root growth. | SETSUKO KOMATSU HIROSATO KONISHI | 2005 | Genomics, Proteomics & Bioinformatics2005，3，3： | 9 |
| 4 | Functional Characterization of Gibberellin-Regulated Genes in Rice Using Microarray System显示文摘Gibberellin (GA) is collectively referred to a group of diterpenoid acids, some of which act as plant hormones and are essential for normal plant growth and de- velopment. DNA microarray technology has become the standard tool for the parallel quantification of large numbers of messenger RNA transcripts. The power of this approach has been demonstrated in dissecting plant physiology and develop- ment, and in unraveling the underlying cellular signaling pathways. To understand the molecular mechanism by which GA regulates the growth and development of plants, with reference to the monocot model plant—rice, it is essential to identify and analyze more genes and their products at the transcription and translation levels that are regulated by GA. With the availability of draft sequences of two major rice types, indica and japonica rice, it has become possible to analyze global expression profiles of genes on a genome scale. In this review, the progress made in finding new genes in rice leaf sheath using microarray system and their char- acterization is discussed. It is believed that the findings made in this regard have important implications for understanding the mechanism by which GA regulates the growth and development of rice. | Asad Jan Setsuko Komatsu | 2006 | Genomics, Proteomics & Bioinformatics2006，4，3： | 3 |
| 5 | Motivation and gender in the Japanese EFL classroom显示文摘 | Setsuko Mori Peter Gobel | 2006 | System2006，，2： | 2 |
| 6 | Role of diet and nutrition in inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs)are closely linked to nutrition.The latest research indicates that diet and nutrition are significantly involved in the etiopathogenesis of the disease,although their specific role throughout its clinical course still remains unclear.This study reviewed how diet and nutrition are associated with IBD development and management.Even though specific diets have been shown to bring about positive outcomes,there is currently no scientific consensus regarding an appropriate diet that would benefit all IBD patients.We suggest that individualized dietary recommendations are of the greatest importance and that diets should be planned to provide individual IBD patients with specific nutrient requirements while keeping all the clinical aspects of the patients in mind.Further research is clearly necessary to investigate nutritional factors involved in IBD development and,especially,to evaluate the applications of the diets during the course of the disease. | Marina Moreira de Castro Lívia Bitencourt Pascoal Karine Mariane Steigleder Beatriz Piatezzi Siqueira Ligiana Pires Corona Maria de Lourdes Setsuko Ayrizono Marciane Milanski Raquel Franco Leal | 2021 | World Journal of Experimental Medicine2021，11，1： | 2 |
| 7 | Lack of Cholecystokinin-A Receptor Enhanced Gallstone Formation: A Study in CCK-A Receptor Gene Knockout Mice显示文摘 | Norikazu Sato Kyoko Miyasaka Shinji Suzuki Setsuko Kanai Minoru Ohta Takako Kawanami Yuki Yoshida Soichi Takiguchi Tetsuo Noda Yutaka Takata Akihiro Funakoshi | 2003 | Digestive Diseases and Sciences2003，，10： | 2 |
| 8 | Facile synthesis of p-tert-butylthia-calixarene by the reaction of p-tert-butylphenol with elemental sulfur in the presence of a base显示文摘 | Mitsuharu Hasegawa Setsuko Miyanari | 1997 | Tetrahedron Lett1997，38，22： | 1 |
| 9 | Determination of glycinin and P-conglycinin in soybean proteins by immunological methods显示文摘 | Setsuko D Fumio Y | 1987 | J Agric Food Chem1987，35，： | 1 |
| 10 | Survival rates of patients with choriocarcinoma treated with chemotherapy without hysterectomy: effects of anticancer agents on subsequent births显示文摘 | Setsuko Goto Kazuhiko Ino Takashi Mitsui Fumitaka Kikkawa Takanobu Suzuki Seiji Nomura Shigehiko Mizutani | 2004 | Gynecologic Oncology2004，，2： | 1 |
| 11 | Formation of intermediate conjugates in the reductive transformation of gonyautoxins to saxitoxins by thiol compounds 显示文摘 | Setsuko S Shigeru S Takehiko O | 2000 | Fisheries Science2000，66，1： | 1 |
| 12 | Validation of an HPLC analytical method coupled to a multifunctional clean-up column for the determination of deoxynivalenol显示文摘 | YOSHIKO S K TOSHITSUGU T SETSUKO T | 2006 | Mycopathologia2006，161，： | 1 |
| 13 | Determination of glycinin and β-conglycinin in soybean protein by immunological methods显示文摘 | Iwabuchi Setsuko Yamauchi Fumio | 1987 | Journal of Agricultural and Food Chemistry1987，35，： | 1 |
| 14 | Determination of glycinin and beta-conglycinin in soybean proteins by immunological methods显示文摘 | SETSUKO I FUMIO Y | 1987 | Agricultural and Food Chemistry1987，35，2： | 1 |
| 15 | Electrophoresis analyses of whey proteins in soybean globulin fractions 显示文摘 | Setsuko Iwabuchi Fumio Yamauchi | 1987 | Journal of Agricultural and Food Chemistry1987，35，2： | 1 |
| 16 | Determination of glycinin and β-conglycinin in soybean proteins by immunmological methods显示文摘 | SETSUKO I FUMIO Y | 1987 | J Agdc Food Chem1987，35，2： | 1 |
| 17 | Molecular cloning and characterization of calreticulin, a calcium binding protein involved in the regenera tion of rice cultured suspension cells 显示文摘 | Zhi jun Li Setsuko Komatsu | 2000 | EurJ Biochem2000，267，： | 1 |
| 18 | Adenovirus-mediated transfer of p53-related genes induces apoptosis of human cancer cells显示文摘 | Setsuko I Toshiharu Y Uichiro N | 2000 | Jan J Cancer Res2000，91，2： | 1 |
| 19 | Val- idation of an HPLC analytical method coupled to a multi- functional clean-up column for the determination of de- oxynivalenol 显示文摘 | YOSHIKO S K TOSHITSUGU T SETSUKO T | 2006 | Mycopathologia2006，161，4： | 1 |
| 20 | Electrophoresis analysos of whey proteins present in soybean globulin fractions显示文摘 | Setsuko lwabuchi Fumio Yamauchi | 1987 | J Agic Food Chem1987，35，2： | 1 |
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